A Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling

Dataset ID Technology Samples
EGAD00001005709 Illumina HiSeq 2000 9

Dataset Description

To identify what factors cause a different reactivity to MLN4924, 15 cells were categorized into high, intermediate, and low MLN4924 resistance groups based on the half-maximal inhibitory concentration (IC50) of MLN4924.
PDC1, PCD2, PDC3, PDC4, and PDC5 showed high MLN4924 sensitivity, whereas PDC12, PDC13, PDC14, and PDC15 showed low MLN4924 sensitivity.
Whole-transcriptome sequencing of these 9 patient-derived glioblastoma stem cells was performed.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

Institute for Refractory Cancer Research (IRCR) Data Access Committee
Contact person: Do-Hyun Nam
Email: nsnam [at] skku [dot] edu
More details: EGAC00001000272


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