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As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Conserved interferon-gamma signaling and decreased immune exclusion programs in responses to immune checkpoint blockade therapy_CM38-RNA

We analyzed baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). Analysis of whole transcriptome data showed that T cell infiltration and interferon-gamma signaling signatures corresponded most highly with clinical response to therapy, with a reciprocal decrease in cell cycle and WNT signaling pathways in responding biopsies. Clinical outcome differences were likely not due to differential melanoma cell responses to interferon-gamma, as 57 human melanoma cell lines exposed in vitro to this cytokine showed a conserved interferon-gamma transcriptome response unless they had mutations that precluded signaling from the interferon-gamma receptor. Therefore, the magnitude of the antitumor T cell response and the corresponding downstream interferon-gamma signaling are the main drivers of clinical response or resistance to immune checkpoint blockade therapy.

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DUO:0000006
version: 2019-01-07

health or medical or biomedical research

This data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.

DUO:0000007
version: 2019-01-07

disease specific research

This data use permission indicates that use is allowed provided it is related to the specified disease.

ModifiersMONDO:0004992 MONDO:0005105

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004545 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00004172723 fastq.gz 2.3 GB Report
EGAF00004172724 fastq.gz 2.4 GB Report
EGAF00004172725 fastq.gz 2.6 GB Report
EGAF00004172726 fastq.gz 2.7 GB Report
EGAF00004172727 fastq.gz 2.7 GB Report
EGAF00004172728 fastq.gz 2.9 GB Report
EGAF00004172729 fastq.gz 2.2 GB Report
EGAF00004172730 fastq.gz 2.3 GB Report
EGAF00004172731 fastq.gz 2.0 GB Report
EGAF00004172732 fastq.gz 2.2 GB Report
EGAF00004172733 fastq.gz 2.5 GB Report
EGAF00004172734 fastq.gz 2.5 GB Report
EGAF00004172735 fastq.gz 2.2 GB Report
EGAF00004172736 fastq.gz 2.4 GB Report
EGAF00004172737 fastq.gz 2.1 GB Report
EGAF00004172738 fastq.gz 2.3 GB Report
EGAF00004172739 fastq.gz 2.1 GB Report
EGAF00004172740 fastq.gz 2.3 GB Report
EGAF00004172741 fastq.gz 2.2 GB Report
EGAF00004172742 fastq.gz 2.4 GB Report
EGAF00004172743 fastq.gz 2.6 GB Report
EGAF00004172744 fastq.gz 2.6 GB Report
EGAF00004172745 fastq.gz 2.4 GB Report
EGAF00004172746 fastq.gz 2.7 GB Report
EGAF00004172747 fastq.gz 2.3 GB Report
EGAF00004172748 fastq.gz 2.3 GB Report
EGAF00004172749 fastq.gz 2.3 GB Report
EGAF00004172750 fastq.gz 2.3 GB Report
EGAF00004172751 fastq.gz 2.6 GB Report
EGAF00004172752 fastq.gz 2.7 GB Report
EGAF00004172753 fastq.gz 2.2 GB Report
EGAF00004172754 fastq.gz 2.3 GB Report
EGAF00004172755 fastq.gz 2.3 GB Report
EGAF00004172756 fastq.gz 2.5 GB Report
EGAF00004172757 fastq.gz 2.3 GB Report
EGAF00004172758 fastq.gz 2.4 GB Report
EGAF00004172759 fastq.gz 2.4 GB Report
EGAF00004172760 fastq.gz 2.6 GB Report
EGAF00004172761 fastq.gz 2.2 GB Report
EGAF00004172762 fastq.gz 2.4 GB Report
EGAF00004172763 fastq.gz 2.2 GB Report
EGAF00004172764 fastq.gz 2.4 GB Report
EGAF00004172765 fastq.gz 2.1 GB Report
EGAF00004172766 fastq.gz 2.3 GB Report
EGAF00004172767 fastq.gz 2.1 GB Report
EGAF00004172768 fastq.gz 2.3 GB Report
EGAF00004172769 fastq.gz 2.2 GB Report
EGAF00004172770 fastq.gz 2.3 GB Report
EGAF00004172771 fastq.gz 4.2 GB Report
EGAF00004172772 fastq.gz 4.2 GB Report
EGAF00004172773 fastq.gz 2.4 GB Report
EGAF00004172774 fastq.gz 2.6 GB Report
EGAF00004172775 fastq.gz 2.1 GB Report
EGAF00004172776 fastq.gz 2.3 GB Report
EGAF00004172777 fastq.gz 2.0 GB Report
EGAF00004172778 fastq.gz 2.2 GB Report
EGAF00004172779 fastq.gz 2.3 GB Report
EGAF00004172780 fastq.gz 2.4 GB Report
EGAF00004172781 fastq.gz 2.1 GB Report
EGAF00004172782 fastq.gz 2.2 GB Report
EGAF00004172783 fastq.gz 2.1 GB Report
EGAF00004172784 fastq.gz 2.2 GB Report
EGAF00004172785 fastq.gz 2.1 GB Report
EGAF00004172786 fastq.gz 2.2 GB Report
EGAF00004172787 fastq.gz 2.2 GB Report
EGAF00004172788 fastq.gz 2.4 GB Report
EGAF00004172789 fastq.gz 2.6 GB Report
EGAF00004172790 fastq.gz 2.6 GB Report
EGAF00004172791 fastq.gz 2.6 GB Report
EGAF00004172792 fastq.gz 2.7 GB Report
EGAF00004172793 fastq.gz 2.1 GB Report
EGAF00004172794 fastq.gz 2.3 GB Report
EGAF00004172795 fastq.gz 2.4 GB Report
EGAF00004172796 fastq.gz 2.5 GB Report
EGAF00004172797 fastq.gz 2.2 GB Report
EGAF00004172798 fastq.gz 2.3 GB Report
EGAF00004172799 fastq.gz 2.6 GB Report
EGAF00004172800 fastq.gz 2.7 GB Report
EGAF00004172801 fastq.gz 2.4 GB Report
EGAF00004172802 fastq.gz 2.5 GB Report
EGAF00004172803 fastq.gz 2.1 GB Report
EGAF00004172804 fastq.gz 2.2 GB Report
EGAF00004172805 fastq.gz 2.2 GB Report
EGAF00004172806 fastq.gz 2.3 GB Report
EGAF00004172807 fastq.gz 2.2 GB Report
EGAF00004172808 fastq.gz 2.3 GB Report
EGAF00004172809 fastq.gz 2.1 GB Report
EGAF00004172810 fastq.gz 2.2 GB Report
EGAF00004172811 fastq.gz 2.1 GB Report
EGAF00004172812 fastq.gz 2.3 GB Report
EGAF00004172813 fastq.gz 2.2 GB Report
EGAF00004172814 fastq.gz 2.3 GB Report
EGAF00004172815 fastq.gz 2.2 GB Report
EGAF00004172816 fastq.gz 2.4 GB Report
EGAF00004172817 fastq.gz 2.1 GB Report
EGAF00004172818 fastq.gz 2.4 GB Report
EGAF00004172819 fastq.gz 2.6 GB Report
EGAF00004172820 fastq.gz 2.8 GB Report
EGAF00004172821 fastq.gz 2.2 GB Report
EGAF00004172822 fastq.gz 2.4 GB Report
EGAF00004172823 fastq.gz 2.2 GB Report
EGAF00004172824 fastq.gz 2.4 GB Report
EGAF00004172825 fastq.gz 2.6 GB Report
EGAF00004172826 fastq.gz 2.7 GB Report
EGAF00004172827 fastq.gz 2.3 GB Report
EGAF00004172828 fastq.gz 2.3 GB Report
EGAF00004172829 fastq.gz 2.1 GB Report
EGAF00004172830 fastq.gz 2.2 GB Report
108 Files (256.3 GB)