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Susceptibility genes for the development of SLE during treatment of IBD

A potential and very serious side effect of treating IBD with antiTNFa therapies (the currentgold standard) is the development of systemic lupus erythematosis (SLE). This side effect israre and unpredictable. Out of several thousand cases having received treatment, theUniversity of Calgary have accumulated 12 individuals with full phenotyping and novelserological antibody discovery panel data. We propose to exome sequence these samples inan effort to identify rare highly-penetrant variants that could be underlying this severephenotype.

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Wellcome Trust Sanger Institute Data Sharing Policy

The data will be submitted to EGA and are accessible under managed data access.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000387 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000249063 bam 4.3 GB
EGAF00000249064 bam 4.4 GB
EGAF00000249065 bam 3.7 GB
EGAF00000249066 bam 4.1 GB
EGAF00000249067 bam 3.5 GB
EGAF00000249068 bam 4.1 GB
EGAF00000249069 bam 4.1 GB
EGAF00000249070 bam 3.8 GB
EGAF00000249071 bam 5.0 GB
EGAF00000249072 bam 5.0 GB
EGAF00000249073 bam 5.0 GB
EGAF00000249074 bam 4.7 GB
EGAF00000249075 bam 4.4 GB
EGAF00000249076 bam 5.2 GB
EGAF00000249077 bam 4.6 GB
EGAF00000251386 bam 4.1 GB
EGAF00000251387 bam 4.2 GB
EGAF00000251388 bam 3.5 GB
EGAF00000251389 bam 3.9 GB
EGAF00000251390 bam 3.4 GB
EGAF00000251391 bam 3.9 GB
EGAF00000251392 bam 3.9 GB
EGAF00000251393 bam 3.7 GB
EGAF00000251394 bam 4.7 GB
EGAF00000251395 bam 4.6 GB
EGAF00000251396 bam 4.6 GB
EGAF00000251397 bam 4.4 GB
EGAF00000251398 bam 4.1 GB
EGAF00000251399 bam 4.9 GB
EGAF00000251400 bam 4.3 GB
30 Files (128.1 GB)