Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts

Dataset ID Technology Samples
EGAD00001003800 Illumina HiSeq 2500,Illumina HiSeq 4000 12

Dataset Description

Whole Exome Sequencing was performed in a dilution series containing known amounts of human and mouse DNA, 3x 100% human 0% mouse, 2x 90/10, 3x 50/50, 2x 25/75 and 3x 0/100. A set of breast cancer clinical samples, matched normal tissue and matched PDTXs (total number = 14) were also analysed. Paired-end 75bp sequences for the dilution series and paired-end 125bp for the clinical samples were obtained on Illumina HiSeq2500; fastq files are provided.
A triplicate analysis of the transcriptome using RNA-seq was also performed for the Universal Human RNA Reference and the Universal Mouse RNA Reference samples. Paired-end 150bp fastq files obtained on Illumina HiSeq4000 are provided.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

Data Access Committee
Contact person: Marion Karniely
Email: marion [dot] karniely [at] cruk [dot] cam [dot] ac [dot] uk
More details: EGAC00001000657


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