Dataset

single-cell RNA-seq Case-Control study of children progressing to Type1 diabetes

Dataset ID Technology Samples
EGAD00001005768 Illumina HiSeq 3000 8

Dataset Description

It was a single-cell RNA sequencing study on the PBMC samples from four Finnish children at risk of developing Type 1 diabetes and their gender age and HLA matched control children. All four Case children were positive for multiple islet specific autoantibodies and two of them also progressed to clinical disease during the follow up whereas the control children remain negative for all autoantibodies. Single-cell analysis confirmed some of the signatures obtained from the bulk data. It identified that high IL32 in case samples in the bulk RNA-seq was contributed mainly by activated T cells and NK cells. Trajectory analysis of the scRNA-seq data suggested that IL32 expression increased as the T cells moved towards activated state.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

DIABIMMUNE Transcriptomics DAC
Contact person: Riitta Lahesmaa
Email: riitta [dot] lahesmaa [at] utu [dot] fi
More details: EGAC00001001443

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