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Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends

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Policy for Plasma DNA data sharing

The CUHK Circulating Nucleic Acids Research Group Data Access Agreement This agreement governs the terms and conditions on which access will be granted to users of the sequencing and genotyping data generated by The Chinese University of Hong Kong (CUHK) Circulating Nucleic Acids Research Group (CNARG). The terms and conditions of access set out in this agreement apply both to the User and the User’s Institution (both as defined below). User is referred to within the agreement as “You” and the term “Your” will be construed accordingly. By signing this agreement, You agree to be bound by the terms and conditions of access set out in this agreement. Definitions: Group means The Chinese University of Hong Kong (CUHK) Circulating Nucleic Acids Research Group (CNARG). Data means all and any human genetic data obtained by User or User’s Institution from the Group via the European Genome-phenome Archive. Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto. In the event that the Data Subject is legally incapable of giving an informed consent, such consent has been given by his/her legal guardian. User means a researcher whose User’s Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance by the Group. Data Access Committee means a committee assigned by the Group for reviewing and approving the data access application of the User. The committee consists of three or more investigators from the Group. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written, electronic, graphical, photographic, recorded (including oral recordings), and verbal presentations of research. User’s Institution means the organisation at which the User is employed, affiliated or enrolled. Terms and Conditions: By signing this agreement: 1. You agree to use the Data only for the advancement of medical and scientific research, according to the consent given by Data Subjects. 2. You agree not to use the Data for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to transfer or disclose the Data, in whole or in part, or any information/material derived from the Data, to others, except as reasonably necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator within the same User’s Institution, the collaborator must make a separate application for access to the Data. 5. You agree to use the Data for the approved purpose and project described in your application only; use of the Data for a new purpose or project will require a new application and approval. 6. You agree to acknowledge in any work based in whole or in part on the Data, the publications from which the Data derives, the version of the Data, and the role of the Group. The wordings of the acknowledgement are “This study makes use of data generated by The Chinese University of Hong Kong (CUHK) Circulating Nucleic Acids Research Group, as reported by Chan et al in Clinical Chemistry (doi:10.1373/clinchem.2012.196014). 7. You accept that the Group, the original data creators, depositors or copyright holders, or the funders of the Group: a) make no warranties or representations with respect to the Data, including but not limited to its fitness for purpose, accuracy or comprehensiveness, the continued access to the Data without interruption; and b) accept no liability for any direct, indirect, consequential, special or incidental, damages or losses arising from or in connection with the use of the Data or this agreement. 8. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that reproduction, except as reasonably required to carry out Your research with the Data in accordance with the approved purpose referred to in paragraph 5 above, or sale of all or part of the Data in any form is not permitted. 9. You agree that nothing in this agreement shall operate to transfer to You or to the User’s Institution any intellectual property rights relating to the Data. 10. You accept that this agreement will be terminated immediately by the Group without notice upon breach of any terms of this agreement by You and You agree to destroy any Data held when required. 11. You accept that it may be necessary for the Group or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Group or its appointed agent will to inform You of any changes. You agree that Your continued use of the Data shall be deemed to represent your consent to any revised terms of the Agreement. 12. You agree that you will submit a report to the Data Access Committee, if requested, on completion of the agreed purpose. The Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User’s Institution. 13. You accept that the Data is protected by the privacy law in the relevant jurisdiction and that You are responsible for ensuring Your use of the Data is in compliance with any such applicable law. Notwithstanding the above, nothing in this agreement shall limit the rights of the Data Subjects under the Personal Data (Privacy) Ordinance (Cap 486) in Hong Kong. The Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the Personal Data (Privacy) Ordinance in Hong Kong. 14. This agreement shall be construed, interpreted and governed by the laws of Hong Kong Special Administrative Region.   For and on behalf of User: Name of Applicant(s): _____________________________________ _____________________________________ _____________________________________ _____________________________________ Signature of Applicant(s): _____________________________________ _____________________________________ _____________________________________ _____________________________________ Date: _____________________________________ For and on behalf of User’s Institution: Signature of Institutional or Administrative Authority: ______________________________________ Print name: ______________________________________ User’s Institution: ______________________________________ Date: ¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬______________________________________ WHEN SUBMITTING THIS DOCUMENT, PLEASE INCLUDE ALL PAGES OF THE AGREEMENT WITH THIS SIGNATURE PAGE

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001882 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001407552 fastq.gz 12.2 GB
EGAF00001407553 fastq.gz 11.9 GB
EGAF00001407554 fastq.gz 14.5 GB
EGAF00001407555 fastq.gz 14.1 GB
EGAF00001407556 fastq.gz 14.9 GB
EGAF00001407557 fastq.gz 14.7 GB
EGAF00001407558 fastq.gz 13.9 GB
EGAF00001407559 fastq.gz 13.7 GB
EGAF00001407560 fastq.gz 14.1 GB
EGAF00001407561 fastq.gz 13.9 GB
EGAF00001407562 fastq.gz 14.1 GB
EGAF00001407563 fastq.gz 13.9 GB
EGAF00001407564 fastq.gz 14.1 GB
EGAF00001407565 fastq.gz 13.9 GB
EGAF00001407566 fastq.gz 15.2 GB
EGAF00001407567 fastq.gz 15.2 GB
EGAF00001407568 fastq.gz 14.8 GB
EGAF00001407569 fastq.gz 14.8 GB
EGAF00001407570 fastq.gz 15.3 GB
EGAF00001407571 fastq.gz 15.3 GB
EGAF00001407572 fastq.gz 14.9 GB
EGAF00001407573 fastq.gz 14.9 GB
EGAF00001407574 fastq.gz 15.4 GB
EGAF00001407575 fastq.gz 15.4 GB
EGAF00001407576 fastq.gz 14.9 GB
EGAF00001407577 fastq.gz 14.9 GB
EGAF00001407578 fastq.gz 15.2 GB
EGAF00001407579 fastq.gz 15.1 GB
EGAF00001407580 fastq.gz 15.1 GB
EGAF00001407581 fastq.gz 15.1 GB
EGAF00001407582 fq.gz 21.0 GB
EGAF00001407583 fq.gz 21.8 GB
EGAF00001407584 fastq.gz 11.0 GB
EGAF00001407585 fastq.gz 11.3 GB
EGAF00001407586 fastq.gz 16.0 GB
EGAF00001407587 fastq.gz 16.9 GB
EGAF00001407588 fastq.gz 16.0 GB
EGAF00001407589 fastq.gz 17.0 GB
EGAF00001407590 fastq.gz 16.0 GB
EGAF00001407591 fastq.gz 17.0 GB
EGAF00001407592 fastq.gz 16.1 GB
EGAF00001407593 fastq.gz 17.0 GB
EGAF00001407594 fastq.gz 16.1 GB
EGAF00001407595 fastq.gz 17.1 GB
EGAF00001407596 fastq.gz 14.9 GB
EGAF00001407597 fastq.gz 14.9 GB
EGAF00001407598 fastq.gz 14.7 GB
EGAF00001407599 fastq.gz 14.7 GB
EGAF00001407600 fastq.gz 15.5 GB
EGAF00001407601 fastq.gz 15.5 GB
EGAF00001407602 fastq.gz 14.1 GB
EGAF00001407603 fastq.gz 14.0 GB
EGAF00001407606 fastq.gz 14.1 GB
EGAF00001407607 fastq.gz 13.9 GB
EGAF00001407610 fastq.gz 14.4 GB
EGAF00001407611 fastq.gz 14.4 GB
EGAF00001407612 fastq.gz 14.3 GB
EGAF00001407613 fastq.gz 14.4 GB
EGAF00001407614 fastq.gz 14.9 GB
EGAF00001407615 fastq.gz 14.9 GB
EGAF00001407616 fastq.gz 15.1 GB
EGAF00001407617 fastq.gz 15.1 GB
EGAF00001407618 fastq.gz 14.9 GB
EGAF00001407619 fastq.gz 15.0 GB
EGAF00001407620 fastq.gz 15.3 GB
EGAF00001407621 fastq.gz 15.2 GB
EGAF00001407622 fq.gz 11.4 GB
EGAF00001407623 fq.gz 11.8 GB
EGAF00001407624 fastq.gz 11.3 GB
EGAF00001407625 fastq.gz 11.4 GB
EGAF00001407626 fastq.gz 11.5 GB
EGAF00001407627 fastq.gz 11.6 GB
EGAF00001407628 fastq.gz 10.3 GB
EGAF00001407629 fastq.gz 10.6 GB
EGAF00001407630 fastq.gz 11.6 GB
EGAF00001407631 fastq.gz 11.9 GB
EGAF00001407632 fastq.gz 11.5 GB
EGAF00001407633 fastq.gz 11.8 GB
EGAF00001407634 fastq.gz 11.1 GB
EGAF00001407635 fastq.gz 11.2 GB
EGAF00001407636 fastq.gz 11.0 GB
EGAF00001407637 fastq.gz 11.2 GB
EGAF00001407638 fastq.gz 10.4 GB
EGAF00001407639 fastq.gz 10.9 GB
EGAF00001407640 fastq.gz 12.0 GB
EGAF00001407641 fastq.gz 11.7 GB
EGAF00001407642 fastq.gz 11.3 GB
EGAF00001407643 fastq.gz 11.4 GB
EGAF00001407644 fastq.gz 11.4 GB
EGAF00001407645 fastq.gz 11.5 GB
EGAF00001407646 fastq.gz 11.3 GB
EGAF00001407647 fastq.gz 11.4 GB
EGAF00001407648 fastq.gz 11.3 GB
EGAF00001407649 fastq.gz 11.4 GB
EGAF00001407650 fastq.gz 11.7 GB
EGAF00001407651 fastq.gz 11.8 GB
EGAF00001407652 fastq.gz 11.7 GB
EGAF00001407653 fastq.gz 11.8 GB
EGAF00001407654 fastq.gz 10.9 GB
EGAF00001407655 fastq.gz 11.0 GB
EGAF00001407656 fastq.gz 11.9 GB
EGAF00001407657 fastq.gz 12.1 GB
EGAF00001407658 fastq.gz 11.8 GB
EGAF00001407659 fastq.gz 12.0 GB
EGAF00001407660 fastq.gz 11.8 GB
EGAF00001407661 fastq.gz 12.0 GB
EGAF00001407662 fastq.gz 14.5 GB
EGAF00001407663 fastq.gz 14.7 GB
EGAF00001407664 fastq.gz 14.4 GB
EGAF00001407665 fastq.gz 14.5 GB
EGAF00001407666 fastq.gz 14.6 GB
EGAF00001407667 fastq.gz 14.7 GB
EGAF00001407668 fastq.gz 14.5 GB
EGAF00001407669 fastq.gz 14.5 GB
EGAF00001407670 fastq.gz 11.1 GB
EGAF00001407671 fastq.gz 11.2 GB
EGAF00001407672 fastq.gz 11.3 GB
EGAF00001407673 fastq.gz 11.3 GB
EGAF00001407674 fastq.gz 11.0 GB
EGAF00001407675 fastq.gz 11.1 GB
EGAF00001407676 fastq.gz 11.0 GB
EGAF00001407677 fastq.gz 11.0 GB
EGAF00001407678 fastq.gz 10.4 GB
EGAF00001407679 fastq.gz 10.4 GB
EGAF00001407680 fastq.gz 11.1 GB
EGAF00001407681 fastq.gz 11.3 GB
EGAF00001407682 fastq.gz 10.9 GB
EGAF00001407683 fastq.gz 11.1 GB
EGAF00001407684 fastq.gz 15.2 GB
EGAF00001407685 fastq.gz 15.2 GB
EGAF00001407686 fastq.gz 15.1 GB
EGAF00001407687 fastq.gz 14.9 GB
EGAF00001407688 fastq.gz 15.1 GB
EGAF00001407689 fastq.gz 15.1 GB
EGAF00001407690 fastq.gz 11.0 GB
EGAF00001407691 fastq.gz 11.5 GB
EGAF00001407692 fastq.gz 10.9 GB
EGAF00001407693 fastq.gz 11.3 GB
EGAF00001407698 fastq.gz 10.2 GB
EGAF00001407699 fastq.gz 10.3 GB
EGAF00001407700 fastq.gz 10.4 GB
EGAF00001407701 fastq.gz 10.6 GB
EGAF00001407702 fastq.gz 10.4 GB
EGAF00001407703 fastq.gz 10.6 GB
EGAF00001407704 fastq.gz 10.3 GB
EGAF00001407705 fastq.gz 10.5 GB
EGAF00001407706 fastq.gz 10.1 GB
EGAF00001407707 fastq.gz 10.3 GB
EGAF00001407708 fastq.gz 10.2 GB
EGAF00001407709 fastq.gz 10.4 GB
EGAF00001407710 fastq.gz 10.5 GB
EGAF00001407711 fastq.gz 10.7 GB
EGAF00001407712 fastq.gz 14.8 GB
EGAF00001407713 fastq.gz 15.5 GB
EGAF00001407714 fastq.gz 10.5 GB
EGAF00001407715 fastq.gz 10.7 GB
EGAF00001407716 fastq.gz 14.7 GB
EGAF00001407717 fastq.gz 15.3 GB
EGAF00001407718 fastq.gz 14.6 GB
EGAF00001407719 fastq.gz 15.0 GB
EGAF00001407722 fastq.gz 14.5 GB
EGAF00001407723 fastq.gz 15.0 GB
EGAF00001407724 fastq.gz 14.5 GB
EGAF00001407725 fastq.gz 15.0 GB
EGAF00001407726 fastq.gz 14.2 GB
EGAF00001407727 fastq.gz 14.0 GB
EGAF00001407728 fastq.gz 14.1 GB
EGAF00001407729 fastq.gz 13.9 GB
EGAF00001407730 fastq.gz 14.0 GB
EGAF00001407731 fastq.gz 13.9 GB
EGAF00001407732 fastq.gz 14.0 GB
EGAF00001407733 fastq.gz 13.8 GB
EGAF00001407734 fastq.gz 13.6 GB
EGAF00001407735 fastq.gz 13.4 GB
EGAF00001407736 fastq.gz 13.6 GB
EGAF00001407737 fastq.gz 13.4 GB
EGAF00001407738 fastq.gz 14.0 GB
EGAF00001407739 fastq.gz 13.8 GB
EGAF00001407740 fastq.gz 14.0 GB
EGAF00001407741 fastq.gz 13.8 GB
EGAF00001407742 fastq.gz 5.3 GB
EGAF00001407743 fastq.gz 5.3 GB
EGAF00001407744 fastq.gz 6.4 GB
EGAF00001407745 fastq.gz 6.4 GB
EGAF00001407746 fastq.gz 6.4 GB
EGAF00001407747 fastq.gz 6.3 GB
EGAF00001407748 fastq.gz 4.9 GB
EGAF00001407749 fastq.gz 4.8 GB
EGAF00001407750 fastq.gz 6.4 GB
EGAF00001407751 fastq.gz 6.4 GB
EGAF00001407752 fastq.gz 6.1 GB
EGAF00001407753 fastq.gz 6.0 GB
EGAF00001407754 fastq.gz 6.1 GB
EGAF00001407755 fastq.gz 6.1 GB
EGAF00001407756 fastq.gz 5.5 GB
EGAF00001407757 fastq.gz 5.5 GB
EGAF00001407758 fastq.gz 14.3 GB
EGAF00001407759 fastq.gz 13.9 GB
EGAF00001407760 fastq.gz 13.9 GB
EGAF00001407761 fastq.gz 13.5 GB
EGAF00001407762 fastq.gz 14.0 GB
EGAF00001407763 fastq.gz 13.6 GB
EGAF00001407764 fastq.gz 13.6 GB
EGAF00001407765 fastq.gz 13.2 GB
EGAF00001407766 fastq.gz 13.9 GB
EGAF00001407767 fastq.gz 13.6 GB
EGAF00001407768 fastq.gz 14.0 GB
EGAF00001407769 fastq.gz 13.5 GB
208 Files (2.6 TB)