LFS Data Access Committee

David D Malkin
david.malkin@sickkids.ca

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Dataset ID	Description	Technology	Samples
EGAD00001010200	We performed whole genome sequencing on 84 LFS family members from 47 families: 22 with wildtype TP53 and 62 with variant TP53. The variant TP53 cohort consists of 49 individuals who developed cancer and 13 individuals who remain cancer-free; 34 were from 13 families with 2-4 individuals sequenced within a given family and the remaining 28 had no family members sequenced. The wildtype cohort consists of 14 individuals who developed cancer and 8 individuals who are cancer-free, from 6 families.	HiSeq X Ten	80
EGAD00010002461	Methylation of peripheral blood leukocytes from patients with Li-Fraumeni syndrome	Illumina HumanMethylation450 BeadChip/Illumina HumanMethylationEPIC BeadChip	400