Dataset

Whole transcriptome sequencing of Acute Myeloid Leukemias with an acquired inv(3)(q21q26) or t(3;3)(q21;q26) aberration

Dataset ID Technology Samples
EGAD00001000726 Illumina HiSeq 2500 30

Dataset Description

In total 30 Acute Myeloid Leukemias with an acquired inv(3)(q21q26) or t(3;3)(q21;q26) have been characterized by whole transcriptome sequencing (RNA-Seq). The 3q-aberration leads to overexpression of the proto-oncogene EVI1, but the mechanism of overexpression has thus far been elusive. The RNA-Seq was integral in determining the precise enhancer inducing the overexpression and led to other key discoveries.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

The Data Access Committee that surveys the appeals for data derived from the study "An oncogenic enhancer-rearrangement causes concomitant deregulation of EVI1 and GATA2 in leukemia" originating from the department Hematology at the Erasmus Medical Center (acronym ERASMUSMC-HEMA).
Contact person: Ruud Delwel
Email: h [dot] delwel [at] erasmusmc [dot] nl
More details: EGAC00001000162

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