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ENU-CCK-81 cetuximab pilot project

Cetuximab is a targeted monoclonal antibody against the epidermal growth factor receptor (EGFR) which is used therapeutically for the treatment of KRAS wild-type colorectal cancer (CRC). The Cetuximab sensitive KRAS wild-type CRC cell line NCI-H508 has been treated with a fixed concentration of ENU for 24 hours and then selected with Cetuximab until drug resistant clones were ready to be picked and grown up as sub-clones of the parental cell line. These will have genes causally implicated in cancer sequenced to identify common point mutations in multiple independently derived drug resistant clones as a forward genetic screen for mechanisms of resistance to Cetuximab in CRC.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001743 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001109071 cram 1.2 GB
EGAF00001109072 cram 2.1 GB
EGAF00001109073 cram 1.9 GB
EGAF00001109074 cram 2.0 GB
EGAF00001109075 cram 1.9 GB
EGAF00001109076 cram 2.2 GB
EGAF00001109077 cram 2.2 GB
EGAF00001109078 cram 2.0 GB
EGAF00001109079 cram 1.9 GB
EGAF00001109080 cram 2.0 GB
EGAF00001109081 cram 2.2 GB
EGAF00001109082 cram 1.9 GB
EGAF00001109083 cram 2.0 GB
EGAF00001109084 cram 2.0 GB
EGAF00001109085 cram 2.4 GB
EGAF00001109086 cram 2.6 GB
EGAF00001109087 cram 1.6 GB
17 Files (34.3 GB)