RNAseq data from the study - Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML

Dataset ID Technology Samples
EGAD00001005949 Illumina HiSeq 2500 39

Dataset Description

This study assessed molecular determinants of response in a cohort of patients with AML that were treated with venetoclax in combination with either DNA methyltransferase inhibitors or low dose cytarabine. RNA sequencing was performed on 31 patients from three different response classes [10 Group A - Durable remission (n=10), Group B - Relapsed (n=10) and Group C - Refractory (n=11)]. Library preparation and sequencing was performed at the Australian Genome Research Facility, using the Truseq Stranded mRNA library kit. Technical and batch replicate samples are included. Gene count data are provided with the original publication. The use of the sequencing data is subject to a data transfer agreement and is restricted to ethically approved research into blood cell malignancies and cannot be used to assess germline variants.

Data Use Conditions


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Label Code Version Modifier
disease specific research DUO:0000007 2019-01-07 HP:0004377
research specific restrictions DUO:0000012 2019-01-07
obsolete research use only DUO:0000014 2019-01-07
ethics approval required DUO:0000021 2019-01-07
time limit on use DUO:0000025 2019-01-07