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BRAF V600E colorectal cancers do not respond to the only currently FDA approved targeted therapy for CRC. There is currently a trial underway in the UK recruiting V600E CRC patients for treatment with a triple therapy combination of Cetuximab, Trametinib and Dabrafenib. We have mutagenized a pool of V600E CRC cell lines and treated with this triple therapy to select out drug resistant clones. We will now sequence these drug resistant clones with the aim of identifying common point mutations engendering resistance to this new therapy.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001777 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001161212 cram 1.5 GB
EGAF00001161213 cram 1.1 GB
EGAF00001161214 cram 1.5 GB
EGAF00001161215 cram 1.4 GB
EGAF00001161216 cram 1.4 GB
EGAF00001161217 cram 1.2 GB
EGAF00001161218 cram 1.6 GB
EGAF00001161219 cram 1.9 GB
EGAF00001161220 cram 1.4 GB
EGAF00001161221 cram 1.4 GB
EGAF00001161222 cram 1.5 GB
EGAF00001161223 cram 1.1 GB
EGAF00001161224 cram 1.6 GB
EGAF00001161225 cram 1.4 GB
EGAF00001161226 cram 1.4 GB
EGAF00001161227 cram 1.2 GB
EGAF00001161228 cram 1.6 GB
EGAF00001161229 cram 1.9 GB
EGAF00001161230 cram 1.4 GB
EGAF00001161231 cram 1.4 GB
EGAF00001161232 cram 1.4 GB
EGAF00001161233 cram 1.4 GB
EGAF00001161234 cram 1.2 GB
EGAF00001161235 cram 1.1 GB
EGAF00001161236 cram 1.2 GB
EGAF00001161237 cram 1.6 GB
EGAF00001161238 cram 1.2 GB
EGAF00001161239 cram 1.3 GB
EGAF00001161240 cram 1.2 GB
EGAF00001161241 cram 1.2 GB
EGAF00001161242 cram 1.4 GB
EGAF00001161243 cram 1.4 GB
EGAF00001161244 cram 1.2 GB
EGAF00001161245 cram 1.1 GB
EGAF00001161246 cram 1.2 GB
EGAF00001161247 cram 1.6 GB
EGAF00001161248 cram 1.2 GB
EGAF00001161249 cram 1.3 GB
EGAF00001161250 cram 1.2 GB
EGAF00001161251 cram 1.3 GB
40 Files (54.6 GB)