DAC
Transcriptomics of CD8 T cells and Immune Checkpoint Blockade
| Dac ID | Contact Person | Access Information | |
|---|---|---|---|
| EGAC00001001482 | Benjamin Fairfax | benjamin [dot] fairfax [at] oncology [dot] ox [dot] ac [dot] uk | No additional information is available |
This DAC controls 1 dataset:
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001005973 | We are interested in inter-individual variation in transcriptional response to immune checkpoint blockade. We have analysed poly A purified RNA expression from CD8 T cells (297 transcriptomes in total) isolated from metastatic melanoma patients (n=106) prior to and during treatment with either single agent (Pembrolizumab) or combination (Ipilimumab/ Nivolumab) immune checkpoint blockade. We compare expression at different stages of treatment and additionally contrast this with that from healthy controls (n=68). | Illumina HiSeq 4000 | 297 |
