About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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ENU-CCK-81 cetuximab pilot project

Cetuximab is a targeted monoclonal antibody against the epidermal growth factor receptor (EGFR) which is used therapeutically for the treatment of KRAS wild-type colorectal cancer (CRC). The Cetuximab sensitive KRAS wild-type CRC cell line NCI-H508 has been treated with a fixed concentration of ENU for 24 hours and then selected with Cetuximab until drug resistant clones were ready to be picked and grown up as sub-clones of the parental cell line. These will have genes causally implicated in cancer sequenced to identify common point mutations in multiple independently derived drug resistant clones as a forward genetic screen for mechanisms of resistance to Cetuximab in CRC.

Request Access

DUO:0000019
version: 2021-02-23

publication required

This data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.

DUO:0000026
version: 2021-02-23

user specific restriction

This data use modifier indicates that use is limited to use by approved users.

DUO:0000028
version: 2021-02-23

institution specific restriction

This data use modifier indicates that use is limited to use within an approved institution.

DUO:0000042
version: 2021-02-23

general research use

This data use permission indicates that use is allowed for general research use for any research purpose.

Wellcome Trust Sanger Institute Cancer Genome Group Data Sharing Policy

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001743 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00001109071 cram 1.2 GB Report
EGAF00001109072 cram 2.1 GB Report
EGAF00001109073 cram 1.9 GB Report
EGAF00001109074 cram 2.0 GB Report
EGAF00001109075 cram 1.9 GB Report
EGAF00001109076 cram 2.2 GB Report
EGAF00001109077 cram 2.2 GB Report
EGAF00001109078 cram 2.0 GB Report
EGAF00001109079 cram 1.9 GB Report
EGAF00001109080 cram 2.0 GB Report
EGAF00001109081 cram 2.2 GB Report
EGAF00001109082 cram 1.9 GB Report
EGAF00001109083 cram 2.0 GB Report
EGAF00001109084 cram 2.0 GB Report
EGAF00001109085 cram 2.4 GB Report
EGAF00001109086 cram 2.6 GB Report
EGAF00001109087 cram 1.6 GB Report
17 Files (34.3 GB)