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Mannheim Liquid Biopsy Unit, Heidelberg University & DKFZ

The dataset consists of sequenced cell free DNA (cfDNA) samples from colorectal cancer patients. The samples were sequenced on an Illumina MiSeq machine using a custom amplicon sequencing approach. These amplicons were designed to cover the most common mutation hotspots in colorectal cancer. The data include 138 cfDNA samples from 34 different patients. For each patient several samples are available derived from blood drawn at different time points during treatment. In addition the data include samples from 22 histology slides and 30 samples derived from HT29/HCT116 cell lines that were used as controls.

Request Access

Data access policy for studies from the Mannheim Liquid Biopsy Unit.

1 Preamble Public genetic sequence databases are a critical part of our academic biomedical research infrastructure. However, human genetic data should only be made public if we can adequately protect the privacy of research subjects. Individual genomic sequence data are sensitive patient data and any attempt to re-identify such data is forbidden under any circumstances. Our efforts to understand disease susceptibility or therapeutic opportunity require access to large genomic data sets. Therefore, the special privacy challenges posed by genomic data are addressed by PROVIDER with this Agreement. In response to the RECIPIENT's request for access to the DATA (as defined below), PROVIDER and the RECIPIENT agree as follows: 2 Definitions “DATA” shall mean all and any human genetic data obtained by the RECIPIENT from the PROVIDER including the Data Subjects’ e.g. age, sex and tumor pathology (as listed in Annex 2). For the avoidance of doubt, Data does not include samples or biological materials; “DATA SUBJECT” shall mean the person (irrespective of the state of health) to whom Data refers and who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto; “COMMERCIAL PURPOSES” shall mean the sale, lease, license, or other transfer and/or the use of the DATA to and/or by a for-profit organization. However, industrially sponsored academic research shall not be considered a use of the DATA for Commercial Purposes per se. “INTELLECTUAL PROPERTY” shall mean (i) patents, designs, trademarks and trade names (whether registered or unregistered), copyright and related rights, database rights, know-how and confidential information; (ii) all other intellectual property rights and similar or equivalent rights (whether registered or unregistered and whether registrable or unregistrable) anywhere in the world which currently exist or are recognized in the future; and (iii) applications, extensions and renewals in relation to any such rights; “RECIPIENT SCIENTIST” shall mean a researcher (or an individual conducting Research under the supervision of a researcher) that is employed by the RECIPIENT and is bound by confidentiality and non-use obligations in respect of DATA and who has accepted the terms of this Agreement in writing (however, for the avoidance of doubt, without being a party to this Agreement) and has received acknowledgement of its acceptance. For the avoidance of doubt and without having explicitly accepted the terms of this Agreement in writing, “RECIPIENT SCIENTIST” may also include any other RECIPIENT’s employees, students, visiting academics, contractors, sub-contractors or independent consultants provided that any of such latter individuals is bound by confidentiality and non- use obligations no less onerous than those binding the RECIPIENT’s employees; “RESEARCH” shall mean research that is seeking to advance the understanding and treatment of cancer and closely related diseases, and work on statistical methods that may be applied to such research; “PROJECT” shall mean a detailed description as in Annex 3; 3 Purpose of the Project The RECIPIENT agrees to use DATA only for RESEARCH as described in the purpose of the PROJECT (Annex 3). 4 Confidentiality The RECIPIENT agrees to preserve, at all times, the confidentiality of DATA pertaining to DATA SUBJECTs. In particular, the RECIPIENT undertakes not to use, or attempt to use the DATA to deliberately compromise or otherwise infringe the confidentiality of information on DATA SUBJECTs and their respective rights to privacy. 5 DATA Protection The Recipient and its RECIPIENT SCIENTIST are covered by and the RECIPIENT shall, and shall procure that its RECIPIENT SCIENTISTS shall, comply with the obligations contained in the applicable German and EU data protection laws and regulations as amended from time to time. In particular, the RECIPIENT and its RECIPIENT SCIENTISTs inter alia understands, and shall procure that its RECIPIENT SCIENTISTs understand, their duties under the German and EU legislation in relation to the handling of DATA and the rights of DATA SUBJECTs. The RECIPIENT agrees that it, and its RECIPIENT SCIENTISTs, shall not analyze or make any use of the DATA in such a way that has the potential to: a) lead to the re-identification of any DATA SUBJECT; or b) compromise the anonymity of any DATA SUBJECT in any way. The RECIPIENT shall, and it shall procure that its RECIPIENT SCIENTISTS shall, adhere to the principles of IT-Security as set forth in Annex 1 hereto. 6 Access and Governance The RECIPIENT agrees that it shall take all (commercially) reasonable security precautions to keep the DATA confidential, such precautions to be no less onerous than in the applicable German and EU data protection laws and regulations. The RECIPIENT agrees to use the DATA solely for RESEARCH in the frame of the purpose of the PROJECT. The RECIPIENT agrees that the DATA shall not be distributed or released to any other location and/or to any other person other than RECIPIENT SCIENTISTs or laboratory personnel under the RECIPIENT SCIENTISTs direct supervision. RECIPIENT does not have the right to sublicense the DATA. RECIPIENT shall inform PROVIDER about any third party requests for the DATA. PROVIDER reserves the right to request and inspect DATA security and management documentation at the RECIPIENT’s premises to ensure the adequacy of DATA protection measures with prior notice during the RECIPIENT’s ordinary working hours. DATA shall not be used for COMMERCIAL PURPOSES (e.g. diagnostic services). In case of intended commercial use of DATA, the RECIPIENT shall start negotiations in good faith leading to a fair market compensation of PROVIDER. Such a disclosure of DATA shall require a binding declaration of consent in writing from the person concerned. 7 Errors The RECIPIENT agrees to notify the PROVIDER of any errors detected in the DATA without undue delay. 8 DATA reissue The RECIPIENT accepts that PROVIDER will reissue DATA from time to time, with suitable versioning. If DATA is reissued at the request of the DATA SUBJECT and/or as the result of other ethical scrutiny, the RECIPIENT agrees to destroy all earlier versions of the DATA without undue delay once he has received such information. This shall not apply to the extent that DATA is saved in automatic back-up systems for which destruction shall follow the regular process of such back-up system, however, such DATA shall be eliminated within a period of four (4) weeks after reception of the respective request to do so or within a period of four (4) weeks upon termination in accordance with this Agreement. 9 INTELLECTUAL PROPERTY The RECIPIENT recognizes that nothing in this Agreement shall operate to transfer to the RECIPIENT or its RECIPIENT SCIENTISTs any INTELLECTUAL PROPERTY rights in or relating to the DATA, i.e. ownership of DATA remains unchanged. The RECIPIENT does not have the right to sublicense the DATA. The RECIPIENT shall inform PROVIDER about any third party requests for the DATA. In case the RECIPIENT and its RECIPIENT SCIENTISTs develops INTELLECTUAL PROPERTY based on or related to DATA as set forth in this Agreement the RECIPIENT shall become owner of such results. The RECIPIENT will inform PROVIDER about all developed INTELLECTUAL PROPERTY based on or related to DATA as set forth in this Agreement without undue delay in writing. The RECIPIENT grants PROVIDER a non-exclusive, non-transferable, royalty-free, perpetual, non-sublicensable right to use such developed INTELLECTUAL PROPERTY for internal research purposes including collaborations with any third parties excluding any COMMERCIAL PURPOSES. 10 Publications The RECIPIENT agrees to acknowledge in any RECIPIENT’s work based in whole or part on the DATA, any PROVIDER publications which encompass and from which DATA derive, the respective version of the DATA obtained, and the role of PROVIDER. The RECIPIENT is also entitled to release publications and, in doing so, agrees to acknowledge any of PROVIDER’s work based in whole or part on the DATA in its publication. The RECIPIENT will also declare in any such work that PROVIDER and its employees bear no responsibility for the further analysis or interpretation of the DATA by the RECIPIENT. 11 Violation/Termination of Agreement This Agreement shall expire automatically three (3) years after its signature by both parties. This Agreement will terminate immediately upon any material breach of a provision of this Agreement. The RECIPIENT accepts that the changing ethical framework of human genetic research may lead to: (i) alteration to the provisions of this Agreement, in which case the RECIPIENT may accept such alterations or terminate this Agreement; or (ii) the withdrawal of this Agreement in extreme circumstances. Either party shall have the right to terminate this Agreement with immediate effect upon giving written notice of termination to the other party. In the event that this Agreement is expired the RECIPIENT is required to destroy/discard any Data held, including but not limited to copies and backup copies. This shall not apply to the extent that DATA is saved in automatic back-up systems for which destruction shall follow the regular process of such back-up system, however, such DATA shall be eliminated within a period of four (4) weeks after the date of termination. Upon request of PROVIDER, the RECIPIENT will certify the destruction of the DATA. Sections 4, 5, 9 and 10 of this Agreement remain in full force and effect in case of termination. Notwithstanding the aforementioned, any provision of this Agreement related to confidentiality and/or DATA protection shall survive the expiration of this Agreement to the extent applicable statutory law provides for a deviating period of validity and effectiveness. Nothing contained in this paragraph shall restrict the right of the PROVIDER to seek injunctive relief to prevent any breach or threatened breach of this agreement, furthermore nothing contained in this paragraph shall prohibit the PROVIDER from pursuing any other remedies available to it for such breach or threatened breach, including the recovery of damages from RECIPIENT. 12 Costs The Data are supplied without cost but the RECIPIENT shall reimburse PROVIDER for any reasonable shipping and related costs that may be incurred when preparing and sending the Data to the RECIPIENT. 13 Legal statement The RECIPIENT acknowledges that PROVIDER and all other parties involved in the creation, funding or protection of the DATA: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of the DATA; and b) Except to the extent prohibited by law, the RECIPIENT assumes all liability for damages which may arise from its use, storage or disposal of the DATA. PROVIDER will not be liable to the RECIPIENT for any loss, claim or demand made by the RECIPIENT, or made against the RECIPIENT by any other party, due to or arising from the use of the data by the RECIPIENT, except to the extent permitted by law when caused by the gross negligence or willful misconduct of PROVIDER. The RECIPIENT understands that all the DATA are protected by INTELLECTUAL PROPERTY rights, such that duplication or sale of all of or part of the DATA on any media is not permitted under any circumstances, except with the prior written consent of PROVIDER. In no event shall PROVIDER be liable for any use by RECIPIENT of the PROVIDER DATA or any loss, claim, damage or liability, of whatsoever kind of nature, which may arise from or in connection with this agreement or the use, handling or storage of the PROVIDER DATA or derived from PROVIDER DATA by the RECIPIENT. 14 Governing Law This Agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this Agreement or its formation) shall be construed, interpreted and governed by the laws of Germany excluding its conflict of law rules and shall be subject to the exclusive jurisdiction of the competent courts in Mannheim. PROVIDER complies with the requirements of the applicable German (LDSG / BDSG) and EU data protection laws and regulations with regard to the collection, storage, processing and disclosure of personal information and is committed to upholding the Act's core data protection principles.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003382 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002318788 fastq.gz 41.7 MB
EGAF00002318789 fastq.gz 67.6 MB
EGAF00002318790 fastq.gz 54.4 MB
EGAF00002318791 fastq.gz 112.3 MB
EGAF00002318792 fastq.gz 57.6 MB
EGAF00002318793 fastq.gz 91.6 MB
EGAF00002318794 fastq.gz 72.3 MB
EGAF00002318795 fastq.gz 89.8 MB
EGAF00002318796 fastq.gz 89.1 MB
EGAF00002318797 fastq.gz 31.2 MB
EGAF00002318798 fastq.gz 101.5 MB
EGAF00002318799 fastq.gz 92.6 MB
EGAF00002318800 fastq.gz 31.1 MB
EGAF00002318801 fastq.gz 47.6 MB
EGAF00002318802 fastq.gz 69.4 MB
EGAF00002318803 fastq.gz 65.5 MB
EGAF00002318804 fastq.gz 79.4 MB
EGAF00002318805 fastq.gz 53.2 MB
EGAF00002318806 fastq.gz 23.1 MB
EGAF00002318807 fastq.gz 23.1 MB
EGAF00002318808 fastq.gz 19.6 MB
EGAF00002318809 fastq.gz 16.3 MB
EGAF00002318810 fastq.gz 14.9 MB
EGAF00002318811 fastq.gz 17.2 MB
EGAF00002318812 fastq.gz 17.8 MB
EGAF00002318813 fastq.gz 14.7 MB
EGAF00002318814 fastq.gz 16.2 MB
EGAF00002318815 fastq.gz 24.6 MB
EGAF00002318816 fastq.gz 15.1 MB
EGAF00002318817 fastq.gz 15.2 MB
EGAF00002318818 fastq.gz 15.5 MB
EGAF00002318819 fastq.gz 16.8 MB
EGAF00002318820 fastq.gz 15.3 MB
EGAF00002318821 fastq.gz 15.8 MB
EGAF00002318822 fastq.gz 17.5 MB
EGAF00002318823 fastq.gz 19.5 MB
EGAF00002318824 fastq.gz 16.2 MB
EGAF00002318825 fastq.gz 14.3 MB
EGAF00002318826 fastq.gz 17.5 MB
EGAF00002318827 fastq.gz 14.6 MB
EGAF00002318828 fastq.gz 13.2 MB
EGAF00002318829 fastq.gz 20.0 MB
EGAF00002318830 fastq.gz 20.1 MB
EGAF00002318831 fastq.gz 18.5 MB
EGAF00002318832 fastq.gz 17.9 MB
EGAF00002318833 fastq.gz 17.1 MB
EGAF00002318834 fastq.gz 18.9 MB
EGAF00002318835 fastq.gz 19.3 MB
EGAF00002318836 fastq.gz 19.6 MB
EGAF00002318837 fastq.gz 30.7 MB
EGAF00002318838 fastq.gz 30.6 MB
EGAF00002318839 fastq.gz 21.0 MB
EGAF00002318840 fastq.gz 22.1 MB
EGAF00002318841 fastq.gz 16.1 MB
EGAF00002318842 fastq.gz 17.9 MB
EGAF00002318843 fastq.gz 19.9 MB
EGAF00002318844 fastq.gz 19.2 MB
EGAF00002318845 fastq.gz 26.5 MB
EGAF00002318846 fastq.gz 15.7 MB
EGAF00002318847 fastq.gz 13.4 MB
EGAF00002318848 fastq.gz 19.0 MB
EGAF00002318849 fastq.gz 52.5 MB
EGAF00002318850 fastq.gz 65.5 MB
EGAF00002318851 fastq.gz 48.1 MB
EGAF00002318852 fastq.gz 49.8 MB
EGAF00002318853 fastq.gz 51.0 MB
EGAF00002318854 fastq.gz 50.4 MB
EGAF00002318855 fastq.gz 36.2 MB
EGAF00002318856 fastq.gz 31.3 MB
EGAF00002318857 fastq.gz 36.7 MB
EGAF00002318858 fastq.gz 47.5 MB
EGAF00002318859 fastq.gz 46.9 MB
EGAF00002318860 fastq.gz 37.4 MB
EGAF00002318861 fastq.gz 57.1 MB
EGAF00002318862 fastq.gz 49.6 MB
EGAF00002318863 fastq.gz 52.0 MB
EGAF00002318864 fastq.gz 33.9 MB
EGAF00002318865 fastq.gz 42.2 MB
EGAF00002318866 fastq.gz 54.7 MB
EGAF00002318867 fastq.gz 51.9 MB
EGAF00002318868 fastq.gz 39.7 MB
EGAF00002318869 fastq.gz 37.3 MB
EGAF00002318870 fastq.gz 33.9 MB
EGAF00002318871 fastq.gz 27.4 MB
EGAF00002318872 fastq.gz 26.7 MB
EGAF00002318873 fastq.gz 25.9 MB
EGAF00002318874 fastq.gz 35.0 MB
EGAF00002318875 fastq.gz 34.6 MB
EGAF00002318876 fastq.gz 25.1 MB
EGAF00002318877 fastq.gz 23.2 MB
EGAF00002318878 fastq.gz 26.4 MB
EGAF00002318879 fastq.gz 24.6 MB
EGAF00002318880 fastq.gz 24.5 MB
EGAF00002318881 fastq.gz 23.6 MB
EGAF00002318882 fastq.gz 15.9 MB
EGAF00002318883 fastq.gz 19.8 MB
EGAF00002318884 fastq.gz 48.4 MB
EGAF00002318885 fastq.gz 40.7 MB
EGAF00002318886 fastq.gz 44.9 MB
EGAF00002318887 fastq.gz 28.7 MB
EGAF00002318888 fastq.gz 33.6 MB
EGAF00002318889 fastq.gz 34.8 MB
EGAF00002318890 fastq.gz 37.0 MB
EGAF00002318891 fastq.gz 30.5 MB
EGAF00002318892 fastq.gz 27.9 MB
EGAF00002318893 fastq.gz 15.8 MB
EGAF00002318894 fastq.gz 15.2 MB
EGAF00002318895 fastq.gz 57.4 MB
EGAF00002318896 fastq.gz 12.0 MB
EGAF00002318897 fastq.gz 47.5 MB
EGAF00002318898 fastq.gz 52.9 MB
EGAF00002318899 fastq.gz 68.6 MB
EGAF00002318900 fastq.gz 39.2 MB
EGAF00002318901 fastq.gz 30.9 MB
EGAF00002318902 fastq.gz 53.8 MB
EGAF00002318903 fastq.gz 55.2 MB
EGAF00002318904 fastq.gz 43.6 MB
EGAF00002318905 fastq.gz 17.1 MB
EGAF00002318906 fastq.gz 36.3 MB
EGAF00002318907 fastq.gz 24.5 MB
EGAF00002318908 fastq.gz 40.9 MB
EGAF00002318909 fastq.gz 52.8 MB
EGAF00002318910 fastq.gz 42.6 MB
EGAF00002318911 fastq.gz 48.8 MB
EGAF00002318912 fastq.gz 31.8 MB
EGAF00002318913 fastq.gz 30.1 MB
EGAF00002318914 fastq.gz 24.3 MB
EGAF00002318915 fastq.gz 41.6 MB
EGAF00002318916 fastq.gz 44.9 MB
EGAF00002318917 fastq.gz 50.5 MB
EGAF00002318918 fastq.gz 27.1 MB
EGAF00002318919 fastq.gz 43.1 MB
EGAF00002318920 fastq.gz 14.8 MB
EGAF00002318921 fastq.gz 32.3 MB
EGAF00002318922 fastq.gz 26.2 MB
EGAF00002318923 fastq.gz 58.9 MB
EGAF00002318924 fastq.gz 42.3 MB
EGAF00002318925 fastq.gz 21.9 MB
EGAF00002318926 fastq.gz 33.1 MB
EGAF00002318927 fastq.gz 52.4 MB
EGAF00002318928 fastq.gz 39.1 MB
EGAF00002318929 fastq.gz 69.7 MB
EGAF00002318930 fastq.gz 72.5 MB
EGAF00002318931 fastq.gz 38.6 MB
EGAF00002318932 fastq.gz 18.8 MB
EGAF00002318933 fastq.gz 28.3 MB
EGAF00002318934 fastq.gz 89.6 MB
EGAF00002318935 fastq.gz 60.8 MB
EGAF00002318936 fastq.gz 26.1 MB
EGAF00002318937 fastq.gz 63.3 MB
EGAF00002318938 fastq.gz 51.7 MB
EGAF00002318939 fastq.gz 32.5 MB
EGAF00002318940 fastq.gz 35.0 MB
EGAF00002318941 fastq.gz 82.3 MB
EGAF00002318942 fastq.gz 37.4 MB
EGAF00002318943 fastq.gz 97.8 MB
EGAF00002318944 fastq.gz 41.0 MB
EGAF00002318945 fastq.gz 71.0 MB
EGAF00002318946 fastq.gz 130.4 MB
EGAF00002318947 fastq.gz 25.1 MB
EGAF00002318948 fastq.gz 86.7 MB
EGAF00002318949 fastq.gz 119.6 MB
EGAF00002318950 fastq.gz 72.1 MB
EGAF00002318951 fastq.gz 31.0 MB
EGAF00002318952 fastq.gz 73.7 MB
EGAF00002318953 fastq.gz 29.8 MB
EGAF00002318954 fastq.gz 69.7 MB
EGAF00002318955 fastq.gz 105.5 MB
EGAF00002318956 fastq.gz 15.4 MB
EGAF00002318957 fastq.gz 25.3 MB
EGAF00002318958 fastq.gz 12.2 MB
EGAF00002318959 fastq.gz 58.1 MB
EGAF00002318960 fastq.gz 20.2 MB
EGAF00002318961 fastq.gz 16.5 MB
EGAF00002318962 fastq.gz 60.1 MB
EGAF00002318963 fastq.gz 30.5 MB
EGAF00002318964 fastq.gz 22.2 MB
EGAF00002318965 fastq.gz 97.0 MB
EGAF00002318966 fastq.gz 97.6 MB
EGAF00002318967 fastq.gz 76.5 MB
EGAF00002318968 fastq.gz 90.0 MB
EGAF00002318969 fastq.gz 98.0 MB
EGAF00002318970 fastq.gz 31.5 MB
EGAF00002318971 fastq.gz 68.9 MB
EGAF00002318972 fastq.gz 15.2 MB
EGAF00002318973 fastq.gz 86.1 MB
EGAF00002318974 fastq.gz 81.5 MB
EGAF00002318975 fastq.gz 84.8 MB
EGAF00002318976 fastq.gz 65.2 MB
189 Files (7.9 GB)