DAC

PLANET study

Dac ID Contact Person Email Access Information
EGAC00001001784 Arife Neslihan Kaya kayaan [at] gis [dot] a-star [dot] edu [dot] sg No additional information is available

This DAC controls 5 datasets:

Dataset ID Description Technology Samples
EGAD00001006570 The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial and phenotypic immune–ITH from multiple tumour sectors and decipher its relationship with tumour evolution and disease progression in hepatocellular carcinomas (HCC). Immune–ITH is associated with tumour transcriptomic-ITH, mutational burden, and distinct immune microenvironments. Tumours with low immune–ITH experience higher immunoselective pressure and escape via loss of heterozygosity in human leukocyte antigens and immunoediting. Instead, the tumours with high immune-ITH evolve to a more immunosuppressive/exhausted microenvironment. This gradient of immune pressure along with immune-ITH represents a hallmark of tumour evolution, which is closely linked to the transcriptome-immune networks that contributes to disease progression and immune inactivation. Remarkably, high immune-ITH and its transcriptomic signature are predictive for worse clinical outcome in HCC patients. This in-depth investigation of ITH provides evidence on tumour-immune co-evolution along HCC progression. HiSeq X Ten,Illumina HiSeq 4000 70
EGAD00001008647 This dataset includes WGS data of samples from our paper titled "Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: The PLANET study." (National Science Review, nwab192. https://doi.org/10.1093/nsr/nwab192) HiSeq X Ten,Illumina HiSeq 4000 0
EGAD00001008648 This dataset includes RNA-seq data of samples from our paper titled "Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: The PLANET study." (National Science Review, nwab192. https://doi.org/10.1093/nsr/nwab192) Illumina HiSeq 4000 0
EGAD00001009041 This dataset includes RNA-seq, DNA and Chip-Seq data of samples from our paper. 0
EGAD00001009042 This dataset includes RNA-seq data of samples from our paper. 18