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Targeted resequencing of Acute Myeloid Leukemia patients with an acquired inv(3)(q21q26) or t(3;3)(q21;q26).

Targeted resequencing on the specific regions chr3:126036241-130672290 and chr3:157712147-175694147 in hg19 centered on the chromosomal regions 3q21 and 3q26 respectively. The focus lies on the detection of the exact breakpoints in Acute Myeloid Leukemia (AML) patients having acquired a inv(3)(q21q26) or t(3;3)(q21;q26). This dataset contains all information to detect all structural variants contained within these regions, including the 3q-aberrations inducing the overexpression of the proto-oncogene EVI1.

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Data access agreement for data generated for the study An oncogenic enhancer-rearrangement causes concomitant deregulation of EVI1 and GATA2 in leukemia

THE ERASMUSMC-HEMA CONSORTIUM DATA ACCESS AGREEMENT This agreement governs the terms on which access will be granted to the genotype data generated by the ERASMUSMC-HEMA Consortium. In signing this agreement, You are agreeing to be bound by the terms and conditions of access set out in this agreement. For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User’s Institution (as defined below). User Institution and User are referred to within the agreement as “You” and “Your” shall be construed accordingly. Definitions: Consortium means the ERASMUSMC-HEMA Consortium, i.e. Drs. Ruud Delwel, Peter Valk, Stefan Gröschel, Mathijs Sanders, Bob Löwenberg and Remco Hoogenboezem. Data means all and any human genetic data obtained from the Consortium. Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto. User means a researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. User Institution means the organization at which the User is employed, affiliated or enrolled. Terms and Conditions: In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the data from the EVI1-3q Cohort or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevant access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outwith the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 8. You agree to abide by the terms outlined in the Consortium 'Publications Policy' as set out in Schedule 1. 9. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the data, and the role of the Consortium and the relevant primary collectors and their funders. Suitable wording is provided in the Publications Policy given in Schedule 1. 10. You accept that the Consortium, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 11. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 12. You recognize that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 13. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 14. You accept that it may be necessary for the Consortium or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Consortium or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 15. You agree that you will submit a report to the Consortium Data Access Committee, if requested, on completion of the agreed purpose. The Consortium Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 16. You accept that the Data is protected by and subject to international laws, and that You are responsible for ensuring compliance with any such applicable law. The Consortium Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA. 17. This agreement shall be construed, interpreted and governed by the laws of the Netherlands and shall be subject to the non-exclusive jurisdiction of the Dutch courts. SCHEDULE 1 Publications Policy The primary purpose of the ERASMUSMC-HEMA Consortium (EMCH) is to accelerate efforts to identify genome sequence variants influencing major causes of human morbidity and mortality, through implementation and analysis of large-scale genome-wide association studies. Additional objectives include the development and validation of informatics and analytical solutions appropriate to the scale and nature of the project, as well as use of the data generated to answer important methodological and biological questions relevant to association studies in general, and in the Netherlands in particular. The Consortium anticipates that data generated from the project will be used by others, such as required for developing new analytical methods, in understanding patterns of polymorphism and in guiding selection of markers to map genes involved in specific diseases. Authors who use data from the project must acknowledge the EMCH using the following wording "This study makes use of data generated by the ERASMUSMC-HEMA Consortium. Cite the relevant primary EMCH publication”. Users should note that the Consortium bears no responsibility for the further analysis or interpretation of these data, over and above that published by the Consortium.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000669 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000493447 fastq.gz 3.2 GB
EGAF00000493448 fastq.gz 3.2 GB
EGAF00000493449 fastq.gz 2.7 GB
EGAF00000493450 fastq.gz 2.6 GB
EGAF00000493451 fastq.gz 2.4 GB
EGAF00000493452 fastq.gz 2.3 GB
EGAF00000493453 fastq.gz 3.3 GB
EGAF00000493454 fastq.gz 3.3 GB
EGAF00000493455 fastq.gz 3.1 GB
EGAF00000493456 fastq.gz 3.0 GB
EGAF00000493457 fastq.gz 3.2 GB
EGAF00000493458 fastq.gz 3.2 GB
EGAF00000493459 fastq.gz 3.4 GB
EGAF00000493460 fastq.gz 3.4 GB
EGAF00000493461 fastq.gz 3.0 GB
EGAF00000493462 fastq.gz 3.0 GB
EGAF00000493463 fastq.gz 3.0 GB
EGAF00000493464 fastq.gz 3.0 GB
EGAF00000493465 fastq.gz 2.9 GB
EGAF00000493466 fastq.gz 2.8 GB
EGAF00000493467 fastq.gz 3.2 GB
EGAF00000493468 fastq.gz 3.2 GB
EGAF00000493469 fastq.gz 3.0 GB
EGAF00000493470 fastq.gz 2.9 GB
EGAF00000493471 fastq.gz 3.0 GB
EGAF00000493472 fastq.gz 3.0 GB
EGAF00000493473 fastq.gz 3.9 GB
EGAF00000493474 fastq.gz 3.9 GB
EGAF00000493475 fastq.gz 2.8 GB
EGAF00000493476 fastq.gz 2.8 GB
EGAF00000493477 fastq.gz 2.8 GB
EGAF00000493478 fastq.gz 2.8 GB
EGAF00000493479 fastq.gz 2.6 GB
EGAF00000493480 fastq.gz 2.6 GB
EGAF00000493481 fastq.gz 3.2 GB
EGAF00000493482 fastq.gz 3.2 GB
EGAF00000493483 fastq.gz 3.0 GB
EGAF00000493484 fastq.gz 3.0 GB
EGAF00000493485 fastq.gz 2.8 GB
EGAF00000493486 fastq.gz 2.8 GB
EGAF00000493487 fastq.gz 3.1 GB
EGAF00000493488 fastq.gz 3.1 GB
EGAF00000493489 fastq.gz 2.9 GB
EGAF00000493490 fastq.gz 2.9 GB
EGAF00000493491 fastq.gz 3.2 GB
EGAF00000493492 fastq.gz 3.2 GB
EGAF00000493493 fastq.gz 3.4 GB
EGAF00000493494 fastq.gz 3.3 GB
EGAF00000493495 fastq.gz 3.3 GB
EGAF00000493496 fastq.gz 3.3 GB
EGAF00000493497 fastq.gz 2.7 GB
EGAF00000493498 fastq.gz 2.7 GB
EGAF00000493499 fastq.gz 3.3 GB
EGAF00000493500 fastq.gz 3.3 GB
EGAF00000493501 fastq.gz 2.6 GB
EGAF00000493502 fastq.gz 2.6 GB
EGAF00000493503 fastq.gz 3.4 GB
EGAF00000493504 fastq.gz 3.4 GB
EGAF00000493505 fastq.gz 2.9 GB
EGAF00000493506 fastq.gz 2.9 GB
EGAF00000493507 fastq.gz 3.4 GB
EGAF00000493508 fastq.gz 3.4 GB
EGAF00000493509 fastq.gz 3.0 GB
EGAF00000493510 fastq.gz 3.0 GB
EGAF00000493511 fastq.gz 2.7 GB
EGAF00000493512 fastq.gz 2.7 GB
EGAF00000493513 fastq.gz 3.3 GB
EGAF00000493514 fastq.gz 3.3 GB
EGAF00000493515 fastq.gz 3.0 GB
EGAF00000493516 fastq.gz 3.0 GB
EGAF00000493517 fastq.gz 3.1 GB
EGAF00000493518 fastq.gz 3.0 GB
EGAF00000493519 fastq.gz 3.1 GB
EGAF00000493520 fastq.gz 3.1 GB
EGAF00000493521 fastq.gz 3.0 GB
EGAF00000493522 fastq.gz 3.0 GB
76 Files (231.0 GB)