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Discovery of resistance mechanisms to the BRAF inhibitor vemurafenib in metastatic BRAF mutant melanoma

We propose to biopsy 20 consented BRAF mutant melanoma patients at Addenbrooke's Hospital pre-treatment with vemurafenib and also upon the development of resistant disease, with the aim of using exome sequence and SNP6 data to identify novel sequence variants and copy number alterations that can be used to validate observed resistance mechanisms in our cell line models and also to use these models to inform as to likely candidate small molecule inhibitors to overcome resistance and that could be tested in the clinical trial setting.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000812 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000655078 cram 1.0 GB
EGAF00000655079 cram 985.1 MB
EGAF00000655080 cram 980.3 MB
EGAF00000655108 cram 996.9 MB
EGAF00000655109 cram 1.1 GB
EGAF00000655110 cram 964.1 MB
EGAF00000655111 cram 1.0 GB
EGAF00000655112 cram 1.1 GB
EGAF00000655113 cram 935.8 MB
EGAF00000655114 cram 986.8 MB
EGAF00000655115 cram 1.1 GB
EGAF00000655116 cram 1.1 GB
EGAF00000655117 cram 1.1 GB
EGAF00000655118 cram 1.1 GB
EGAF00000655119 cram 1.2 GB
EGAF00000655120 cram 1.1 GB
EGAF00000655121 cram 835.4 MB
EGAF00000655122 cram 952.0 MB
EGAF00000655123 cram 904.7 MB
EGAF00000655124 cram 897.3 MB
EGAF00000655125 cram 1.1 GB
EGAF00000655126 cram 948.7 MB
EGAF00000655127 cram 987.7 MB
EGAF00000655128 cram 969.3 MB
EGAF00000655129 cram 807.2 MB
EGAF00000655130 cram 1.1 GB
EGAF00000655131 cram 916.1 MB
EGAF00000655132 cram 890.4 MB
EGAF00000655133 cram 1.0 GB
EGAF00000655134 cram 980.2 MB
EGAF00000655162 cram 993.1 MB
EGAF00000655163 cram 1.0 GB
EGAF00000655164 cram 852.5 MB
33 Files (32.9 GB)