Need Help?

Gene panel sequencing of paired samples from primary and relapsed IDH-wt glioblastomas

This dataset contains gene panel sequencing data from 43 sample pairs of primary and relapsed IDH-wt glioblastomas. The gene panel covers 50 glioma-associated genes. 14 of the sequenced sample pairs were sequenced with whole genome sequencing also and are accessible under EGAD00001004563.

Request Access

Data Transfer Agreement for the German Cancer Research Center

Data Transfer Agreement of Human Genomic Data for Research PurposesBetween:(1)Deutsches Krebsforschungszentrum (DKFZ), Stiftung des öffentlichen Rechts, legally represented by its Directors, Prof. Dr. med. Dr. h.c. mult. Otmar D. Wiestler and Prof. Dr. rer. pol. Josef Puchta Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany (“PROVIDER“) and(2)[INSERT INSTITUTION DETAILS] (“RECIPIENT”).1PreamblePublic genetic sequence databases are a critical part of our academic biomedical research infrastructure. However, human genetic data should only be made public if we can adequately protect the privacy of research subjects. Individual genomic sequence data are sensible patient data and any attempt to re-identify such data is forbidden under any circumstances. Our efforts to understand disease susceptibility or therapeutic opportunity require access to large genomic data sets. Therefore, the special privacy challenges posed by genomic data are addressed by PROVIDER with this Agreement.In response to the RECIPIENT's request for access to the DATA (as defined below), PROVIDER and the RECIPIENT agree as follows:2Definitions“DATA” shall mean all and any human genetic data obtained by the RECIPIENT from the PROVIDER including the Data Subjects’ e.g. age, sex and tumor pathology (as listed in Annex 2). For the avoidance of doubt, Data does not include samples or biological materials;“DATA SUBJECT” shall mean the person (irrespective of the state of health) to whom Data refers and who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto;“COMMERCIAL PURPOSES” shall mean the sale, lease, license, or other transfer and/or the use of the DATA to and/or by a for-profit organization. However, industrially sponsored academic research shall not be considered a use of the DATA for Commercial Purposes per se.“INTELLECTUAL PROPERTY” shall mean (i) patents, designs, trademarks and trade names (whether registered or unregistered), copyright and related rights, database rights, know-how and confidential information; (ii) all other intellectual property rights and similar or equivalent rights (whether registered or unregistered and whether registrable or unregistrable) anywhere in the world which currently exist or are recognized in the future; and (iii) applications, extensions and renewals in relation to any such rights;“RECIPIENT SCIENTIST” shall mean a researcher (or an individual conducting Research under the supervision of a researcher) that is employed by the RECIPIENT and is bound by confidentiality and non-use obligations in respect of DATA and who has accepted the terms of this Agreement in writing (however, for the avoidance of doubt, without being a party to this Agreement) and has received acknowledgement of its acceptance. For the avoidance of doubt and without having explicitly accepted the terms of this Agreement in writing, “RECIPIENT SCIENTIST” may also include any other RECIPIENT’s employees, students, visiting academics, contractors, sub-contractors or independent consultants provided that any of such latter individuals is bound by confidentiality and non- use obligations no less onerous then those binding the RECIPIENT’s employees;“RESEARCH” shall mean research that is seeking to advance the understanding and treatment of cancer and closely related diseases, and work on statistical methods that may be applied to such research;“PROJECT” shall mean a detailed description as in Annex 3;3Purpose of the ProjectThe RECIPIENT agrees to use DATA only for RESEARCH as described in the purpose of the PROJECT (Annex 3).4ConfidentialityThe RECIPIENT agrees to preserve, at all times, the confidentiality of DATA pertaining to DATA SUBJECTs. In particular, the RECIPIENT undertakes not to use, or attempt to use the DATA to deliberately compromise or otherwise infringe the confidentiality of information on DATA SUBJECTs and their respective rights to privacy.5DATA ProtectionThe Recipient and its RECIPIENT SCIENTIST are covered by and the RECIPIENT shall, and shall procure that its RECIPIENT SCIENTISTS shall, comply with the obligations contained in the applicable German and EU data protection laws and regulations as amended from time to time. In particular, the RECIPIENT and its RECIPIENT SCIENTISTs inter alia understands, and shall procure that its RECIPIENT SCIENTISTs understand, their duties under the German and EU legislation in relation to the handling of DATA and the rights of DATA SUBJECTs.The RECIPIENT agrees that it, and its RECIPIENT SCIENTISTs, shall not analyze or make any use of the DATA in such a way that has the potential to:a) lead to the re-identification of any DATA SUBJECT; orb) compromise the anonymity of any DATA SUBJECT in any way.The RECIPIENT shall, and it shall procure that its RECIPIENT SCIENTISTS shall, adhere to the principles of IT-Security as set forth in Annex 1 hereto.6Access and GovernanceThe RECIPIENT agrees that it shall take all (commercially) reasonable security precautions to keep the DATA confidential, such precautions to be no less onerous than in the applicable German and EU data protection laws and regulations.The RECIPIENT agrees to use the DATA solely for RESEARCH in the frame of the purpose of the PROJECT.The RECIPIENT agrees that the DATA shall not be distributed or released to any other location and/or to any other person other than RECIPIENT SCIENTISTs or laboratory personnel under the RECIPIENT SCIENTISTs direct supervision. RECIPIENT does not have the right to sublicense the DATA. RECIPIENT shall inform PROVIDER about any third party requests for the DATA.PROVIDER reserves the right to request and inspect DATA security and management documentation at the RECIPIENT’s premises to ensure the adequacy of DATA protection measures with prior notice during the RECIPIENT’s ordinary working hours.DATA shall not be used for COMMERCIAL PURPOSES (e.g. diagnostic services). In case of intended commercial use of DATA, the RECIPIENT shall start negotiations in good faith leading to a fair market compensation of PROVIDER. Such a disclosure of DATA shall require a binding declaration of consent in writing from the person concerned.7ErrorsThe RECIPIENT agrees to notify the PROVIDER of any errors detected in the DATA without undue delay.8DATA reissueThe RECIPIENT accepts that PROVIDER will reissue DATA from time to time, with suitable versioning. If DATA is reissued at the request of the DATA SUBJECT and/or as the result of other ethical scrutiny, the RECIPIENT agrees to destroy all earlier versions of the DATA without undue delay once he has received such information. This shall not apply to the extent that DATA is saved in automatic back-up systems for which destruction shall follow the regular process of such back-up system, however, such DATA shall be eliminated within a period of four (4) weeks after reception of the respective request to do so or within a period of four (4) weeks upon termination in accordance with this Agreement.9INTELLECTUAL PROPERTYThe RECIPIENT recognizes that nothing in this Agreement shall operate to transfer to the RECIPIENT or its RECIPIENT SCIENTISTs any INTELLECTUAL PROPERTY rights in or relating to the DATA, i.e. ownership of DATA remains unchanged. The RECIPIENT does not have the right to sublicense the DATA. The RECIPIENT shall inform PROVIDER about any third party requests for the DATA.In case the RECIPIENT and its RECIPIENT SCIENTISTs developsINTELLECTUAL PROPERTY based on or related to DATA as set forth in this Agreement the RECIPIENT shall become owner of such results.The RECIPIENT will inform PROVIDER about all developed INTELLECTUAL PROPERTY based on or related to DATA as set forth in this Agreement without undue delay in writing. The RECIPIENT grants PROVIDER a non-exclusive, non-transferable, royalty-free, perpetual, non-sublicensable right to use such developed INTELLECTUAL PROPERTY for internal research purposes including collaborations with any third parties excluding any COMMERCIAL PURPOSES.10PublicationsThe RECIPIENT agrees to acknowledge in any PROVIDER’s work based in whole or part on the DATA, any PROVIDER publications which encompass and from which DATA derive, the respective version of the DATA obtained, and the role of PROVIDER. The RECIPIENT is also entitled to release publications and, in doing so, agrees to acknowledge any of PROVIDER’s work based in whole or part on the DATA in its publication. The RECIPIENT will also declare in any such work that PROVIDER and its employees bear no responsibility for the further analysis or interpretation of the DATA by the RECIPIENT. 11Violation/Termination of AgreementThis Agreement shall expire automatically three (3) years after its signature by both parties.This Agreement will terminate immediately upon any material breach of a provision of this Agreement.The RECIPIENT accepts that the changing ethical framework of human genetic research may lead to: (i) alteration to the provisions of this Agreement, in which case the RECIPIENT may accept such alterations or terminate this Agreement; or (ii) the withdrawal of this Agreement in extreme circumstances.Either party shall have the right to terminate this Agreement with immediate effect upon giving written notice of termination to the other party.In the event that this Agreement is expired the RECIPIENT is required to destroy/discard any Data held, including but not limited to copies and backup copies. This shall not apply to the extent that DATA is saved in automatic back-up systems for which destruction shall follow the regular process of such back-up system, however, such DATA shall be eliminated within a period of four (4) weeks after the date of termination. Upon request of PROVIDER, the RECIPIENT will certify the destruction of the DATA. Sections 4, 5, 9 and 10 of this Agreement remain in full force and effect in case of termination.Notwithstanding the aforementioned, any provision of this Agreement related to confidentiality and/or DATA protection shall survive the expiration of this Agreement to the extent applicable statutory law provides for a deviating period of validity and effectiveness.Nothing contained in this paragraph shall restrict the right of the PROVIDER to seek injunctive relieve to prevent any breach or threatened breach of this agreement, furthermore nothing contained in this paragraph shall prohibit the PROVIDER from pursuing any other remedies available to it for such breach or threatened breach, including the recovery of damages from RECIPIENT. 12CostsThe RECIPIENT acknowledges that PROVIDER shall incur costs in providing the DATA to the RECIPIENT, including but not limited to administrative costs and the cost of obtaining appropriate data storage devices. The RECIPIENT agrees to pay, at the request of PROVIDER, such reasonable costs as PROVIDER may incur in providing the DATA, within thirty (30) days after having received an invoice by PROVIDER consistent with the current provisions of the German VAT Act (Umsatzsteuergesetz - UStG) as amended from time to time.13Legal statementThe RECIPIENT acknowledges that PROVIDER and all other parties involved in the creation, funding or protection of the DATA:a)make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of the DATA; andb)Except to the extent prohibited by law, the RECIPIENT assumes all liability for damages which may arise from its use, storage or disposal of the DATA. PROVIDER will not be liable to the RECIPIENT for any loss, claim or demand made by the RECIPIENT, or made against the RECIPIENT by any other party, due to or arising from the use of the data by the RECIPIENT, except to the extent permitted by law when caused by the gross negligence or willful misconduct of PROVIDER. The RECIPIENT understands that all the DATA are protected by INTELLECTUAL PROPERTY rights, such that duplication or sale of all of or part of the DATA on any media is not permitted under any circumstances, except with the prior written consent of PROVIDER.In no event shall PROVIDER be liable for any use by RECIPIENT of the PROVIDER DATA or any loss, claim, damage or liability, of whatsoever kind of nature, which may arise from or in connection with this agreement or the use, handling or storage of the PROVIDER DATA or derived from PROVIDER DATA by the RECIPIENT.14Governing LawThis Agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this Agreement or its formation) shall be construed, interpreted and governed by the laws of Germany excluding its conflict of law rules and shall be subject to the exclusive jurisdiction of the competent courts in Mannheim.PROVIDER complies with the requirements of the applicable German (LDSG / BDSG) and EU data protection laws and regulations with regard to the collection, storage, processing and disclosure of personal information and is committed to upholding the Act's core data protection principles. AGREED by the parties through their authorised signatoriesPROVIDER:AuthorisedSignature:Name:Prof. Dr. Michael Boutros (interim)Title:Scientific DirectorDate:AuthorisedSignature:Name:Prof. Dr. Josef PuchtaTitle:Administrative DirectorDate:PROVIDER scientist acknowledges the contents of this Agreement and confirms that the DATA SUBJECT's declarations of consent for the provided DATA as set forth in Annex 2 are in full force and effect and allow the DATA transfer to the RECIPIENT: Signature:Name:Title:Date:RECIPIENT INSTITUTION:AuthorisedSignature:Name:Title:Date:RECIPIENT SCIENTIST:The RECIPIENT SCIENTIST acknowledges the contents of this Agreement and agrees to comply with the obligations herein. For the avoidance of doubt the RECIPIENT SCIENTIST is not a party to this Agreement. (see Annex 1 for further reading and information)Signature:Name:Title:Date:Email: Annex 1 toData Transfer Agreement of Human Data for Research Purposes IT SecurityAccess to Data covered by this Data Transfer Agreement is a procedure that entails legal and ethical obligations. We require that you and your institution has adequateinformation technology (IT) policies in place that meet industry standards and include, in particular, the following items:Should personal data be automatically processed or used, this shall be organised within the agency or company to ensure that it meets data protection requirements. Depending on the type of personal data or data categories to be protected, the measures taken shall, 1. Deny unauthorized access to data processing facilities in which personal data is processed or used (physical access controls),2. Prevent unauthorised persons from using data processing systems (access controls),3. Ensure that authorised users only have access to the data to which they have access rights, and that personal data cannot be read, copied, modified or deleted by unauthorised persons during processing or use, and after storage (user-access control),4. Ensure that personal data cannot be read, copied, modified or deleted by unauthorised persons during electronic transmission or during their transport or their storage on data carriers, and that it can be verified and established at which points a transmission of personal data by data transmission equipment (transmission control) is foreseen,5. Ensure that it can be subsequently verified and established whether and by whom personal data are entered, modified or deleted in the data processing systems (input control),6. Ensure that personal data which are processed on behalf of clients can be processed only in accordance with the instructions of the client (job control),7. Ensure that personal data are protected against accidental destruction or loss (availability control),8. Ensure that data collected for different purposes can be processed separately.One measure, in particular, to be taken in compliance with paragraph 2, numbers 2-4, is the use of state-of-the-art encryption methods.In the event that the Recipient becomes aware that there has been a breach or suspected breach of the agreement, the Recipient shall immediately notify PROVIDER by telephone followed by written notice.6.RECIPIENT SCIENTIST:Signature:Name:Title:Date:Email: Annex 2 toData Transfer Agreement of Human Data for Research Purposes Data Annex 3 toData Transfer Agreement of Human Data for Research Purposes Purpose of the Project Please send completed forms to:PROVIDERDKFZOffice of Technology Transfer, T010Im Neuenheimer Feld 28069120 Heidelberg/Germany

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003184 Other
ID File Type Size Located in
EGAF00002277238 bam 852.0 MB
EGAF00002277239 bam 1.2 GB
EGAF00002277241 bam 301.2 MB
EGAF00002277242 bam 1.0 GB
EGAF00002277243 bam 923.0 MB
EGAF00002277245 bam 527.4 MB
EGAF00002277246 bam 10.3 MB
EGAF00002277247 bam 572.1 MB
EGAF00002277250 bam 742.9 MB
EGAF00002277251 bam 917.4 MB
EGAF00002277255 bam 912.4 MB
EGAF00002277258 bam 965.5 MB
EGAF00002277259 bam 934.4 MB
EGAF00002277260 bam 1.1 GB
EGAF00002277261 bam 453.6 MB
EGAF00002277262 bam 773.6 MB
EGAF00002277263 bam 819.6 MB
EGAF00002277268 bam 295.2 MB
EGAF00002277269 bam 959.1 MB
EGAF00002277271 bam 1.1 GB
EGAF00002277272 bam 305.5 MB
EGAF00002277273 bam 917.9 MB
EGAF00002277274 bam 726.6 MB
EGAF00002277275 bam 1.0 GB
EGAF00002277276 bam 1.0 GB
EGAF00002277277 bam 211.6 MB
EGAF00002277279 bam 437.3 MB
EGAF00002277280 bam 530.0 MB
EGAF00002277281 bam 2.2 MB
EGAF00002277282 bam 1.1 GB
EGAF00002277283 bam 562.1 MB
EGAF00002277284 bam 414.2 MB
EGAF00002277285 bam 932.8 MB
EGAF00002277288 bam 630.9 MB
EGAF00002277289 bam 871.5 MB
EGAF00002277291 bam 838.2 MB
EGAF00002277294 bam 553.7 MB
EGAF00002277295 bam 1.3 GB
EGAF00002277296 bam 1.2 GB
EGAF00002277297 bam 900.6 MB
EGAF00002277299 bam 1.3 GB
EGAF00002277301 bam 774.2 MB
EGAF00002277302 bam 881.6 MB
EGAF00002277305 bam 1.0 GB
EGAF00002277311 bam 2.0 GB
EGAF00002277312 bam 653.6 MB
EGAF00002277313 bam 537.9 MB
EGAF00002277314 bam 1.1 GB
EGAF00002277315 bam 898.3 MB
EGAF00002277316 bam 708.1 MB
EGAF00002277317 bam 949.3 MB
EGAF00002277318 bam 1.8 GB
EGAF00002277319 bam 1.1 GB
EGAF00002277320 bam 1.0 GB
EGAF00002277323 bam 1.0 GB
EGAF00002277324 bam 762.4 MB
EGAF00002277325 bam 972.1 MB
EGAF00002277329 bam 746.7 MB
EGAF00002277330 bam 529.2 MB
EGAF00002277331 bam 857.1 MB
EGAF00002277338 bam 874.8 MB
EGAF00002277341 bam 296.5 MB
EGAF00002277342 bam 487.5 MB
EGAF00002277343 bam 483.2 MB
EGAF00002277344 bam 945.0 MB
EGAF00002277345 bam 1.0 GB
EGAF00002277346 bam 880.3 MB
EGAF00002277347 bam 721.3 MB
EGAF00002277348 bam 718.9 MB
EGAF00002277351 bam 575.5 MB
EGAF00002277352 bam 539.6 MB
EGAF00002277353 bam 624.2 MB
EGAF00002277354 bam 723.6 MB
EGAF00002277355 bam 888.0 MB
EGAF00002277357 bam 635.9 MB
EGAF00002277359 bam 834.8 MB
EGAF00002277363 bam 1.0 GB
EGAF00002277364 bam 914.0 MB
EGAF00002277365 bam 648.1 MB
EGAF00002277368 bam 836.5 MB
EGAF00002277370 bam 818.8 MB
EGAF00002277371 bam 927.0 MB
EGAF00002277373 bam 1.0 GB
EGAF00002277374 bam 295.1 MB
EGAF00002277375 bam 462.3 MB
EGAF00002277378 bam 1.0 GB
EGAF00002277380 bam 799.4 MB
EGAF00002277381 bam 948.5 MB
EGAF00002277383 bam 601.8 MB
EGAF00002277384 bam 1.1 GB
EGAF00002277387 bam 978.7 MB
EGAF00002277388 bam 829.5 MB
EGAF00002277389 bam 889.2 MB
EGAF00002277390 bam 919.9 MB
EGAF00002277391 bam 1.0 GB
EGAF00002277392 bam 1.1 GB
EGAF00002277393 bam 894.1 MB
EGAF00002277394 bam 887.7 MB
EGAF00002277395 bam 1.0 GB
EGAF00002277396 bam 889.1 MB
EGAF00002277399 bam 1.0 GB
EGAF00002277400 bam 406.6 MB
EGAF00002277401 bam 454.8 MB
EGAF00002277402 bam 854.3 MB
EGAF00002277403 bam 1.9 GB
EGAF00002277404 bam 302.4 MB
EGAF00002277405 bam 885.6 MB
EGAF00002277407 bam 992.5 MB
EGAF00002277408 bam 915.7 MB
EGAF00002277409 bam 1.3 GB
EGAF00002277410 bam 526.2 MB
EGAF00002277412 bam 845.1 MB
EGAF00002277413 bam 864.8 MB
EGAF00002277414 bam 864.3 MB
EGAF00002277415 bam 782.2 MB
EGAF00002277417 bam 1.1 GB
EGAF00002277418 bam 981.6 MB
EGAF00002277419 bam 1.0 GB
EGAF00002277422 bam 1.1 GB
EGAF00002277423 bam 669.5 MB
EGAF00002277426 bam 771.9 MB
EGAF00002277429 bam 870.3 MB
EGAF00002277430 bam 982.2 MB
EGAF00002277431 bam 795.3 MB
EGAF00002277432 bam 819.3 MB
EGAF00002277433 bam 908.3 MB
EGAF00002277434 bam 1.0 GB
EGAF00002277437 bam 734.8 MB
EGAF00002277440 bam 161.0 MB
EGAF00002277442 bam 1.1 GB
EGAF00002277445 bam 299.5 MB
EGAF00002277451 bam 789.5 MB
EGAF00002277452 bam 948.8 MB
EGAF00002277453 bam 939.7 MB
EGAF00002277454 bam 772.0 MB
EGAF00002277455 bam 742.5 MB
EGAF00002277456 bam 856.8 MB
EGAF00002277457 bam 1.1 GB
EGAF00002277458 bam 193.2 MB
EGAF00002277463 bam 1.1 GB
EGAF00002277464 bam 1.1 GB
EGAF00002277465 bam 253.1 MB
EGAF00002277466 bam 801.6 MB
EGAF00002277468 bam 777.5 MB
EGAF00002277469 bam 787.7 MB
EGAF00002277475 bam 953.6 MB
EGAF00002277476 bam 2.0 MB
EGAF00002277477 bam 957.5 MB
EGAF00002277478 bam 471.6 MB
EGAF00002277480 bam 466.6 MB
EGAF00002277481 bam 977.0 MB
EGAF00002277482 bam 875.9 MB
EGAF00002277485 bam 2.0 GB
EGAF00002277486 bam 862.4 MB
EGAF00002277494 bam 1.2 GB
EGAF00002277495 bam 517.1 MB
EGAF00002277501 bam 755.7 MB
EGAF00002277502 bam 637.0 MB
EGAF00002277505 bam 1.1 GB
EGAF00002277506 bam 1.8 GB
EGAF00002277507 bam 865.9 MB
EGAF00002277511 bam 758.8 MB
EGAF00002277513 bam 508.1 MB
EGAF00002277514 bam 793.4 MB
EGAF00002277522 bam 352.4 MB
EGAF00002277523 bam 795.3 MB
EGAF00002277524 bam 1.3 GB
EGAF00002277525 bam 884.7 MB
EGAF00002277619 bam 1.1 GB
EGAF00002277621 bam 501.7 MB
EGAF00002277622 bam 1.2 GB
171 Files (141.6 GB)