Need Help?

Deep whole genome ctDNA chronology of treatment-resistant prostate cancer

Circulating tumor DNA (ctDNA) in blood plasma is an emerging tool for clinical cancer genotyping and longitudinal disease monitoring. We performed deep whole-genome sequencing of serial plasma and synchronous metastases in patients with aggressive prostate cancer. We comprehensively assess all classes of genomic alterations and demonstrate that ctDNA harbors multiple dominant populations whose evolutionary histories frequently indicate whole-genome doubling and shifts in mutational processes. Although tissue and ctDNA showed concordant clonally-expanded cancer driver alterations, each individual metastasis contributed only a minor share of total ctDNA. By comparing serial ctDNA before and after clinical progression on potent androgen receptor (AR) pathway inhibitors, we reveal population restructuring converging solely on AR augmentation as the dominant genomic driver of acquired treatment-resistance. Finally we leverage nucleosome footprints in ctDNA to infer mRNA abundance in synchronously biopsied metastases, including treatment-induced changes in AR pathway transcriptional activity.

Request Access

Data Access Policy for the DNA sequencing data generated in the study "Somatic chronology of treatment-resistant prostate cancer via deep whole-genome ctDNA sequencing"

The following data access agreement (DAA) must be filled out by the requester, to be granted access to the data: https://docs.google.com/forms/d/e/1FAIpQLScy4KzxU8JA_3gU3hmHgZYE7mVgvBKYmpZkwBB0vASA9zqAQQ/viewform?usp=sf_link

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005783 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005761909 fq.gz 227.4 GB
EGAF00005761910 fq.gz 240.1 GB
EGAF00005761911 fq.gz 242.0 GB
EGAF00005761912 fq.gz 269.6 GB
EGAF00005761913 fq.gz 29.7 GB
EGAF00005761914 fq.gz 31.0 GB
EGAF00005761915 fq.gz 222.2 GB
EGAF00005761916 fq.gz 245.0 GB
EGAF00005761917 fq.gz 212.6 GB
EGAF00005761918 fq.gz 231.4 GB
EGAF00005761919 fq.gz 213.9 GB
EGAF00005761920 fq.gz 234.6 GB
EGAF00005761921 fq.gz 183.3 GB
EGAF00005761922 fq.gz 203.1 GB
EGAF00005761923 fq.gz 192.9 GB
EGAF00005761924 fq.gz 211.1 GB
EGAF00005761925 fq.gz 33.0 GB
EGAF00005761926 fq.gz 34.9 GB
EGAF00005761927 fq.gz 169.5 GB
EGAF00005761928 fq.gz 186.3 GB
EGAF00005761929 fq.gz 34.7 GB
EGAF00005761930 fq.gz 37.7 GB
EGAF00005761931 fq.gz 228.7 GB
EGAF00005761932 fq.gz 232.3 GB
EGAF00005761933 fq.gz 32.7 GB
EGAF00005761934 fq.gz 34.5 GB
EGAF00005761935 fq.gz 204.8 GB
EGAF00005761936 fq.gz 205.1 GB
EGAF00005761937 fq.gz 212.7 GB
EGAF00005761938 fq.gz 220.4 GB
EGAF00005761939 fq.gz 34.8 GB
EGAF00005761940 fq.gz 36.7 GB
EGAF00005761941 fq.gz 161.6 GB
EGAF00005761942 fq.gz 159.5 GB
EGAF00005761943 fq.gz 34.8 GB
EGAF00005761944 fq.gz 34.0 GB
EGAF00006127311 fq.gz 45.3 GB
EGAF00006127312 fq.gz 46.2 GB
EGAF00006127313 fq.gz 206.0 GB
EGAF00006127314 fq.gz 221.3 GB
EGAF00006127315 fq.gz 213.9 GB
EGAF00006127316 fq.gz 232.7 GB
EGAF00006127317 fq.gz 56.8 GB
EGAF00006127318 fq.gz 59.1 GB
EGAF00006127319 fq.gz 198.3 GB
EGAF00006127320 fq.gz 207.2 GB
EGAF00006127321 fq.gz 203.2 GB
EGAF00006127322 fq.gz 229.5 GB
EGAF00006127323 fq.gz 31.6 GB
EGAF00006127324 fq.gz 31.9 GB
EGAF00006127325 fq.gz 214.6 GB
EGAF00006127326 fq.gz 228.0 GB
EGAF00006127327 fq.gz 57.7 GB
EGAF00006127328 fq.gz 60.2 GB
EGAF00006127329 fq.gz 203.8 GB
EGAF00006127330 fq.gz 215.3 GB
EGAF00006127331 fq.gz 200.6 GB
EGAF00006127332 fq.gz 213.1 GB
EGAF00006127333 fq.gz 211.1 GB
EGAF00006127334 fq.gz 214.5 GB
EGAF00006127335 fq.gz 246.3 GB
EGAF00006127336 fq.gz 268.7 GB
EGAF00006127337 fq.gz 208.0 GB
EGAF00006127338 fq.gz 226.1 GB
EGAF00006127339 fq.gz 239.1 GB
EGAF00006127340 fq.gz 267.9 GB
EGAF00006127341 fq.gz 201.7 GB
EGAF00006127342 fq.gz 223.3 GB
EGAF00006127343 fq.gz 32.2 GB
EGAF00006127344 fq.gz 33.1 GB
EGAF00006127345 fq.gz 33.9 GB
EGAF00006127346 fq.gz 36.2 GB
EGAF00006127347 fq.gz 34.8 GB
EGAF00006127348 fq.gz 37.2 GB
EGAF00006127349 fq.gz 204.3 GB
EGAF00006127350 fq.gz 217.3 GB
EGAF00006127351 fq.gz 40.4 GB
EGAF00006127352 fq.gz 40.1 GB
EGAF00006127353 fq.gz 65.4 GB
EGAF00006127354 fq.gz 64.8 GB
EGAF00006127355 fq.gz 61.4 GB
EGAF00006127356 fq.gz 65.4 GB
EGAF00006127357 fq.gz 203.2 GB
EGAF00006127358 fq.gz 212.8 GB
EGAF00006127359 fq.gz 47.5 GB
EGAF00006127360 fq.gz 48.2 GB
EGAF00006127361 fq.gz 193.9 GB
EGAF00006127362 fq.gz 197.5 GB
EGAF00006127363 fq.gz 233.2 GB
EGAF00006127364 fq.gz 254.4 GB
EGAF00006127365 fq.gz 245.8 GB
EGAF00006127366 fq.gz 271.8 GB
EGAF00006127367 fq.gz 189.4 GB
EGAF00006127368 fq.gz 190.6 GB
EGAF00006127369 fq.gz 49.6 GB
EGAF00006127370 fq.gz 54.5 GB
EGAF00006127371 fq.gz 34.6 GB
EGAF00006127372 fq.gz 35.7 GB
EGAF00006127373 fq.gz 209.9 GB
EGAF00006127374 fq.gz 226.9 GB
EGAF00006144270 fq.gz 189.1 GB
EGAF00006144271 fq.gz 203.6 GB
EGAF00006144272 fq.gz 199.2 GB
EGAF00006144273 fq.gz 213.2 GB
EGAF00006144274 fq.gz 189.0 GB
EGAF00006144275 fq.gz 196.5 GB
EGAF00006144276 fq.gz 185.7 GB
EGAF00006144277 fq.gz 203.6 GB
EGAF00006144278 fq.gz 208.2 GB
EGAF00006144279 fq.gz 221.9 GB
EGAF00006144280 fq.gz 34.8 GB
EGAF00006144281 fq.gz 37.1 GB
EGAF00006144282 fq.gz 204.0 GB
EGAF00006144283 fq.gz 226.5 GB
EGAF00006144284 fq.gz 207.0 GB
EGAF00006144285 fq.gz 221.4 GB
EGAF00006144286 fq.gz 222.0 GB
EGAF00006144287 fq.gz 238.3 GB
EGAF00006144288 fq.gz 33.5 GB
EGAF00006144289 fq.gz 35.2 GB
EGAF00006144290 fq.gz 216.0 GB
EGAF00006144291 fq.gz 233.6 GB
EGAF00006144292 fq.gz 31.3 GB
EGAF00006144293 fq.gz 35.3 GB
EGAF00006144294 fq.gz 198.9 GB
EGAF00006144295 fq.gz 216.2 GB
EGAF00006144296 fq.gz 64.3 GB
EGAF00006144297 fq.gz 72.0 GB
EGAF00006144298 fq.gz 152.0 GB
EGAF00006144299 fq.gz 168.1 GB
EGAF00006144300 fq.gz 169.6 GB
EGAF00006144301 fq.gz 191.8 GB
EGAF00006144302 fq.gz 203.8 GB
EGAF00006144303 fq.gz 220.2 GB
EGAF00006144304 fq.gz 34.2 GB
EGAF00006144305 fq.gz 36.1 GB
EGAF00006144306 fq.gz 61.6 GB
EGAF00006144307 fq.gz 71.5 GB
EGAF00006144308 fq.gz 223.7 GB
EGAF00006144309 fq.gz 244.1 GB
EGAF00006144310 fq.gz 32.6 GB
EGAF00006144311 fq.gz 32.3 GB
EGAF00006144312 fq.gz 210.0 GB
EGAF00006144313 fq.gz 224.6 GB
EGAF00006144314 fq.gz 32.5 GB
EGAF00006144315 fq.gz 34.5 GB
EGAF00006144316 fq.gz 162.8 GB
EGAF00006144317 fq.gz 179.2 GB
EGAF00006144318 fq.gz 155.1 GB
EGAF00006144319 fq.gz 169.5 GB
EGAF00006144320 fq.gz 31.5 GB
EGAF00006144321 fq.gz 35.2 GB
EGAF00006144322 fq.gz 178.6 GB
EGAF00006144323 fq.gz 187.2 GB
EGAF00006144324 fq.gz 34.1 GB
EGAF00006144325 fq.gz 36.0 GB
EGAF00006144326 fq.gz 33.4 GB
EGAF00006144327 fq.gz 36.1 GB
EGAF00006144328 fq.gz 34.7 GB
EGAF00006144329 fq.gz 34.5 GB
EGAF00006144330 fq.gz 170.4 GB
EGAF00006144331 fq.gz 186.8 GB
EGAF00006144332 fq.gz 31.5 GB
EGAF00006144333 fq.gz 34.5 GB
EGAF00006144334 fq.gz 33.7 GB
EGAF00006144335 fq.gz 36.6 GB
EGAF00006144336 fq.gz 33.0 GB
EGAF00006144337 fq.gz 35.2 GB
EGAF00006144342 fq.gz 63.9 GB
EGAF00006144343 fq.gz 69.5 GB
EGAF00006201206 fq.gz 117.5 GB
EGAF00006201207 fq.gz 134.8 GB
EGAF00006201208 fq.gz 65.6 GB
EGAF00006201209 fq.gz 87.1 GB
EGAF00006201210 fq.gz 70.3 GB
EGAF00006201211 fq.gz 99.3 GB
EGAF00006201212 fq.gz 66.7 GB
EGAF00006201213 fq.gz 93.3 GB
EGAF00006201214 fq.gz 62.6 GB
EGAF00006201215 fq.gz 80.6 GB
EGAF00006201216 fq.gz 74.4 GB
EGAF00006201217 fq.gz 98.8 GB
EGAF00006201218 fq.gz 200.4 GB
EGAF00006201219 fq.gz 212.3 GB
EGAF00006201220 fq.gz 61.6 GB
EGAF00006201221 fq.gz 85.3 GB
EGAF00006201222 fq.gz 207.3 GB
EGAF00006201223 fq.gz 207.2 GB
EGAF00006201224 fq.gz 67.5 GB
EGAF00006201225 fq.gz 94.3 GB
EGAF00006201226 fq.gz 220.9 GB
EGAF00006201227 fq.gz 230.2 GB
EGAF00006201228 fq.gz 68.2 GB
EGAF00006201229 fq.gz 89.2 GB
EGAF00006201230 fq.gz 176.9 GB
EGAF00006201231 fq.gz 172.0 GB
EGAF00006201232 fq.gz 67.8 GB
EGAF00006201233 fq.gz 93.7 GB
EGAF00006201234 fq.gz 171.4 GB
EGAF00006201235 fq.gz 189.1 GB
EGAF00006201236 fq.gz 65.7 GB
EGAF00006201237 fq.gz 86.5 GB
EGAF00006201238 fq.gz 229.6 GB
EGAF00006201239 fq.gz 238.0 GB
EGAF00006201240 fq.gz 70.2 GB
EGAF00006201241 fq.gz 94.6 GB
EGAF00006201242 fq.gz 68.6 GB
EGAF00006201243 fq.gz 95.6 GB
EGAF00006201244 fq.gz 66.5 GB
EGAF00006201245 fq.gz 87.3 GB
EGAF00006201246 fq.gz 66.1 GB
EGAF00006201247 fq.gz 87.4 GB
EGAF00006204849 fq.gz 31.4 GB
EGAF00006204850 fq.gz 32.5 GB
EGAF00006204851 fq.gz 30.6 GB
EGAF00006204852 fq.gz 32.1 GB
EGAF00006204853 fq.gz 33.3 GB
EGAF00006204854 fq.gz 37.8 GB
EGAF00006204855 fq.gz 165.4 GB
EGAF00006204856 fq.gz 171.4 GB
EGAF00006204857 fq.gz 162.5 GB
EGAF00006204858 fq.gz 180.0 GB
EGAF00006204859 fq.gz 28.7 GB
EGAF00006204860 fq.gz 33.8 GB
EGAF00006204861 fq.gz 196.7 GB
EGAF00006204862 fq.gz 217.9 GB
EGAF00006204863 fq.gz 30.9 GB
EGAF00006204864 fq.gz 35.3 GB
EGAF00006204865 fq.gz 217.5 GB
EGAF00006204866 fq.gz 235.8 GB
EGAF00006204867 fq.gz 33.3 GB
EGAF00006204868 fq.gz 38.3 GB
EGAF00006204869 fq.gz 212.4 GB
EGAF00006204870 fq.gz 237.2 GB
234 Files (31.3 TB)