Dataset

RNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controls

Dataset ID Technology Samples
EGAD00001005973 Illumina HiSeq 4000 297

Dataset Description

We are interested in inter-individual variation in transcriptional response to immune checkpoint blockade. We have analysed poly A purified RNA expression from CD8 T cells (297 transcriptomes in total) isolated from metastatic melanoma patients (n=106) prior to and during treatment with either single agent (Pembrolizumab) or combination (Ipilimumab/ Nivolumab) immune checkpoint blockade. We compare expression at different stages of treatment and additionally contrast this with that from healthy controls (n=68).

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

Transcriptomics of CD8 T cells and Immune Checkpoint Blockade
Contact person: Benjamin Fairfax
Email: benjamin [dot] fairfax [at] oncology [dot] ox [dot] ac [dot] uk
More details: EGAC00001001482

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