The Adhesion GPCR ADGRL2 Engages Galpha13 to Enable Epidermal Differentiation

We sought to determine the role of ADGRL2 in epidermal homeostasis. Primary neonatal foreskin keratinocytes were obtained from discarded surgical samples at a California hospital. Samples were anonymous and not selected. ADGRL2, working through GNA13, was found to promote epidermal differentiation through the ADGRL2 intracellular loop 3 (ICL3) loop, using the methods of RNA-seq and Perturb-seq.

• Type: RNA Sequencing
• Archiver: The database of Genotypes and Phenotypes (dbGaP)