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CD8+ T-cell exhaustion induced by leukemic cells drives progression in Chronic Lymphocytic Leukemia

Exome sequencing data from patient with Chronic Lymphocytic Leukemia. DNA was extracted from sorted B-CLL and T cells or granulocytes.

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In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the data or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevent access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outwith the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 8. You agree to abide by the terms outlined in the Consortium 'Publications Policy' as set out in Schedule 1. 9. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the data, and the role of the Consortium and the relevant primary collectors and their funders. Suitable wording is provided in the Publications Policy given in Schedule 1. 10. You accept that the Consortium, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 11. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 12. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 13. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 14. You accept that it may be necessary for the Consortium or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Consortium or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 15. You agree that you will submit a report to the Consortium Data Access Committee, if requested, on completion of the agreed purpose. The Consortium Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 16. You accept that the Data is protected by and subject to international laws, including but not limited to the UK Data Protection Act 1998, and that You are responsible for ensuring compliance with any such applicable law. The Consortium Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004116 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00003090384 fastq.gz 1.1 GB
EGAF00003090385 fastq.gz 1.1 GB
EGAF00003090386 fastq.gz 1.0 GB
EGAF00003090387 fastq.gz 1.0 GB
EGAF00003090388 fastq.gz 2.0 GB
EGAF00003090389 fastq.gz 2.0 GB
EGAF00003090390 fastq.gz 2.3 GB
EGAF00003090391 fastq.gz 2.3 GB
EGAF00003090392 fastq.gz 900.0 MB
EGAF00003090393 fastq.gz 929.4 MB
EGAF00003090394 fastq.gz 1.2 GB
EGAF00003090395 fastq.gz 1.2 GB
EGAF00003090396 fastq.gz 417.3 MB
EGAF00003090397 fastq.gz 427.8 MB
EGAF00003090398 fastq.gz 1.5 GB
EGAF00003090399 fastq.gz 1.5 GB
EGAF00003090400 fastq.gz 2.1 GB
EGAF00003090401 fastq.gz 2.1 GB
EGAF00003090402 fastq.gz 792.4 MB
EGAF00003090403 fastq.gz 811.7 MB
EGAF00003090404 fastq.gz 1.3 GB
EGAF00003090405 fastq.gz 1.3 GB
EGAF00003090406 fastq.gz 1.8 GB
EGAF00003090407 fastq.gz 1.8 GB
EGAF00003090408 fastq.gz 2.1 GB
EGAF00003090409 fastq.gz 2.2 GB
EGAF00003090410 fastq.gz 2.4 GB
EGAF00003090411 fastq.gz 2.5 GB
EGAF00003090412 fastq.gz 1.7 GB
EGAF00003090413 fastq.gz 1.7 GB
EGAF00003090414 fastq.gz 2.0 GB
EGAF00003090415 fastq.gz 2.0 GB
EGAF00003090416 fastq.gz 1.8 GB
EGAF00003090417 fastq.gz 1.8 GB
EGAF00003090418 fastq.gz 1.7 GB
EGAF00003090419 fastq.gz 1.7 GB
EGAF00003090420 fastq.gz 1.8 GB
EGAF00003090421 fastq.gz 1.9 GB
EGAF00003090422 fastq.gz 2.8 GB
EGAF00003090423 fastq.gz 2.8 GB
EGAF00003090424 fastq.gz 1.9 GB
EGAF00003090425 fastq.gz 2.0 GB
EGAF00003090426 fastq.gz 1.8 GB
EGAF00003090427 fastq.gz 1.9 GB
EGAF00003090428 fastq.gz 2.8 GB
EGAF00003090429 fastq.gz 2.8 GB
EGAF00003090430 fastq.gz 1.6 GB
EGAF00003090431 fastq.gz 1.7 GB
EGAF00003090432 fastq.gz 2.2 GB
EGAF00003090433 fastq.gz 2.3 GB
EGAF00003090434 fastq.gz 426.5 MB
EGAF00003090435 fastq.gz 438.8 MB
EGAF00003090436 fastq.gz 1.6 GB
EGAF00003090437 fastq.gz 1.6 GB
EGAF00003090438 fastq.gz 481.3 MB
EGAF00003090439 fastq.gz 494.2 MB
EGAF00003090440 fastq.gz 1.5 GB
EGAF00003090441 fastq.gz 1.5 GB
EGAF00003090442 fastq.gz 1.8 GB
EGAF00003090443 fastq.gz 1.9 GB
EGAF00003090444 fastq.gz 2.1 GB
EGAF00003090445 fastq.gz 2.2 GB
EGAF00003090446 fastq.gz 397.8 MB
EGAF00003090447 fastq.gz 423.5 MB
EGAF00003090448 fastq.gz 1.5 GB
EGAF00003090449 fastq.gz 1.5 GB
EGAF00003090450 fastq.gz 1.9 GB
EGAF00003090451 fastq.gz 2.0 GB
EGAF00003090452 fastq.gz 741.7 MB
EGAF00003090453 fastq.gz 756.5 MB
EGAF00003090454 fastq.gz 1.2 GB
EGAF00003090455 fastq.gz 1.2 GB
EGAF00003090456 fastq.gz 1.9 GB
EGAF00003090457 fastq.gz 1.9 GB
EGAF00003090458 fastq.gz 1.8 GB
EGAF00003090459 fastq.gz 1.9 GB
EGAF00003090460 fastq.gz 841.5 MB
EGAF00003090461 fastq.gz 865.2 MB
EGAF00003090462 fastq.gz 1.0 GB
EGAF00003090463 fastq.gz 1.0 GB
EGAF00003090464 fastq.gz 1.8 GB
EGAF00003090465 fastq.gz 1.9 GB
EGAF00003090466 fastq.gz 471.0 MB
EGAF00003090467 fastq.gz 479.1 MB
EGAF00003090468 fastq.gz 351.8 MB
EGAF00003090469 fastq.gz 358.7 MB
EGAF00003090470 fastq.gz 1.1 GB
EGAF00003090471 fastq.gz 1.1 GB
EGAF00003090472 fastq.gz 1.3 GB
EGAF00003090473 fastq.gz 1.3 GB
EGAF00003090474 fastq.gz 992.2 MB
EGAF00003090475 fastq.gz 1.0 GB
EGAF00003090476 fastq.gz 1.7 GB
EGAF00003090477 fastq.gz 1.7 GB
EGAF00003090478 fastq.gz 2.3 GB
EGAF00003090479 fastq.gz 2.4 GB
96 Files (146.2 GB)