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RNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controls

We are interested in inter-individual variation in transcriptional response to immune checkpoint blockade. We have analysed poly A purified RNA expression from CD8 T cells (297 transcriptomes in total) isolated from metastatic melanoma patients (n=106) prior to and during treatment with either single agent (Pembrolizumab) or combination (Ipilimumab/ Nivolumab) immune checkpoint blockade. We compare expression at different stages of treatment and additionally contrast this with that from healthy controls (n=68).

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These data correspond to samples used in the paper: Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma, Fairfax et al, 2020, Nature Medicine. They are the raw RNA sequencing files as used in all downstream analysis.

All sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research via a data access agreement. Users will need to complete a standard University of Oxford data transfer agreement which can be provided by either Benjamin Fairfax or Isar Nassiri upon application.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004081 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00003446136 bam 2.0 GB
EGAF00003446137 bam 1.9 GB
EGAF00003446138 bam 2.2 GB
EGAF00003446139 bam 260.2 MB
EGAF00003446140 bam 1.8 GB
EGAF00003446141 bam 1.6 GB
EGAF00003446142 bam 1.6 GB
EGAF00003446143 bam 1.9 GB
EGAF00003446144 bam 2.0 GB
EGAF00003446145 bam 1.9 GB
EGAF00003446146 bam 2.3 GB
EGAF00003446147 bam 1.8 GB
EGAF00003446148 bam 1.2 GB
EGAF00003446149 bam 1.9 GB
EGAF00003446150 bam 982.8 MB
EGAF00003446151 bam 1.6 GB
EGAF00003446152 bam 2.2 GB
EGAF00003446153 bam 2.0 GB
EGAF00003446154 bam 2.0 GB
EGAF00003446155 bam 1.9 GB
EGAF00003446156 bam 1.6 GB
EGAF00003446157 bam 1.8 GB
EGAF00003446158 bam 1.9 GB
EGAF00003446159 bam 2.1 GB
EGAF00003446160 bam 1.7 GB
EGAF00003446161 bam 2.0 GB
EGAF00003446162 bam 1.9 GB
EGAF00003446163 bam 2.0 GB
EGAF00003446164 bam 2.1 GB
EGAF00003446165 bam 1.8 GB
EGAF00003446166 bam 1.6 GB
EGAF00003446167 bam 1.9 GB
EGAF00003446168 bam 2.1 GB
EGAF00003446169 bam 1.9 GB
EGAF00003446170 bam 2.5 GB
EGAF00003446171 bam 2.1 GB
EGAF00003446172 bam 2.0 GB
EGAF00003446173 bam 2.0 GB
EGAF00003446174 bam 1.4 GB
EGAF00003446175 bam 2.2 GB
EGAF00003446176 bam 1.7 GB
EGAF00003446177 bam 1.8 GB
EGAF00003446178 bam 2.0 GB
EGAF00003446179 bam 1.8 GB
EGAF00003446180 bam 1.4 GB
EGAF00003446181 bam 1.8 GB
EGAF00003446182 bam 2.2 GB
EGAF00003446183 bam 1.8 GB
EGAF00003446184 bam 1.1 GB
EGAF00003446185 bam 2.0 GB
EGAF00003446186 bam 1.8 GB
EGAF00003446187 bam 2.1 GB
EGAF00003446188 bam 1.9 GB
EGAF00003446189 bam 1.6 GB
EGAF00003446190 bam 2.2 GB
EGAF00003446191 bam 2.2 GB
EGAF00003446192 bam 1.8 GB
EGAF00003446193 bam 2.1 GB
EGAF00003446194 bam 2.0 GB
EGAF00003446195 bam 2.2 GB
EGAF00003446196 bam 2.2 GB
EGAF00003446197 bam 2.2 GB
EGAF00003446198 bam 2.1 GB
EGAF00003446199 bam 2.0 GB
EGAF00003446200 bam 2.3 GB
EGAF00003446201 bam 2.3 GB
EGAF00003446202 bam 2.2 GB
EGAF00003446203 bam 2.0 GB
EGAF00003446204 bam 2.1 GB
EGAF00003446205 bam 2.1 GB
EGAF00003446206 bam 2.2 GB
EGAF00003446207 bam 2.0 GB
EGAF00003446208 bam 2.1 GB
EGAF00003446209 bam 2.1 GB
EGAF00003446210 bam 2.1 GB
EGAF00003446211 bam 2.0 GB
EGAF00003446212 bam 1.6 GB
EGAF00003446213 bam 1.9 GB
EGAF00003446214 bam 1.9 GB
EGAF00003446215 bam 2.1 GB
EGAF00003446216 bam 2.1 GB
EGAF00003446217 bam 2.2 GB
EGAF00003446218 bam 2.0 GB
EGAF00003446219 bam 2.0 GB
EGAF00003446220 bam 1.7 GB
EGAF00003446221 bam 2.0 GB
EGAF00003446222 bam 2.1 GB
EGAF00003446223 bam 2.2 GB
EGAF00003446224 bam 2.1 GB
EGAF00003446225 bam 2.0 GB
EGAF00003446226 bam 2.1 GB
EGAF00003446227 bam 2.0 GB
EGAF00003446228 bam 2.1 GB
EGAF00003446229 bam 2.3 GB
EGAF00003446230 bam 3.2 GB
EGAF00003446231 bam 2.1 GB
EGAF00003446232 bam 2.1 GB
EGAF00003446233 bam 2.1 GB
EGAF00003446234 bam 1.7 GB
EGAF00003446235 bam 1.0 GB
EGAF00003446236 bam 2.1 GB
EGAF00003446237 bam 1.6 GB
EGAF00003446238 bam 1.7 GB
EGAF00003446239 bam 1.6 GB
EGAF00003446240 bam 2.4 GB
EGAF00003446241 bam 4.0 GB
EGAF00003446242 bam 2.1 GB
EGAF00003446243 bam 2.2 GB
EGAF00003446244 bam 2.2 GB
EGAF00003446245 bam 2.3 GB
EGAF00003446246 bam 2.3 GB
EGAF00003446247 bam 2.2 GB
EGAF00003446248 bam 2.2 GB
EGAF00003446249 bam 2.1 GB
EGAF00003446250 bam 2.1 GB
EGAF00003446251 bam 2.7 GB
EGAF00003446252 bam 1.6 GB
EGAF00003446253 bam 2.5 GB
EGAF00003446254 bam 2.3 GB
EGAF00003446255 bam 2.2 GB
EGAF00003446256 bam 2.3 GB
EGAF00003446257 bam 2.2 GB
EGAF00003446258 bam 2.1 GB
EGAF00003446259 bam 4.2 GB
EGAF00003446260 bam 2.2 GB
EGAF00003446261 bam 2.4 GB
EGAF00003446262 bam 5.2 GB
EGAF00003446263 bam 2.6 GB
EGAF00003446264 bam 2.1 GB
EGAF00003446265 bam 2.5 GB
EGAF00003446266 bam 2.1 GB
EGAF00003446267 bam 1.8 GB
EGAF00003446268 bam 1.9 GB
EGAF00003446269 bam 2.1 GB
EGAF00003446270 bam 2.1 GB
EGAF00003446271 bam 2.3 GB
EGAF00003446272 bam 2.4 GB
EGAF00003446273 bam 4.1 GB
EGAF00003446274 bam 5.1 GB
EGAF00003446275 bam 4.3 GB
EGAF00003446276 bam 1.9 GB
EGAF00003446277 bam 2.0 GB
EGAF00003446278 bam 1.8 GB
EGAF00003446279 bam 2.2 GB
EGAF00003446280 bam 2.3 GB
EGAF00003446281 bam 2.3 GB
EGAF00003446282 bam 2.5 GB
EGAF00003446283 bam 1.8 GB
EGAF00003446284 bam 1.7 GB
EGAF00003446285 bam 1.5 GB
EGAF00003446286 bam 2.2 GB
EGAF00003446287 bam 2.0 GB
EGAF00003446288 bam 2.1 GB
EGAF00003446289 bam 2.2 GB
EGAF00003446290 bam 2.2 GB
EGAF00003446291 bam 1.7 GB
EGAF00003446292 bam 1.9 GB
EGAF00003446293 bam 2.5 GB
EGAF00003446294 bam 2.5 GB
EGAF00003446295 bam 2.1 GB
EGAF00003446296 bam 2.3 GB
EGAF00003446297 bam 2.4 GB
EGAF00003446298 bam 2.3 GB
EGAF00003446299 bam 2.5 GB
EGAF00003446300 bam 1.7 GB
EGAF00003446301 bam 4.2 GB
EGAF00003446302 bam 2.2 GB
EGAF00003446303 bam 4.6 GB
EGAF00003446304 bam 1.9 GB
EGAF00003446305 bam 1.9 GB
EGAF00003446306 bam 3.7 GB
EGAF00003446307 bam 2.0 GB
EGAF00003446308 bam 2.0 GB
EGAF00003446309 bam 4.2 GB
EGAF00003446310 bam 2.3 GB
EGAF00003446311 bam 2.2 GB
EGAF00003446312 bam 4.3 GB
EGAF00003446313 bam 4.3 GB
EGAF00003446314 bam 4.6 GB
EGAF00003446315 bam 2.9 GB
EGAF00003446316 bam 4.5 GB
EGAF00003446317 bam 3.9 GB
EGAF00003446318 bam 4.3 GB
EGAF00003446319 bam 4.1 GB
EGAF00003446320 bam 3.5 GB
EGAF00003446321 bam 4.1 GB
EGAF00003446322 bam 4.5 GB
EGAF00003446323 bam 4.6 GB
EGAF00003446324 bam 4.2 GB
EGAF00003446325 bam 4.6 GB
EGAF00003446326 bam 4.0 GB
EGAF00003446327 bam 4.5 GB
EGAF00003446328 bam 4.3 GB
EGAF00003446329 bam 4.1 GB
EGAF00003446330 bam 4.4 GB
EGAF00003446331 bam 4.7 GB
EGAF00003446332 bam 4.6 GB
EGAF00003446333 bam 4.7 GB
EGAF00003446334 bam 4.7 GB
EGAF00003446335 bam 3.9 GB
EGAF00003446336 bam 4.4 GB
EGAF00003446337 bam 3.3 GB
EGAF00003446338 bam 4.2 GB
EGAF00003446339 bam 4.1 GB
EGAF00003446340 bam 4.2 GB
EGAF00003446341 bam 4.2 GB
EGAF00003446342 bam 5.5 GB
EGAF00003446343 bam 4.9 GB
EGAF00003446344 bam 6.3 GB
EGAF00003446345 bam 4.2 GB
EGAF00003446346 bam 4.5 GB
EGAF00003446347 bam 4.3 GB
EGAF00003446348 bam 4.0 GB
EGAF00003446349 bam 4.6 GB
EGAF00003446350 bam 3.3 GB
EGAF00003446351 bam 4.3 GB
EGAF00003446352 bam 4.2 GB
EGAF00003446353 bam 4.6 GB
EGAF00003446354 bam 4.7 GB
EGAF00003446355 bam 4.9 GB
EGAF00003446356 bam 4.2 GB
EGAF00003446357 bam 4.2 GB
EGAF00003446358 bam 4.2 GB
EGAF00003446359 bam 4.5 GB
EGAF00003446360 bam 4.7 GB
EGAF00003446361 bam 4.5 GB
EGAF00003446362 bam 5.1 GB
EGAF00003446363 bam 4.4 GB
EGAF00003446364 bam 3.9 GB
EGAF00003446365 bam 2.1 GB
EGAF00003446366 bam 1.8 GB
EGAF00003446367 bam 1.9 GB
EGAF00003446368 bam 1.9 GB
EGAF00003446369 bam 1.5 GB
EGAF00003446370 bam 1.9 GB
EGAF00003446371 bam 2.0 GB
EGAF00003446372 bam 2.0 GB
EGAF00003446373 bam 2.4 GB
EGAF00003446374 bam 1.9 GB
EGAF00003446375 bam 2.2 GB
EGAF00003446376 bam 2.1 GB
EGAF00003446377 bam 2.1 GB
EGAF00003446378 bam 2.0 GB
EGAF00003446379 bam 2.1 GB
EGAF00003446380 bam 2.1 GB
EGAF00003446381 bam 4.8 GB
EGAF00003446382 bam 4.1 GB
EGAF00003446383 bam 4.4 GB
EGAF00003446384 bam 4.2 GB
EGAF00003446385 bam 4.1 GB
EGAF00003446386 bam 4.8 GB
EGAF00003446387 bam 4.3 GB
EGAF00003446388 bam 4.3 GB
EGAF00003446389 bam 4.4 GB
EGAF00003446390 bam 4.5 GB
EGAF00003446391 bam 4.6 GB
EGAF00003446392 bam 4.2 GB
EGAF00003446393 bam 1.7 GB
EGAF00003446394 bam 4.0 GB
EGAF00003446395 bam 4.8 GB
EGAF00003446396 bam 4.4 GB
EGAF00003446397 bam 4.5 GB
EGAF00003446398 bam 4.2 GB
EGAF00003446399 bam 4.4 GB
EGAF00003446400 bam 5.9 GB
EGAF00003446401 bam 4.9 GB
EGAF00003446402 bam 4.3 GB
EGAF00003446403 bam 4.8 GB
EGAF00003446404 bam 2.1 GB
EGAF00003446405 bam 4.7 GB
EGAF00003446406 bam 4.0 GB
EGAF00003446407 bam 4.3 GB
EGAF00003446408 bam 4.1 GB
EGAF00003446409 bam 3.8 GB
EGAF00003446410 bam 4.6 GB
EGAF00003446411 bam 4.4 GB
EGAF00003446412 bam 4.2 GB
EGAF00003446413 bam 1.7 GB
EGAF00003446414 bam 1.7 GB
EGAF00003446415 bam 4.5 GB
EGAF00003446416 bam 4.5 GB
EGAF00003446417 bam 2.2 GB
EGAF00003446418 bam 1.9 GB
EGAF00003446419 bam 4.6 GB
EGAF00003446420 bam 1.7 GB
EGAF00003446421 bam 4.2 GB
EGAF00003446422 bam 4.2 GB
EGAF00003446423 bam 1.6 GB
EGAF00003446424 bam 4.1 GB
EGAF00003446425 bam 4.2 GB
EGAF00003446426 bam 4.3 GB
EGAF00003446427 bam 4.5 GB
EGAF00003446428 bam 3.9 GB
EGAF00003446429 bam 4.1 GB
EGAF00003446430 bam 3.8 GB
EGAF00003446431 bam 3.8 GB
EGAF00003446432 bam 4.1 GB
297 Files (846.8 GB)