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Dataset

Primary breast tumor heterogeneity through therapy

Dataset ID Technology Samples
EGAD00001004306 Illumina HiSeq 2500 42

Dataset Description

We performed whole-exome sequencing on multiple regions (n=2-3) from four primary untreated breast tumors (n=1 HER2+, n=2 ER+/HER2-, n=1 triple-negative), as well as matched normal. We also performed whole-exome sequencing on one region from the pre-treatment diagnostic core biopsy and multiple regions (n=2-6) from the post-treatment surgical specimen for five HER2+ primary breast tumors, as well as matched normal; all were treated with combination chemotherapy and trastuzumab. Analysis of these specimens allows characterization of breast tumor heterogeneity and clonal evolution.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

Stanford Data Access Committee for Breast Cancer Tumor Heterogeneity through Treatment
Contact person: Christina Curtis
Email: cncurtis [at] stanford [dot] edu
More details: EGAC00001000993

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