DAC

DAC for Pediatric GBM

Dac ID Contact Person Email Access Information
EGAC00001001621 Zeynep Erson-Omay zeynep [dot] erson [at] yale [dot] edu No additional information is available

This DAC controls 1 dataset:

Dataset ID Description Technology Samples
EGAD00001006202 This case represented the genomic findings of a pediatric glioblastoma patient who underwent multiple surgical resections and treated with standard chemoradiation, as well as a novel recombinant poliovirus vaccine therapy. The results present the preservation of a STAG2 mutated clone, besides elimination and emergence of other clones with oncogenic mutations through disease progression under different treatment modalities. Although STAG2 deficiency comprises only a small subset of gliomas, this case adds clinical evidence to existing preclinical data supporting a role for STAG2 mutations in gliomagenesis and resistance to standard therapies. 3