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TCR β-chain repertoire sequences of regulatory and conventional T cells in peripheral blood from breast cancer patients and healthy individuals

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The Data Access Policy for the study Treg in breast cancer and healthy individuals

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. XXXXX: Your Institution details here 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638). In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of Germany and shall be subject to the exclusive jurisdiction of the German courts. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638). Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) Name of project that created the dataset Treg in breast cancer and healthy individuals Names of other data producers/collaborators Maria Xydia, Till Michels and Philipp Beckhove (RCI Regensburg Centre for Interventional Immunology, Germany), Eliana Ruggiero, Raffaele Fronza, Stefan Wilkening, Manfred Schmidt and Christoph von Kalle (NCT National Centre for Tumor Diseases, Heidelberg, Germany), Raheleh Rahbari and Thierry Voet (Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK), Alejandro Sifrim (KU Leuven, Belgium), Dr. Christoph Domschke and Prof. Dr. Florian Schütz (Brustzentrum, Universitätsklinikum Heidelberg, Germany), Prof. Dr. med. Michael Müller-Steinhardt (DRK-Blutspendedienst, Institut Mannheim, Germany). Specific limitations on areas of research Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY The DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 12 months after these data were first made available on the relevant hosting database, unless the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638) has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with the DAC for study Treg in breast cancer and healthy individuals (EGAC00001000638).

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002699 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001775038 fastq.gz 65.4 MB
EGAF00001775039 fq.gz 1.3 MB
EGAF00001775040 fastq.gz 32.3 MB
EGAF00001775041 fq.gz 1.6 MB
EGAF00001775042 fastq.gz 37.7 MB
EGAF00001775043 fq.gz 1.6 MB
EGAF00001775044 fq.gz 2.2 MB
EGAF00001775045 fq.gz 1.1 MB
EGAF00001775046 fq.gz 1.7 MB
EGAF00001775047 fq.gz 1.8 MB
EGAF00001775048 fastq.gz 38.8 MB
EGAF00001775049 fastq.gz 48.1 MB
EGAF00001775050 fastq.gz 70.8 MB
EGAF00001775051 fastq.gz 64.7 MB
EGAF00001775052 fq.gz 1.8 MB
EGAF00001775053 fq.gz 2.1 MB
EGAF00001775054 fq.gz 1.3 MB
EGAF00001775055 fq.gz 1.7 MB
EGAF00001775056 fq.gz 1.1 MB
EGAF00001775057 fq.gz 2.4 MB
EGAF00001775058 fq.gz 1.3 MB
EGAF00001775059 fastq.gz 361 Bytes
EGAF00001775060 fastq.gz 406 Bytes
EGAF00001775061 fastq.gz 453 Bytes
EGAF00001775062 fastq.gz 375 Bytes
EGAF00001775063 fastq.gz 334 Bytes
EGAF00001775064 fastq.gz 474 Bytes
EGAF00001775065 fastq.gz 455 Bytes
EGAF00001775066 fastq.gz 442 Bytes
EGAF00001775067 fastq.gz 476 Bytes
EGAF00001775068 fastq.gz 445 Bytes
EGAF00001775069 fastq.gz 424 Bytes
EGAF00001775070 fastq.gz 373 Bytes
EGAF00001775071 fastq.gz 816 Bytes
EGAF00001775072 fastq.gz 481 Bytes
EGAF00001775073 fastq.gz 398 Bytes
EGAF00001775074 fastq.gz 467 Bytes
EGAF00001775075 fastq.gz 398 Bytes
EGAF00001775076 fastq.gz 371 Bytes
EGAF00001775077 fastq.gz 415 Bytes
EGAF00001775078 fastq.gz 393 Bytes
EGAF00001775079 fastq.gz 361 Bytes
EGAF00001775080 fastq.gz 434 Bytes
EGAF00001775081 fastq.gz 430 Bytes
EGAF00001775082 fastq.gz 467 Bytes
EGAF00001775083 fastq.gz 489 Bytes
EGAF00001775084 fastq.gz 424 Bytes
EGAF00001775085 fastq.gz 467 Bytes
EGAF00001775086 fastq.gz 377 Bytes
EGAF00001775087 fastq.gz 467 Bytes
EGAF00001775088 fastq.gz 461 Bytes
EGAF00001775089 fastq.gz 423 Bytes
EGAF00001775090 fastq.gz 377 Bytes
EGAF00001775091 fastq.gz 494 Bytes
EGAF00001775092 fastq.gz 470 Bytes
EGAF00001775093 fastq.gz 495 Bytes
EGAF00001775094 fastq.gz 468 Bytes
EGAF00001775095 fastq.gz 433 Bytes
EGAF00001775096 fastq.gz 410 Bytes
EGAF00001775097 fastq.gz 565 Bytes
EGAF00001775098 fastq.gz 382 Bytes
EGAF00001775099 fastq.gz 434 Bytes
EGAF00001775100 fastq.gz 378 Bytes
EGAF00001775101 fastq.gz 384 Bytes
EGAF00001775102 fastq.gz 473 Bytes
EGAF00001775103 fastq.gz 384 Bytes
EGAF00001775104 fastq.gz 469 Bytes
EGAF00001775105 fastq.gz 450 Bytes
EGAF00001775106 fastq.gz 386 Bytes
EGAF00001775107 fastq.gz 418 Bytes
EGAF00001775108 fastq.gz 460 Bytes
EGAF00001775109 fastq.gz 442 Bytes
EGAF00001775110 fastq.gz 435 Bytes
EGAF00001775111 fastq.gz 389 Bytes
EGAF00001775112 fastq.gz 399 Bytes
EGAF00001775113 fastq.gz 575 Bytes
EGAF00001775114 fastq.gz 465 Bytes
EGAF00001775115 fastq.gz 400 Bytes
EGAF00001775116 fastq.gz 707 Bytes
EGAF00001775117 fastq.gz 386 Bytes
EGAF00001775118 fastq.gz 395 Bytes
EGAF00001775119 fastq.gz 394 Bytes
EGAF00001775120 fastq.gz 370 Bytes
EGAF00001775121 fastq.gz 782 Bytes
EGAF00001775122 fastq.gz 754 Bytes
EGAF00001775123 fastq.gz 489 Bytes
EGAF00001775124 fastq.gz 380 Bytes
EGAF00001775125 fastq.gz 395 Bytes
EGAF00001775126 fastq.gz 429 Bytes
EGAF00001775127 fastq.gz 366 Bytes
EGAF00001775128 fastq.gz 399 Bytes
EGAF00001775129 fastq.gz 383 Bytes
EGAF00001775130 fastq.gz 822 Bytes
EGAF00001775131 fastq.gz 649 Bytes
EGAF00001775132 fastq.gz 540 Bytes
EGAF00001775133 fastq.gz 535 Bytes
EGAF00001775134 fastq.gz 376 Bytes
EGAF00001775135 fastq.gz 361 Bytes
EGAF00001775136 fastq.gz 375 Bytes
EGAF00001775137 fastq.gz 371 Bytes
EGAF00001775138 fastq.gz 400 Bytes
EGAF00001775139 fastq.gz 678 Bytes
EGAF00001775140 fastq.gz 779 Bytes
EGAF00001775141 fastq.gz 744 Bytes
EGAF00001775142 fastq.gz 396 Bytes
EGAF00001775143 fastq.gz 526 Bytes
EGAF00001775144 fastq.gz 491 Bytes
EGAF00001775145 fastq.gz 396 Bytes
EGAF00001775146 fastq.gz 392 Bytes
EGAF00001775147 fastq.gz 503 Bytes
EGAF00001775148 fastq.gz 402 Bytes
EGAF00001775149 fastq.gz 408 Bytes
EGAF00001775150 fastq.gz 524 Bytes
EGAF00001775151 fastq.gz 368 Bytes
EGAF00001775152 fastq.gz 413 Bytes
EGAF00001775153 fastq.gz 390 Bytes
EGAF00001775154 fastq.gz 658 Bytes
EGAF00001775155 fastq.gz 382 Bytes
EGAF00001775156 fastq.gz 549 Bytes
EGAF00001775157 fastq.gz 517 Bytes
EGAF00001775158 fastq.gz 469 Bytes
EGAF00001775159 fastq.gz 374 Bytes
EGAF00001775160 fastq.gz 460 Bytes
EGAF00001775161 fastq.gz 701 Bytes
EGAF00001775162 fastq.gz 503 Bytes
EGAF00001775163 fastq.gz 551 Bytes
EGAF00001775164 fastq.gz 565 Bytes
EGAF00001775165 fastq.gz 575 Bytes
EGAF00001775166 fastq.gz 383 Bytes
EGAF00001775167 fastq.gz 533 Bytes
EGAF00001775168 fastq.gz 382 Bytes
EGAF00001775169 fastq.gz 366 Bytes
EGAF00001775170 fastq.gz 401 Bytes
EGAF00001775171 fastq.gz 520 Bytes
EGAF00001775172 fastq.gz 564 Bytes
EGAF00001775173 fastq.gz 363 Bytes
EGAF00001775174 fastq.gz 387 Bytes
EGAF00001775175 fastq.gz 519 Bytes
EGAF00001775176 fastq.gz 593 Bytes
EGAF00001775177 fastq.gz 483 Bytes
EGAF00001775178 fastq.gz 450 Bytes
EGAF00001775179 fastq.gz 568 Bytes
EGAF00001775180 fastq.gz 754 Bytes
EGAF00001775181 fastq.gz 401 Bytes
EGAF00001775182 fastq.gz 706 Bytes
EGAF00001775183 fastq.gz 377 Bytes
EGAF00001775184 fastq.gz 478 Bytes
EGAF00001775185 fastq.gz 751 Bytes
EGAF00001775186 fastq.gz 412 Bytes
EGAF00001775187 fastq.gz 410 Bytes
EGAF00001775188 fastq.gz 439 Bytes
EGAF00001775189 fastq.gz 418 Bytes
EGAF00001775190 fastq.gz 370 Bytes
EGAF00001775191 fastq.gz 495 Bytes
EGAF00001775192 fastq.gz 396 Bytes
EGAF00001775193 fastq.gz 391 Bytes
EGAF00001775194 fastq.gz 425 Bytes
EGAF00001775195 fastq.gz 450 Bytes
EGAF00001775196 fastq.gz 425 Bytes
EGAF00001775197 fastq.gz 357 Bytes
EGAF00001775198 fastq.gz 405 Bytes
EGAF00001775199 fastq.gz 393 Bytes
EGAF00001775200 fastq.gz 397 Bytes
EGAF00001775201 fastq.gz 416 Bytes
EGAF00001775202 fastq.gz 389 Bytes
EGAF00001775203 fastq.gz 384 Bytes
EGAF00001775204 fastq.gz 448 Bytes
EGAF00001775205 fastq.gz 376 Bytes
EGAF00001775206 fastq.gz 382 Bytes
EGAF00001775207 fastq.gz 434 Bytes
EGAF00001775208 fastq.gz 374 Bytes
171 Files (380.7 MB)