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Open Targets 020 Epigenomes of Cell Lines (2018-10-23)

There is currently a drive to establish cell based assay systems of greater human biological and disease relevance through the use of well characterised transformed cell lines, primary cells and complex cellular models (e.g. co-culture, 3D models). However, although the field is gaining valuable experience in running more non-standard & complex cell assays for target validation and compound pharmacology studies, there is the lack of a systematic approach to determine if this expansion in cell assay models is reflected in increased human biological and disease relevance. The increasing wealth of publically available transcriptomic, and epigenome (ENCODE and Epigenome Roadmap) data represents an ideal reference mechanism for determining the relationship between cell types used for target & compound studies to primary human cells and tissues from both healthy volunteers & patients. The CTTV020 epigenomes of cell line project aims to generate epigenetic and transcriptomic profiles of cell lines and compare these with existing and newly generated reference data sets from human tissue and cell types. The aim is to identify assay systems which will provide greater confidence in translating target biology and compound pharmacology to patients. Multiple cell types commonly used within research have been grouped according to biology. Examples include erythroid, lung epithelial, hepatocyte cell types and immortalised models of monocyte / macrophage biology. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see . This dataset contains all the data available for this study on 2018-10-23.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003137 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002211266 cram 2.1 GB
EGAF00002211267 cram 2.4 GB
EGAF00002211268 cram 2.3 GB
EGAF00002211269 cram 2.1 GB
EGAF00002211270 cram 1.8 GB
EGAF00002211271 cram 2.7 GB
EGAF00002211272 cram 1.9 GB
EGAF00002211273 cram 2.8 GB
EGAF00002211274 cram 2.5 GB
EGAF00002211275 cram 2.1 GB
EGAF00002211276 cram 2.9 GB
EGAF00002211277 cram 3.2 GB
12 Files (28.8 GB)