Targeted resequencing of Acute Myeloid Leukemia patients with an acquired inv(3)(q21q26) or t(3;3)(q21;q26).

Dataset ID Technology Samples
EGAD00001000727 Illumina HiSeq 2500 38

Dataset Description

Targeted resequencing on the specific regions chr3:126036241-130672290 and chr3:157712147-175694147 in hg19 centered on the chromosomal regions 3q21 and 3q26 respectively. The focus lies on the detection of the exact breakpoints in Acute Myeloid Leukemia (AML) patients having acquired a inv(3)(q21q26) or t(3;3)(q21;q26). This dataset contains all information to detect all structural variants contained within these regions, including the 3q-aberrations inducing the overexpression of the proto-oncogene EVI1.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

The Data Access Committee that surveys the appeals for data derived from the study "An oncogenic enhancer-rearrangement causes concomitant deregulation of EVI1 and GATA2 in leukemia" originating from the department Hematology at the Erasmus Medical Center (acronym ERASMUSMC-HEMA).
Contact person: Ruud Delwel
Email: h [dot] delwel [at] erasmusmc [dot] nl
More details: EGAC00001000162


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