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DAC to control the access to the RRBS raw data of the glioblastom progression study (GBMatch).

Contact Information

Johannes Hainfellner
johannes.hainfellner@meduniwien.ac.at

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This DAC controls 4 datasets

Dataset ID	Description	Technology	Samples
EGAD00001003427	Genome-wide profiling of DNA methylation levels by RRBS in 349 samples, derived from 112 glioblastoma (IDH wildtype) patients, 13 IDH muated brain tumor patients, and 5 normal brain controls. For each patient samples from at least two and up to six tumor resections are available. For 6 patients multiple regions of each tumor were sampled.	Illumina HiSeq 2000 Illumina HiSeq 3000 Illumina HiSeq 4000	349
EGAD00001004074	Genome-wide profiling of DNA methylation levels by RRBS in 150 glioblastoma tumor samples. Patients were selected to represent the general population of glioblastoma patients based on Austrian Brain Tumor Registry. These DNA methylation profiles were created for the validation of the glioblastoma progression study (GBMatch) and consist of 106 profiles from FFPE samples and 44 profiles from fresh-frozen samples. For the 44 fresh-frozen samples also WGS data (43 genomes) and RNA-seq data (37 transcriptomes) have been produced for validation purposes.	Illumina HiSeq 3000	150
EGAD00001004076	37 transcriptomes derived from fresh-frozen glioblastoma tumor samples. These transcriptomes have been produced for validation purposes and match the corresponding RRBS and WGS profiles in that DNA and RNA was extracted from the same tumor samples.	Illumina HiSeq 3000	37
EGAD00001004077	43 low-coverage genomes derived from fresh-frozen glioblastoma tumor samples. These genomes have been produced for validation purposes and match the corresponding RRBS and RNA-seq profiles in that DNA and RNA was extracted from the same tumor samples.	Illumina HiSeq 3000	43