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Field effect of healthy and diseased livers (2019-04-08)

Recent work in the Campbell group has revealed somatic mutations present in normal, non-cancerous human skin. A subset of the mutations conferred selective advantages to the host cells, leading to clonal expansions and raising the risk for future cancer development. Capturing such somatic mutations in normal tissue is important to advance our understanding about carcinogenesis and could provide prospective medical insights. In this project, our goal is to detect somatic mutations in normal (pre-cancerous) liver tissue. Using Laser Microdissection technology, we will dissect individual liver lobules from patient samples and submit these to sequencing. For each patient sample, we aim to sequence multiple lobules to characterise the mutagenic burden. Samples will be taken from patients with different liver disease aetiologies, including alcoholism and obesity, with a view on distinguishing the prevalent mutation types occurring in each disease context. We will perform targeted sequencing, initially using the WTSI cancer panel. Later we aim to use a novel bait set that captures both cancer genes as well as genes relevant to the non-cancerous samples (ie. genes implicated in hereditary disorders, immune sequences). . This dataset contains all the data available for this study on 2019-04-08.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002382 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002047745 cram 3.0 GB
EGAF00002047746 cram 2.1 GB
EGAF00002047747 cram 3.2 GB
EGAF00002047748 cram 3.1 GB
EGAF00002047749 cram 3.0 GB
EGAF00002047750 cram 2.1 GB
EGAF00002047751 cram 3.2 GB
EGAF00002047752 cram 3.1 GB
EGAF00002047753 cram 1.3 GB
EGAF00002047754 cram 1.3 GB
EGAF00002047755 cram 1.2 GB
EGAF00002047756 cram 1.4 GB
EGAF00002047757 cram 1.3 GB
EGAF00002047758 cram 1.2 GB
EGAF00002047759 cram 1.3 GB
EGAF00002047760 cram 1.6 GB
EGAF00002047761 cram 1.6 GB
EGAF00002047762 cram 907.5 MB
EGAF00002067061 cram 11.6 GB
EGAF00002441717 cram 854.1 MB
EGAF00002441718 cram 946.4 MB
EGAF00002441719 cram 814.8 MB
EGAF00002441720 cram 849.3 MB
EGAF00002441721 cram 941.4 MB
EGAF00002441722 cram 686.4 MB
EGAF00002441723 cram 670.2 MB
EGAF00002441724 cram 791.4 MB
EGAF00002441725 cram 876.1 MB
EGAF00002441726 cram 826.8 MB
EGAF00002441727 cram 937.4 MB
EGAF00002441728 cram 882.5 MB
EGAF00002441729 cram 809.9 MB
EGAF00002441730 cram 774.0 MB
EGAF00002441731 cram 892.3 MB
EGAF00002441732 cram 939.8 MB
EGAF00002441733 cram 729.8 MB
EGAF00002441734 cram 749.1 MB
EGAF00002441735 cram 743.6 MB
EGAF00002441736 cram 859.6 MB
EGAF00002441737 cram 812.3 MB
EGAF00002441738 cram 764.9 MB
EGAF00002441739 cram 920.1 MB
EGAF00002441740 cram 842.4 MB
EGAF00002441741 cram 935.8 MB
EGAF00002441742 cram 971.8 MB
EGAF00002441743 cram 1.0 GB
EGAF00002441744 cram 737.6 MB
EGAF00002441745 cram 780.2 MB
EGAF00002441746 cram 822.3 MB
EGAF00002441747 cram 1.0 GB
EGAF00002441748 cram 834.9 MB
EGAF00002441749 cram 792.6 MB
EGAF00002441750 cram 894.7 MB
EGAF00002441751 cram 954.9 MB
EGAF00002441752 cram 796.8 MB
EGAF00002441753 cram 752.3 MB
EGAF00002441754 cram 1.1 GB
EGAF00002441755 cram 956.1 MB
EGAF00002441756 cram 501.2 MB
EGAF00002441757 cram 782.3 MB
EGAF00002441758 cram 871.0 MB
EGAF00002441759 cram 820.9 MB
EGAF00002441760 cram 839.5 MB
EGAF00002441761 cram 439.5 MB
EGAF00002441762 cram 786.4 MB
EGAF00002441763 cram 722.1 MB
EGAF00002441764 cram 769.2 MB
67 Files (87.4 GB)