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PSCP_mutation analysis in hESCs

Many studies over the past 10 years, culminating in the recent report of the International Stem Cell Initiative (ISCI, 2011) have shown that hPSC acquire genetic and epigenetic changes during their time in culture. Many of the genetic changes are non-random and recurrent, probably because they provide a selective growth advantage to the undifferentiated cells. Some are shared by embryonal carcinoma cells, the malignant counterparts of ES cells. The origins of these growth advantages are poorly understood, but may come from altered cell cycle dynamics, resistance to apoptosis or altered patterns of differentiation. Less is known about the nature and consequences of epigenetic changes, but it is likely that these similarly affect hPSC behaviour; e.g., enhanced expression of DLK1, an imprinted gene, is associated with altered hPSC growth (Enver et al 2005). Inevitably, these genetic and epigenetic changes will impact on our ability to use hPSC for regenerative medicine, either because malignant transformation of the undifferentiated cells or their differentiated derivatives to be used for transplantation compromises safety, or because they impede the function of those differentiated derivatives, or because they affect the efficiency with which the undifferentiated cells can be expanded and differentiated into desired cell types. Focusing initially upon the existing clinical grade hESC lines, later moving to iPSC, we will Consolidate and extend knowledge of the rate, type and functional impact of the genetic variations that occur during hPSC culture. We will use whole genome and exome sequencing as well as SNP arrays, together with clonal analysis and other cytogenetics techniques. Common changes will be compared with those found in the normal human population, at low frequency in the original cell population or observed during iPSC generation in the HIPSCI project currently based at the WTSI. These studies will provide a better understanding of the range of genetic changes that occur in hPSC beyond the CNVs already identified. In conjunction with cancer genome resources and expertise at WTSI, bioinformatic analyses of these hPSC data will allow us to assess potential impact on hPSC behaviour pertinent to applications in regenerative medicine, notably the likelihood that specific changes arising in undifferentiated PSC cultures may be associated with potential malignant transformation of differentiated progeny. This data is part of a pre-publication release. For information on the proper use of pre-publication data shred by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001561 Whole Genome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001053400 cram 3.9 GB
EGAF00001053401 cram 4.3 GB
EGAF00001053402 cram 3.7 GB
EGAF00001053403 cram 3.8 GB
EGAF00001053404 cram 3.4 GB
EGAF00001053405 cram 3.8 GB
EGAF00001053406 cram 3.8 GB
EGAF00001053407 cram 3.2 GB
EGAF00001053408 cram 3.5 GB
EGAF00001053409 cram 3.8 GB
EGAF00001053410 cram 5.1 GB
EGAF00001053411 cram 4.8 GB
EGAF00001053412 cram 4.9 GB
EGAF00001053413 cram 3.4 GB
EGAF00001053414 cram 3.6 GB
EGAF00001053415 cram 3.8 GB
EGAF00001053416 cram 3.6 GB
EGAF00001053417 cram 3.4 GB
EGAF00001053418 cram 3.3 GB
EGAF00001053419 cram 3.9 GB
EGAF00001053420 cram 3.6 GB
EGAF00001053421 cram 3.6 GB
EGAF00001053422 cram 3.2 GB
EGAF00001053423 cram 3.9 GB
EGAF00001053424 cram 3.8 GB
EGAF00001053425 cram 4.2 GB
EGAF00001053426 cram 3.9 GB
EGAF00001053427 cram 3.9 GB
EGAF00001053428 cram 3.7 GB
EGAF00001053429 cram 4.2 GB
EGAF00001053430 cram 3.8 GB
EGAF00001053431 cram 3.7 GB
EGAF00001053432 cram 3.5 GB
EGAF00001053433 cram 4.3 GB
EGAF00001053434 cram 4.2 GB
EGAF00001053435 cram 4.7 GB
EGAF00001053436 cram 4.1 GB
EGAF00001053437 cram 4.1 GB
EGAF00001053438 cram 4.3 GB
EGAF00001053439 cram 4.5 GB
EGAF00001053440 cram 3.3 GB
EGAF00001053441 cram 4.6 GB
EGAF00001053442 cram 3.7 GB
EGAF00001053443 cram 4.5 GB
EGAF00001053444 cram 4.2 GB
EGAF00001053445 cram 4.5 GB
EGAF00001053446 cram 4.4 GB
EGAF00001053447 cram 3.8 GB
EGAF00001053448 cram 4.5 GB
EGAF00001053449 cram 3.8 GB
EGAF00001053450 cram 4.3 GB
EGAF00001053451 cram 4.6 GB
EGAF00001053493 cram 3.7 GB
EGAF00001053494 cram 3.6 GB
EGAF00001053495 cram 3.8 GB
EGAF00001053496 cram 4.0 GB
EGAF00001053497 cram 3.0 GB
EGAF00001053498 cram 4.0 GB
EGAF00001053499 cram 3.4 GB
EGAF00001053500 cram 4.0 GB
EGAF00001053501 cram 3.9 GB
EGAF00001053502 cram 4.1 GB
EGAF00001053503 cram 4.0 GB
EGAF00001053504 cram 3.4 GB
EGAF00001053505 cram 4.1 GB
EGAF00001053506 cram 3.5 GB
EGAF00001053507 cram 3.9 GB
EGAF00001053508 cram 4.1 GB
EGAF00001053509 cram 4.6 GB
EGAF00001053510 cram 3.9 GB
EGAF00001053511 cram 4.0 GB
EGAF00001053512 cram 3.6 GB
EGAF00001053513 cram 3.7 GB
EGAF00001053514 cram 3.9 GB
EGAF00001053515 cram 3.7 GB
EGAF00001053516 cram 3.4 GB
EGAF00001053517 cram 3.9 GB
EGAF00001053518 cram 3.7 GB
EGAF00001053519 cram 5.4 GB
EGAF00001053520 cram 4.5 GB
EGAF00001053521 cram 4.6 GB
EGAF00001053522 cram 4.1 GB
EGAF00001053523 cram 4.3 GB
EGAF00001053524 cram 4.6 GB
EGAF00001053525 cram 4.4 GB
EGAF00001053526 cram 3.9 GB
EGAF00001053527 cram 4.6 GB
EGAF00001053528 cram 4.4 GB
EGAF00001053529 cram 4.1 GB
EGAF00001053530 cram 5.1 GB
EGAF00001053531 cram 5.1 GB
EGAF00001053532 cram 4.5 GB
EGAF00001053533 cram 3.6 GB
EGAF00001053534 cram 4.0 GB
EGAF00001053535 cram 4.4 GB
EGAF00001053536 cram 5.0 GB
EGAF00001053537 cram 4.8 GB
EGAF00001053538 cram 4.7 GB
EGAF00001053539 cram 4.5 GB
EGAF00001053540 cram 4.2 GB
EGAF00001053541 cram 3.9 GB
EGAF00001053542 cram 5.2 GB
EGAF00001053543 cram 4.7 GB
EGAF00001053544 cram 4.3 GB
EGAF00001053597 cram 3.6 GB
EGAF00001053598 cram 4.4 GB
EGAF00001053599 cram 4.4 GB
EGAF00001053600 cram 3.9 GB
EGAF00001053601 cram 3.0 GB
EGAF00001053602 cram 3.5 GB
EGAF00001053603 cram 3.7 GB
EGAF00001053604 cram 4.2 GB
EGAF00001053605 cram 4.0 GB
EGAF00001053606 cram 4.0 GB
EGAF00001053607 cram 3.8 GB
EGAF00001053608 cram 3.6 GB
EGAF00001053609 cram 3.4 GB
EGAF00001053610 cram 4.3 GB
EGAF00001053611 cram 4.0 GB
EGAF00001053612 cram 3.7 GB
EGAF00001053613 cram 3.8 GB
EGAF00001053614 cram 3.9 GB
EGAF00001053615 cram 4.1 GB
EGAF00001053616 cram 4.2 GB
EGAF00001053617 cram 3.5 GB
EGAF00001053618 cram 3.6 GB
EGAF00001053619 cram 4.1 GB
EGAF00001053620 cram 3.9 GB
EGAF00001053621 cram 2.6 GB
EGAF00001053622 cram 3.7 GB
EGAF00001053623 cram 4.5 GB
EGAF00001053624 cram 4.7 GB
EGAF00001053625 cram 4.7 GB
EGAF00001053626 cram 5.2 GB
EGAF00001053627 cram 4.4 GB
EGAF00001053628 cram 4.3 GB
EGAF00001053629 cram 5.0 GB
EGAF00001053630 cram 4.8 GB
EGAF00001053631 cram 3.2 GB
EGAF00001053632 cram 4.6 GB
EGAF00001053633 cram 4.5 GB
EGAF00001053634 cram 5.7 GB
EGAF00001053635 cram 4.5 GB
EGAF00001053636 cram 4.9 GB
EGAF00001053637 cram 4.4 GB
EGAF00001053638 cram 4.4 GB
EGAF00001053639 cram 4.0 GB
EGAF00001053640 cram 4.4 GB
EGAF00001053641 cram 4.4 GB
EGAF00001053642 cram 3.8 GB
EGAF00001053643 cram 4.1 GB
EGAF00001053644 cram 4.5 GB
EGAF00001053645 cram 6.0 GB
EGAF00001053646 cram 5.7 GB
EGAF00001053647 cram 5.0 GB
EGAF00001053648 cram 3.6 GB
EGAF00001053701 cram 3.7 GB
EGAF00001053702 cram 4.6 GB
EGAF00001053703 cram 3.8 GB
EGAF00001053704 cram 4.0 GB
EGAF00001053705 cram 3.5 GB
EGAF00001053706 cram 3.6 GB
EGAF00001053707 cram 3.2 GB
EGAF00001053708 cram 3.4 GB
EGAF00001053709 cram 3.4 GB
EGAF00001053710 cram 3.0 GB
EGAF00001053711 cram 3.3 GB
EGAF00001053712 cram 3.4 GB
EGAF00001053713 cram 4.8 GB
EGAF00001053714 cram 4.6 GB
EGAF00001053715 cram 5.0 GB
EGAF00001053716 cram 3.6 GB
EGAF00001053717 cram 3.5 GB
EGAF00001053718 cram 3.9 GB
EGAF00001053719 cram 3.7 GB
EGAF00001053720 cram 3.7 GB
EGAF00001053721 cram 3.4 GB
EGAF00001053722 cram 3.9 GB
EGAF00001053723 cram 3.5 GB
EGAF00001053724 cram 3.5 GB
EGAF00001053725 cram 3.3 GB
EGAF00001053726 cram 4.0 GB
EGAF00001053727 cram 3.6 GB
EGAF00001053728 cram 3.9 GB
EGAF00001053729 cram 3.7 GB
EGAF00001053730 cram 3.7 GB
EGAF00001053731 cram 3.5 GB
EGAF00001053732 cram 4.0 GB
EGAF00001053733 cram 3.6 GB
EGAF00001053734 cram 3.5 GB
EGAF00001053735 cram 3.2 GB
EGAF00001053736 cram 3.9 GB
EGAF00001053737 cram 3.7 GB
EGAF00001053738 cram 4.2 GB
EGAF00001053739 cram 3.6 GB
EGAF00001053740 cram 3.7 GB
EGAF00001053741 cram 3.9 GB
EGAF00001053742 cram 4.1 GB
EGAF00001053743 cram 3.0 GB
EGAF00001053744 cram 4.2 GB
EGAF00001053745 cram 3.4 GB
EGAF00001053746 cram 4.1 GB
EGAF00001053747 cram 3.9 GB
EGAF00001053748 cram 4.2 GB
EGAF00001053749 cram 4.1 GB
EGAF00001053750 cram 3.5 GB
EGAF00001053751 cram 4.2 GB
EGAF00001053752 cram 3.5 GB
EGAF00001053805 cram 3.8 GB
EGAF00001053806 cram 4.3 GB
EGAF00001053807 cram 3.7 GB
EGAF00001053808 cram 3.8 GB
EGAF00001053809 cram 4.0 GB
EGAF00001053810 cram 4.1 GB
EGAF00001053811 cram 3.1 GB
EGAF00001053812 cram 4.4 GB
EGAF00001053813 cram 3.3 GB
EGAF00001053814 cram 4.2 GB
EGAF00001053815 cram 3.7 GB
EGAF00001053816 cram 4.1 GB
EGAF00001053817 cram 3.9 GB
EGAF00001053818 cram 3.5 GB
EGAF00001053819 cram 4.1 GB
EGAF00001053820 cram 3.4 GB
EGAF00001053821 cram 3.9 GB
EGAF00001053822 cram 4.2 GB
EGAF00001053823 cram 4.7 GB
EGAF00001053824 cram 3.9 GB
EGAF00001053825 cram 3.9 GB
EGAF00001053826 cram 3.5 GB
EGAF00001053827 cram 3.8 GB
EGAF00001053828 cram 4.0 GB
EGAF00001053829 cram 3.8 GB
EGAF00001053830 cram 3.4 GB
EGAF00001053831 cram 4.0 GB
EGAF00001053832 cram 4.3 GB
EGAF00001053833 cram 4.6 GB
EGAF00001053834 cram 3.9 GB
EGAF00001053835 cram 3.9 GB
EGAF00001053836 cram 3.5 GB
EGAF00001053837 cram 3.7 GB
EGAF00001053838 cram 3.9 GB
EGAF00001053839 cram 3.8 GB
EGAF00001053840 cram 3.4 GB
EGAF00001053841 cram 3.9 GB
EGAF00001053842 cram 3.8 GB
EGAF00001053843 cram 3.6 GB
EGAF00001053844 cram 4.5 GB
EGAF00001053845 cram 4.6 GB
EGAF00001053846 cram 4.0 GB
EGAF00001053847 cram 3.2 GB
EGAF00001053848 cram 3.6 GB
EGAF00001053849 cram 3.9 GB
EGAF00001053850 cram 4.4 GB
EGAF00001053851 cram 4.3 GB
EGAF00001053852 cram 4.2 GB
EGAF00001053853 cram 3.9 GB
EGAF00001053854 cram 3.6 GB
EGAF00001053855 cram 3.3 GB
EGAF00001053856 cram 4.4 GB
EGAF00001053909 cram 3.9 GB
EGAF00001053910 cram 3.8 GB
EGAF00001053911 cram 3.5 GB
EGAF00001053912 cram 4.3 GB
EGAF00001053913 cram 4.5 GB
EGAF00001053914 cram 3.9 GB
EGAF00001053915 cram 3.1 GB
EGAF00001053916 cram 3.4 GB
EGAF00001053917 cram 3.9 GB
EGAF00001053918 cram 4.3 GB
EGAF00001053919 cram 4.3 GB
EGAF00001053920 cram 4.1 GB
EGAF00001053921 cram 4.0 GB
EGAF00001053922 cram 3.7 GB
EGAF00001053923 cram 3.4 GB
EGAF00001053924 cram 4.5 GB
EGAF00001053925 cram 4.1 GB
EGAF00001053926 cram 3.8 GB
EGAF00001053927 cram 3.9 GB
EGAF00001053928 cram 3.9 GB
EGAF00001053929 cram 4.2 GB
EGAF00001053930 cram 4.6 GB
EGAF00001053931 cram 3.8 GB
EGAF00001053932 cram 3.6 GB
EGAF00001053933 cram 4.3 GB
EGAF00001053934 cram 4.1 GB
EGAF00001053935 cram 4.0 GB
EGAF00001053936 cram 3.7 GB
EGAF00001053937 cram 3.9 GB
EGAF00001053938 cram 3.9 GB
EGAF00001053939 cram 4.0 GB
EGAF00001053940 cram 4.4 GB
EGAF00001053941 cram 3.7 GB
EGAF00001053942 cram 3.6 GB
EGAF00001053943 cram 4.2 GB
EGAF00001053944 cram 4.1 GB
EGAF00001053945 cram 2.7 GB
EGAF00001053946 cram 3.9 GB
EGAF00001053947 cram 3.9 GB
EGAF00001053948 cram 4.8 GB
EGAF00001053949 cram 3.9 GB
EGAF00001053950 cram 4.2 GB
EGAF00001053951 cram 3.4 GB
EGAF00001053952 cram 3.5 GB
EGAF00001053953 cram 3.1 GB
EGAF00001053954 cram 3.4 GB
EGAF00001053955 cram 3.4 GB
EGAF00001053956 cram 2.9 GB
EGAF00001053957 cram 3.2 GB
EGAF00001053958 cram 3.5 GB
EGAF00001053959 cram 4.7 GB
EGAF00001053960 cram 4.4 GB
EGAF00001054013 cram 2.8 GB
EGAF00001054014 cram 3.9 GB
EGAF00001054015 cram 3.9 GB
EGAF00001054016 cram 4.9 GB
EGAF00001054017 cram 3.9 GB
EGAF00001054018 cram 4.2 GB
EGAF00001054019 cram 3.8 GB
EGAF00001054020 cram 3.8 GB
EGAF00001054021 cram 3.4 GB
EGAF00001054022 cram 3.8 GB
EGAF00001054023 cram 3.8 GB
EGAF00001054024 cram 3.2 GB
EGAF00001054025 cram 3.5 GB
EGAF00001054026 cram 3.9 GB
EGAF00001054027 cram 5.2 GB
EGAF00001054028 cram 4.9 GB
EGAF00001054029 cram 4.9 GB
EGAF00001054030 cram 3.5 GB
EGAF00001054031 cram 3.5 GB
EGAF00001054032 cram 3.8 GB
EGAF00001054033 cram 3.6 GB
EGAF00001054034 cram 3.5 GB
EGAF00001054035 cram 3.4 GB
EGAF00001054036 cram 3.8 GB
EGAF00001054037 cram 3.5 GB
EGAF00001054038 cram 3.5 GB
EGAF00001054091 cram 3.2 GB
EGAF00001054092 cram 3.9 GB
EGAF00001054093 cram 3.8 GB
EGAF00001054094 cram 4.3 GB
EGAF00001054095 cram 3.7 GB
EGAF00001054096 cram 3.8 GB
EGAF00001054097 cram 3.9 GB
EGAF00001054098 cram 4.1 GB
EGAF00001054099 cram 3.1 GB
EGAF00001054100 cram 4.2 GB
EGAF00001054101 cram 3.3 GB
EGAF00001054102 cram 4.0 GB
EGAF00001054103 cram 3.7 GB
EGAF00001054104 cram 4.0 GB
EGAF00001054105 cram 3.9 GB
EGAF00001054106 cram 3.4 GB
EGAF00001054107 cram 4.0 GB
EGAF00001054108 cram 3.3 GB
EGAF00001054109 cram 3.8 GB
EGAF00001054110 cram 4.0 GB
EGAF00001054111 cram 4.6 GB
EGAF00001054112 cram 3.9 GB
EGAF00001054113 cram 4.0 GB
EGAF00001054114 cram 3.5 GB
EGAF00001054115 cram 3.7 GB
EGAF00001054116 cram 4.0 GB
EGAF00001054169 cram 3.8 GB
EGAF00001054170 cram 3.4 GB
EGAF00001054171 cram 3.9 GB
EGAF00001054172 cram 3.8 GB
EGAF00001054173 cram 3.5 GB
EGAF00001054174 cram 4.3 GB
EGAF00001054175 cram 4.4 GB
EGAF00001054176 cram 3.8 GB
EGAF00001054177 cram 3.0 GB
EGAF00001054178 cram 3.4 GB
EGAF00001054179 cram 3.8 GB
EGAF00001054180 cram 4.2 GB
EGAF00001054181 cram 4.1 GB
EGAF00001054182 cram 4.0 GB
EGAF00001054183 cram 3.8 GB
EGAF00001054184 cram 3.6 GB
EGAF00001054185 cram 3.3 GB
EGAF00001054186 cram 4.3 GB
EGAF00001054187 cram 3.9 GB
EGAF00001054188 cram 3.6 GB
EGAF00001054189 cram 3.8 GB
EGAF00001054190 cram 3.8 GB
EGAF00001054191 cram 4.0 GB
EGAF00001054192 cram 4.3 GB
EGAF00001054193 cram 3.7 GB
EGAF00001054194 cram 3.6 GB
EGAF00001054247 cram 4.2 GB
EGAF00001054248 cram 4.1 GB
EGAF00001054249 cram 2.7 GB
EGAF00001054250 cram 3.9 GB
EGAF00001054251 cram 3.9 GB
EGAF00001054252 cram 4.8 GB
EGAF00001054253 cram 3.8 GB
EGAF00001054254 cram 4.2 GB
EGAF00001054255 cram 3.5 GB
EGAF00001054256 cram 3.6 GB
EGAF00001054257 cram 3.2 GB
EGAF00001054258 cram 3.5 GB
EGAF00001054259 cram 3.5 GB
EGAF00001054260 cram 3.0 GB
EGAF00001054261 cram 3.3 GB
EGAF00001054262 cram 3.6 GB
EGAF00001054263 cram 4.8 GB
EGAF00001054264 cram 4.6 GB
EGAF00001054265 cram 4.6 GB
EGAF00001054266 cram 3.3 GB
EGAF00001054267 cram 3.3 GB
EGAF00001054268 cram 3.6 GB
EGAF00001054269 cram 3.4 GB
EGAF00001054270 cram 3.3 GB
EGAF00001054271 cram 3.2 GB
EGAF00001054272 cram 3.6 GB
EGAF00001054325 cram 3.3 GB
EGAF00001054326 cram 3.3 GB
EGAF00001054327 cram 3.0 GB
EGAF00001054328 cram 3.7 GB
EGAF00001054329 cram 3.5 GB
EGAF00001054330 cram 4.0 GB
EGAF00001054331 cram 3.4 GB
EGAF00001054332 cram 3.5 GB
EGAF00001054333 cram 3.6 GB
EGAF00001054334 cram 3.8 GB
EGAF00001054335 cram 2.8 GB
EGAF00001054336 cram 4.0 GB
EGAF00001054337 cram 3.1 GB
EGAF00001054338 cram 3.9 GB
EGAF00001054339 cram 3.5 GB
EGAF00001054340 cram 3.8 GB
EGAF00001054341 cram 3.7 GB
EGAF00001054342 cram 3.2 GB
EGAF00001054343 cram 3.8 GB
EGAF00001054344 cram 3.2 GB
EGAF00001054345 cram 3.6 GB
EGAF00001054346 cram 3.9 GB
EGAF00001054347 cram 4.3 GB
EGAF00001054348 cram 3.6 GB
EGAF00001054349 cram 3.7 GB
EGAF00001054350 cram 3.3 GB
EGAF00001054397 cram 3.7 GB
EGAF00001054398 cram 4.1 GB
EGAF00001054399 cram 3.6 GB
EGAF00001054400 cram 3.6 GB
EGAF00001054401 cram 3.7 GB
EGAF00001054402 cram 3.9 GB
EGAF00001054403 cram 3.4 GB
EGAF00001054404 cram 3.7 GB
EGAF00001054405 cram 3.5 GB
EGAF00001054406 cram 3.1 GB
EGAF00001054407 cram 3.6 GB
EGAF00001054408 cram 3.5 GB
EGAF00001054409 cram 3.2 GB
EGAF00001054410 cram 4.0 GB
EGAF00001054411 cram 4.1 GB
EGAF00001054412 cram 3.5 GB
EGAF00001054413 cram 2.8 GB
EGAF00001054414 cram 3.2 GB
EGAF00001054415 cram 3.5 GB
EGAF00001054416 cram 3.9 GB
EGAF00001054417 cram 3.9 GB
EGAF00001054418 cram 3.7 GB
EGAF00001054419 cram 3.6 GB
EGAF00001054420 cram 3.4 GB
EGAF00001054421 cram 3.1 GB
EGAF00001054422 cram 4.0 GB
EGAF00001054423 cram 3.7 GB
EGAF00001054424 cram 3.4 GB
EGAF00001054425 cram 3.6 GB
EGAF00001054426 cram 3.6 GB
EGAF00001054427 cram 3.8 GB
EGAF00001054428 cram 4.1 GB
EGAF00001054455 cram 2.9 GB
EGAF00001054456 cram 3.3 GB
EGAF00001054457 cram 3.8 GB
EGAF00001054458 cram 3.7 GB
EGAF00001054459 cram 3.9 GB
EGAF00001054460 cram 3.8 GB
EGAF00001054461 cram 3.3 GB
EGAF00001054462 cram 3.9 GB
EGAF00001054463 cram 3.3 GB
EGAF00001054464 cram 3.7 GB
EGAF00001054465 cram 3.9 GB
EGAF00001054466 cram 4.5 GB
EGAF00001054467 cram 3.8 GB
EGAF00001054468 cram 3.9 GB
EGAF00001054469 cram 3.5 GB
EGAF00001054470 cram 3.6 GB
EGAF00001054471 cram 3.8 GB
EGAF00001054472 cram 3.6 GB
EGAF00001054473 cram 3.3 GB
EGAF00001054474 cram 3.8 GB
EGAF00001054475 cram 3.6 GB
EGAF00001054476 cram 3.4 GB
EGAF00001054477 cram 4.2 GB
EGAF00001054478 cram 4.3 GB
EGAF00001054479 cram 3.7 GB
EGAF00001054480 cram 2.9 GB
EGAF00001054481 cram 3.4 GB
EGAF00001054482 cram 3.4 GB
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EGAF00001054486 cram 3.6 GB
EGAF00001054487 cram 3.6 GB
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EGAF00001054490 cram 3.9 GB
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EGAF00001054720 cram 3.8 GB
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EGAF00001054723 cram 3.6 GB
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EGAF00001054725 cram 3.6 GB
EGAF00001054726 cram 3.9 GB
EGAF00001054727 cram 3.4 GB
EGAF00001054728 cram 3.4 GB
EGAF00001054729 cram 3.0 GB
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EGAF00001054731 cram 3.3 GB
EGAF00001054732 cram 2.9 GB
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EGAF00001054736 cram 4.3 GB
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EGAF00001064975 cram 3.9 GB
EGAF00001064976 cram 4.3 GB
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EGAF00001064982 cram 3.8 GB
EGAF00001064983 cram 3.8 GB
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EGAF00001064985 cram 3.8 GB
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EGAF00001064988 cram 3.5 GB
EGAF00001064989 cram 3.1 GB
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EGAF00001065017 cram 3.4 GB
EGAF00001065018 cram 3.0 GB
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EGAF00001065020 cram 3.5 GB
EGAF00001065021 cram 4.7 GB
EGAF00001065022 cram 4.5 GB
EGAF00001065378 cram 4.6 GB
EGAF00001065379 cram 3.3 GB
EGAF00001065380 cram 3.4 GB
EGAF00001065381 cram 3.7 GB
EGAF00001065382 cram 3.4 GB
EGAF00001065383 cram 3.3 GB
EGAF00001065384 cram 3.2 GB
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EGAF00001065387 cram 3.3 GB
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EGAF00001065389 cram 3.8 GB
EGAF00001065390 cram 3.6 GB
EGAF00001065391 cram 4.1 GB
EGAF00001065392 cram 3.5 GB
EGAF00001065393 cram 3.5 GB
EGAF00001065394 cram 3.7 GB
EGAF00001065395 cram 3.9 GB
EGAF00001065396 cram 2.9 GB
EGAF00001065397 cram 4.0 GB
EGAF00001065398 cram 3.2 GB
EGAF00001174789 cram 4.9 GB
EGAF00001174790 cram 3.4 GB
EGAF00001174791 cram 3.6 GB
EGAF00001174792 cram 3.8 GB
EGAF00001174793 cram 3.6 GB
EGAF00001174794 cram 3.5 GB
EGAF00001174795 cram 3.3 GB
EGAF00001174796 cram 3.8 GB
EGAF00001174797 cram 3.6 GB
EGAF00001174798 cram 3.5 GB
EGAF00001174799 cram 3.2 GB
EGAF00001174800 cram 3.9 GB
EGAF00001174801 cram 4.0 GB
EGAF00001174802 cram 4.9 GB
EGAF00001174803 cram 3.5 GB
EGAF00001174804 cram 3.5 GB
EGAF00001174805 cram 3.9 GB
EGAF00001174806 cram 3.6 GB
EGAF00001174807 cram 3.6 GB
EGAF00001174808 cram 3.4 GB
EGAF00001174809 cram 3.9 GB
EGAF00001174810 cram 3.6 GB
EGAF00001174811 cram 3.5 GB
EGAF00001174812 cram 3.5 GB
EGAF00001174813 cram 4.3 GB
EGAF00001174814 cram 4.0 GB
EGAF00001174815 cram 4.5 GB
EGAF00001174816 cram 4.0 GB
EGAF00001174817 cram 4.1 GB
EGAF00001174818 cram 4.1 GB
EGAF00001174819 cram 4.4 GB
EGAF00001174820 cram 3.2 GB
EGAF00001174821 cram 4.0 GB
EGAF00001174822 cram 3.4 GB
EGAF00001174823 cram 4.2 GB
EGAF00001174824 cram 3.8 GB
EGAF00001174825 cram 4.1 GB
EGAF00001174826 cram 4.2 GB
800 Files (3.1 TB)