Dataset

Pediatric Glioblastoma with Persistent STAG2 Mutation

Dataset ID Technology Samples
EGAD00001006202 N/A 3

Dataset Description

This case represented the genomic findings of a pediatric glioblastoma patient who underwent multiple surgical resections and treated with standard chemoradiation, as well as a novel recombinant poliovirus vaccine therapy. The results present the preservation of a STAG2 mutated clone, besides elimination and emergence of other clones with oncogenic mutations through disease progression under different treatment modalities. Although STAG2 deficiency comprises only a small subset of gliomas, this case adds clinical evidence to existing preclinical data supporting a role for STAG2 mutations in gliomagenesis and resistance to standard therapies.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

DAC for Pediatric GBM
Contact person: Zeynep Erson-Omay
Email: zeynep [dot] erson [at] yale [dot] edu
More details: EGAC00001001621

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