A Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling
To identify what factors cause a different reactivity to MLN4924, 15 cells were categorized into high, intermediate, and low MLN4924 resistance groups based on the half-maximal inhibitory concentration (IC50) of MLN4924. PDC1, PCD2, PDC3, PDC4, and PDC5 showed high MLN4924 sensitivity, whereas PDC12, PDC13, PDC14, and PDC15 showed low MLN4924 sensitivity. Whole-transcriptome sequencing of these 9 patient-derived glioblastoma stem cells was performed.
- 02/12/2019
- 9 samples
- DAC: EGAC00001000272
- Technology: Illumina HiSeq 2000
Institute for Refractory Cancer (IRCR) Data Access Policy
IRCR data access policy generally respects the guidelines of NIH genomic data sharing policy (http://gds.nih.gov/PDF/NIH_GDS_Policy.pdf), but can be overridden by consensual decision of DAC in exceptional cases.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001004018 | Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
i
|
|---|---|---|---|---|
| EGAF00002883601 | fq.gz | 8.4 GB | Report |
|
| EGAF00002883602 | fq.gz | 8.7 GB | Report |
|
| EGAF00002883603 | fq.gz | 1.8 GB | Report |
|
| EGAF00002883604 | fq.gz | 1.9 GB | Report |
|
| EGAF00002883605 | fq.gz | 2.1 GB | Report |
|
| EGAF00002883606 | fq.gz | 2.2 GB | Report |
|
| EGAF00002883607 | fq.gz | 5.3 GB | Report |
|
| EGAF00002883608 | fq.gz | 5.6 GB | Report |
|
| EGAF00002883609 | fq.gz | 3.9 GB | Report |
|
| EGAF00002883610 | fq.gz | 3.9 GB | Report |
|
| EGAF00002883611 | fq.gz | 5.1 GB | Report |
|
| EGAF00002883612 | fq.gz | 5.3 GB | Report |
|
| EGAF00002883613 | fq.gz | 4.1 GB | Report |
|
| EGAF00002883614 | fq.gz | 4.2 GB | Report |
|
| EGAF00002883615 | fq.gz | 4.3 GB | Report |
|
| EGAF00002883616 | fq.gz | 4.5 GB | Report |
|
| EGAF00002883617 | fq.gz | 2.3 GB | Report |
|
| EGAF00002883618 | fq.gz | 2.3 GB | Report |
|
| 18 Files (76.0 GB) | ||||