B Cell Lymphocytosis and Reprogramming due to a CARD11 Bi-Allelic Gain-of-Function Mutation

This is a single-cell RNA sequencing (scRNA-seq) study using peripheral blood mononuclear cells (PBMC) from 2 healthy donors and 2 patients with B cell Expansion with NF-κB and T cell Anergy (BENTA). Samples were not hashed or multiplexed. The 10X Genomics Platform was used for sequencing. Principal findings include transcriptome changes due to mono- or bi-allelic mutations in the gene CARD11. FASTA files will be available through dbGaP.

• Type: Case-Control
• Archiver: The database of Genotypes and Phenotypes (dbGaP)