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RNA-seq FASTQ files from newborn screening dried blood spot samples

Paired-end RNA-seq FASTQ files from 21 newborn screening dried blood spot (DBS) samples. These DBS samples were obtained from extremely low gestional age newborns, where 10 of them were affected by a fetal inflammatory response (FIR) before birth, and 11 were unaffected. Total RNA was sequenced using an Illumina NextSeq-500 instrument. The sample preparation protocol included the depletion of rRNA and globin mRNA using the Globin Zero Gold rRNA Removal Kit from Illumina. Libraries were prepared using the NebNext Ultra TM II Directionl RNA LIbrary Prep Kit (New England Biolabs). Each sample was sequenced in 4 lanes, leading to 8 FASTQ files per sample and a total of 21x8=168 FASTQ files. There is an additional number of 8 FASTQ files corresponding to sample BS13, which was downsampled to 1/4 of its original depth (see BS13_README file for details).

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This the data access policy for the study of dried blood spots in extremely low gestational age newborns from Barcelona.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom Universitat Pompeu Fabra and Hospital Clínic de Barcelona grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Universitat Pompeu Fabra and Hospital Clínic de Barcelona and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. Universitat Pompeu Fabra: Universitat Pompeu Fabra is a university hospital founded in 1906 that belongs to the Catalan Public Hospital Network (XHUP). Contact details: Villarroel, 170, E-08036 Barcelona, Spain. Hospital Clínic de Barcelona: Hospital Clínic de Barcelona is a public university founded in 1990 that belongs to the Catalan Higher Education System. Contact details: Plaça de la Mercè, 10-12, E-08002 Barcelona, Spain. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes, which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify Universitat Pompeu Fabra and Hospital Clínic de Barcelona within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify Universitat Pompeu Fabra and Hospital Clinic de Barcelona prior to any significant changes to the protocol for the Project. 14. The User Institution will notify Universitat Pompeu Fabra and Hospital Clinic de Barcelona as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. Universitat Pompeu Fabra and Hospital Clinic de Barcelona may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than Universitat Pompeu Fabra and Hospital Clinic de Barcelona. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of Spain and Catalonia and shall be subject to the exclusive jurisdiction of the Spanish courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003635 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002454626 fastq.gz 256.3 MB
EGAF00002454627 fastq.gz 268.1 MB
EGAF00002454628 fastq.gz 256.5 MB
EGAF00002454629 fastq.gz 269.0 MB
EGAF00002454630 fastq.gz 257.6 MB
EGAF00002454631 fastq.gz 270.7 MB
EGAF00002454632 fastq.gz 257.4 MB
EGAF00002454633 fastq.gz 269.5 MB
EGAF00002454634 fastq.gz 247.8 MB
EGAF00002454635 fastq.gz 251.9 MB
EGAF00002454636 fastq.gz 248.9 MB
EGAF00002454637 fastq.gz 253.9 MB
EGAF00002454638 fastq.gz 250.5 MB
EGAF00002454639 fastq.gz 255.9 MB
EGAF00002454640 fastq.gz 250.2 MB
EGAF00002454641 fastq.gz 254.6 MB
EGAF00002454642 fastq.gz 271.1 MB
EGAF00002454643 fastq.gz 280.4 MB
EGAF00002454644 fastq.gz 271.9 MB
EGAF00002454645 fastq.gz 282.1 MB
EGAF00002454646 fastq.gz 274.0 MB
EGAF00002454647 fastq.gz 284.8 MB
EGAF00002454648 fastq.gz 273.6 MB
EGAF00002454649 fastq.gz 283.3 MB
EGAF00002454650 fastq.gz 1.1 GB
EGAF00002454651 fastq.gz 1.1 GB
EGAF00002454652 fastq.gz 1.1 GB
EGAF00002454653 fastq.gz 1.1 GB
EGAF00002454654 fastq.gz 1.1 GB
EGAF00002454655 fastq.gz 1.2 GB
EGAF00002454656 fastq.gz 1.1 GB
EGAF00002454657 fastq.gz 1.1 GB
EGAF00002454658 fastq.gz 257.3 MB
EGAF00002454659 fastq.gz 262.1 MB
EGAF00002454660 fastq.gz 253.7 MB
EGAF00002454661 fastq.gz 259.2 MB
EGAF00002454662 fastq.gz 259.0 MB
EGAF00002454663 fastq.gz 265.4 MB
EGAF00002454664 fastq.gz 258.3 MB
EGAF00002454665 fastq.gz 262.9 MB
EGAF00002454666 fastq.gz 317.1 MB
EGAF00002454667 fastq.gz 320.4 MB
EGAF00002454668 fastq.gz 318.0 MB
EGAF00002454669 fastq.gz 322.6 MB
EGAF00002454670 fastq.gz 320.7 MB
EGAF00002454671 fastq.gz 325.8 MB
EGAF00002454672 fastq.gz 320.6 MB
EGAF00002454673 fastq.gz 324.6 MB
EGAF00002454674 fastq.gz 262.5 MB
EGAF00002454675 fastq.gz 273.3 MB
EGAF00002454676 fastq.gz 263.9 MB
EGAF00002454677 fastq.gz 275.6 MB
EGAF00002454678 fastq.gz 264.8 MB
EGAF00002454679 fastq.gz 277.0 MB
EGAF00002454680 fastq.gz 264.3 MB
EGAF00002454681 fastq.gz 275.3 MB
EGAF00002454682 fastq.gz 282.7 MB
EGAF00002454683 fastq.gz 291.3 MB
EGAF00002454684 fastq.gz 283.7 MB
EGAF00002454685 fastq.gz 293.3 MB
EGAF00002454686 fastq.gz 286.5 MB
EGAF00002454687 fastq.gz 296.6 MB
EGAF00002454688 fastq.gz 285.8 MB
EGAF00002454689 fastq.gz 294.5 MB
EGAF00002454690 fastq.gz 272.2 MB
EGAF00002454691 fastq.gz 278.8 MB
EGAF00002454692 fastq.gz 272.0 MB
EGAF00002454693 fastq.gz 279.5 MB
EGAF00002454694 fastq.gz 275.4 MB
EGAF00002454695 fastq.gz 283.4 MB
EGAF00002454696 fastq.gz 275.1 MB
EGAF00002454697 fastq.gz 282.1 MB
EGAF00002454698 fastq.gz 307.1 MB
EGAF00002454699 fastq.gz 340.6 MB
EGAF00002454700 fastq.gz 308.5 MB
EGAF00002454701 fastq.gz 342.7 MB
EGAF00002454702 fastq.gz 309.6 MB
EGAF00002454703 fastq.gz 344.6 MB
EGAF00002454704 fastq.gz 309.3 MB
EGAF00002454705 fastq.gz 343.9 MB
EGAF00002454706 fastq.gz 284.9 MB
EGAF00002454707 fastq.gz 291.5 MB
EGAF00002454708 fastq.gz 285.0 MB
EGAF00002454709 fastq.gz 292.7 MB
EGAF00002454710 fastq.gz 287.6 MB
EGAF00002454711 fastq.gz 295.7 MB
EGAF00002454712 fastq.gz 288.4 MB
EGAF00002454713 fastq.gz 295.5 MB
EGAF00002454714 fastq.gz 305.5 MB
EGAF00002454715 fastq.gz 312.7 MB
EGAF00002454716 fastq.gz 305.4 MB
EGAF00002454717 fastq.gz 313.7 MB
EGAF00002454718 fastq.gz 308.3 MB
EGAF00002454719 fastq.gz 317.1 MB
EGAF00002454720 fastq.gz 309.2 MB
EGAF00002454721 fastq.gz 316.7 MB
EGAF00002454722 fastq.gz 288.5 MB
EGAF00002454723 fastq.gz 298.3 MB
EGAF00002454724 fastq.gz 289.2 MB
EGAF00002454725 fastq.gz 300.1 MB
EGAF00002454726 fastq.gz 291.8 MB
EGAF00002454727 fastq.gz 303.1 MB
EGAF00002454728 fastq.gz 292.3 MB
EGAF00002454729 fastq.gz 302.6 MB
EGAF00002454730 fastq.gz 276.1 MB
EGAF00002454731 fastq.gz 279.1 MB
EGAF00002454732 fastq.gz 276.3 MB
EGAF00002454733 fastq.gz 280.3 MB
EGAF00002454734 fastq.gz 281.5 MB
EGAF00002454735 fastq.gz 285.7 MB
EGAF00002454736 fastq.gz 280.4 MB
EGAF00002454737 fastq.gz 283.9 MB
EGAF00002454738 fastq.gz 270.9 MB
EGAF00002454739 fastq.gz 280.7 MB
EGAF00002454740 fastq.gz 269.3 MB
EGAF00002454741 fastq.gz 280.0 MB
EGAF00002454742 fastq.gz 271.9 MB
EGAF00002454743 fastq.gz 282.9 MB
EGAF00002454744 fastq.gz 272.2 MB
EGAF00002454745 fastq.gz 282.6 MB
EGAF00002454746 fastq.gz 217.3 MB
EGAF00002454747 fastq.gz 219.6 MB
EGAF00002454748 fastq.gz 218.5 MB
EGAF00002454749 fastq.gz 221.7 MB
EGAF00002454750 fastq.gz 219.4 MB
EGAF00002454751 fastq.gz 222.8 MB
EGAF00002454752 fastq.gz 219.5 MB
EGAF00002454753 fastq.gz 222.1 MB
EGAF00002454754 fastq.gz 249.5 MB
EGAF00002454755 fastq.gz 253.4 MB
EGAF00002454756 fastq.gz 249.5 MB
EGAF00002454757 fastq.gz 254.4 MB
EGAF00002454758 fastq.gz 251.3 MB
EGAF00002454759 fastq.gz 256.5 MB
EGAF00002454760 fastq.gz 251.3 MB
EGAF00002454761 fastq.gz 255.5 MB
EGAF00002454762 fastq.gz 292.5 MB
EGAF00002454763 fastq.gz 293.9 MB
EGAF00002454764 fastq.gz 288.4 MB
EGAF00002454765 fastq.gz 290.9 MB
EGAF00002454766 fastq.gz 294.6 MB
EGAF00002454767 fastq.gz 297.4 MB
EGAF00002454768 fastq.gz 294.1 MB
EGAF00002454769 fastq.gz 296.1 MB
EGAF00002454770 fastq.gz 259.4 MB
EGAF00002454771 fastq.gz 267.2 MB
EGAF00002454772 fastq.gz 259.9 MB
EGAF00002454773 fastq.gz 268.6 MB
EGAF00002454774 fastq.gz 261.8 MB
EGAF00002454775 fastq.gz 270.9 MB
EGAF00002454776 fastq.gz 261.7 MB
EGAF00002454777 fastq.gz 270.0 MB
EGAF00002454778 fastq.gz 249.8 MB
EGAF00002454779 fastq.gz 256.4 MB
EGAF00002454780 fastq.gz 251.0 MB
EGAF00002454781 fastq.gz 258.5 MB
EGAF00002454782 fastq.gz 251.9 MB
EGAF00002454783 fastq.gz 259.9 MB
EGAF00002454784 fastq.gz 251.7 MB
EGAF00002454785 fastq.gz 258.6 MB
EGAF00002454786 fastq.gz 322.2 MB
EGAF00002454787 fastq.gz 326.7 MB
EGAF00002454788 fastq.gz 322.2 MB
EGAF00002454789 fastq.gz 327.8 MB
EGAF00002454790 fastq.gz 324.8 MB
EGAF00002454791 fastq.gz 331.0 MB
EGAF00002454792 fastq.gz 324.7 MB
EGAF00002454793 fastq.gz 329.3 MB
EGAF00002454794 fastq.gz 275.5 MB
EGAF00002454795 fastq.gz 283.3 MB
EGAF00002454796 fastq.gz 275.9 MB
EGAF00002454797 fastq.gz 284.8 MB
EGAF00002454798 fastq.gz 277.0 MB
EGAF00002454799 fastq.gz 286.3 MB
EGAF00002454800 fastq.gz 276.9 MB
EGAF00002454801 fastq.gz 285.1 MB
176 Files (56.1 GB)