About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas

Background: The disease course of patients with diffuse low-grade glioma is notoriously unpredictable. Temporal and spatially distinct samples may provide insight into the evolution of clinically relevant copy number aberrations (CNAs). The purpose of this study is to identify CNAs that are indicative of aggressive tumor behaviour and can thereby complement the prognostically favorable 1p/19q co-deletion. Results: Genome-wide, 50 base pair single-end, sequencing was performed to detect CNAs in a clinically well-characterized cohort of 98 formalin-fixed paraffin-embedded low-grade gliomas. CNAs are correlated with overall survival as an endpoint. Seventy-five additional samples from spatially distinct regions and paired recurrent tumors of the discovery cohort were analysed to interrogate the intratumoral heterogeneity and spatial evolution. Loss of 10q25.2-qter is a frequent subclonal event and significantly correlates with an unfavorable prognosis. A significant correlation is furthermore observed in a validation set of 126 and confirmation set of 184 patients. Loss of 10q25.2-qter arises in a longitudinal manner in paired recurrent tumor specimens, whereas the prognostically favorable 1p/ 19q co-deletion is the only CNA that is stable across spatial regions and recurrent tumors. Conclusions: CNAs in low-grade gliomas display extensive intratumoral heterogeneity. Distal loss of 10q is a late onset event and a marker for reduced overall survival in low-grade glioma patients. Intratumoral heterogeneity and higher frequencies of distal 10q loss in recurrences suggest this event is involved in outgrowth to the recurrent tumor.

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Data originating from patient samples

The Amsterdam UMC, tumor genome analysis core, allows access to published datasets upon written application and signature of a Data Access Agreement (DAA). In addition, applications to clinical datasets require approval by a Data Access Committee (DAC), who assess whether the proposed work is allowed given patient consent, as well as the scientific purpose. To aid this process we ask you to provide the information below. Requests will be prioritised according to novelty of the research question. Applications with insufficient detail on objectives, justification, and methods/planned analyses are unlikely to be accepted. 1.Reference number for the dataset 2.Full legal name and address of university/institution 3.Name(s) of the Principle Investigator who will use the data: 4.Name(s) and job title(s) of any other investigators who will use the data: 5.Please provide a minimum of one reference to a publication that can be found on PubMed and where the Principle Investigator is an author: 6.How will the data be stored and where will it be stored? 7.What is the proposed study title and what are the objectives and outcomes of the study in which the data will be used 8.Please provide a brief justification or rationale for the proposed study (max 250 words) 9.Please provide a brief description of planned data analyses (max 250 words): 10.Will the results arising from use of the data be used for the creation of products for sale or for any commercial purpose?

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000643 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00000605176 fastq.gz 477.1 MB Report
EGAF00000605177 fastq.gz 441.2 MB Report
EGAF00000605178 fastq.gz 415.3 MB Report
EGAF00000605179 fastq.gz 333.4 MB Report
EGAF00000605180 fastq.gz 511.0 MB Report
EGAF00000605181 fastq.gz 340.4 MB Report
EGAF00000605182 fastq.gz 1.3 GB Report
EGAF00000605183 fastq.gz 263.5 MB Report
EGAF00000605184 fastq.gz 364.5 MB Report
EGAF00000605185 fastq.gz 343.1 MB Report
EGAF00000605186 fastq.gz 886.1 MB Report
EGAF00000605187 fastq.gz 501.0 MB Report
EGAF00000605188 fastq.gz 348.7 MB Report
EGAF00000605189 fastq.gz 345.5 MB Report
EGAF00000605190 fastq.gz 484.9 MB Report
EGAF00000605191 fastq.gz 358.9 MB Report
EGAF00000605192 fastq.gz 358.4 MB Report
EGAF00000605193 fastq.gz 670.2 MB Report
EGAF00000605194 fastq.gz 396.5 MB Report
EGAF00000605195 fastq.gz 366.8 MB Report
EGAF00000605196 fastq.gz 332.4 MB Report
EGAF00000605197 fastq.gz 321.3 MB Report
EGAF00000605198 fastq.gz 558.9 MB Report
EGAF00000605199 fastq.gz 488.8 MB Report
EGAF00000605200 fastq.gz 229.8 MB Report
EGAF00000605201 fastq.gz 647.3 MB Report
EGAF00000605202 fastq.gz 431.9 MB Report
EGAF00000605203 fastq.gz 280.9 MB Report
EGAF00000605204 fastq.gz 312.4 MB Report
EGAF00000605205 fastq.gz 528.5 MB Report
EGAF00000605206 fastq.gz 573.3 MB Report
EGAF00000605207 fastq.gz 480.9 MB Report
EGAF00000605208 fastq.gz 568.4 MB Report
EGAF00000605209 fastq.gz 527.0 MB Report
EGAF00000605210 fastq.gz 597.1 MB Report
EGAF00000605211 fastq.gz 496.4 MB Report
EGAF00000605212 fastq.gz 373.1 MB Report
EGAF00000605213 fastq.gz 569.1 MB Report
EGAF00000605214 fastq.gz 663.8 MB Report
EGAF00000605215 fastq.gz 751.4 MB Report
EGAF00000605216 fastq.gz 258.7 MB Report
EGAF00000605217 fastq.gz 226.3 MB Report
EGAF00000605218 fastq.gz 637.3 MB Report
EGAF00000605219 fastq.gz 536.8 MB Report
EGAF00000605220 fastq.gz 446.3 MB Report
EGAF00000605221 fastq.gz 264.5 MB Report
EGAF00000605222 fastq.gz 1.2 GB Report
EGAF00000605223 fastq.gz 267.2 MB Report
EGAF00000605224 fastq.gz 334.1 MB Report
EGAF00000605225 fastq.gz 1.9 GB Report
EGAF00000605226 fastq.gz 344.6 MB Report
EGAF00000605227 fastq.gz 599.2 MB Report
EGAF00000605228 fastq.gz 304.5 MB Report
EGAF00000605229 fastq.gz 556.8 MB Report
EGAF00000605230 fastq.gz 232.0 MB Report
EGAF00000605231 fastq.gz 468.1 MB Report
EGAF00000605232 fastq.gz 180.4 MB Report
EGAF00000605233 fastq.gz 273.3 MB Report
EGAF00000605234 fastq.gz 257.7 MB Report
EGAF00000605235 fastq.gz 621.5 MB Report
EGAF00000605236 fastq.gz 308.0 MB Report
EGAF00000605237 fastq.gz 403.6 MB Report
EGAF00000605238 fastq.gz 274.4 MB Report
EGAF00000605239 fastq.gz 305.5 MB Report
EGAF00000605240 fastq.gz 317.1 MB Report
EGAF00000605241 fastq.gz 354.1 MB Report
EGAF00000605242 fastq.gz 372.7 MB Report
EGAF00000605243 fastq.gz 431.4 MB Report
EGAF00000605244 fastq.gz 692.9 MB Report
EGAF00000605245 fastq.gz 385.2 MB Report
EGAF00000605246 fastq.gz 503.1 MB Report
EGAF00000605247 fastq.gz 348.1 MB Report
EGAF00000605248 fastq.gz 579.3 MB Report
EGAF00000605249 fastq.gz 511.7 MB Report
EGAF00000605250 fastq.gz 583.1 MB Report
EGAF00000605251 fastq.gz 478.9 MB Report
EGAF00000605252 fastq.gz 1.6 GB Report
EGAF00000605253 fastq.gz 332.3 MB Report
EGAF00000605254 fastq.gz 282.3 MB Report
EGAF00000605255 fastq.gz 481.1 MB Report
EGAF00000605256 fastq.gz 530.7 MB Report
EGAF00000605257 fastq.gz 429.6 MB Report
EGAF00000605258 fastq.gz 447.0 MB Report
EGAF00000605259 fastq.gz 331.8 MB Report
EGAF00000605260 fastq.gz 337.6 MB Report
EGAF00000605261 fastq.gz 392.9 MB Report
EGAF00000605262 fastq.gz 2.9 GB Report
EGAF00000605263 fastq.gz 1.9 GB Report
EGAF00000605264 fastq.gz 2.2 GB Report
EGAF00000605265 fastq.gz 1.2 GB Report
EGAF00000605266 fastq.gz 1.5 GB Report
EGAF00000605267 fastq.gz 2.6 GB Report
EGAF00000605268 fastq.gz 1.4 GB Report
EGAF00000605269 fastq.gz 1.0 GB Report
EGAF00000605270 fastq.gz 1.5 GB Report
EGAF00000605271 fastq.gz 1.5 GB Report
EGAF00000605272 fastq.gz 1.1 GB Report
EGAF00000605273 fastq.gz 3.0 GB Report
EGAF00000605274 fastq.gz 1.4 GB Report
EGAF00000605275 fastq.gz 1.3 GB Report
EGAF00000605276 fastq.gz 1.8 GB Report
EGAF00000605277 fastq.gz 1.6 GB Report
EGAF00000605278 fastq.gz 2.0 GB Report
EGAF00000605279 fastq.gz 416.5 MB Report
EGAF00000605280 fastq.gz 1.3 GB Report
EGAF00000605281 fastq.gz 3.1 GB Report
EGAF00000605282 fastq.gz 1.6 GB Report
EGAF00000605283 fastq.gz 1.3 GB Report
EGAF00000605284 fastq.gz 715.0 MB Report
EGAF00000605285 fastq.gz 544.0 MB Report
EGAF00000605286 fastq.gz 1.5 GB Report
EGAF00000605287 fastq.gz 1.4 GB Report
EGAF00000605288 fastq.gz 980.5 MB Report
EGAF00000605289 fastq.gz 1.7 GB Report
EGAF00000605290 fastq.gz 308.5 MB Report
EGAF00000605291 fastq.gz 1.7 GB Report
EGAF00000605292 fastq.gz 1.2 GB Report
EGAF00000605293 fastq.gz 1.7 GB Report
EGAF00000605294 fastq.gz 2.1 GB Report
EGAF00000605295 fastq.gz 1.9 GB Report
EGAF00000605296 fastq.gz 2.1 GB Report
EGAF00000605297 fastq.gz 1.8 GB Report
EGAF00000605298 fastq.gz 474.5 MB Report
EGAF00000605299 fastq.gz 271.5 MB Report
EGAF00000605300 fastq.gz 349.8 MB Report
EGAF00000605301 fastq.gz 852.9 MB Report
EGAF00000605302 fastq.gz 566.6 MB Report
EGAF00000605303 fastq.gz 372.2 MB Report
EGAF00000605304 fastq.gz 613.8 MB Report
EGAF00000605305 fastq.gz 239.6 MB Report
EGAF00000605306 fastq.gz 684.5 MB Report
EGAF00000605307 fastq.gz 187.0 MB Report
EGAF00000605308 fastq.gz 193.7 MB Report
EGAF00000605309 fastq.gz 296.2 MB Report
EGAF00000605310 fastq.gz 272.6 MB Report
EGAF00000605311 fastq.gz 311.6 MB Report
EGAF00000605312 fastq.gz 1.2 GB Report
EGAF00000605313 fastq.gz 995.1 MB Report
EGAF00000605314 fastq.gz 1.3 GB Report
EGAF00000605315 fastq.gz 396.9 MB Report
EGAF00000605316 fastq.gz 457.6 MB Report
EGAF00000605317 fastq.gz 256.3 MB Report
EGAF00000605318 fastq.gz 345.0 MB Report
EGAF00000605319 fastq.gz 333.0 MB Report
EGAF00000605320 fastq.gz 309.7 MB Report
EGAF00000605321 fastq.gz 1.1 GB Report
EGAF00000605322 fastq.gz 807.4 MB Report
EGAF00000605323 fastq.gz 1.5 GB Report
EGAF00000605324 fastq.gz 661.7 MB Report
EGAF00000605325 fastq.gz 769.0 MB Report
EGAF00000605326 fastq.gz 309.1 MB Report
EGAF00000605327 fastq.gz 581.0 MB Report
EGAF00000605328 fastq.gz 3.0 GB Report
EGAF00000605329 fastq.gz 1.7 GB Report
EGAF00000605330 fastq.gz 2.9 GB Report
EGAF00000605331 fastq.gz 699.4 MB Report
EGAF00000605332 fastq.gz 681.7 MB Report
EGAF00000605333 fastq.gz 1.5 GB Report
EGAF00000605334 fastq.gz 1.6 GB Report
EGAF00000605335 fastq.gz 315.2 MB Report
EGAF00000605336 fastq.gz 1.1 GB Report
EGAF00000605337 fastq.gz 686.5 MB Report
EGAF00000605338 fastq.gz 1.0 GB Report
EGAF00000605339 fastq.gz 710.3 MB Report
EGAF00000605340 fastq.gz 2.0 GB Report
EGAF00000605341 fastq.gz 1.2 GB Report
EGAF00000605342 fastq.gz 1.5 GB Report
EGAF00000605343 fastq.gz 819.9 MB Report
EGAF00000605344 fastq.gz 695.2 MB Report
EGAF00000605345 fastq.gz 2.3 GB Report
EGAF00000605346 fastq.gz 1.3 GB Report
EGAF00000605347 fastq.gz 1.6 GB Report
EGAF00000605348 fastq.gz 1.9 GB Report
EGAF00000605349 fastq.gz 1.8 GB Report
EGAF00000605350 fastq.gz 2.0 GB Report
EGAF00000605351 fastq.gz 2.3 GB Report
EGAF00000605352 fastq.gz 2.6 GB Report
EGAF00000605353 fastq.gz 962.9 MB Report
EGAF00000605354 fastq.gz 2.3 GB Report
EGAF00000605355 fastq.gz 2.2 GB Report
EGAF00000605356 fastq.gz 2.0 GB Report
EGAF00000605357 fastq.gz 1.6 GB Report
EGAF00000605358 fastq.gz 208.5 MB Report
EGAF00000605359 fastq.gz 576.5 MB Report
EGAF00000605360 fastq.gz 2.8 GB Report
EGAF00000605361 fastq.gz 2.8 GB Report
EGAF00000605362 fastq.gz 3.3 GB Report
EGAF00000605363 fastq.gz 204.0 MB Report
EGAF00000605364 fastq.gz 319.5 MB Report
EGAF00000605365 fastq.gz 188.7 MB Report
EGAF00000605366 fastq.gz 327.2 MB Report
EGAF00000605367 fastq.gz 1.8 GB Report
EGAF00000605368 fastq.gz 3.7 GB Report
EGAF00000605369 fastq.gz 1.3 GB Report
EGAF00000605370 fastq.gz 2.4 GB Report
EGAF00000605371 fastq.gz 1.6 GB Report
EGAF00000605372 fastq.gz 1.1 GB Report
EGAF00000605373 fastq.gz 970.8 MB Report
EGAF00000605374 fastq.gz 2.7 GB Report
EGAF00000605375 fastq.gz 267.9 MB Report
EGAF00000605376 fastq.gz 926.4 MB Report
EGAF00000605377 fastq.gz 1.1 GB Report
EGAF00000605378 fastq.gz 2.0 GB Report
EGAF00000605379 fastq.gz 2.8 GB Report
EGAF00000605380 fastq.gz 662.6 MB Report
EGAF00000605381 fastq.gz 1.9 GB Report
EGAF00000605382 fastq.gz 642.3 MB Report
EGAF00000605383 fastq.gz 1.0 GB Report
EGAF00000605384 fastq.gz 1.0 GB Report
EGAF00000605385 fastq.gz 1.6 GB Report
EGAF00000605386 fastq.gz 388.4 MB Report
EGAF00000605387 fastq.gz 762.0 MB Report
EGAF00000605388 fastq.gz 1.2 GB Report
EGAF00000605389 fastq.gz 454.1 MB Report
EGAF00000605390 fastq.gz 1.2 GB Report
EGAF00000605391 fastq.gz 307.5 MB Report
EGAF00000605392 fastq.gz 431.6 MB Report
EGAF00000605393 fastq.gz 1.1 GB Report
EGAF00000605394 fastq.gz 2.3 GB Report
EGAF00000605395 fastq.gz 904.7 MB Report
EGAF00000605396 fastq.gz 196.3 MB Report
EGAF00000605397 fastq.gz 284.1 MB Report
EGAF00000605398 fastq.gz 1.8 GB Report
EGAF00000605399 fastq.gz 255.3 MB Report
EGAF00000605400 fastq.gz 383.4 MB Report
EGAF00000605401 fastq.gz 384.4 MB Report
EGAF00000605402 fastq.gz 1.1 GB Report
EGAF00000605403 fastq.gz 229.9 MB Report
EGAF00000605404 fastq.gz 369.9 MB Report
EGAF00000605405 fastq.gz 381.6 MB Report
EGAF00000605406 fastq.gz 463.1 MB Report
EGAF00000605407 fastq.gz 272.5 MB Report
EGAF00000605408 fastq.gz 253.9 MB Report
EGAF00000605409 fastq.gz 211.9 MB Report
EGAF00000605410 fastq.gz 452.6 MB Report
EGAF00000605411 fastq.gz 340.6 MB Report
EGAF00000605412 fastq.gz 304.1 MB Report
EGAF00000605413 fastq.gz 562.5 MB Report
EGAF00000605414 fastq.gz 740.9 MB Report
EGAF00000605415 fastq.gz 629.2 MB Report
EGAF00000605416 fastq.gz 443.2 MB Report
EGAF00000605417 fastq.gz 264.4 MB Report
EGAF00000605418 fastq.gz 532.5 MB Report
EGAF00000605419 fastq.gz 520.9 MB Report
EGAF00000605420 fastq.gz 308.1 MB Report
EGAF00000605421 fastq.gz 563.9 MB Report
EGAF00000605422 fastq.gz 758.5 MB Report
EGAF00000605423 fastq.gz 950.7 MB Report
EGAF00000605424 fastq.gz 826.8 MB Report
EGAF00000605425 fastq.gz 385.5 MB Report
EGAF00000605426 fastq.gz 327.2 MB Report
EGAF00000605427 fastq.gz 295.2 MB Report
EGAF00000605428 fastq.gz 476.8 MB Report
EGAF00000605429 fastq.gz 771.5 MB Report
EGAF00000605430 fastq.gz 384.2 MB Report
EGAF00000605431 fastq.gz 646.1 MB Report
EGAF00000605432 fastq.gz 319.7 MB Report
EGAF00000605433 fastq.gz 291.5 MB Report
EGAF00000605434 fastq.gz 372.1 MB Report
EGAF00000605435 fastq.gz 424.7 MB Report
EGAF00000605436 fastq.gz 551.2 MB Report
EGAF00000605437 fastq.gz 210.8 MB Report
EGAF00000605438 fastq.gz 523.6 MB Report
EGAF00000605439 fastq.gz 443.2 MB Report
EGAF00000605440 fastq.gz 333.9 MB Report
EGAF00000605441 fastq.gz 613.9 MB Report
EGAF00000605442 fastq.gz 477.3 MB Report
EGAF00000605443 fastq.gz 342.0 MB Report
EGAF00000605444 fastq.gz 301.7 MB Report
EGAF00000605445 fastq.gz 287.7 MB Report
EGAF00000605446 fastq.gz 775.3 MB Report
EGAF00000605447 fastq.gz 334.5 MB Report
EGAF00000605448 fastq.gz 373.1 MB Report
EGAF00000605449 fastq.gz 235.5 MB Report
EGAF00000605450 fastq.gz 483.7 MB Report
EGAF00000605451 fastq.gz 369.6 MB Report
EGAF00000605452 fastq.gz 397.3 MB Report
EGAF00000605453 fastq.gz 284.6 MB Report
EGAF00000605454 fastq.gz 360.4 MB Report
EGAF00000605455 fastq.gz 275.7 MB Report
EGAF00000605456 fastq.gz 288.0 MB Report
EGAF00000605457 fastq.gz 837.1 MB Report
EGAF00000605458 fastq.gz 726.8 MB Report
EGAF00000605459 fastq.gz 319.7 MB Report
EGAF00000605460 fastq.gz 512.7 MB Report
EGAF00000605461 fastq.gz 351.2 MB Report
EGAF00000605462 fastq.gz 222.0 MB Report
EGAF00000605463 fastq.gz 379.9 MB Report
EGAF00000605464 fastq.gz 525.1 MB Report
EGAF00000605465 fastq.gz 336.8 MB Report
EGAF00000605466 fastq.gz 213.4 MB Report
EGAF00000605467 fastq.gz 430.5 MB Report
EGAF00000605468 fastq.gz 299.3 MB Report
EGAF00000605469 fastq.gz 335.0 MB Report
EGAF00000605470 fastq.gz 114.0 MB Report
EGAF00000605471 fastq.gz 323.8 MB Report
296 Files (245.2 GB)