RNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controls
We are interested in inter-individual variation in transcriptional response to immune checkpoint blockade. We have analysed poly A purified RNA expression from CD8 T cells (297 transcriptomes in total) isolated from metastatic melanoma patients (n=106) prior to and during treatment with either single agent (Pembrolizumab) or combination (Ipilimumab/ Nivolumab) immune checkpoint blockade. We compare expression at different stages of treatment and additionally contrast this with that from healthy controls (n=68).
- 14/02/2020
- 297 samples
- DAC: EGAC00001001482
- Technology: Illumina HiSeq 4000
These data correspond to samples used in the paper: Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma, Fairfax et al, 2020, Nature Medicine. They are the raw RNA sequencing files as used in all downstream analysis.
All sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research via a data access agreement. Users will need to complete a standard University of Oxford data transfer agreement which can be provided by either Benjamin Fairfax or Isar Nassiri upon application.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001004081 | Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
i
|
|---|---|---|---|---|
| EGAF00003446136 | bam | 2.0 GB | Report |
|
| EGAF00003446137 | bam | 1.9 GB | Report |
|
| EGAF00003446138 | bam | 2.2 GB | Report |
|
| EGAF00003446139 | bam | 260.2 MB | Report |
|
| EGAF00003446140 | bam | 1.8 GB | Report |
|
| EGAF00003446141 | bam | 1.6 GB | Report |
|
| EGAF00003446142 | bam | 1.6 GB | Report |
|
| EGAF00003446143 | bam | 1.9 GB | Report |
|
| EGAF00003446144 | bam | 2.0 GB | Report |
|
| EGAF00003446145 | bam | 1.9 GB | Report |
|
| EGAF00003446146 | bam | 2.3 GB | Report |
|
| EGAF00003446147 | bam | 1.8 GB | Report |
|
| EGAF00003446148 | bam | 1.2 GB | Report |
|
| EGAF00003446149 | bam | 1.9 GB | Report |
|
| EGAF00003446150 | bam | 982.8 MB | Report |
|
| EGAF00003446151 | bam | 1.6 GB | Report |
|
| EGAF00003446152 | bam | 2.2 GB | Report |
|
| EGAF00003446153 | bam | 2.0 GB | Report |
|
| EGAF00003446154 | bam | 2.0 GB | Report |
|
| EGAF00003446155 | bam | 1.9 GB | Report |
|
| EGAF00003446156 | bam | 1.6 GB | Report |
|
| EGAF00003446157 | bam | 1.8 GB | Report |
|
| EGAF00003446158 | bam | 1.9 GB | Report |
|
| EGAF00003446159 | bam | 2.1 GB | Report |
|
| EGAF00003446160 | bam | 1.7 GB | Report |
|
| EGAF00003446161 | bam | 2.0 GB | Report |
|
| EGAF00003446162 | bam | 1.9 GB | Report |
|
| EGAF00003446163 | bam | 2.0 GB | Report |
|
| EGAF00003446164 | bam | 2.1 GB | Report |
|
| EGAF00003446165 | bam | 1.8 GB | Report |
|
| EGAF00003446166 | bam | 1.6 GB | Report |
|
| EGAF00003446167 | bam | 1.9 GB | Report |
|
| EGAF00003446168 | bam | 2.1 GB | Report |
|
| EGAF00003446169 | bam | 1.9 GB | Report |
|
| EGAF00003446170 | bam | 2.5 GB | Report |
|
| EGAF00003446171 | bam | 2.1 GB | Report |
|
| EGAF00003446172 | bam | 2.0 GB | Report |
|
| EGAF00003446173 | bam | 2.0 GB | Report |
|
| EGAF00003446174 | bam | 1.4 GB | Report |
|
| EGAF00003446175 | bam | 2.2 GB | Report |
|
| EGAF00003446176 | bam | 1.7 GB | Report |
|
| EGAF00003446177 | bam | 1.8 GB | Report |
|
| EGAF00003446178 | bam | 2.0 GB | Report |
|
| EGAF00003446179 | bam | 1.8 GB | Report |
|
| EGAF00003446180 | bam | 1.4 GB | Report |
|
| EGAF00003446181 | bam | 1.8 GB | Report |
|
| EGAF00003446182 | bam | 2.2 GB | Report |
|
| EGAF00003446183 | bam | 1.8 GB | Report |
|
| EGAF00003446184 | bam | 1.1 GB | Report |
|
| EGAF00003446185 | bam | 2.0 GB | Report |
|
| EGAF00003446186 | bam | 1.8 GB | Report |
|
| EGAF00003446187 | bam | 2.1 GB | Report |
|
| EGAF00003446188 | bam | 1.9 GB | Report |
|
| EGAF00003446189 | bam | 1.6 GB | Report |
|
| EGAF00003446190 | bam | 2.2 GB | Report |
|
| EGAF00003446191 | bam | 2.2 GB | Report |
|
| EGAF00003446192 | bam | 1.8 GB | Report |
|
| EGAF00003446193 | bam | 2.1 GB | Report |
|
| EGAF00003446194 | bam | 2.0 GB | Report |
|
| EGAF00003446195 | bam | 2.2 GB | Report |
|
| EGAF00003446196 | bam | 2.2 GB | Report |
|
| EGAF00003446197 | bam | 2.2 GB | Report |
|
| EGAF00003446198 | bam | 2.1 GB | Report |
|
| EGAF00003446199 | bam | 2.0 GB | Report |
|
| EGAF00003446200 | bam | 2.3 GB | Report |
|
| EGAF00003446201 | bam | 2.3 GB | Report |
|
| EGAF00003446202 | bam | 2.2 GB | Report |
|
| EGAF00003446203 | bam | 2.0 GB | Report |
|
| EGAF00003446204 | bam | 2.1 GB | Report |
|
| EGAF00003446205 | bam | 2.1 GB | Report |
|
| EGAF00003446206 | bam | 2.2 GB | Report |
|
| EGAF00003446207 | bam | 2.0 GB | Report |
|
| EGAF00003446208 | bam | 2.1 GB | Report |
|
| EGAF00003446209 | bam | 2.1 GB | Report |
|
| EGAF00003446210 | bam | 2.1 GB | Report |
|
| EGAF00003446211 | bam | 2.0 GB | Report |
|
| EGAF00003446212 | bam | 1.6 GB | Report |
|
| EGAF00003446213 | bam | 1.9 GB | Report |
|
| EGAF00003446214 | bam | 1.9 GB | Report |
|
| EGAF00003446215 | bam | 2.1 GB | Report |
|
| EGAF00003446216 | bam | 2.1 GB | Report |
|
| EGAF00003446217 | bam | 2.2 GB | Report |
|
| EGAF00003446218 | bam | 2.0 GB | Report |
|
| EGAF00003446219 | bam | 2.0 GB | Report |
|
| EGAF00003446220 | bam | 1.7 GB | Report |
|
| EGAF00003446221 | bam | 2.0 GB | Report |
|
| EGAF00003446222 | bam | 2.1 GB | Report |
|
| EGAF00003446223 | bam | 2.2 GB | Report |
|
| EGAF00003446224 | bam | 2.1 GB | Report |
|
| EGAF00003446225 | bam | 2.0 GB | Report |
|
| EGAF00003446226 | bam | 2.1 GB | Report |
|
| EGAF00003446227 | bam | 2.0 GB | Report |
|
| EGAF00003446228 | bam | 2.1 GB | Report |
|
| EGAF00003446229 | bam | 2.3 GB | Report |
|
| EGAF00003446230 | bam | 3.2 GB | Report |
|
| EGAF00003446231 | bam | 2.1 GB | Report |
|
| EGAF00003446232 | bam | 2.1 GB | Report |
|
| EGAF00003446233 | bam | 2.1 GB | Report |
|
| EGAF00003446234 | bam | 1.7 GB | Report |
|
| EGAF00003446235 | bam | 1.0 GB | Report |
|
| EGAF00003446236 | bam | 2.1 GB | Report |
|
| EGAF00003446237 | bam | 1.6 GB | Report |
|
| EGAF00003446238 | bam | 1.7 GB | Report |
|
| EGAF00003446239 | bam | 1.6 GB | Report |
|
| EGAF00003446240 | bam | 2.4 GB | Report |
|
| EGAF00003446241 | bam | 4.0 GB | Report |
|
| EGAF00003446242 | bam | 2.1 GB | Report |
|
| EGAF00003446243 | bam | 2.2 GB | Report |
|
| EGAF00003446244 | bam | 2.2 GB | Report |
|
| EGAF00003446245 | bam | 2.3 GB | Report |
|
| EGAF00003446246 | bam | 2.3 GB | Report |
|
| EGAF00003446247 | bam | 2.2 GB | Report |
|
| EGAF00003446248 | bam | 2.2 GB | Report |
|
| EGAF00003446249 | bam | 2.1 GB | Report |
|
| EGAF00003446250 | bam | 2.1 GB | Report |
|
| EGAF00003446251 | bam | 2.7 GB | Report |
|
| EGAF00003446252 | bam | 1.6 GB | Report |
|
| EGAF00003446253 | bam | 2.5 GB | Report |
|
| EGAF00003446254 | bam | 2.3 GB | Report |
|
| EGAF00003446255 | bam | 2.2 GB | Report |
|
| EGAF00003446256 | bam | 2.3 GB | Report |
|
| EGAF00003446257 | bam | 2.2 GB | Report |
|
| EGAF00003446258 | bam | 2.1 GB | Report |
|
| EGAF00003446259 | bam | 4.2 GB | Report |
|
| EGAF00003446260 | bam | 2.2 GB | Report |
|
| EGAF00003446261 | bam | 2.4 GB | Report |
|
| EGAF00003446262 | bam | 5.2 GB | Report |
|
| EGAF00003446263 | bam | 2.6 GB | Report |
|
| EGAF00003446264 | bam | 2.1 GB | Report |
|
| EGAF00003446265 | bam | 2.5 GB | Report |
|
| EGAF00003446266 | bam | 2.1 GB | Report |
|
| EGAF00003446267 | bam | 1.8 GB | Report |
|
| EGAF00003446268 | bam | 1.9 GB | Report |
|
| EGAF00003446269 | bam | 2.1 GB | Report |
|
| EGAF00003446270 | bam | 2.1 GB | Report |
|
| EGAF00003446271 | bam | 2.3 GB | Report |
|
| EGAF00003446272 | bam | 2.4 GB | Report |
|
| EGAF00003446273 | bam | 4.1 GB | Report |
|
| EGAF00003446274 | bam | 5.1 GB | Report |
|
| EGAF00003446275 | bam | 4.3 GB | Report |
|
| EGAF00003446276 | bam | 1.9 GB | Report |
|
| EGAF00003446277 | bam | 2.0 GB | Report |
|
| EGAF00003446278 | bam | 1.8 GB | Report |
|
| EGAF00003446279 | bam | 2.2 GB | Report |
|
| EGAF00003446280 | bam | 2.3 GB | Report |
|
| EGAF00003446281 | bam | 2.3 GB | Report |
|
| EGAF00003446282 | bam | 2.5 GB | Report |
|
| EGAF00003446283 | bam | 1.8 GB | Report |
|
| EGAF00003446284 | bam | 1.7 GB | Report |
|
| EGAF00003446285 | bam | 1.5 GB | Report |
|
| EGAF00003446286 | bam | 2.2 GB | Report |
|
| EGAF00003446287 | bam | 2.0 GB | Report |
|
| EGAF00003446288 | bam | 2.1 GB | Report |
|
| EGAF00003446289 | bam | 2.2 GB | Report |
|
| EGAF00003446290 | bam | 2.2 GB | Report |
|
| EGAF00003446291 | bam | 1.7 GB | Report |
|
| EGAF00003446292 | bam | 1.9 GB | Report |
|
| EGAF00003446293 | bam | 2.5 GB | Report |
|
| EGAF00003446294 | bam | 2.5 GB | Report |
|
| EGAF00003446295 | bam | 2.1 GB | Report |
|
| EGAF00003446296 | bam | 2.3 GB | Report |
|
| EGAF00003446297 | bam | 2.4 GB | Report |
|
| EGAF00003446298 | bam | 2.3 GB | Report |
|
| EGAF00003446299 | bam | 2.5 GB | Report |
|
| EGAF00003446300 | bam | 1.7 GB | Report |
|
| EGAF00003446301 | bam | 4.2 GB | Report |
|
| EGAF00003446302 | bam | 2.2 GB | Report |
|
| EGAF00003446303 | bam | 4.6 GB | Report |
|
| EGAF00003446304 | bam | 1.9 GB | Report |
|
| EGAF00003446305 | bam | 1.9 GB | Report |
|
| EGAF00003446306 | bam | 3.7 GB | Report |
|
| EGAF00003446307 | bam | 2.0 GB | Report |
|
| EGAF00003446308 | bam | 2.0 GB | Report |
|
| EGAF00003446309 | bam | 4.2 GB | Report |
|
| EGAF00003446310 | bam | 2.3 GB | Report |
|
| EGAF00003446311 | bam | 2.2 GB | Report |
|
| EGAF00003446312 | bam | 4.3 GB | Report |
|
| EGAF00003446313 | bam | 4.3 GB | Report |
|
| EGAF00003446314 | bam | 4.6 GB | Report |
|
| EGAF00003446315 | bam | 2.9 GB | Report |
|
| EGAF00003446316 | bam | 4.5 GB | Report |
|
| EGAF00003446317 | bam | 3.9 GB | Report |
|
| EGAF00003446318 | bam | 4.3 GB | Report |
|
| EGAF00003446319 | bam | 4.1 GB | Report |
|
| EGAF00003446320 | bam | 3.5 GB | Report |
|
| EGAF00003446321 | bam | 4.1 GB | Report |
|
| EGAF00003446322 | bam | 4.5 GB | Report |
|
| EGAF00003446323 | bam | 4.6 GB | Report |
|
| EGAF00003446324 | bam | 4.2 GB | Report |
|
| EGAF00003446325 | bam | 4.6 GB | Report |
|
| EGAF00003446326 | bam | 4.0 GB | Report |
|
| EGAF00003446327 | bam | 4.5 GB | Report |
|
| EGAF00003446328 | bam | 4.3 GB | Report |
|
| EGAF00003446329 | bam | 4.1 GB | Report |
|
| EGAF00003446330 | bam | 4.4 GB | Report |
|
| EGAF00003446331 | bam | 4.7 GB | Report |
|
| EGAF00003446332 | bam | 4.6 GB | Report |
|
| EGAF00003446333 | bam | 4.7 GB | Report |
|
| EGAF00003446334 | bam | 4.7 GB | Report |
|
| EGAF00003446335 | bam | 3.9 GB | Report |
|
| EGAF00003446336 | bam | 4.4 GB | Report |
|
| EGAF00003446337 | bam | 3.3 GB | Report |
|
| EGAF00003446338 | bam | 4.2 GB | Report |
|
| EGAF00003446339 | bam | 4.1 GB | Report |
|
| EGAF00003446340 | bam | 4.2 GB | Report |
|
| EGAF00003446341 | bam | 4.2 GB | Report |
|
| EGAF00003446342 | bam | 5.5 GB | Report |
|
| EGAF00003446343 | bam | 4.9 GB | Report |
|
| EGAF00003446344 | bam | 6.3 GB | Report |
|
| EGAF00003446345 | bam | 4.2 GB | Report |
|
| EGAF00003446346 | bam | 4.5 GB | Report |
|
| EGAF00003446347 | bam | 4.3 GB | Report |
|
| EGAF00003446348 | bam | 4.0 GB | Report |
|
| EGAF00003446349 | bam | 4.6 GB | Report |
|
| EGAF00003446350 | bam | 3.3 GB | Report |
|
| EGAF00003446351 | bam | 4.3 GB | Report |
|
| EGAF00003446352 | bam | 4.2 GB | Report |
|
| EGAF00003446353 | bam | 4.6 GB | Report |
|
| EGAF00003446354 | bam | 4.7 GB | Report |
|
| EGAF00003446355 | bam | 4.9 GB | Report |
|
| EGAF00003446356 | bam | 4.2 GB | Report |
|
| EGAF00003446357 | bam | 4.2 GB | Report |
|
| EGAF00003446358 | bam | 4.2 GB | Report |
|
| EGAF00003446359 | bam | 4.5 GB | Report |
|
| EGAF00003446360 | bam | 4.7 GB | Report |
|
| EGAF00003446361 | bam | 4.5 GB | Report |
|
| EGAF00003446362 | bam | 5.1 GB | Report |
|
| EGAF00003446363 | bam | 4.4 GB | Report |
|
| EGAF00003446364 | bam | 3.9 GB | Report |
|
| EGAF00003446365 | bam | 2.1 GB | Report |
|
| EGAF00003446366 | bam | 1.8 GB | Report |
|
| EGAF00003446367 | bam | 1.9 GB | Report |
|
| EGAF00003446368 | bam | 1.9 GB | Report |
|
| EGAF00003446369 | bam | 1.5 GB | Report |
|
| EGAF00003446370 | bam | 1.9 GB | Report |
|
| EGAF00003446371 | bam | 2.0 GB | Report |
|
| EGAF00003446372 | bam | 2.0 GB | Report |
|
| EGAF00003446373 | bam | 2.4 GB | Report |
|
| EGAF00003446374 | bam | 1.9 GB | Report |
|
| EGAF00003446375 | bam | 2.2 GB | Report |
|
| EGAF00003446376 | bam | 2.1 GB | Report |
|
| EGAF00003446377 | bam | 2.1 GB | Report |
|
| EGAF00003446378 | bam | 2.0 GB | Report |
|
| EGAF00003446379 | bam | 2.1 GB | Report |
|
| EGAF00003446380 | bam | 2.1 GB | Report |
|
| EGAF00003446381 | bam | 4.8 GB | Report |
|
| EGAF00003446382 | bam | 4.1 GB | Report |
|
| EGAF00003446383 | bam | 4.4 GB | Report |
|
| EGAF00003446384 | bam | 4.2 GB | Report |
|
| EGAF00003446385 | bam | 4.1 GB | Report |
|
| EGAF00003446386 | bam | 4.8 GB | Report |
|
| EGAF00003446387 | bam | 4.3 GB | Report |
|
| EGAF00003446388 | bam | 4.3 GB | Report |
|
| EGAF00003446389 | bam | 4.4 GB | Report |
|
| EGAF00003446390 | bam | 4.5 GB | Report |
|
| EGAF00003446391 | bam | 4.6 GB | Report |
|
| EGAF00003446392 | bam | 4.2 GB | Report |
|
| EGAF00003446393 | bam | 1.7 GB | Report |
|
| EGAF00003446394 | bam | 4.0 GB | Report |
|
| EGAF00003446395 | bam | 4.8 GB | Report |
|
| EGAF00003446396 | bam | 4.4 GB | Report |
|
| EGAF00003446397 | bam | 4.5 GB | Report |
|
| EGAF00003446398 | bam | 4.2 GB | Report |
|
| EGAF00003446399 | bam | 4.4 GB | Report |
|
| EGAF00003446400 | bam | 5.9 GB | Report |
|
| EGAF00003446401 | bam | 4.9 GB | Report |
|
| EGAF00003446402 | bam | 4.3 GB | Report |
|
| EGAF00003446403 | bam | 4.8 GB | Report |
|
| EGAF00003446404 | bam | 2.1 GB | Report |
|
| EGAF00003446405 | bam | 4.7 GB | Report |
|
| EGAF00003446406 | bam | 4.0 GB | Report |
|
| EGAF00003446407 | bam | 4.3 GB | Report |
|
| EGAF00003446408 | bam | 4.1 GB | Report |
|
| EGAF00003446409 | bam | 3.8 GB | Report |
|
| EGAF00003446410 | bam | 4.6 GB | Report |
|
| EGAF00003446411 | bam | 4.4 GB | Report |
|
| EGAF00003446412 | bam | 4.2 GB | Report |
|
| EGAF00003446413 | bam | 1.7 GB | Report |
|
| EGAF00003446414 | bam | 1.7 GB | Report |
|
| EGAF00003446415 | bam | 4.5 GB | Report |
|
| EGAF00003446416 | bam | 4.5 GB | Report |
|
| EGAF00003446417 | bam | 2.2 GB | Report |
|
| EGAF00003446418 | bam | 1.9 GB | Report |
|
| EGAF00003446419 | bam | 4.6 GB | Report |
|
| EGAF00003446420 | bam | 1.7 GB | Report |
|
| EGAF00003446421 | bam | 4.2 GB | Report |
|
| EGAF00003446422 | bam | 4.2 GB | Report |
|
| EGAF00003446423 | bam | 1.6 GB | Report |
|
| EGAF00003446424 | bam | 4.1 GB | Report |
|
| EGAF00003446425 | bam | 4.2 GB | Report |
|
| EGAF00003446426 | bam | 4.3 GB | Report |
|
| EGAF00003446427 | bam | 4.5 GB | Report |
|
| EGAF00003446428 | bam | 3.9 GB | Report |
|
| EGAF00003446429 | bam | 4.1 GB | Report |
|
| EGAF00003446430 | bam | 3.8 GB | Report |
|
| EGAF00003446431 | bam | 3.8 GB | Report |
|
| EGAF00003446432 | bam | 4.1 GB | Report |
|
| 297 Files (846.8 GB) | ||||