Single cell multiomics sequencing and analyses of human colorectal cancer

Whole genome sequencing data of tumor tissues, adjacent normal tissues, and peripheral blood from CRC patients.

107 samples
DAC: EGAC00001000902
Technology: Illumina HiSeq 4000

Access Policy1 Study Files

Metadata

Request Access

None DUO:0000001 (version: 2019-01-07)data use permissionA data item that is used to indicate consent permissions for datasets and/or materials, and relates to the purposes for which datasets and/or material might be removed, stored or used.
RU DUO:0000014 (version: 2019-01-07)research use onlyThis data use limitation indicates that use is limited to research purposes (e.g., does not include its use in clinical care).
NPUNCU DUO:0000018 (version: 2019-01-07)not for profit, non commercial use onlyThis data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.
PUB DUO:0000019 (version: 2019-01-07)publication requiredThis data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.

Data access policy of sequencing data from BIOPIC, Peking University

Data access policy of sequencing data from BIOPIC, Peking University --------------------------------------------------------------------------------- DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom Peking University BIOPIC Data Access Committee (PUBDAC) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Peking University BIOPIC Data Access Committee (PUBDAC) and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. Peking University BIOPIC Data Access Committee (PUBDAC): PUBDAC is composed of senior employees with appropriate scientific, bioethics, and human subjects’ research expertise. Members may be appointed for a specified term as defined by the convening Institute or serve more than one term. Consultants with specific expertise may be invited to meetings or to provide written consultation. Consultants may be PKU or non-PKU employees, and are not voting members of the DAC. Timelines for responding to requests for data access will vary, but PKUDAC will strive to provide decisions or feedback to requesting investigators in a timely manner. ?1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (https://wellcome.ac.uk/sites/default/files/wtd003207.pdf) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify Peking University BIOPIC Data Access Committee (PUBDAC) within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify Peking University BIOPIC Data Access Committee (PUBDAC) prior to any significant changes to the protocol for the Project. 14. The User Institution will notify Peking University BIOPIC Data Access Committee (PUBDAC) as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. Peking University BIOPIC Data Access Committee (PUBDAC) may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than Peking University BIOPIC Data Access Committee (PUBDAC). In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of China and shall be subject to the exclusive jurisdiction of the Chinese courts. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for Peking University BIOPIC Data Access Committee (PUBDAC) Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID	Study Title	Study Type
EGAS00001003242	Genomic DNA of tumor tissues, adjacent normal tissues, and peripheral blood were extracted using QIAamp DNA mini Kit (QIAGEN, cat. #51306)	Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID	File Type	Size
EGAF00002197566	fastq.gz	3.6 GB
EGAF00002197567	fastq.gz	4.3 GB
EGAF00002197568	fastq.gz	3.0 GB
EGAF00002197569	fastq.gz	3.4 GB
EGAF00002197570	fastq.gz	2.8 GB
EGAF00002197571	fastq.gz	3.2 GB
EGAF00002197572	fastq.gz	2.8 GB
EGAF00002197573	fastq.gz	3.2 GB
EGAF00002197574	fastq.gz	6.7 GB
EGAF00002197575	fastq.gz	7.5 GB
EGAF00002197576	fastq.gz	2.0 GB
EGAF00002197577	fastq.gz	2.5 GB
EGAF00002197578	fastq.gz	2.0 GB
EGAF00002197579	fastq.gz	2.3 GB
EGAF00002197580	fastq.gz	1.4 GB
EGAF00002197581	fastq.gz	1.5 GB
EGAF00002197582	fastq.gz	2.0 GB
EGAF00002197583	fastq.gz	2.3 GB
EGAF00002197584	fastq.gz	2.3 GB
EGAF00002197585	fastq.gz	2.5 GB
EGAF00002197586	fastq.gz	2.3 GB
EGAF00002197587	fastq.gz	2.6 GB
EGAF00002197588	fastq.gz	2.6 GB
EGAF00002197589	fastq.gz	2.8 GB
EGAF00002197590	fastq.gz	2.3 GB
EGAF00002197591	fastq.gz	2.8 GB
EGAF00002197592	fastq.gz	2.3 GB
EGAF00002197593	fastq.gz	2.6 GB
EGAF00002197594	fastq.gz	1.6 GB
EGAF00002197595	fastq.gz	1.7 GB
EGAF00002197596	fastq.gz	2.3 GB
EGAF00002197597	fastq.gz	2.6 GB
EGAF00002197598	fastq.gz	2.5 GB
EGAF00002197599	fastq.gz	2.8 GB
EGAF00002197600	fastq.gz	2.6 GB
EGAF00002197601	fastq.gz	2.9 GB
EGAF00002197602	fastq.gz	2.9 GB
EGAF00002197603	fastq.gz	3.2 GB
EGAF00002197604	fastq.gz	2.1 GB
EGAF00002197605	fastq.gz	2.6 GB
EGAF00002197606	fastq.gz	2.1 GB
EGAF00002197607	fastq.gz	2.3 GB
EGAF00002197608	fastq.gz	1.4 GB
EGAF00002197609	fastq.gz	1.5 GB
EGAF00002197610	fastq.gz	2.1 GB
EGAF00002197611	fastq.gz	2.3 GB
EGAF00002197612	fastq.gz	2.3 GB
EGAF00002197613	fastq.gz	2.5 GB
EGAF00002197614	fastq.gz	2.4 GB
EGAF00002197615	fastq.gz	2.6 GB
EGAF00002197616	fastq.gz	2.6 GB
EGAF00002197617	fastq.gz	2.9 GB
EGAF00002197618	fastq.gz	2.0 GB
EGAF00002197619	fastq.gz	2.5 GB
EGAF00002197620	fastq.gz	1.9 GB
EGAF00002197621	fastq.gz	2.2 GB
EGAF00002197622	fastq.gz	1.3 GB
EGAF00002197623	fastq.gz	1.5 GB
EGAF00002197624	fastq.gz	1.9 GB
EGAF00002197625	fastq.gz	2.2 GB
EGAF00002197626	fastq.gz	2.1 GB
EGAF00002197627	fastq.gz	2.4 GB
EGAF00002197628	fastq.gz	2.2 GB
EGAF00002197629	fastq.gz	2.5 GB
EGAF00002197630	fastq.gz	2.5 GB
EGAF00002197631	fastq.gz	2.7 GB
EGAF00002197632	fastq.gz	2.1 GB
EGAF00002197633	fastq.gz	2.5 GB
EGAF00002197634	fastq.gz	2.1 GB
EGAF00002197635	fastq.gz	2.3 GB
EGAF00002197636	fastq.gz	1.4 GB
EGAF00002197637	fastq.gz	1.6 GB
EGAF00002197638	fastq.gz	2.1 GB
EGAF00002197639	fastq.gz	2.3 GB
EGAF00002197640	fastq.gz	2.3 GB
EGAF00002197641	fastq.gz	2.5 GB
EGAF00002197642	fastq.gz	2.4 GB
EGAF00002197643	fastq.gz	2.6 GB
EGAF00002197644	fastq.gz	2.7 GB
EGAF00002197645	fastq.gz	2.9 GB
EGAF00002197646	fastq.gz	2.3 GB
EGAF00002197647	fastq.gz	2.7 GB
EGAF00002197648	fastq.gz	2.2 GB
EGAF00002197649	fastq.gz	2.5 GB
EGAF00002197650	fastq.gz	1.5 GB
EGAF00002197651	fastq.gz	1.6 GB
EGAF00002197652	fastq.gz	2.2 GB
EGAF00002197653	fastq.gz	2.5 GB
EGAF00002197654	fastq.gz	2.4 GB
EGAF00002197655	fastq.gz	2.7 GB
EGAF00002197656	fastq.gz	2.5 GB
EGAF00002197657	fastq.gz	2.8 GB
EGAF00002197658	fastq.gz	2.9 GB
EGAF00002197659	fastq.gz	3.1 GB
EGAF00002197660	fastq.gz	1.9 GB
EGAF00002197661	fastq.gz	2.3 GB
EGAF00002197662	fastq.gz	1.9 GB
EGAF00002197663	fastq.gz	2.1 GB
EGAF00002197664	fastq.gz	1.3 GB
EGAF00002197665	fastq.gz	1.4 GB
EGAF00002197666	fastq.gz	1.9 GB
EGAF00002197667	fastq.gz	2.1 GB
EGAF00002197668	fastq.gz	2.1 GB
EGAF00002197669	fastq.gz	2.3 GB
EGAF00002197670	fastq.gz	2.1 GB
EGAF00002197671	fastq.gz	2.3 GB
EGAF00002197672	fastq.gz	2.4 GB
EGAF00002197673	fastq.gz	2.6 GB
EGAF00002197674	fastq.gz	2.0 GB
EGAF00002197675	fastq.gz	2.3 GB
EGAF00002197676	fastq.gz	1.9 GB
EGAF00002197677	fastq.gz	2.1 GB
EGAF00002197678	fastq.gz	1.3 GB
EGAF00002197679	fastq.gz	1.4 GB
EGAF00002197680	fastq.gz	1.9 GB
EGAF00002197681	fastq.gz	2.1 GB
EGAF00002197682	fastq.gz	2.1 GB
EGAF00002197683	fastq.gz	2.3 GB
EGAF00002197684	fastq.gz	2.2 GB
EGAF00002197685	fastq.gz	2.4 GB
EGAF00002197686	fastq.gz	2.5 GB
EGAF00002197687	fastq.gz	2.6 GB
EGAF00002197688	fastq.gz	1.5 GB
EGAF00002197689	fastq.gz	1.8 GB
EGAF00002197690	fastq.gz	1.8 GB
EGAF00002197691	fastq.gz	2.1 GB
EGAF00002197692	fastq.gz	2.9 GB
EGAF00002197693	fastq.gz	3.4 GB
EGAF00002197694	fastq.gz	2.8 GB
EGAF00002197695	fastq.gz	3.2 GB
EGAF00002197696	fastq.gz	1.6 GB
EGAF00002197697	fastq.gz	1.9 GB
EGAF00002197698	fastq.gz	1.5 GB
EGAF00002197699	fastq.gz	1.8 GB
EGAF00002197700	fastq.gz	1.5 GB
EGAF00002197701	fastq.gz	1.8 GB
EGAF00002197702	fastq.gz	1.5 GB
EGAF00002197703	fastq.gz	1.8 GB
EGAF00002197704	fastq.gz	1.3 GB
EGAF00002197705	fastq.gz	1.4 GB
EGAF00002197706	fastq.gz	2.0 GB
EGAF00002197707	fastq.gz	2.2 GB
EGAF00002197708	fastq.gz	1.9 GB
EGAF00002197709	fastq.gz	2.1 GB
EGAF00002197710	fastq.gz	2.0 GB
EGAF00002197711	fastq.gz	2.3 GB
EGAF00002197712	fastq.gz	5.4 GB
EGAF00002197713	fastq.gz	6.0 GB
EGAF00002197714	fastq.gz	6.9 GB
EGAF00002197715	fastq.gz	8.0 GB
EGAF00002197716	fastq.gz	2.7 GB
EGAF00002197717	fastq.gz	2.9 GB
EGAF00002197718	fastq.gz	2.2 GB
EGAF00002197719	fastq.gz	2.5 GB
EGAF00002197720	fastq.gz	5.4 GB
EGAF00002197721	fastq.gz	6.1 GB
EGAF00002197722	fastq.gz	5.0 GB
EGAF00002197723	fastq.gz	5.5 GB
EGAF00002197724	fastq.gz	4.7 GB
EGAF00002197725	fastq.gz	4.9 GB
EGAF00002197726	fastq.gz	2.4 GB
EGAF00002197727	fastq.gz	2.6 GB
EGAF00002197728	fastq.gz	5.3 GB
EGAF00002197729	fastq.gz	5.9 GB
EGAF00002197730	fastq.gz	4.8 GB
EGAF00002197731	fastq.gz	5.3 GB
EGAF00002197732	fastq.gz	4.5 GB
EGAF00002197733	fastq.gz	4.7 GB
EGAF00002197734	fastq.gz	2.5 GB
EGAF00002197735	fastq.gz	2.6 GB
EGAF00002197736	fastq.gz	7.5 GB
EGAF00002197737	fastq.gz	8.2 GB
EGAF00002197738	fastq.gz	9.0 GB
EGAF00002197739	fastq.gz	9.7 GB
EGAF00002197740	fastq.gz	9.9 GB
EGAF00002197741	fastq.gz	11.2 GB
EGAF00002197742	fastq.gz	7.5 GB
EGAF00002197743	fastq.gz	8.0 GB
EGAF00002197744	fastq.gz	11.6 GB
EGAF00002197745	fastq.gz	12.7 GB
EGAF00002197746	fastq.gz	6.9 GB
EGAF00002197747	fastq.gz	7.6 GB
EGAF00002197748	fastq.gz	8.4 GB
EGAF00002197749	fastq.gz	9.0 GB
EGAF00002197750	fastq.gz	9.2 GB
EGAF00002197751	fastq.gz	10.5 GB
EGAF00002197752	fastq.gz	7.0 GB
EGAF00002197753	fastq.gz	7.5 GB
EGAF00002197754	fastq.gz	10.9 GB
EGAF00002197755	fastq.gz	11.9 GB
EGAF00002197756	fastq.gz	7.5 GB
EGAF00002197757	fastq.gz	7.8 GB
EGAF00002197758	fastq.gz	5.7 GB
EGAF00002197759	fastq.gz	5.9 GB
EGAF00002197760	fastq.gz	3.5 GB
EGAF00002197761	fastq.gz	3.7 GB
EGAF00002197762	fastq.gz	7.8 GB
EGAF00002197763	fastq.gz	8.3 GB
EGAF00002197764	fastq.gz	6.0 GB
EGAF00002197765	fastq.gz	6.4 GB
EGAF00002197766	fastq.gz	3.8 GB
EGAF00002197767	fastq.gz	4.1 GB
EGAF00002197768	fastq.gz	3.1 GB
EGAF00002197769	fastq.gz	3.7 GB
EGAF00002197770	fastq.gz	2.7 GB
EGAF00002197771	fastq.gz	3.2 GB
EGAF00002197772	fastq.gz	2.5 GB
EGAF00002197773	fastq.gz	3.0 GB
EGAF00002197774	fastq.gz	3.3 GB
EGAF00002197775	fastq.gz	4.0 GB
EGAF00002197776	fastq.gz	3.0 GB
EGAF00002197777	fastq.gz	3.6 GB
EGAF00002197778	fastq.gz	3.8 GB
EGAF00002197779	fastq.gz	4.6 GB
214 Files (743.7 GB)