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Integrative genome profiling in AML

AML emerges as a consequence of accumulating independent genetic aberrations that direct regulation and/or dysfunction of genes resulting in aberrant activation of signalling pathways, resistance to apoptosis and uncontrolled proliferation. Given the significant heterogeneity of AML genomes, AML patients demonstrate a highly variable response rate and poor median survival in response to current chemotherapy regimens. For the past 4 years we have conducted gene expression profiling on purified bone marrow populations equating to normal haematopoietic stem and progenitor cells from healthy subjects and patients with de novo AML in order to identify AML signatures of aberrantly expressed genes in cancer versus normal. We are now applying a series of bioinformatic methodologies combined with clinical and conventional diagnostic data to establish novel genomics strategies for improved prognostication of AML. Additionally, we use our AML signatures to unravel oncogenic signalling pathway activities in AML patients and test inhibitory drugs for these pathways inn preclinical therapeutic programmes. We consider that superimposing GEP and clinical data for our AML patient cohort with additional data on their mutational status will significantly improve the prognostic power of the study as well as unravel yet unknown mutations associated with aberrant signalling activities of oncogenic pathways.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001000858 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000902000 cram 347.9 MB
EGAF00000902001 cram 290.4 MB
EGAF00000902446 cram 335.2 MB
EGAF00000902447 cram 409.4 MB
EGAF00000902448 cram 348.2 MB
EGAF00000902449 cram 344.0 MB
EGAF00000902450 cram 337.9 MB
EGAF00000902451 cram 346.5 MB
EGAF00000902452 cram 364.6 MB
EGAF00000902453 cram 251.9 MB
EGAF00000902454 cram 257.8 MB
EGAF00000902455 cram 251.5 MB
EGAF00000902456 cram 258.5 MB
EGAF00000902457 cram 321.1 MB
EGAF00000902458 cram 568.1 MB
EGAF00000902459 cram 325.5 MB
EGAF00000902460 cram 228.7 MB
EGAF00000902461 cram 264.6 MB
EGAF00000902462 cram 339.9 MB
EGAF00000902463 cram 339.3 MB
EGAF00000902464 cram 314.2 MB
EGAF00000902465 cram 309.6 MB
EGAF00000902466 cram 314.8 MB
EGAF00000902467 cram 440.0 MB
EGAF00000902468 cram 312.3 MB
EGAF00000902469 cram 327.4 MB
EGAF00000902470 cram 340.4 MB
EGAF00000902471 cram 335.1 MB
EGAF00000902472 cram 332.4 MB
EGAF00000902473 cram 336.6 MB
EGAF00000902474 cram 348.3 MB
EGAF00000902475 cram 345.7 MB
EGAF00000902476 cram 375.7 MB
EGAF00000902477 cram 317.1 MB
EGAF00000902478 cram 350.6 MB
EGAF00000902479 cram 330.0 MB
EGAF00000908963 cram 270.0 MB
EGAF00000908964 cram 491.7 MB
EGAF00000908965 cram 357.0 MB
EGAF00000908966 cram 284.6 MB
EGAF00000908967 cram 320.8 MB
EGAF00000908968 cram 244.5 MB
EGAF00000908969 cram 280.2 MB
EGAF00000908970 cram 294.4 MB
EGAF00000908971 cram 268.2 MB
EGAF00000908972 cram 283.8 MB
EGAF00000908973 cram 255.0 MB
EGAF00000908974 cram 272.4 MB
EGAF00000908975 cram 257.1 MB
EGAF00000909428 cram 285.7 MB
EGAF00000909429 cram 286.0 MB
EGAF00000909430 cram 339.1 MB
EGAF00000909431 cram 284.7 MB
EGAF00000909432 cram 287.8 MB
EGAF00000909433 cram 331.1 MB
EGAF00000909434 cram 309.8 MB
EGAF00000909435 cram 320.0 MB
EGAF00000909436 cram 380.0 MB
EGAF00000909437 cram 272.2 MB
EGAF00000909438 cram 300.7 MB
EGAF00000909439 cram 243.0 MB
EGAF00000909440 cram 321.6 MB
EGAF00000909441 cram 254.9 MB
EGAF00000909442 cram 311.7 MB
EGAF00000909443 cram 298.5 MB
EGAF00000909444 cram 252.0 MB
EGAF00000909445 cram 263.3 MB
EGAF00000909446 cram 281.9 MB
EGAF00000909447 cram 266.1 MB
EGAF00000909448 cram 237.2 MB
EGAF00000909449 cram 276.8 MB
EGAF00000909450 cram 287.3 MB
EGAF00000909451 cram 233.8 MB
EGAF00000909452 cram 245.4 MB
EGAF00000909453 cram 250.9 MB
EGAF00000909454 cram 271.9 MB
EGAF00000909455 cram 261.6 MB
EGAF00000909456 cram 340.2 MB
EGAF00000909457 cram 212.7 MB
EGAF00000909669 cram 340.3 MB
EGAF00000909670 cram 294.4 MB
EGAF00000909671 cram 310.8 MB
EGAF00000909672 cram 260.8 MB
EGAF00000909673 cram 332.9 MB
EGAF00000909674 cram 361.5 MB
EGAF00000909675 cram 330.1 MB
EGAF00000909676 cram 245.1 MB
EGAF00000909677 cram 265.7 MB
EGAF00000909678 cram 294.6 MB
EGAF00000909679 cram 275.9 MB
EGAF00000909680 cram 305.2 MB
EGAF00000909681 cram 245.8 MB
EGAF00000909682 cram 224.7 MB
EGAF00000909941 cram 278.7 MB
EGAF00000909942 cram 260.6 MB
EGAF00000909943 cram 307.0 MB
EGAF00000909944 cram 307.0 MB
EGAF00000909945 cram 280.5 MB
EGAF00000909972 cram 282.6 MB
EGAF00000909973 cram 319.4 MB
EGAF00000909974 cram 292.9 MB
EGAF00000909975 cram 296.3 MB
EGAF00000909976 cram 282.9 MB
EGAF00000909977 cram 300.4 MB
EGAF00000909978 cram 279.6 MB
EGAF00000909979 cram 271.6 MB
EGAF00000909980 cram 287.0 MB
EGAF00000909981 cram 362.1 MB
EGAF00000909982 cram 318.8 MB
EGAF00000909983 cram 282.0 MB
EGAF00000909984 cram 326.9 MB
EGAF00000909985 cram 317.6 MB
EGAF00000909986 cram 328.5 MB
EGAF00000909987 cram 338.5 MB
EGAF00000909988 cram 290.2 MB
EGAF00000909989 cram 244.3 MB
EGAF00000909990 cram 288.4 MB
EGAF00000909991 cram 275.5 MB
EGAF00000909992 cram 279.8 MB
EGAF00000909993 cram 229.9 MB
EGAF00000909994 cram 267.7 MB
EGAF00000909995 cram 266.3 MB
EGAF00000909996 cram 245.5 MB
EGAF00000909997 cram 276.5 MB
EGAF00000910024 cram 278.0 MB
EGAF00000910025 cram 236.6 MB
EGAF00000910026 cram 306.3 MB
EGAF00000910027 cram 248.0 MB
EGAF00000910028 cram 274.7 MB
EGAF00000910029 cram 253.9 MB
EGAF00000910030 cram 227.0 MB
EGAF00000910031 cram 350.9 MB
EGAF00000910032 cram 273.5 MB
EGAF00000910033 cram 307.4 MB
EGAF00000910034 cram 288.1 MB
EGAF00000910035 cram 278.3 MB
EGAF00000910036 cram 252.6 MB
EGAF00000910037 cram 222.9 MB
EGAF00000910038 cram 217.3 MB
EGAF00000910039 cram 253.4 MB
EGAF00000910040 cram 303.6 MB
EGAF00000910041 cram 304.4 MB
EGAF00000910042 cram 252.6 MB
EGAF00000910043 cram 265.3 MB
EGAF00000961502 cram 275.1 MB
EGAF00000961503 cram 303.7 MB
EGAF00000961504 cram 250.3 MB
EGAF00000961505 cram 287.1 MB
EGAF00000961506 cram 326.2 MB
EGAF00000961507 cram 307.0 MB
EGAF00000961508 cram 316.4 MB
EGAF00000961509 cram 275.4 MB
EGAF00000961510 cram 325.5 MB
EGAF00000961511 cram 259.7 MB
EGAF00000961512 cram 275.2 MB
EGAF00000961513 cram 269.8 MB
EGAF00000961514 cram 271.6 MB
EGAF00000961515 cram 244.0 MB
EGAF00000961516 cram 365.8 MB
EGAF00000961517 cram 297.6 MB
EGAF00000961518 cram 285.7 MB
EGAF00000961519 cram 290.5 MB
EGAF00000961520 cram 277.0 MB
EGAF00000961521 cram 250.4 MB
EGAF00000961522 cram 259.3 MB
EGAF00000961523 cram 266.7 MB
EGAF00000961524 cram 253.3 MB
EGAF00000961525 cram 266.3 MB
EGAF00000961526 cram 259.5 MB
EGAF00000961527 cram 245.0 MB
EGAF00000961528 cram 274.7 MB
EGAF00000961529 cram 268.4 MB
EGAF00000961530 cram 237.3 MB
EGAF00000961531 cram 242.8 MB
EGAF00000961532 cram 284.9 MB
EGAF00000961533 cram 265.9 MB
EGAF00000961534 cram 287.9 MB
EGAF00000961535 cram 256.5 MB
EGAF00000961536 cram 267.0 MB
EGAF00000961537 cram 329.5 MB
EGAF00000961538 cram 261.1 MB
EGAF00000961539 cram 218.5 MB
EGAF00000961540 cram 255.6 MB
EGAF00000961541 cram 241.9 MB
EGAF00000961542 cram 252.7 MB
EGAF00000961543 cram 270.4 MB
EGAF00000961544 cram 261.5 MB
EGAF00000961545 cram 248.4 MB
EGAF00000961546 cram 249.2 MB
EGAF00000961547 cram 223.1 MB
EGAF00000961548 cram 255.6 MB
EGAF00000961549 cram 237.0 MB
EGAF00000961550 cram 276.5 MB
EGAF00000961551 cram 254.3 MB
EGAF00000961552 cram 222.9 MB
EGAF00000961553 cram 192.6 MB
EGAF00000961554 cram 218.4 MB
EGAF00000961555 cram 292.2 MB
EGAF00000961556 cram 248.3 MB
EGAF00000961557 cram 297.7 MB
EGAF00000961558 cram 279.0 MB
EGAF00000961559 cram 280.2 MB
EGAF00000961560 cram 290.9 MB
EGAF00000961561 cram 309.9 MB
EGAF00000961562 cram 263.7 MB
EGAF00000961563 cram 257.5 MB
EGAF00000961564 cram 268.9 MB
EGAF00000961565 cram 310.8 MB
EGAF00000961566 cram 296.4 MB
EGAF00000961567 cram 294.2 MB
EGAF00000961568 cram 378.8 MB
EGAF00000961569 cram 304.5 MB
EGAF00000961570 cram 264.6 MB
EGAF00000961571 cram 303.3 MB
EGAF00000961572 cram 262.8 MB
215 Files (62.2 GB)