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Mechanisms of patient response to Dabrafenib in Melanoma

Samples will be from the BRF113683 (BREAK-3) study which is a Phase III Randomized, Open-label Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma (n=250 enrolled)*NGS [Agilent capture (Sanger V2 panel): 360 genes and 20 gene fusions; Illumina HiSEQ Sequencing]*CNV: [via NGS or Affy SNP 6.0 or Illumina Omni (TBD)]Bioinformatics: Analysis will be performed using core Sanger informatics pipelines similar to those previously described (Papaemmanuil E et al. (2013) Blood. 22:3616 -3627). Briefly, copy number analysis will be performed using the ASCAT algorithm, and base substitutions, small insertions and deletions using the CAVEMAN and Pindel algorithms, respectively. Statistical approaches including generalized linear models will be used to predict clinical variables such as maximum clinical response and duration of response using genetic data. Sanger and EBI to conduct analysis; Raw data and correlation with clinical endpoints to be analyzed by both EBI/Sanger and GSK (unique pipeline analyses to increase call confidence)

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000946 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000769119 cram 582.7 MB
EGAF00000769120 cram 21.7 MB
EGAF00000769121 cram 111.9 MB
EGAF00000769122 cram 484.8 MB
EGAF00000769123 cram 460.7 MB
EGAF00000769124 cram 307.7 MB
EGAF00000769125 cram 552.9 MB
EGAF00000769126 cram 585.5 MB
EGAF00000769127 cram 500.6 MB
EGAF00000769128 cram 339.6 MB
EGAF00000769129 cram 331.5 MB
EGAF00000769130 cram 589.9 MB
EGAF00000769131 cram 431.2 MB
EGAF00000769132 cram 544.7 MB
EGAF00000769133 cram 566.0 MB
EGAF00000769186 cram 467.0 MB
EGAF00000769187 cram 332.0 MB
EGAF00000769188 cram 60.7 MB
EGAF00000769189 cram 638.2 MB
EGAF00000769190 cram 305.4 MB
EGAF00000769191 cram 642.3 MB
EGAF00000769192 cram 714.7 MB
EGAF00000769193 cram 199.1 MB
EGAF00000769194 cram 558.5 MB
EGAF00000769195 cram 612.6 MB
EGAF00000769196 cram 613.0 MB
EGAF00000769197 cram 739.2 MB
EGAF00000769198 cram 677.6 MB
EGAF00000769199 cram 646.6 MB
EGAF00000769200 cram 593.7 MB
EGAF00000769201 cram 22.1 MB
EGAF00000769202 cram 113.5 MB
EGAF00000769203 cram 493.5 MB
EGAF00000769204 cram 468.0 MB
EGAF00000769205 cram 312.0 MB
EGAF00000769206 cram 564.6 MB
EGAF00000769207 cram 597.1 MB
EGAF00000769208 cram 510.8 MB
EGAF00000769209 cram 344.1 MB
EGAF00000769210 cram 337.3 MB
EGAF00000769211 cram 600.5 MB
EGAF00000769212 cram 438.1 MB
EGAF00000769248 cram 552.6 MB
EGAF00000769249 cram 573.9 MB
EGAF00000769250 cram 474.7 MB
EGAF00000769251 cram 337.1 MB
EGAF00000769252 cram 61.4 MB
EGAF00000769253 cram 650.2 MB
EGAF00000769254 cram 309.0 MB
EGAF00000769255 cram 654.4 MB
EGAF00000769256 cram 728.3 MB
EGAF00000769257 cram 202.5 MB
EGAF00000769258 cram 568.1 MB
EGAF00000769259 cram 625.9 MB
EGAF00000769260 cram 623.3 MB
EGAF00000769261 cram 746.8 MB
EGAF00000769262 cram 688.3 MB
EGAF00000769263 cram 659.7 MB
EGAF00000800594 cram 1.2 GB
EGAF00000800595 cram 1.2 GB
EGAF00000800596 cram 1.4 GB
EGAF00000800597 cram 1.6 GB
EGAF00000800598 cram 1.4 GB
EGAF00000800599 cram 1.3 GB
EGAF00000800600 cram 1.4 GB
EGAF00000800601 cram 985.7 MB
EGAF00000800602 cram 1.5 GB
EGAF00000800603 cram 1.2 GB
EGAF00000800604 cram 1.2 GB
EGAF00000800605 cram 1.3 GB
EGAF00000800606 cram 1.4 GB
EGAF00000800607 cram 1.7 GB
EGAF00000800608 cram 1.4 GB
EGAF00000800609 cram 1.3 GB
EGAF00000800610 cram 1.4 GB
EGAF00000800611 cram 1.0 GB
EGAF00000800612 cram 1.5 GB
EGAF00000800613 cram 1.3 GB
EGAF00000800614 cram 740.0 MB
EGAF00000800615 cram 870.4 MB
EGAF00000800616 cram 795.7 MB
EGAF00000800617 cram 751.2 MB
EGAF00000800618 cram 951.5 MB
EGAF00000800619 cram 701.2 MB
EGAF00000800620 cram 784.4 MB
EGAF00000800621 cram 735.9 MB
EGAF00000800622 cram 839.1 MB
EGAF00000800623 cram 777.6 MB
EGAF00000800624 cram 626.8 MB
EGAF00000800625 cram 783.9 MB
EGAF00000800626 cram 764.4 MB
EGAF00000800627 cram 846.1 MB
EGAF00000800628 cram 737.9 MB
EGAF00000800629 cram 718.4 MB
EGAF00000800630 cram 839.6 MB
EGAF00000800631 cram 768.9 MB
EGAF00000800632 cram 728.2 MB
EGAF00000800633 cram 919.9 MB
EGAF00000800634 cram 679.7 MB
EGAF00000800635 cram 762.8 MB
EGAF00000800636 cram 708.2 MB
EGAF00000800637 cram 809.8 MB
EGAF00000800638 cram 749.0 MB
EGAF00000800639 cram 603.3 MB
EGAF00000800640 cram 755.9 MB
EGAF00000800641 cram 738.0 MB
EGAF00000800642 cram 812.5 MB
EGAF00000800643 cram 711.4 MB
EGAF00000800644 cram 714.0 MB
EGAF00000800645 cram 755.8 MB
EGAF00000800646 cram 684.8 MB
EGAF00000800647 cram 645.6 MB
EGAF00000800648 cram 779.3 MB
EGAF00000800649 cram 636.1 MB
EGAF00000800650 cram 874.2 MB
EGAF00000800651 cram 632.5 MB
EGAF00000800652 cram 680.7 MB
EGAF00000800653 cram 709.5 MB
EGAF00000800654 cram 690.1 MB
EGAF00000800655 cram 743.0 MB
EGAF00000800656 cram 776.4 MB
EGAF00000800657 cram 865.1 MB
EGAF00000800658 cram 666.0 MB
EGAF00000800659 cram 786.5 MB
EGAF00000800660 cram 723.0 MB
EGAF00000800661 cram 766.5 MB
EGAF00000800662 cram 699.1 MB
EGAF00000800663 cram 657.7 MB
EGAF00000800664 cram 792.4 MB
EGAF00000800665 cram 642.4 MB
EGAF00000800666 cram 892.3 MB
EGAF00000800667 cram 644.1 MB
EGAF00000800668 cram 693.8 MB
EGAF00000800669 cram 718.7 MB
EGAF00000800670 cram 701.7 MB
EGAF00000800671 cram 758.9 MB
EGAF00000800672 cram 792.0 MB
EGAF00000800673 cram 879.4 MB
EGAF00000800674 cram 677.2 MB
EGAF00000800675 cram 800.3 MB
EGAF00000800676 cram 950.5 MB
EGAF00000800677 cram 1.2 GB
EGAF00000800678 cram 1.0 GB
EGAF00000800679 cram 1.2 GB
EGAF00000800680 cram 1.3 GB
EGAF00000800681 cram 987.4 MB
EGAF00000800682 cram 1.2 GB
EGAF00000800683 cram 1.3 GB
EGAF00000800684 cram 1.2 GB
EGAF00000800685 cram 1.2 GB
EGAF00000800686 cram 1.1 GB
EGAF00000800687 cram 1.0 GB
EGAF00000800688 cram 935.0 MB
EGAF00000800689 cram 1.2 GB
EGAF00000800690 cram 1.0 GB
EGAF00000800691 cram 1.2 GB
EGAF00000800692 cram 1.3 GB
EGAF00000800693 cram 975.5 MB
EGAF00000800694 cram 1.2 GB
EGAF00000800695 cram 1.3 GB
EGAF00000800696 cram 1.1 GB
EGAF00000800697 cram 1.2 GB
EGAF00000800698 cram 1.1 GB
EGAF00000800699 cram 1.0 GB
EGAF00000800700 cram 727.4 MB
EGAF00000800701 cram 873.3 MB
EGAF00000800702 cram 690.5 MB
EGAF00000800703 cram 837.4 MB
EGAF00000800704 cram 694.9 MB
EGAF00000800705 cram 871.8 MB
EGAF00000800706 cram 877.0 MB
EGAF00000800707 cram 901.9 MB
EGAF00000800708 cram 893.5 MB
EGAF00000800709 cram 884.5 MB
EGAF00000800710 cram 908.9 MB
EGAF00000800711 cram 977.7 MB
EGAF00000800712 cram 721.9 MB
EGAF00000800713 cram 866.5 MB
EGAF00000800714 cram 687.1 MB
EGAF00000800715 cram 831.4 MB
EGAF00000800716 cram 689.1 MB
EGAF00000800717 cram 863.4 MB
EGAF00000800718 cram 870.9 MB
EGAF00000800719 cram 893.2 MB
EGAF00000800720 cram 885.6 MB
EGAF00000800721 cram 878.6 MB
EGAF00000800722 cram 902.8 MB
EGAF00000800723 cram 968.4 MB
EGAF00000810122 cram 826.1 MB
EGAF00000810123 cram 977.1 MB
EGAF00000810124 cram 984.1 MB
EGAF00000810125 cram 812.7 MB
EGAF00000810126 cram 754.6 MB
EGAF00000810127 cram 790.7 MB
EGAF00000810128 cram 594.0 MB
EGAF00000810129 cram 748.4 MB
EGAF00000810130 cram 739.8 MB
EGAF00000810131 cram 878.3 MB
EGAF00000810132 cram 868.9 MB
EGAF00000810133 cram 943.5 MB
EGAF00000810134 cram 825.9 MB
EGAF00000810135 cram 988.3 MB
EGAF00000810136 cram 874.7 MB
EGAF00000810137 cram 962.4 MB
EGAF00000810138 cram 792.9 MB
EGAF00000810139 cram 739.3 MB
EGAF00000810140 cram 776.3 MB
EGAF00000810141 cram 585.3 MB
EGAF00000810142 cram 734.6 MB
EGAF00000810143 cram 726.2 MB
EGAF00000810144 cram 864.0 MB
EGAF00000810145 cram 849.2 MB
EGAF00000810146 cram 925.2 MB
EGAF00000810147 cram 809.3 MB
EGAF00000810148 cram 968.8 MB
EGAF00000810149 cram 856.5 MB
EGAF00000810150 cram 1.8 GB
EGAF00000810151 cram 2.3 GB
EGAF00000810152 cram 1.8 GB
EGAF00000810153 cram 2.3 GB
EGAF00000810154 cram 1.8 GB
EGAF00000810155 cram 1.8 GB
EGAF00000810156 cram 2.3 GB
EGAF00000810157 cram 1.8 GB
EGAF00000810158 cram 2.3 GB
EGAF00000810159 cram 1.9 GB
EGAF00000810160 cram 769.3 MB
EGAF00000810161 cram 810.5 MB
EGAF00000810162 cram 740.7 MB
EGAF00000810163 cram 783.7 MB
EGAF00000810164 cram 933.4 MB
EGAF00000810165 cram 958.7 MB
EGAF00000810166 cram 781.7 MB
EGAF00000810167 cram 1.1 GB
EGAF00000810168 cram 904.8 MB
EGAF00000810169 cram 785.1 MB
EGAF00000810170 cram 792.7 MB
EGAF00000810171 cram 910.7 MB
EGAF00000810172 cram 707.5 MB
EGAF00000810173 cram 763.8 MB
EGAF00000810174 cram 777.2 MB
EGAF00000810175 cram 818.4 MB
EGAF00000810176 cram 747.5 MB
EGAF00000810177 cram 795.1 MB
EGAF00000810178 cram 946.8 MB
EGAF00000810179 cram 970.2 MB
EGAF00000810180 cram 791.2 MB
EGAF00000810181 cram 1.1 GB
EGAF00000810182 cram 915.8 MB
EGAF00000810183 cram 795.3 MB
EGAF00000810184 cram 801.8 MB
EGAF00000810185 cram 922.3 MB
EGAF00000810186 cram 716.9 MB
EGAF00000810187 cram 770.4 MB
EGAF00000810188 cram 1.7 GB
EGAF00000810189 cram 1.8 GB
EGAF00000810190 cram 1.3 GB
EGAF00000810191 cram 1.4 GB
EGAF00000810192 cram 1.6 GB
EGAF00000810193 cram 1.6 GB
EGAF00000810194 cram 1.1 GB
EGAF00000810195 cram 1.6 GB
EGAF00000810196 cram 1.3 GB
EGAF00000810197 cram 1.6 GB
EGAF00000810198 cram 1.7 GB
EGAF00000810199 cram 1.3 GB
EGAF00000810200 cram 1.4 GB
EGAF00000810201 cram 1.5 GB
EGAF00000810202 cram 1.6 GB
EGAF00000810203 cram 1.1 GB
EGAF00000810204 cram 1.5 GB
EGAF00000810205 cram 1.3 GB
EGAF00000810234 cram 1.2 GB
EGAF00000810235 cram 1.5 GB
EGAF00000810236 cram 810.5 MB
EGAF00000810237 cram 1.3 GB
EGAF00000810238 cram 1.1 GB
EGAF00000810239 cram 1.2 GB
EGAF00000810240 cram 1.2 GB
EGAF00000810241 cram 981.6 MB
EGAF00000810242 cram 826.8 MB
EGAF00000810243 cram 978.0 MB
EGAF00000810244 cram 1.2 GB
EGAF00000810245 cram 1.5 GB
EGAF00000810246 cram 809.3 MB
EGAF00000810247 cram 1.3 GB
EGAF00000810248 cram 1.1 GB
EGAF00000810249 cram 1.2 GB
EGAF00000810250 cram 1.2 GB
EGAF00000810251 cram 981.4 MB
EGAF00000814365 cram 1.6 GB
EGAF00000814366 cram 1.3 GB
EGAF00000814367 cram 3.6 GB
EGAF00000814413 cram 89.8 kB
EGAF00000814414 cram 1.9 GB
EGAF00000814415 cram 2.0 GB
EGAF00000814416 cram 3.6 GB
EGAF00000814417 cram 1.7 GB
EGAF00000814418 cram 1.4 GB
EGAF00000814419 cram 3.7 GB
EGAF00000814420 cram 92.2 kB
EGAF00000814421 cram 1.9 GB
EGAF00000814422 cram 2.0 GB
EGAF00000814423 cram 3.8 GB
EGAF00000814424 cram 1.3 GB
EGAF00000814425 cram 864.7 MB
EGAF00000814426 cram 2.3 GB
EGAF00000814427 cram 2.1 GB
EGAF00000814428 cram 2.2 GB
EGAF00000814429 cram 1.7 GB
EGAF00000814430 cram 1.4 GB
EGAF00000814431 cram 1.3 GB
EGAF00000814432 cram 856.8 MB
EGAF00000814433 cram 2.2 GB
EGAF00000814434 cram 2.1 GB
EGAF00000814435 cram 2.2 GB
EGAF00000814436 cram 1.7 GB
EGAF00000814437 cram 1.4 GB
EGAF00000881588 cram 1.6 GB
EGAF00000881589 cram 1.4 GB
EGAF00000881590 cram 1.2 GB
EGAF00000881591 cram 1.1 GB
EGAF00000881592 cram 1.2 GB
EGAF00000881593 cram 1.5 GB
EGAF00000881594 cram 1.6 GB
EGAF00000881595 cram 1.7 GB
EGAF00000881596 cram 1.7 GB
EGAF00000881597 cram 1.2 GB
EGAF00000881598 cram 1.6 GB
EGAF00000881599 cram 1.3 GB
EGAF00000881600 cram 1.2 GB
EGAF00000881601 cram 1.1 GB
EGAF00000881602 cram 1.2 GB
EGAF00000881603 cram 1.5 GB
EGAF00000881604 cram 1.6 GB
EGAF00000881605 cram 1.7 GB
EGAF00000881606 cram 1.6 GB
EGAF00000881607 cram 1.2 GB
338 Files (342.1 GB)