Stanford Data Access Committee for Breast Cancer Tumor Heterogeneity through Treatment

Dac ID	Contact Person	Email	Access Information
EGAC00001000993	Christina Curtis	cncurtis [at] stanford [dot] edu	No additional information is available

Dataset ID	Description	Technology	Samples
EGAD00001004306	We performed whole-exome sequencing on multiple regions (n=2-3) from four primary untreated breast tumors (n=1 HER2+, n=2 ER+/HER2-, n=1 triple-negative), as well as matched normal. We also performed whole-exome sequencing on one region from the pre-treatment diagnostic core biopsy and multiple regions (n=2-6) from the post-treatment surgical specimen for five HER2+ primary breast tumors, as well as matched normal; all were treated with combination chemotherapy and trastuzumab. Analysis of these specimens allows characterization of breast tumor heterogeneity and clonal evolution.	Illumina HiSeq 2500	42

Dataset ID

Description

Technology

Samples

EGAD00001004306

We performed whole-exome sequencing on multiple regions (n=2-3) from four primary untreated breast tumors (n=1 HER2+, n=2 ER+/HER2-, n=1 triple-negative), as well as matched normal. We also performed whole-exome sequencing on one region from the pre-treatment diagnostic core biopsy and multiple regions (n=2-6) from the post-treatment surgical specimen for five HER2+ primary breast tumors, as well as matched normal; all were treated with combination chemotherapy and trastuzumab. Analysis of these specimens allows characterization of breast tumor heterogeneity and clonal evolution.

Illumina HiSeq 2500

DAC

This DAC controls 1 dataset:

The European Genome-phenome Archive (EGA) is part of the ELIXIR infrastructure.