About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Prognostic relevance of microenvironmental factors CD163 and CD8 combined with EZH2 and chromosome 18 gain in a validation cohort of follicular lymphoma patients of the Lunenburg Lymphoma Biomarker Consortium

Background: In follicular lymphoma (FL), studies addressing the prognostic value of microenvironment-related immunohistochemical (IHC) markers and tumor cell-related genetic markers have yielded conflicting results, precluding implementation in practice. Therefore, the Lunenburg Lymphoma Biomarker Consortium (LLBC) performed a validation study for published markers. Methods: To maximize sensitivity, an end-of-spectrum design was applied for 122 uniformly immunochemotherapy-treated FL patients retrieved from international trials and registries; early failure (EF): progression or lymphoma-related death <2 years versus long remission: response duration of >5 years. IHC staining for T-cells and macrophages was performed on tissue microarrays from initial biopsy and scored with a validated computer-assisted protocol. Shallow whole-genome and deep targeted sequencing was performed on the same samples. Results: 96/122 cases with complete molecular and immunohistochemical data were included in the analysis. EZH2 wild-type (p=0.006), gain of chromosome 18 (p=0.002), low percentages of CD8+ cells (p=0.011) and CD163+ areas (p=0.038) were associated with EF. No significant differences in other markers were observed, thereby refuting previous claims on their prognostic significance. Conclusion: Using an optimized study design, this LLBC study validates wild-type EZH2 status, gain of chromosome 18, low percentages of CD8+ cells and CD163+ area as predictors of EF to immunochemotherapy in FL.

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Data originating from patient samples

The Amsterdam UMC, tumor genome analysis core, allows access to published datasets upon written application and signature of a Data Access Agreement (DAA). In addition, applications to clinical datasets require approval by a Data Access Committee (DAC), who assess whether the proposed work is allowed given patient consent, as well as the scientific purpose. To aid this process we ask you to provide the information below. Requests will be prioritised according to novelty of the research question. Applications with insufficient detail on objectives, justification, and methods/planned analyses are unlikely to be accepted. 1.Reference number for the dataset 2.Full legal name and address of university/institution 3.Name(s) of the Principle Investigator who will use the data: 4.Name(s) and job title(s) of any other investigators who will use the data: 5.Please provide a minimum of one reference to a publication that can be found on PubMed and where the Principle Investigator is an author: 6.How will the data be stored and where will it be stored? 7.What is the proposed study title and what are the objectives and outcomes of the study in which the data will be used 8.Please provide a brief justification or rationale for the proposed study (max 250 words) 9.Please provide a brief description of planned data analyses (max 250 words): 10.Will the results arising from use of the data be used for the creation of products for sale or for any commercial purpose?

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002049 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00001386226 fastq.gz 501.4 MB Report
EGAF00001386227 fastq.gz 429.2 MB Report
EGAF00001386228 fastq.gz 594.4 MB Report
EGAF00001386229 fastq.gz 231.7 MB Report
EGAF00001386230 fastq.gz 254.1 MB Report
EGAF00001386231 fastq.gz 474.9 MB Report
EGAF00001386232 fastq.gz 524.9 MB Report
EGAF00001386233 fastq.gz 800.4 MB Report
EGAF00001386234 fastq.gz 295.1 MB Report
EGAF00001386235 fastq.gz 445.6 MB Report
EGAF00001386236 fastq.gz 635.7 MB Report
EGAF00001386237 fastq.gz 535.8 MB Report
EGAF00001386238 fastq.gz 274.8 MB Report
EGAF00001386239 fastq.gz 318.8 MB Report
EGAF00001386240 fastq.gz 676.7 MB Report
EGAF00001386241 fastq.gz 580.9 MB Report
EGAF00001386242 fastq.gz 540.3 MB Report
EGAF00001386243 fastq.gz 527.9 MB Report
EGAF00001386244 fastq.gz 476.0 MB Report
EGAF00001386245 fastq.gz 590.2 MB Report
EGAF00001386246 fastq.gz 869.1 MB Report
EGAF00001386247 fastq.gz 440.9 MB Report
EGAF00001386248 fastq.gz 462.4 MB Report
EGAF00001386249 fastq.gz 642.7 MB Report
EGAF00001386250 fastq.gz 535.7 MB Report
EGAF00001386251 fastq.gz 1.7 GB Report
EGAF00001386252 fastq.gz 408.7 MB Report
EGAF00001386253 fastq.gz 429.3 MB Report
EGAF00001386254 fastq.gz 605.4 MB Report
EGAF00001386255 fastq.gz 390.6 MB Report
EGAF00001386256 fastq.gz 638.3 MB Report
EGAF00001386257 fastq.gz 424.6 MB Report
EGAF00001386258 fastq.gz 530.3 MB Report
EGAF00001386259 fastq.gz 284.6 MB Report
EGAF00001386260 fastq.gz 232.1 MB Report
EGAF00001386261 fastq.gz 525.3 MB Report
EGAF00001386262 fastq.gz 540.6 MB Report
EGAF00001386263 fastq.gz 743.1 MB Report
EGAF00001386264 fastq.gz 413.1 MB Report
EGAF00001386265 fastq.gz 558.8 MB Report
EGAF00001386266 fastq.gz 531.7 MB Report
EGAF00001386267 fastq.gz 577.7 MB Report
EGAF00001386268 fastq.gz 604.6 MB Report
EGAF00001386269 fastq.gz 650.4 MB Report
EGAF00001386270 fastq.gz 381.3 MB Report
EGAF00001386271 fastq.gz 367.3 MB Report
EGAF00001386272 fastq.gz 456.5 MB Report
EGAF00001386273 fastq.gz 384.9 MB Report
EGAF00001386274 fastq.gz 564.6 MB Report
EGAF00001386275 fastq.gz 375.4 MB Report
EGAF00001386276 fastq.gz 400.4 MB Report
EGAF00001386277 fastq.gz 592.8 MB Report
EGAF00001386278 fastq.gz 628.1 MB Report
EGAF00001386279 fastq.gz 650.4 MB Report
EGAF00001386280 fastq.gz 179.2 MB Report
EGAF00001386281 fastq.gz 228.8 MB Report
EGAF00001386282 fastq.gz 186.1 MB Report
EGAF00001386283 fastq.gz 217.4 MB Report
EGAF00001386284 fastq.gz 540.3 MB Report
EGAF00001386285 fastq.gz 453.6 MB Report
EGAF00001386286 fastq.gz 366.5 MB Report
EGAF00001386287 fastq.gz 447.4 MB Report
EGAF00001386288 fastq.gz 765.0 MB Report
EGAF00001386289 fastq.gz 202.9 MB Report
EGAF00001386290 fastq.gz 950.5 MB Report
EGAF00001386291 fastq.gz 227.2 MB Report
EGAF00001386292 fastq.gz 239.2 MB Report
EGAF00001386293 fastq.gz 1.8 GB Report
EGAF00001386294 fastq.gz 4.2 GB Report
EGAF00001386295 fastq.gz 486.5 MB Report
EGAF00001386296 fastq.gz 258.6 MB Report
EGAF00001386297 fastq.gz 273.4 MB Report
EGAF00001386298 fastq.gz 883.9 MB Report
EGAF00001386299 fastq.gz 557.3 MB Report
EGAF00001386300 fastq.gz 347.7 MB Report
EGAF00001386301 fastq.gz 463.5 MB Report
EGAF00001386302 fastq.gz 1.4 GB Report
EGAF00001386303 fastq.gz 1.2 GB Report
EGAF00001386304 fastq.gz 1.1 GB Report
EGAF00001386305 fastq.gz 1.4 GB Report
EGAF00001386306 fastq.gz 1.3 GB Report
EGAF00001386307 fastq.gz 1.3 GB Report
EGAF00001386308 fastq.gz 1.2 GB Report
EGAF00001386309 fastq.gz 1.2 GB Report
EGAF00001386310 fastq.gz 1.2 GB Report
EGAF00001386311 fastq.gz 1.5 GB Report
EGAF00001386312 fastq.gz 1.4 GB Report
EGAF00001386313 fastq.gz 1.5 GB Report
EGAF00001386314 fastq.gz 1.5 GB Report
EGAF00001386315 fastq.gz 1.5 GB Report
EGAF00001386316 fastq.gz 1.4 GB Report
EGAF00001386317 fastq.gz 1.1 GB Report
EGAF00001386318 fastq.gz 994.2 MB Report
EGAF00001386319 fastq.gz 1.3 GB Report
EGAF00001386320 fastq.gz 1.3 GB Report
EGAF00001386321 fastq.gz 896.1 MB Report
EGAF00001386322 fastq.gz 853.4 MB Report
EGAF00001386323 fastq.gz 1.5 GB Report
EGAF00001386324 fastq.gz 1.5 GB Report
EGAF00001386325 fastq.gz 2.1 GB Report
EGAF00001386326 fastq.gz 2.0 GB Report
EGAF00001386327 fastq.gz 574.4 MB Report
EGAF00001386328 fastq.gz 564.5 MB Report
EGAF00001386329 fastq.gz 4.0 GB Report
EGAF00001386330 fastq.gz 4.1 GB Report
EGAF00001386331 fastq.gz 1.2 GB Report
EGAF00001386332 fastq.gz 1.1 GB Report
EGAF00001386333 fastq.gz 1.1 GB Report
EGAF00001386334 fastq.gz 1.1 GB Report
EGAF00001386335 fastq.gz 1.7 GB Report
EGAF00001386336 fastq.gz 1.6 GB Report
EGAF00001386337 fastq.gz 1.1 GB Report
EGAF00001386338 fastq.gz 1.1 GB Report
EGAF00001386339 fastq.gz 1.9 GB Report
EGAF00001386340 fastq.gz 1.8 GB Report
EGAF00001386341 fastq.gz 2.2 GB Report
EGAF00001386342 fastq.gz 2.1 GB Report
EGAF00001386343 fastq.gz 1.3 GB Report
EGAF00001386344 fastq.gz 1.3 GB Report
EGAF00001386345 fastq.gz 1.2 GB Report
EGAF00001386346 fastq.gz 1.2 GB Report
EGAF00001386347 fastq.gz 2.4 GB Report
EGAF00001386348 fastq.gz 2.3 GB Report
EGAF00001386349 fastq.gz 1.5 GB Report
EGAF00001386350 fastq.gz 1.4 GB Report
EGAF00001386351 fastq.gz 2.4 GB Report
EGAF00001386352 fastq.gz 2.6 GB Report
EGAF00001386353 fastq.gz 788.2 MB Report
EGAF00001386354 fastq.gz 751.0 MB Report
EGAF00001386355 fastq.gz 1.3 GB Report
EGAF00001386356 fastq.gz 1.3 GB Report
EGAF00001386357 fastq.gz 1.4 GB Report
EGAF00001386358 fastq.gz 1.4 GB Report
EGAF00001386359 fastq.gz 1.2 GB Report
EGAF00001386360 fastq.gz 1.1 GB Report
EGAF00001386361 fastq.gz 1.6 GB Report
EGAF00001386362 fastq.gz 1.5 GB Report
EGAF00001386363 fastq.gz 251.6 MB Report
EGAF00001386364 fastq.gz 252.1 MB Report
EGAF00001386365 fastq.gz 468.5 MB Report
EGAF00001386366 fastq.gz 270.3 MB Report
EGAF00001386367 fastq.gz 353.3 MB Report
EGAF00001386368 fastq.gz 784.5 MB Report
EGAF00001386369 fastq.gz 1.1 GB Report
EGAF00001386370 fastq.gz 994.2 MB Report
EGAF00001386371 fastq.gz 352.7 MB Report
EGAF00001386372 fastq.gz 614.9 MB Report
EGAF00001386373 fastq.gz 896.1 MB Report
EGAF00001386374 fastq.gz 261.4 MB Report
EGAF00001386375 fastq.gz 371.1 MB Report
EGAF00001386376 fastq.gz 327.7 MB Report
EGAF00001386377 fastq.gz 410.0 MB Report
EGAF00001386378 fastq.gz 1.0 GB Report
EGAF00001386379 fastq.gz 208.9 MB Report
EGAF00001386380 fastq.gz 223.8 MB Report
EGAF00001386381 fastq.gz 235.5 MB Report
EGAF00001386382 fastq.gz 1.2 GB Report
EGAF00001386383 fastq.gz 1.2 GB Report
EGAF00001386384 fastq.gz 1.9 GB Report
EGAF00001386385 fastq.gz 1.8 GB Report
EGAF00001386386 fastq.gz 1.6 GB Report
EGAF00001386387 fastq.gz 1.5 GB Report
EGAF00001386388 fastq.gz 1.1 GB Report
EGAF00001386389 fastq.gz 1.1 GB Report
EGAF00001386390 fastq.gz 1.1 GB Report
EGAF00001386391 fastq.gz 1.1 GB Report
EGAF00001386392 fastq.gz 1.6 GB Report
EGAF00001386393 fastq.gz 1.5 GB Report
EGAF00001386394 fastq.gz 1.4 GB Report
EGAF00001386395 fastq.gz 1.3 GB Report
EGAF00001386396 fastq.gz 2.0 GB Report
EGAF00001386397 fastq.gz 1.9 GB Report
EGAF00001386398 fastq.gz 640.1 MB Report
EGAF00001386399 fastq.gz 642.0 MB Report
EGAF00001386400 fastq.gz 699.9 MB Report
EGAF00001386401 fastq.gz 707.1 MB Report
EGAF00001386402 fastq.gz 899.0 MB Report
EGAF00001386403 fastq.gz 881.7 MB Report
EGAF00001386404 fastq.gz 943.8 MB Report
EGAF00001386405 fastq.gz 881.0 MB Report
EGAF00001386406 fastq.gz 1.0 GB Report
EGAF00001386407 fastq.gz 1.0 GB Report
EGAF00001386408 fastq.gz 1.1 GB Report
EGAF00001386409 fastq.gz 1.1 GB Report
EGAF00001386410 fastq.gz 5.2 GB Report
EGAF00001386411 fastq.gz 5.3 GB Report
EGAF00001386412 fastq.gz 7.0 GB Report
EGAF00001386413 fastq.gz 7.0 GB Report
EGAF00001386414 fastq.gz 735.6 MB Report
EGAF00001386415 fastq.gz 690.3 MB Report
EGAF00001386416 fastq.gz 1.5 GB Report
EGAF00001386417 fastq.gz 1.4 GB Report
EGAF00001386418 fastq.gz 1.5 GB Report
EGAF00001386419 fastq.gz 1.4 GB Report
EGAF00001386420 fastq.gz 2.1 GB Report
EGAF00001386421 fastq.gz 2.0 GB Report
EGAF00001386422 fastq.gz 1.6 GB Report
EGAF00001386423 fastq.gz 1.5 GB Report
EGAF00001386424 fastq.gz 1.2 GB Report
EGAF00001386425 fastq.gz 1.2 GB Report
EGAF00001386426 fastq.gz 1.3 GB Report
EGAF00001386427 fastq.gz 1.3 GB Report
EGAF00001386428 fastq.gz 1.8 GB Report
EGAF00001386429 fastq.gz 1.7 GB Report
EGAF00001386430 fastq.gz 1.4 GB Report
EGAF00001386431 fastq.gz 1.3 GB Report
EGAF00001386432 fastq.gz 1.3 GB Report
EGAF00001386433 fastq.gz 1.2 GB Report
EGAF00001386434 fastq.gz 1.3 GB Report
EGAF00001386435 fastq.gz 1.2 GB Report
EGAF00001386436 fastq.gz 1.3 GB Report
EGAF00001386437 fastq.gz 1.2 GB Report
EGAF00001386438 fastq.gz 1.0 GB Report
EGAF00001386439 fastq.gz 979.7 MB Report
EGAF00001386440 fastq.gz 1.3 GB Report
EGAF00001386441 fastq.gz 1.3 GB Report
EGAF00001386442 fastq.gz 604.8 MB Report
EGAF00001386443 fastq.gz 620.3 MB Report
EGAF00001386444 fastq.gz 608.5 MB Report
EGAF00001386445 fastq.gz 598.1 MB Report
EGAF00001386446 fastq.gz 118.5 MB Report
EGAF00001386447 fastq.gz 114.2 MB Report
EGAF00001386448 fastq.gz 978.1 MB Report
EGAF00001386449 fastq.gz 908.5 MB Report
EGAF00001386450 fastq.gz 328.0 MB Report
EGAF00001386451 fastq.gz 318.5 MB Report
EGAF00001386452 fastq.gz 1.2 GB Report
EGAF00001386453 fastq.gz 1.1 GB Report
EGAF00001386454 fastq.gz 755.3 MB Report
EGAF00001386455 fastq.gz 769.5 MB Report
EGAF00001386456 fastq.gz 1.9 GB Report
EGAF00001386457 fastq.gz 1.8 GB Report
EGAF00001386458 fastq.gz 788.2 MB Report
EGAF00001386459 fastq.gz 801.5 MB Report
EGAF00001386460 fastq.gz 1.2 GB Report
EGAF00001386461 fastq.gz 1.2 GB Report
EGAF00001386462 fastq.gz 1.1 GB Report
EGAF00001386463 fastq.gz 1.1 GB Report
EGAF00001386464 fastq.gz 1.4 GB Report
EGAF00001386465 fastq.gz 1.4 GB Report
EGAF00001386466 fastq.gz 981.5 MB Report
EGAF00001386467 fastq.gz 924.1 MB Report
EGAF00001386468 fastq.gz 1.0 GB Report
EGAF00001386469 fastq.gz 929.4 MB Report
EGAF00001386470 fastq.gz 1.3 GB Report
EGAF00001386471 fastq.gz 1.2 GB Report
EGAF00001386472 fastq.gz 1.4 GB Report
EGAF00001386473 fastq.gz 1.3 GB Report
EGAF00001386474 fastq.gz 1.4 GB Report
EGAF00001386475 fastq.gz 1.3 GB Report
EGAF00001386476 fastq.gz 1.5 GB Report
EGAF00001386477 fastq.gz 1.5 GB Report
EGAF00001386478 fastq.gz 1.3 GB Report
EGAF00001386479 fastq.gz 1.3 GB Report
EGAF00001386480 fastq.gz 739.4 MB Report
EGAF00001386481 fastq.gz 731.2 MB Report
EGAF00001386482 fastq.gz 1.3 GB Report
EGAF00001386483 fastq.gz 1.2 GB Report
EGAF00001386484 fastq.gz 1.2 GB Report
EGAF00001386485 fastq.gz 1.2 GB Report
EGAF00001386486 fastq.gz 2.5 GB Report
EGAF00001386487 fastq.gz 2.4 GB Report
EGAF00001386488 fastq.gz 3.8 GB Report
EGAF00001386489 fastq.gz 3.6 GB Report
EGAF00001386490 fastq.gz 2.7 GB Report
EGAF00001386491 fastq.gz 2.5 GB Report
EGAF00001386492 fastq.gz 1.2 GB Report
EGAF00001386493 fastq.gz 1.2 GB Report
EGAF00001386494 fastq.gz 1.8 GB Report
EGAF00001386495 fastq.gz 1.7 GB Report
EGAF00001386496 fastq.gz 2.1 GB Report
EGAF00001386497 fastq.gz 2.1 GB Report
EGAF00001386498 fastq.gz 288.6 MB Report
EGAF00001386499 fastq.gz 278.4 MB Report
EGAF00001386500 fastq.gz 1.3 GB Report
EGAF00001386501 fastq.gz 1.4 GB Report
EGAF00001386502 fastq.gz 1.6 GB Report
EGAF00001386503 fastq.gz 1.6 GB Report
EGAF00001386504 fastq.gz 1.6 GB Report
EGAF00001386505 fastq.gz 1.6 GB Report
EGAF00001386506 fastq.gz 3.4 GB Report
EGAF00001386507 fastq.gz 3.2 GB Report
EGAF00001386508 fastq.gz 1.1 GB Report
EGAF00001386509 fastq.gz 1.0 GB Report
EGAF00001386510 fastq.gz 1.5 GB Report
EGAF00001386511 fastq.gz 1.4 GB Report
EGAF00001386512 fastq.gz 1.5 GB Report
EGAF00001386513 fastq.gz 1.4 GB Report
288 Files (335.5 GB)