Rapid Idiosyncratic Mechanisms of Clinical Resistance to KRAS G12C Inhibition

Using deep RNA and whole exome sequencing of pre- and post-treatment autopsy samples, we reveal diverse clonal populations that occurred through altered cell intrinsic, tumor microenvironment and immunologic remodeling mechanisms of resistance.

• Type: Case Set
• Archiver: The database of Genotypes and Phenotypes (dbGaP)