HeartShare - Extant Datasets - Harmonized Clinical Trials Collection
Heart failure with preserved ejection fraction (HFpEF) prevalence is rising with an aging population and contributing comorbidities, such as obesity and diabetes. The Get With The Guidelines - Heart Failure (GWTG-HF) study showed that the proportion of hospitalized HFpEF patients rose from 2005 to 2010, and this trajectory continued to increase through 2020. HFpEF patients have a poor 5-year outcome with a 75% mortality rate. Taken together, these data suggest that HFpEF may be the dominant HF subtype in the future, affecting approximately 1 in 10 adults during their lifetime.
In addition to its increasing prevalence, HFpEF is a heterogeneous syndrome with multiple pathophysiological processes and varied clinical presentations. There is an urgent need to improve understanding of different HFpEF phenotypes to match patients with interventions based on their unique subtype. Phenomapping studies have identified between two and six HFpEF clusters/phenogroups with shared features. Of these, three overlapping phenotypes repeatedly arise: an 'older, vascular aging' phenotype, 'metabolic, obese' phenotype, and 'relatively younger, natriuretic peptide (NP) deficiency' phenotype. Continued refinement of these HFpEF subtypes is needed to identify distinct characteristics and underlying biologic and molecular mechanisms towards therapeutic development and future precision trials with improved diagnostic criteria and treatment including prevention.
The HeartShare extant datasets collection consists of selected completed trials on HFpEF which have been harmonized for the purpose identifying and defining subtypes. The goal is to identify HFpEF subtypes that have a common pathophysiology. Through the HeartShare extant datasets collection, users can request access to both the harmonized data and the individual trial datasets.
To request access to this study collection, select phs003989 in the dbGaP when submitting a data access request.
The following clinical trials and harmonized data is available through this collection:
| Study Name | Handle | Accession | Consent Groups |
| Surgical Treatment for Ischemic Heart Failure | BioLINCC_STICH | phs003493.v1.p1 | GRU |
| Heart Failure Network Aldosterone Targeted Neurohormonal Combined with Natriuresis Therapy | BioLINCC_HFN_ATHENA | phs003506.v1.p1 | GRU |
| Heart Failure Network - Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome | BioLINCC_HFN_CARRESS | phs003510.v1.p1 | GRU |
| Heart Failure Network: Diuretic Optimization Strategies Evaluation in Acute Heart Failure | BioLINCC_HFN_DOSE | phs003524.v1.p1 | GRU |
| Heart Failure Network - Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients | BioLINCC_EXACT_HF | phs003533.v1.p1 | GRU |
| Heart Failure Network: Functional Impact of GLP-1 for Heart Failure Treatment | BioLINCC_HFN_FIGHT | phs003542.v1.p1 | GRU |
| Heart Failure Network - Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction | BioLINCC_HFN_NEAT | phs003548.v1.p1 | GRU |
| Heart Failure Network - Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure | BioLINCC_HFN_RELAX | phs003565.v1.p1 | GRU |
| Heart Failure Network - Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea | BioLINCC_HFN_ROSE | phs003589.v1.p1 | GRU |
| Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training | BioLINCC_HF_ACTION | phs003599.v1.p1 | HMB |
| Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training | BioLINCC_HF_ACTION | phs003599.v1.p1 | HMB-NPU |
| Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure | BioLINCC_GUIDE_IT | phs003621.v1.p1 | GRU |
| Sudden Cardiac Death in Heart Failure Trial | BioLINCC_SCD_HeFT | phs003654.v1.p1 | GRU |
| Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist | BioLINCC_TOPCAT | phs003665.v1.p1 | HMB-MDS |
| Heart Failure Network - Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF | BioLINCC_HFN_INDIE | phs003667.v1.p1 | GRU |
| Studies of Left Ventricular Dysfunction | BioLINCC_SOLVD | phs003668.v1.p1 | GRU |
| Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness | BioLINCC_ESCAPE | phs003782.v1.p1 | GRU |
- Type: Clinical Trial
- Archiver: The database of Genotypes and Phenotypes (dbGaP)