Need Help?

PSCP_mutation analysis in hESCs

Many studies over the past 10 years, culminating in the recent report of the International Stem Cell Initiative (ISCI, 2011) have shown that hPSC acquire genetic and epigenetic changes during their time in culture. Many of the genetic changes are non-random and recurrent, probably because they provide a selective growth advantage to the undifferentiated cells. Some are shared by embryonal carcinoma cells, the malignant counterparts of ES cells. The origins of these growth advantages are poorly understood, but may come from altered cell cycle dynamics, resistance to apoptosis or altered patterns of differentiation. Less is known about the nature and consequences of epigenetic changes, but it is likely that these similarly affect hPSC behaviour; e.g., enhanced expression of DLK1, an imprinted gene, is associated with altered hPSC growth (Enver et al 2005). Inevitably, these genetic and epigenetic changes will impact on our ability to use hPSC for regenerative medicine, either because malignant transformation of the undifferentiated cells or their differentiated derivatives to be used for transplantation compromises safety, or because they impede the function of those differentiated derivatives, or because they affect the efficiency with which the undifferentiated cells can be expanded and differentiated into desired cell types. Focusing initially upon the existing clinical grade hESC lines, later moving to iPSC, we will Consolidate and extend knowledge of the rate, type and functional impact of the genetic variations that occur during hPSC culture. We will use whole genome and exome sequencing as well as SNP arrays, together with clonal analysis and other cytogenetics techniques. Common changes will be compared with those found in the normal human population, at low frequency in the original cell population or observed during iPSC generation in the HIPSCI project currently based at the WTSI. These studies will provide a better understanding of the range of genetic changes that occur in hPSC beyond the CNVs already identified. In conjunction with cancer genome resources and expertise at WTSI, bioinformatic analyses of these hPSC data will allow us to assess potential impact on hPSC behaviour pertinent to applications in regenerative medicine, notably the likelihood that specific changes arising in undifferentiated PSC cultures may be associated with potential malignant transformation of differentiated progeny. This data is part of a pre-publication release. For information on the proper use of pre-publication data shred by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

Request Access

Wellcome Trust Sanger Institute Data Sharing Policy

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001561 Whole Genome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF00001053400 cram 3.9 GB Report
EGAF00001053401 cram 4.3 GB Report
EGAF00001053402 cram 3.7 GB Report
EGAF00001053403 cram 3.8 GB Report
EGAF00001053404 cram 3.4 GB Report
EGAF00001053405 cram 3.8 GB Report
EGAF00001053406 cram 3.8 GB Report
EGAF00001053407 cram 3.2 GB Report
EGAF00001053408 cram 3.5 GB Report
EGAF00001053409 cram 3.8 GB Report
EGAF00001053410 cram 5.1 GB Report
EGAF00001053411 cram 4.8 GB Report
EGAF00001053412 cram 4.9 GB Report
EGAF00001053413 cram 3.4 GB Report
EGAF00001053414 cram 3.6 GB Report
EGAF00001053415 cram 3.8 GB Report
EGAF00001053416 cram 3.6 GB Report
EGAF00001053417 cram 3.4 GB Report
EGAF00001053418 cram 3.3 GB Report
EGAF00001053419 cram 3.9 GB Report
EGAF00001053420 cram 3.6 GB Report
EGAF00001053421 cram 3.6 GB Report
EGAF00001053422 cram 3.2 GB Report
EGAF00001053423 cram 3.9 GB Report
EGAF00001053424 cram 3.8 GB Report
EGAF00001053425 cram 4.2 GB Report
EGAF00001053426 cram 3.9 GB Report
EGAF00001053427 cram 3.9 GB Report
EGAF00001053428 cram 3.7 GB Report
EGAF00001053429 cram 4.2 GB Report
EGAF00001053430 cram 3.8 GB Report
EGAF00001053431 cram 3.7 GB Report
EGAF00001053432 cram 3.5 GB Report
EGAF00001053433 cram 4.3 GB Report
EGAF00001053434 cram 4.2 GB Report
EGAF00001053435 cram 4.7 GB Report
EGAF00001053436 cram 4.1 GB Report
EGAF00001053437 cram 4.1 GB Report
EGAF00001053438 cram 4.3 GB Report
EGAF00001053439 cram 4.5 GB Report
EGAF00001053440 cram 3.3 GB Report
EGAF00001053441 cram 4.6 GB Report
EGAF00001053442 cram 3.7 GB Report
EGAF00001053443 cram 4.5 GB Report
EGAF00001053444 cram 4.2 GB Report
EGAF00001053445 cram 4.5 GB Report
EGAF00001053446 cram 4.4 GB Report
EGAF00001053447 cram 3.8 GB Report
EGAF00001053448 cram 4.5 GB Report
EGAF00001053449 cram 3.8 GB Report
EGAF00001053450 cram 4.3 GB Report
EGAF00001053451 cram 4.6 GB Report
EGAF00001053493 cram 3.7 GB Report
EGAF00001053494 cram 3.6 GB Report
EGAF00001053495 cram 3.8 GB Report
EGAF00001053496 cram 4.0 GB Report
EGAF00001053497 cram 3.0 GB Report
EGAF00001053498 cram 4.0 GB Report
EGAF00001053499 cram 3.4 GB Report
EGAF00001053500 cram 4.0 GB Report
EGAF00001053501 cram 3.9 GB Report
EGAF00001053502 cram 4.1 GB Report
EGAF00001053503 cram 4.0 GB Report
EGAF00001053504 cram 3.4 GB Report
EGAF00001053505 cram 4.1 GB Report
EGAF00001053506 cram 3.5 GB Report
EGAF00001053507 cram 3.9 GB Report
EGAF00001053508 cram 4.1 GB Report
EGAF00001053509 cram 4.6 GB Report
EGAF00001053510 cram 3.9 GB Report
EGAF00001053511 cram 4.0 GB Report
EGAF00001053512 cram 3.6 GB Report
EGAF00001053513 cram 3.7 GB Report
EGAF00001053514 cram 3.9 GB Report
EGAF00001053515 cram 3.7 GB Report
EGAF00001053516 cram 3.4 GB Report
EGAF00001053517 cram 3.9 GB Report
EGAF00001053518 cram 3.7 GB Report
EGAF00001053519 cram 5.4 GB Report
EGAF00001053520 cram 4.5 GB Report
EGAF00001053521 cram 4.6 GB Report
EGAF00001053522 cram 4.1 GB Report
EGAF00001053523 cram 4.3 GB Report
EGAF00001053524 cram 4.6 GB Report
EGAF00001053525 cram 4.4 GB Report
EGAF00001053526 cram 3.9 GB Report
EGAF00001053527 cram 4.6 GB Report
EGAF00001053528 cram 4.4 GB Report
EGAF00001053529 cram 4.1 GB Report
EGAF00001053530 cram 5.1 GB Report
EGAF00001053531 cram 5.1 GB Report
EGAF00001053532 cram 4.5 GB Report
EGAF00001053533 cram 3.6 GB Report
EGAF00001053534 cram 4.0 GB Report
EGAF00001053535 cram 4.4 GB Report
EGAF00001053536 cram 5.0 GB Report
EGAF00001053537 cram 4.8 GB Report
EGAF00001053538 cram 4.7 GB Report
EGAF00001053539 cram 4.5 GB Report
EGAF00001053540 cram 4.2 GB Report
EGAF00001053541 cram 3.9 GB Report
EGAF00001053542 cram 5.2 GB Report
EGAF00001053543 cram 4.7 GB Report
EGAF00001053544 cram 4.3 GB Report
EGAF00001053597 cram 3.6 GB Report
EGAF00001053598 cram 4.4 GB Report
EGAF00001053599 cram 4.4 GB Report
EGAF00001053600 cram 3.9 GB Report
EGAF00001053601 cram 3.0 GB Report
EGAF00001053602 cram 3.5 GB Report
EGAF00001053603 cram 3.7 GB Report
EGAF00001053604 cram 4.2 GB Report
EGAF00001053605 cram 4.0 GB Report
EGAF00001053606 cram 4.0 GB Report
EGAF00001053607 cram 3.8 GB Report
EGAF00001053608 cram 3.6 GB Report
EGAF00001053609 cram 3.4 GB Report
EGAF00001053610 cram 4.3 GB Report
EGAF00001053611 cram 4.0 GB Report
EGAF00001053612 cram 3.7 GB Report
EGAF00001053613 cram 3.8 GB Report
EGAF00001053614 cram 3.9 GB Report
EGAF00001053615 cram 4.1 GB Report
EGAF00001053616 cram 4.2 GB Report
EGAF00001053617 cram 3.5 GB Report
EGAF00001053618 cram 3.6 GB Report
EGAF00001053619 cram 4.1 GB Report
EGAF00001053620 cram 3.9 GB Report
EGAF00001053621 cram 2.6 GB Report
EGAF00001053622 cram 3.7 GB Report
EGAF00001053623 cram 4.5 GB Report
EGAF00001053624 cram 4.7 GB Report
EGAF00001053625 cram 4.7 GB Report
EGAF00001053626 cram 5.2 GB Report
EGAF00001053627 cram 4.4 GB Report
EGAF00001053628 cram 4.3 GB Report
EGAF00001053629 cram 5.0 GB Report
EGAF00001053630 cram 4.8 GB Report
EGAF00001053631 cram 3.2 GB Report
EGAF00001053632 cram 4.6 GB Report
EGAF00001053633 cram 4.5 GB Report
EGAF00001053634 cram 5.7 GB Report
EGAF00001053635 cram 4.5 GB Report
EGAF00001053636 cram 4.9 GB Report
EGAF00001053637 cram 4.4 GB Report
EGAF00001053638 cram 4.4 GB Report
EGAF00001053639 cram 4.0 GB Report
EGAF00001053640 cram 4.4 GB Report
EGAF00001053641 cram 4.4 GB Report
EGAF00001053642 cram 3.8 GB Report
EGAF00001053643 cram 4.1 GB Report
EGAF00001053644 cram 4.5 GB Report
EGAF00001053645 cram 6.0 GB Report
EGAF00001053646 cram 5.7 GB Report
EGAF00001053647 cram 5.0 GB Report
EGAF00001053648 cram 3.6 GB Report
EGAF00001053701 cram 3.7 GB Report
EGAF00001053702 cram 4.6 GB Report
EGAF00001053703 cram 3.8 GB Report
EGAF00001053704 cram 4.0 GB Report
EGAF00001053705 cram 3.5 GB Report
EGAF00001053706 cram 3.6 GB Report
EGAF00001053707 cram 3.2 GB Report
EGAF00001053708 cram 3.4 GB Report
EGAF00001053709 cram 3.4 GB Report
EGAF00001053710 cram 3.0 GB Report
EGAF00001053711 cram 3.3 GB Report
EGAF00001053712 cram 3.4 GB Report
EGAF00001053713 cram 4.8 GB Report
EGAF00001053714 cram 4.6 GB Report
EGAF00001053715 cram 5.0 GB Report
EGAF00001053716 cram 3.6 GB Report
EGAF00001053717 cram 3.5 GB Report
EGAF00001053718 cram 3.9 GB Report
EGAF00001053719 cram 3.7 GB Report
EGAF00001053720 cram 3.7 GB Report
EGAF00001053721 cram 3.4 GB Report
EGAF00001053722 cram 3.9 GB Report
EGAF00001053723 cram 3.5 GB Report
EGAF00001053724 cram 3.5 GB Report
EGAF00001053725 cram 3.3 GB Report
EGAF00001053726 cram 4.0 GB Report
EGAF00001053727 cram 3.6 GB Report
EGAF00001053728 cram 3.9 GB Report
EGAF00001053729 cram 3.7 GB Report
EGAF00001053730 cram 3.7 GB Report
EGAF00001053731 cram 3.5 GB Report
EGAF00001053732 cram 4.0 GB Report
EGAF00001053733 cram 3.6 GB Report
EGAF00001053734 cram 3.5 GB Report
EGAF00001053735 cram 3.2 GB Report
EGAF00001053736 cram 3.9 GB Report
EGAF00001053737 cram 3.7 GB Report
EGAF00001053738 cram 4.2 GB Report
EGAF00001053739 cram 3.6 GB Report
EGAF00001053740 cram 3.7 GB Report
EGAF00001053741 cram 3.9 GB Report
EGAF00001053742 cram 4.1 GB Report
EGAF00001053743 cram 3.0 GB Report
EGAF00001053744 cram 4.2 GB Report
EGAF00001053745 cram 3.4 GB Report
EGAF00001053746 cram 4.1 GB Report
EGAF00001053747 cram 3.9 GB Report
EGAF00001053748 cram 4.2 GB Report
EGAF00001053749 cram 4.1 GB Report
EGAF00001053750 cram 3.5 GB Report
EGAF00001053751 cram 4.2 GB Report
EGAF00001053752 cram 3.5 GB Report
EGAF00001053805 cram 3.8 GB Report
EGAF00001053806 cram 4.3 GB Report
EGAF00001053807 cram 3.7 GB Report
EGAF00001053808 cram 3.8 GB Report
EGAF00001053809 cram 4.0 GB Report
EGAF00001053810 cram 4.1 GB Report
EGAF00001053811 cram 3.1 GB Report
EGAF00001053812 cram 4.4 GB Report
EGAF00001053813 cram 3.3 GB Report
EGAF00001053814 cram 4.2 GB Report
EGAF00001053815 cram 3.7 GB Report
EGAF00001053816 cram 4.1 GB Report
EGAF00001053817 cram 3.9 GB Report
EGAF00001053818 cram 3.5 GB Report
EGAF00001053819 cram 4.1 GB Report
EGAF00001053820 cram 3.4 GB Report
EGAF00001053821 cram 3.9 GB Report
EGAF00001053822 cram 4.2 GB Report
EGAF00001053823 cram 4.7 GB Report
EGAF00001053824 cram 3.9 GB Report
EGAF00001053825 cram 3.9 GB Report
EGAF00001053826 cram 3.5 GB Report
EGAF00001053827 cram 3.8 GB Report
EGAF00001053828 cram 4.0 GB Report
EGAF00001053829 cram 3.8 GB Report
EGAF00001053830 cram 3.4 GB Report
EGAF00001053831 cram 4.0 GB Report
EGAF00001053832 cram 4.3 GB Report
EGAF00001053833 cram 4.6 GB Report
EGAF00001053834 cram 3.9 GB Report
EGAF00001053835 cram 3.9 GB Report
EGAF00001053836 cram 3.5 GB Report
EGAF00001053837 cram 3.7 GB Report
EGAF00001053838 cram 3.9 GB Report
EGAF00001053839 cram 3.8 GB Report
EGAF00001053840 cram 3.4 GB Report
EGAF00001053841 cram 3.9 GB Report
EGAF00001053842 cram 3.8 GB Report
EGAF00001053843 cram 3.6 GB Report
EGAF00001053844 cram 4.5 GB Report
EGAF00001053845 cram 4.6 GB Report
EGAF00001053846 cram 4.0 GB Report
EGAF00001053847 cram 3.2 GB Report
EGAF00001053848 cram 3.6 GB Report
EGAF00001053849 cram 3.9 GB Report
EGAF00001053850 cram 4.4 GB Report
EGAF00001053851 cram 4.3 GB Report
EGAF00001053852 cram 4.2 GB Report
EGAF00001053853 cram 3.9 GB Report
EGAF00001053854 cram 3.6 GB Report
EGAF00001053855 cram 3.3 GB Report
EGAF00001053856 cram 4.4 GB Report
EGAF00001053909 cram 3.9 GB Report
EGAF00001053910 cram 3.8 GB Report
EGAF00001053911 cram 3.5 GB Report
EGAF00001053912 cram 4.3 GB Report
EGAF00001053913 cram 4.5 GB Report
EGAF00001053914 cram 3.9 GB Report
EGAF00001053915 cram 3.1 GB Report
EGAF00001053916 cram 3.4 GB Report
EGAF00001053917 cram 3.9 GB Report
EGAF00001053918 cram 4.3 GB Report
EGAF00001053919 cram 4.3 GB Report
EGAF00001053920 cram 4.1 GB Report
EGAF00001053921 cram 4.0 GB Report
EGAF00001053922 cram 3.7 GB Report
EGAF00001053923 cram 3.4 GB Report
EGAF00001053924 cram 4.5 GB Report
EGAF00001053925 cram 4.1 GB Report
EGAF00001053926 cram 3.8 GB Report
EGAF00001053927 cram 3.9 GB Report
EGAF00001053928 cram 3.9 GB Report
EGAF00001053929 cram 4.2 GB Report
EGAF00001053930 cram 4.6 GB Report
EGAF00001053931 cram 3.8 GB Report
EGAF00001053932 cram 3.6 GB Report
EGAF00001053933 cram 4.3 GB Report
EGAF00001053934 cram 4.1 GB Report
EGAF00001053935 cram 4.0 GB Report
EGAF00001053936 cram 3.7 GB Report
EGAF00001053937 cram 3.9 GB Report
EGAF00001053938 cram 3.9 GB Report
EGAF00001053939 cram 4.0 GB Report
EGAF00001053940 cram 4.4 GB Report
EGAF00001053941 cram 3.7 GB Report
EGAF00001053942 cram 3.6 GB Report
EGAF00001053943 cram 4.2 GB Report
EGAF00001053944 cram 4.1 GB Report
EGAF00001053945 cram 2.7 GB Report
EGAF00001053946 cram 3.9 GB Report
EGAF00001053947 cram 3.9 GB Report
EGAF00001053948 cram 4.8 GB Report
EGAF00001053949 cram 3.9 GB Report
EGAF00001053950 cram 4.2 GB Report
EGAF00001053951 cram 3.4 GB Report
EGAF00001053952 cram 3.5 GB Report
EGAF00001053953 cram 3.1 GB Report
EGAF00001053954 cram 3.4 GB Report
EGAF00001053955 cram 3.4 GB Report
EGAF00001053956 cram 2.9 GB Report
EGAF00001053957 cram 3.2 GB Report
EGAF00001053958 cram 3.5 GB Report
EGAF00001053959 cram 4.7 GB Report
EGAF00001053960 cram 4.4 GB Report
EGAF00001054013 cram 2.8 GB Report
EGAF00001054014 cram 3.9 GB Report
EGAF00001054015 cram 3.9 GB Report
EGAF00001054016 cram 4.9 GB Report
EGAF00001054017 cram 3.9 GB Report
EGAF00001054018 cram 4.2 GB Report
EGAF00001054019 cram 3.8 GB Report
EGAF00001054020 cram 3.8 GB Report
EGAF00001054021 cram 3.4 GB Report
EGAF00001054022 cram 3.8 GB Report
EGAF00001054023 cram 3.8 GB Report
EGAF00001054024 cram 3.2 GB Report
EGAF00001054025 cram 3.5 GB Report
EGAF00001054026 cram 3.9 GB Report
EGAF00001054027 cram 5.2 GB Report
EGAF00001054028 cram 4.9 GB Report
EGAF00001054029 cram 4.9 GB Report
EGAF00001054030 cram 3.5 GB Report
EGAF00001054031 cram 3.5 GB Report
EGAF00001054032 cram 3.8 GB Report
EGAF00001054033 cram 3.6 GB Report
EGAF00001054034 cram 3.5 GB Report
EGAF00001054035 cram 3.4 GB Report
EGAF00001054036 cram 3.8 GB Report
EGAF00001054037 cram 3.5 GB Report
EGAF00001054038 cram 3.5 GB Report
EGAF00001054091 cram 3.2 GB Report
EGAF00001054092 cram 3.9 GB Report
EGAF00001054093 cram 3.8 GB Report
EGAF00001054094 cram 4.3 GB Report
EGAF00001054095 cram 3.7 GB Report
EGAF00001054096 cram 3.8 GB Report
EGAF00001054097 cram 3.9 GB Report
EGAF00001054098 cram 4.1 GB Report
EGAF00001054099 cram 3.1 GB Report
EGAF00001054100 cram 4.2 GB Report
EGAF00001054101 cram 3.3 GB Report
EGAF00001054102 cram 4.0 GB Report
EGAF00001054103 cram 3.7 GB Report
EGAF00001054104 cram 4.0 GB Report
EGAF00001054105 cram 3.9 GB Report
EGAF00001054106 cram 3.4 GB Report
EGAF00001054107 cram 4.0 GB Report
EGAF00001054108 cram 3.3 GB Report
EGAF00001054109 cram 3.8 GB Report
EGAF00001054110 cram 4.0 GB Report
EGAF00001054111 cram 4.6 GB Report
EGAF00001054112 cram 3.9 GB Report
EGAF00001054113 cram 4.0 GB Report
EGAF00001054114 cram 3.5 GB Report
EGAF00001054115 cram 3.7 GB Report
EGAF00001054116 cram 4.0 GB Report
EGAF00001054169 cram 3.8 GB Report
EGAF00001054170 cram 3.4 GB Report
EGAF00001054171 cram 3.9 GB Report
EGAF00001054172 cram 3.8 GB Report
EGAF00001054173 cram 3.5 GB Report
EGAF00001054174 cram 4.3 GB Report
EGAF00001054175 cram 4.4 GB Report
EGAF00001054176 cram 3.8 GB Report
EGAF00001054177 cram 3.0 GB Report
EGAF00001054178 cram 3.4 GB Report
EGAF00001054179 cram 3.8 GB Report
EGAF00001054180 cram 4.2 GB Report
EGAF00001054181 cram 4.1 GB Report
EGAF00001054182 cram 4.0 GB Report
EGAF00001054183 cram 3.8 GB Report
EGAF00001054184 cram 3.6 GB Report
EGAF00001054185 cram 3.3 GB Report
EGAF00001054186 cram 4.3 GB Report
EGAF00001054187 cram 3.9 GB Report
EGAF00001054188 cram 3.6 GB Report
EGAF00001054189 cram 3.8 GB Report
EGAF00001054190 cram 3.8 GB Report
EGAF00001054191 cram 4.0 GB Report
EGAF00001054192 cram 4.3 GB Report
EGAF00001054193 cram 3.7 GB Report
EGAF00001054194 cram 3.6 GB Report
EGAF00001054247 cram 4.2 GB Report
EGAF00001054248 cram 4.1 GB Report
EGAF00001054249 cram 2.7 GB Report
EGAF00001054250 cram 3.9 GB Report
EGAF00001054251 cram 3.9 GB Report
EGAF00001054252 cram 4.8 GB Report
EGAF00001054253 cram 3.8 GB Report
EGAF00001054254 cram 4.2 GB Report
EGAF00001054255 cram 3.5 GB Report
EGAF00001054256 cram 3.6 GB Report
EGAF00001054257 cram 3.2 GB Report
EGAF00001054258 cram 3.5 GB Report
EGAF00001054259 cram 3.5 GB Report
EGAF00001054260 cram 3.0 GB Report
EGAF00001054261 cram 3.3 GB Report
EGAF00001054262 cram 3.6 GB Report
EGAF00001054263 cram 4.8 GB Report
EGAF00001054264 cram 4.6 GB Report
EGAF00001054265 cram 4.6 GB Report
EGAF00001054266 cram 3.3 GB Report
EGAF00001054267 cram 3.3 GB Report
EGAF00001054268 cram 3.6 GB Report
EGAF00001054269 cram 3.4 GB Report
EGAF00001054270 cram 3.3 GB Report
EGAF00001054271 cram 3.2 GB Report
EGAF00001054272 cram 3.6 GB Report
EGAF00001054325 cram 3.3 GB Report
EGAF00001054326 cram 3.3 GB Report
EGAF00001054327 cram 3.0 GB Report
EGAF00001054328 cram 3.7 GB Report
EGAF00001054329 cram 3.5 GB Report
EGAF00001054330 cram 4.0 GB Report
EGAF00001054331 cram 3.4 GB Report
EGAF00001054332 cram 3.5 GB Report
EGAF00001054333 cram 3.6 GB Report
EGAF00001054334 cram 3.8 GB Report
EGAF00001054335 cram 2.8 GB Report
EGAF00001054336 cram 4.0 GB Report
EGAF00001054337 cram 3.1 GB Report
EGAF00001054338 cram 3.9 GB Report
EGAF00001054339 cram 3.5 GB Report
EGAF00001054340 cram 3.8 GB Report
EGAF00001054341 cram 3.7 GB Report
EGAF00001054342 cram 3.2 GB Report
EGAF00001054343 cram 3.8 GB Report
EGAF00001054344 cram 3.2 GB Report
EGAF00001054345 cram 3.6 GB Report
EGAF00001054346 cram 3.9 GB Report
EGAF00001054347 cram 4.3 GB Report
EGAF00001054348 cram 3.6 GB Report
EGAF00001054349 cram 3.7 GB Report
EGAF00001054350 cram 3.3 GB Report
EGAF00001054397 cram 3.7 GB Report
EGAF00001054398 cram 4.1 GB Report
EGAF00001054399 cram 3.6 GB Report
EGAF00001054400 cram 3.6 GB Report
EGAF00001054401 cram 3.7 GB Report
EGAF00001054402 cram 3.9 GB Report
EGAF00001054403 cram 3.4 GB Report
EGAF00001054404 cram 3.7 GB Report
EGAF00001054405 cram 3.5 GB Report
EGAF00001054406 cram 3.1 GB Report
EGAF00001054407 cram 3.6 GB Report
EGAF00001054408 cram 3.5 GB Report
EGAF00001054409 cram 3.2 GB Report
EGAF00001054410 cram 4.0 GB Report
EGAF00001054411 cram 4.1 GB Report
EGAF00001054412 cram 3.5 GB Report
EGAF00001054413 cram 2.8 GB Report
EGAF00001054414 cram 3.2 GB Report
EGAF00001054415 cram 3.5 GB Report
EGAF00001054416 cram 3.9 GB Report
EGAF00001054417 cram 3.9 GB Report
EGAF00001054418 cram 3.7 GB Report
EGAF00001054419 cram 3.6 GB Report
EGAF00001054420 cram 3.4 GB Report
EGAF00001054421 cram 3.1 GB Report
EGAF00001054422 cram 4.0 GB Report
EGAF00001054423 cram 3.7 GB Report
EGAF00001054424 cram 3.4 GB Report
EGAF00001054425 cram 3.6 GB Report
EGAF00001054426 cram 3.6 GB Report
EGAF00001054427 cram 3.8 GB Report
EGAF00001054428 cram 4.1 GB Report
EGAF00001054455 cram 2.9 GB Report
EGAF00001054456 cram 3.3 GB Report
EGAF00001054457 cram 3.8 GB Report
EGAF00001054458 cram 3.7 GB Report
EGAF00001054459 cram 3.9 GB Report
EGAF00001054460 cram 3.8 GB Report
EGAF00001054461 cram 3.3 GB Report
EGAF00001054462 cram 3.9 GB Report
EGAF00001054463 cram 3.3 GB Report
EGAF00001054464 cram 3.7 GB Report
EGAF00001054465 cram 3.9 GB Report
EGAF00001054466 cram 4.5 GB Report
EGAF00001054467 cram 3.8 GB Report
EGAF00001054468 cram 3.9 GB Report
EGAF00001054469 cram 3.5 GB Report
EGAF00001054470 cram 3.6 GB Report
EGAF00001054471 cram 3.8 GB Report
EGAF00001054472 cram 3.6 GB Report
EGAF00001054473 cram 3.3 GB Report
EGAF00001054474 cram 3.8 GB Report
EGAF00001054475 cram 3.6 GB Report
EGAF00001054476 cram 3.4 GB Report
EGAF00001054477 cram 4.2 GB Report
EGAF00001054478 cram 4.3 GB Report
EGAF00001054479 cram 3.7 GB Report
EGAF00001054480 cram 2.9 GB Report
EGAF00001054481 cram 3.4 GB Report
EGAF00001054482 cram 3.4 GB Report
EGAF00001054483 cram 3.9 GB Report
EGAF00001054484 cram 3.8 GB Report
EGAF00001054485 cram 2.5 GB Report
EGAF00001054486 cram 3.6 GB Report
EGAF00001054487 cram 3.6 GB Report
EGAF00001054488 cram 4.4 GB Report
EGAF00001054489 cram 3.6 GB Report
EGAF00001054490 cram 3.9 GB Report
EGAF00001054491 cram 3.4 GB Report
EGAF00001054492 cram 3.4 GB Report
EGAF00001054493 cram 3.0 GB Report
EGAF00001054494 cram 3.4 GB Report
EGAF00001054495 cram 3.4 GB Report
EGAF00001054496 cram 2.9 GB Report
EGAF00001054497 cram 3.1 GB Report
EGAF00001054498 cram 3.4 GB Report
EGAF00001054499 cram 4.6 GB Report
EGAF00001054500 cram 4.4 GB Report
EGAF00001054501 cram 4.4 GB Report
EGAF00001054502 cram 3.1 GB Report
EGAF00001054503 cram 3.2 GB Report
EGAF00001054504 cram 3.5 GB Report
EGAF00001054505 cram 3.3 GB Report
EGAF00001054506 cram 3.2 GB Report
EGAF00001054533 cram 3.4 GB Report
EGAF00001054534 cram 3.6 GB Report
EGAF00001054535 cram 4.0 GB Report
EGAF00001054536 cram 3.9 GB Report
EGAF00001054537 cram 3.8 GB Report
EGAF00001054538 cram 3.7 GB Report
EGAF00001054539 cram 3.6 GB Report
EGAF00001054540 cram 3.3 GB Report
EGAF00001054541 cram 4.3 GB Report
EGAF00001054542 cram 3.9 GB Report
EGAF00001054543 cram 3.6 GB Report
EGAF00001054544 cram 3.7 GB Report
EGAF00001054545 cram 3.8 GB Report
EGAF00001054546 cram 4.0 GB Report
EGAF00001054547 cram 4.2 GB Report
EGAF00001054548 cram 3.5 GB Report
EGAF00001054549 cram 3.6 GB Report
EGAF00001054550 cram 4.1 GB Report
EGAF00001054551 cram 4.0 GB Report
EGAF00001054552 cram 2.6 GB Report
EGAF00001054553 cram 3.8 GB Report
EGAF00001054554 cram 3.7 GB Report
EGAF00001054555 cram 4.6 GB Report
EGAF00001054556 cram 3.8 GB Report
EGAF00001054557 cram 4.0 GB Report
EGAF00001054558 cram 3.5 GB Report
EGAF00001054559 cram 3.1 GB Report
EGAF00001054560 cram 3.5 GB Report
EGAF00001054561 cram 3.2 GB Report
EGAF00001054562 cram 3.2 GB Report
EGAF00001054563 cram 3.0 GB Report
EGAF00001054564 cram 3.6 GB Report
EGAF00001054565 cram 3.5 GB Report
EGAF00001054566 cram 3.9 GB Report
EGAF00001054567 cram 3.4 GB Report
EGAF00001054568 cram 3.4 GB Report
EGAF00001054569 cram 3.6 GB Report
EGAF00001054570 cram 3.8 GB Report
EGAF00001054571 cram 2.8 GB Report
EGAF00001054572 cram 3.9 GB Report
EGAF00001054573 cram 3.1 GB Report
EGAF00001054574 cram 3.8 GB Report
EGAF00001054575 cram 3.5 GB Report
EGAF00001054576 cram 3.8 GB Report
EGAF00001054577 cram 3.6 GB Report
EGAF00001054578 cram 3.2 GB Report
EGAF00001054579 cram 3.7 GB Report
EGAF00001054580 cram 3.1 GB Report
EGAF00001054581 cram 3.6 GB Report
EGAF00001054582 cram 3.8 GB Report
EGAF00001054583 cram 4.4 GB Report
EGAF00001054584 cram 3.7 GB Report
EGAF00001054611 cram 3.6 GB Report
EGAF00001054612 cram 3.2 GB Report
EGAF00001054613 cram 3.5 GB Report
EGAF00001054614 cram 3.5 GB Report
EGAF00001054615 cram 3.0 GB Report
EGAF00001054616 cram 3.3 GB Report
EGAF00001054617 cram 3.5 GB Report
EGAF00001054618 cram 4.8 GB Report
EGAF00001054619 cram 4.5 GB Report
EGAF00001054620 cram 4.0 GB Report
EGAF00001054621 cram 3.5 GB Report
EGAF00001054622 cram 4.1 GB Report
EGAF00001054623 cram 3.5 GB Report
EGAF00001054624 cram 3.9 GB Report
EGAF00001054625 cram 4.8 GB Report
EGAF00001054626 cram 4.1 GB Report
EGAF00001054627 cram 4.1 GB Report
EGAF00001054628 cram 3.7 GB Report
EGAF00001054629 cram 3.9 GB Report
EGAF00001054630 cram 4.1 GB Report
EGAF00001054631 cram 4.0 GB Report
EGAF00001054632 cram 3.5 GB Report
EGAF00001054633 cram 4.1 GB Report
EGAF00001054634 cram 4.0 GB Report
EGAF00001054635 cram 3.6 GB Report
EGAF00001054636 cram 4.4 GB Report
EGAF00001054637 cram 3.8 GB Report
EGAF00001054638 cram 3.4 GB Report
EGAF00001054639 cram 3.5 GB Report
EGAF00001054640 cram 3.8 GB Report
EGAF00001054641 cram 3.6 GB Report
EGAF00001054642 cram 3.2 GB Report
EGAF00001054643 cram 3.7 GB Report
EGAF00001054644 cram 3.6 GB Report
EGAF00001054645 cram 3.3 GB Report
EGAF00001054646 cram 4.1 GB Report
EGAF00001054647 cram 4.1 GB Report
EGAF00001054648 cram 3.6 GB Report
EGAF00001054649 cram 2.8 GB Report
EGAF00001054650 cram 3.3 GB Report
EGAF00001054651 cram 3.5 GB Report
EGAF00001054652 cram 3.9 GB Report
EGAF00001054653 cram 3.9 GB Report
EGAF00001054654 cram 3.7 GB Report
EGAF00001054655 cram 3.6 GB Report
EGAF00001054656 cram 3.5 GB Report
EGAF00001054657 cram 3.2 GB Report
EGAF00001054658 cram 4.2 GB Report
EGAF00001054659 cram 3.8 GB Report
EGAF00001054660 cram 3.5 GB Report
EGAF00001054661 cram 3.6 GB Report
EGAF00001054662 cram 3.7 GB Report
EGAF00001054689 cram 4.5 GB Report
EGAF00001054690 cram 3.9 GB Report
EGAF00001054691 cram 3.1 GB Report
EGAF00001054692 cram 3.5 GB Report
EGAF00001054693 cram 3.8 GB Report
EGAF00001054694 cram 4.3 GB Report
EGAF00001054695 cram 4.3 GB Report
EGAF00001054696 cram 4.1 GB Report
EGAF00001054697 cram 4.0 GB Report
EGAF00001054698 cram 3.8 GB Report
EGAF00001054699 cram 3.4 GB Report
EGAF00001054700 cram 4.5 GB Report
EGAF00001054701 cram 4.2 GB Report
EGAF00001054702 cram 3.8 GB Report
EGAF00001054703 cram 4.0 GB Report
EGAF00001054704 cram 4.0 GB Report
EGAF00001054705 cram 4.2 GB Report
EGAF00001054706 cram 4.6 GB Report
EGAF00001054707 cram 3.8 GB Report
EGAF00001054708 cram 3.7 GB Report
EGAF00001054709 cram 4.3 GB Report
EGAF00001054710 cram 4.2 GB Report
EGAF00001054711 cram 2.8 GB Report
EGAF00001054712 cram 4.0 GB Report
EGAF00001054713 cram 4.0 GB Report
EGAF00001054714 cram 4.9 GB Report
EGAF00001054715 cram 3.8 GB Report
EGAF00001054716 cram 4.1 GB Report
EGAF00001054717 cram 3.4 GB Report
EGAF00001054718 cram 3.4 GB Report
EGAF00001054719 cram 3.9 GB Report
EGAF00001054720 cram 3.8 GB Report
EGAF00001054721 cram 2.5 GB Report
EGAF00001054722 cram 3.6 GB Report
EGAF00001054723 cram 3.6 GB Report
EGAF00001054724 cram 4.4 GB Report
EGAF00001054725 cram 3.6 GB Report
EGAF00001054726 cram 3.9 GB Report
EGAF00001054727 cram 3.4 GB Report
EGAF00001054728 cram 3.4 GB Report
EGAF00001054729 cram 3.0 GB Report
EGAF00001054730 cram 3.3 GB Report
EGAF00001054731 cram 3.3 GB Report
EGAF00001054732 cram 2.9 GB Report
EGAF00001054733 cram 3.1 GB Report
EGAF00001054734 cram 3.4 GB Report
EGAF00001054735 cram 4.5 GB Report
EGAF00001054736 cram 4.3 GB Report
EGAF00001054737 cram 5.3 GB Report
EGAF00001054738 cram 3.8 GB Report
EGAF00001054739 cram 3.8 GB Report
EGAF00001054740 cram 4.2 GB Report
EGAF00001064912 cram 3.9 GB Report
EGAF00001064913 cram 3.7 GB Report
EGAF00001064914 cram 3.9 GB Report
EGAF00001064915 cram 3.8 GB Report
EGAF00001064916 cram 3.3 GB Report
EGAF00001064917 cram 3.9 GB Report
EGAF00001064918 cram 3.3 GB Report
EGAF00001064919 cram 3.7 GB Report
EGAF00001064920 cram 4.0 GB Report
EGAF00001064921 cram 4.7 GB Report
EGAF00001064922 cram 4.0 GB Report
EGAF00001064923 cram 4.0 GB Report
EGAF00001064924 cram 3.5 GB Report
EGAF00001064925 cram 3.7 GB Report
EGAF00001064926 cram 4.0 GB Report
EGAF00001064927 cram 3.8 GB Report
EGAF00001064928 cram 3.4 GB Report
EGAF00001064929 cram 3.9 GB Report
EGAF00001064930 cram 3.8 GB Report
EGAF00001064931 cram 3.5 GB Report
EGAF00001064932 cram 4.3 GB Report
EGAF00001064933 cram 4.4 GB Report
EGAF00001064934 cram 3.8 GB Report
EGAF00001064935 cram 3.0 GB Report
EGAF00001064936 cram 3.4 GB Report
EGAF00001064937 cram 3.7 GB Report
EGAF00001064964 cram 4.2 GB Report
EGAF00001064965 cram 4.0 GB Report
EGAF00001064966 cram 3.9 GB Report
EGAF00001064967 cram 3.7 GB Report
EGAF00001064968 cram 3.5 GB Report
EGAF00001064969 cram 3.2 GB Report
EGAF00001064970 cram 4.2 GB Report
EGAF00001064971 cram 3.9 GB Report
EGAF00001064972 cram 3.6 GB Report
EGAF00001064973 cram 3.7 GB Report
EGAF00001064974 cram 3.7 GB Report
EGAF00001064975 cram 3.9 GB Report
EGAF00001064976 cram 4.3 GB Report
EGAF00001064977 cram 3.6 GB Report
EGAF00001064978 cram 3.6 GB Report
EGAF00001064979 cram 4.1 GB Report
EGAF00001064980 cram 4.0 GB Report
EGAF00001064981 cram 2.7 GB Report
EGAF00001064982 cram 3.8 GB Report
EGAF00001064983 cram 3.8 GB Report
EGAF00001064984 cram 4.7 GB Report
EGAF00001064985 cram 3.8 GB Report
EGAF00001064986 cram 4.1 GB Report
EGAF00001064987 cram 3.4 GB Report
EGAF00001064988 cram 3.5 GB Report
EGAF00001064989 cram 3.1 GB Report
EGAF00001065016 cram 3.4 GB Report
EGAF00001065017 cram 3.4 GB Report
EGAF00001065018 cram 3.0 GB Report
EGAF00001065019 cram 3.2 GB Report
EGAF00001065020 cram 3.5 GB Report
EGAF00001065021 cram 4.7 GB Report
EGAF00001065022 cram 4.5 GB Report
EGAF00001065378 cram 4.6 GB Report
EGAF00001065379 cram 3.3 GB Report
EGAF00001065380 cram 3.4 GB Report
EGAF00001065381 cram 3.7 GB Report
EGAF00001065382 cram 3.4 GB Report
EGAF00001065383 cram 3.3 GB Report
EGAF00001065384 cram 3.2 GB Report
EGAF00001065385 cram 3.6 GB Report
EGAF00001065386 cram 3.4 GB Report
EGAF00001065387 cram 3.3 GB Report
EGAF00001065388 cram 3.1 GB Report
EGAF00001065389 cram 3.8 GB Report
EGAF00001065390 cram 3.6 GB Report
EGAF00001065391 cram 4.1 GB Report
EGAF00001065392 cram 3.5 GB Report
EGAF00001065393 cram 3.5 GB Report
EGAF00001065394 cram 3.7 GB Report
EGAF00001065395 cram 3.9 GB Report
EGAF00001065396 cram 2.9 GB Report
EGAF00001065397 cram 4.0 GB Report
EGAF00001065398 cram 3.2 GB Report
EGAF00001174789 cram 4.9 GB Report
EGAF00001174790 cram 3.4 GB Report
EGAF00001174791 cram 3.6 GB Report
EGAF00001174792 cram 3.8 GB Report
EGAF00001174793 cram 3.6 GB Report
EGAF00001174794 cram 3.5 GB Report
EGAF00001174795 cram 3.3 GB Report
EGAF00001174796 cram 3.8 GB Report
EGAF00001174797 cram 3.6 GB Report
EGAF00001174798 cram 3.5 GB Report
EGAF00001174799 cram 3.2 GB Report
EGAF00001174800 cram 3.9 GB Report
EGAF00001174801 cram 4.0 GB Report
EGAF00001174802 cram 4.9 GB Report
EGAF00001174803 cram 3.5 GB Report
EGAF00001174804 cram 3.5 GB Report
EGAF00001174805 cram 3.9 GB Report
EGAF00001174806 cram 3.6 GB Report
EGAF00001174807 cram 3.6 GB Report
EGAF00001174808 cram 3.4 GB Report
EGAF00001174809 cram 3.9 GB Report
EGAF00001174810 cram 3.6 GB Report
EGAF00001174811 cram 3.5 GB Report
EGAF00001174812 cram 3.5 GB Report
EGAF00001174813 cram 4.3 GB Report
EGAF00001174814 cram 4.0 GB Report
EGAF00001174815 cram 4.5 GB Report
EGAF00001174816 cram 4.0 GB Report
EGAF00001174817 cram 4.1 GB Report
EGAF00001174818 cram 4.1 GB Report
EGAF00001174819 cram 4.4 GB Report
EGAF00001174820 cram 3.2 GB Report
EGAF00001174821 cram 4.0 GB Report
EGAF00001174822 cram 3.4 GB Report
EGAF00001174823 cram 4.2 GB Report
EGAF00001174824 cram 3.8 GB Report
EGAF00001174825 cram 4.1 GB Report
EGAF00001174826 cram 4.2 GB Report
800 Files (3.1 TB)