Data Access Committee for COLO829 Somatic reference standard for cancer genome sequencing

Dac ID Contact Person Email Access Information
EGAC00001000408 TGEN EGAdata [at] tgen [dot] org

This DAC controls 1 dataset:

Dataset ID Description Technology Samples
EGAD00001002142 Paired PCR-free whole genome sequencing data of a matched metastatic melanoma cell line (COLO829) and normal across three lineages and across separate institutions, with independent library preparations, sequencing, and analysis. The data was generated with mean mapped coverages of 99X for COLO829 and 103X for the paired normal across three institutions. Overall, common events include >35,000 point mutations, 446 small insertion/deletions, and >6,000 genes affected by copy number changes. We present this reference to the community as an initial standard for enabling quantitative evaluation of somatic mutation pipelines across institutions. 24