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MutWP1: CRUK Grand Challenge Mutographs of Cancer: pancreas (2019-04-03)

The Mutographs project aims to advance our understanding of the causes of cancer through studies of mutational signatures. Led by Mike Stratton, together with Paul Brennan, Ludmil Alexandrov, Allan Balmain, David Phillips and Peter Campbell, this large-scale international research endeavour was awarded a Cancer Research UK Grand Challenge. Different patterns of somatic mutation are generated by the different environmental, lifestyle and genetic factors that cause cancer, many of them are still unknown. Within Mutographs, the International Agency for Research on Cancer is coordinating the recruitment of 5000 individuals with cancer (colorectal, renal, pancreatic, oesophageal adenocarcinoma or oesophageal squamous cancers) across 5 continents to explore whether different mutational signatures explain marked variation in incidence. In brief, through an international network of collaborators around the world, biological materials are collected, along with demographic, histological, clinical and questionnaire data. Whole genome sequences of tumour-germline DNA pairs are generated at the Wellcome Trust Sanger Institute (Illumina HiSeqX, 40X and 20X depth respectively). Somatic mutational signatures are subsequently extracted by non-negative matrix factorisation methods and correlated with risk factors data. Through an enhanced understanding of cancer aetiology, Mutographs unprecedented effort is anticipated to outline modifiable risk factors, lead to new approaches to prevent cancer, and provide opportunities to empower early detection, refine high-risk groups and contribute to further therapeutic development. . This dataset contains all the data available for this study on 2019-04-03.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002726 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002219647 cram 5.5 GB
EGAF00002219648 cram 5.8 GB
EGAF00002219649 cram 5.9 GB
EGAF00002219650 cram 5.0 GB
EGAF00002219651 cram 5.5 GB
EGAF00002219652 cram 5.6 GB
EGAF00002219653 cram 5.6 GB
EGAF00002219654 cram 5.9 GB
EGAF00002219655 cram 5.9 GB
EGAF00002219656 cram 5.0 GB
EGAF00002219657 cram 5.5 GB
EGAF00002219658 cram 5.6 GB
EGAF00002219659 cram 5.5 GB
EGAF00002219660 cram 5.8 GB
EGAF00002219661 cram 5.9 GB
EGAF00002219662 cram 5.0 GB
EGAF00002222539 cram 6.2 GB
EGAF00002222540 cram 6.5 GB
EGAF00002222541 cram 6.4 GB
EGAF00002222542 cram 6.7 GB
EGAF00002222543 cram 6.5 GB
EGAF00002222544 cram 7.1 GB
EGAF00002222545 cram 5.9 GB
EGAF00002222546 cram 6.1 GB
EGAF00002222547 cram 6.0 GB
EGAF00002222548 cram 6.3 GB
EGAF00002222549 cram 6.1 GB
EGAF00002222550 cram 6.7 GB
EGAF00002222551 cram 5.9 GB
EGAF00002222552 cram 6.1 GB
EGAF00002222553 cram 6.0 GB
EGAF00002222554 cram 6.3 GB
EGAF00002222555 cram 6.1 GB
EGAF00002222556 cram 6.7 GB
EGAF00002222557 cram 6.3 GB
EGAF00002222558 cram 6.6 GB
EGAF00002222559 cram 6.5 GB
EGAF00002222560 cram 6.8 GB
EGAF00002222561 cram 6.4 GB
EGAF00002222562 cram 7.0 GB
EGAF00002222563 cram 5.8 GB
EGAF00002222564 cram 6.0 GB
EGAF00002222855 cram 5.9 GB
EGAF00002222856 cram 6.2 GB
EGAF00002222857 cram 6.0 GB
EGAF00002222858 cram 6.6 GB
EGAF00002222859 cram 5.8 GB
EGAF00002222860 cram 5.9 GB
EGAF00002222861 cram 5.9 GB
EGAF00002222862 cram 6.1 GB
EGAF00002222863 cram 6.0 GB
EGAF00002222864 cram 6.6 GB
EGAF00002222865 cram 5.6 GB
EGAF00002222866 cram 5.8 GB
EGAF00002222867 cram 5.7 GB
EGAF00002222868 cram 6.0 GB
EGAF00002222869 cram 5.8 GB
EGAF00002222870 cram 6.4 GB
EGAF00002222871 cram 5.6 GB
EGAF00002222872 cram 5.9 GB
EGAF00002222873 cram 5.8 GB
EGAF00002222874 cram 6.1 GB
EGAF00002222875 cram 5.9 GB
EGAF00002222876 cram 6.4 GB
EGAF00002222877 cram 5.5 GB
EGAF00002222878 cram 5.4 GB
EGAF00002222879 cram 5.0 GB
EGAF00002222880 cram 5.3 GB
EGAF00002222881 cram 5.2 GB
EGAF00002222882 cram 5.3 GB
EGAF00002222883 cram 5.4 GB
EGAF00002223174 cram 5.4 GB
EGAF00002223175 cram 5.0 GB
EGAF00002223176 cram 5.3 GB
EGAF00002223177 cram 5.2 GB
EGAF00002223178 cram 5.3 GB
EGAF00002223179 cram 5.5 GB
EGAF00002223180 cram 5.5 GB
EGAF00002223181 cram 5.0 GB
EGAF00002223182 cram 5.3 GB
EGAF00002223183 cram 5.2 GB
EGAF00002223184 cram 5.3 GB
EGAF00002223185 cram 5.7 GB
EGAF00002223186 cram 5.6 GB
EGAF00002223187 cram 5.2 GB
EGAF00002223188 cram 5.5 GB
EGAF00002223189 cram 5.4 GB
EGAF00002223190 cram 5.5 GB
EGAF00002223191 cram 5.9 GB
EGAF00002223192 cram 5.8 GB
EGAF00002223193 cram 5.3 GB
EGAF00002223194 cram 5.6 GB
EGAF00002223195 cram 5.6 GB
EGAF00002223196 cram 5.7 GB
EGAF00002223197 cram 6.1 GB
EGAF00002223198 cram 6.1 GB
EGAF00002223199 cram 5.6 GB
EGAF00002223200 cram 5.9 GB
EGAF00002223201 cram 5.8 GB
EGAF00002223202 cram 6.0 GB
EGAF00002223493 cram 5.5 GB
EGAF00002223494 cram 5.4 GB
EGAF00002223495 cram 4.9 GB
EGAF00002223496 cram 5.2 GB
EGAF00002223497 cram 5.2 GB
EGAF00002223498 cram 5.3 GB
EGAF00002223499 cram 5.5 GB
EGAF00002223500 cram 5.4 GB
EGAF00002223501 cram 5.0 GB
EGAF00002223502 cram 5.3 GB
EGAF00002223503 cram 5.2 GB
EGAF00002223504 cram 5.3 GB
EGAF00002223505 cram 5.3 GB
EGAF00002223506 cram 5.3 GB
EGAF00002223507 cram 5.3 GB
EGAF00002223508 cram 5.0 GB
EGAF00002223509 cram 5.3 GB
EGAF00002223510 cram 5.6 GB
EGAF00002223511 cram 5.3 GB
EGAF00002223512 cram 5.2 GB
EGAF00002223513 cram 5.2 GB
EGAF00002223514 cram 5.0 GB
EGAF00002223515 cram 5.2 GB
EGAF00002223516 cram 5.5 GB
EGAF00002223517 cram 5.2 GB
EGAF00002223518 cram 5.1 GB
EGAF00002223519 cram 5.1 GB
EGAF00002223520 cram 4.9 GB
EGAF00002223521 cram 5.1 GB
EGAF00002223812 cram 5.4 GB
EGAF00002223813 cram 5.2 GB
EGAF00002223814 cram 5.1 GB
EGAF00002223815 cram 5.1 GB
EGAF00002223816 cram 4.9 GB
EGAF00002223817 cram 5.1 GB
EGAF00002223818 cram 5.4 GB
EGAF00002223819 cram 5.2 GB
EGAF00002223820 cram 5.1 GB
EGAF00002223821 cram 5.1 GB
EGAF00002223822 cram 4.9 GB
EGAF00002223823 cram 5.1 GB
EGAF00002223824 cram 5.4 GB
EGAF00002223825 cram 5.2 GB
EGAF00002223826 cram 5.1 GB
EGAF00002223827 cram 5.1 GB
EGAF00002223828 cram 4.9 GB
EGAF00002223829 cram 5.2 GB
EGAF00002223830 cram 5.4 GB
EGAF00002223831 cram 5.1 GB
EGAF00002223832 cram 5.0 GB
EGAF00002223833 cram 5.1 GB
EGAF00002223834 cram 4.9 GB
EGAF00002223835 cram 5.1 GB
EGAF00002223836 cram 5.4 GB
EGAF00002223837 cram 5.0 GB
EGAF00002223838 cram 4.9 GB
EGAF00002223839 cram 5.0 GB
EGAF00002223840 cram 4.8 GB
EGAF00002224143 cram 5.0 GB
EGAF00002224144 cram 5.3 GB
EGAF00002224145 cram 5.4 GB
EGAF00002224146 cram 6.0 GB
EGAF00002224147 cram 6.2 GB
EGAF00002224148 cram 5.3 GB
EGAF00002224149 cram 5.5 GB
EGAF00002224150 cram 5.4 GB
EGAF00002224151 cram 5.5 GB
EGAF00002224152 cram 6.1 GB
EGAF00002224153 cram 6.3 GB
EGAF00002224154 cram 5.4 GB
EGAF00002224155 cram 5.6 GB
EGAF00002224156 cram 5.4 GB
EGAF00002224157 cram 5.5 GB
EGAF00002224158 cram 6.1 GB
EGAF00002224159 cram 6.3 GB
EGAF00002224160 cram 5.5 GB
EGAF00002224161 cram 5.6 GB
EGAF00002224162 cram 5.5 GB
EGAF00002224163 cram 5.4 GB
EGAF00002224164 cram 6.0 GB
EGAF00002224165 cram 6.2 GB
EGAF00002224166 cram 5.4 GB
EGAF00002224167 cram 5.5 GB
EGAF00002224168 cram 5.4 GB
EGAF00002224169 cram 6.0 GB
EGAF00002224170 cram 6.5 GB
EGAF00002224171 cram 6.2 GB
EGAF00002224491 cram 5.8 GB
EGAF00002224492 cram 5.8 GB
EGAF00002224493 cram 5.7 GB
EGAF00002224494 cram 5.5 GB
EGAF00002224495 cram 5.9 GB
EGAF00002224496 cram 5.6 GB
EGAF00002224497 cram 5.3 GB
EGAF00002224498 cram 5.3 GB
EGAF00002224499 cram 5.2 GB
EGAF00002224500 cram 5.6 GB
EGAF00002224501 cram 6.0 GB
EGAF00002224502 cram 5.8 GB
EGAF00002224503 cram 5.4 GB
EGAF00002224504 cram 5.4 GB
EGAF00002224505 cram 5.3 GB
EGAF00002224506 cram 5.6 GB
EGAF00002224507 cram 6.0 GB
EGAF00002224508 cram 5.7 GB
EGAF00002224509 cram 5.3 GB
EGAF00002224510 cram 5.4 GB
EGAF00002224511 cram 5.3 GB
EGAF00002224512 cram 5.5 GB
EGAF00002224513 cram 5.6 GB
EGAF00002224514 cram 5.5 GB
EGAF00002224515 cram 5.8 GB
EGAF00002224516 cram 5.8 GB
EGAF00002224517 cram 5.0 GB
EGAF00002224518 cram 5.5 GB
EGAF00002224519 cram 5.6 GB
216 Files (1.2 TB)