Need Help?

MutWP1: CRUK Grand Challenge Mutographs of Cancer: Kidney (1)

The Mutographs project aims to advance our understanding of the causes of cancer through studies of mutational signatures. Led by Mike Stratton, together with Paul Brennan, Ludmil Alexandrov, Allan Balmain, David Phillips and Peter Campbell, this large-scale international research endeavour was awarded a Cancer Research UK Grand Challenge. Different patterns of somatic mutation are generated by the different environmental, lifestyle and genetic factors that cause cancer, many of them are still unknown. Within Mutographs, the International Agency for Research on Cancer is coordinating the recruitment of 5000 individuals with cancer (colorectal, renal, pancreatic, oesophageal adenocarcinoma or oesophageal squamous cancers) across 5 continents to explore whether different mutational signatures explain marked variation in incidence. In brief, through an international network of collaborators around the world, biological materials are collected, along with demographic, histological, clinical and questionnaire data. Whole genome sequences of tumour-germline DNA pairs are generated at the Wellcome Trust Sanger Institute. Somatic mutational signatures are subsequently extracted by non-negative matrix factorisation methods and correlated with risk factors data. Through an enhanced understanding of cancer aetiology, Mutographs unprecedented effort is anticipated to outline modifiable risk factors, lead to new approaches to prevent cancer, and provide opportunities to empower early detection, refine high-risk groups and contribute to further therapeutic development.

Request Access

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003542 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004454989 cram 16.3 GB
EGAF00004454990 cram 16.5 GB
EGAF00004454991 cram 16.4 GB
EGAF00004454992 cram 15.3 GB
EGAF00004454993 cram 18.3 GB
EGAF00004454994 cram 17.9 GB
EGAF00004454995 cram 16.0 GB
EGAF00004454996 cram 16.4 GB
EGAF00004454997 cram 17.5 GB
EGAF00004454998 cram 17.9 GB
EGAF00004454999 cram 17.0 GB
EGAF00004455000 cram 15.4 GB
EGAF00004455001 cram 16.9 GB
EGAF00004455002 cram 19.0 GB
EGAF00004455003 cram 18.7 GB
EGAF00004455006 cram 17.8 GB
EGAF00004455007 cram 16.0 GB
EGAF00004455008 cram 18.0 GB
EGAF00004455009 cram 19.7 GB
EGAF00004455010 cram 16.6 GB
EGAF00004455011 cram 16.2 GB
EGAF00004455012 cram 18.4 GB
EGAF00004455013 cram 19.2 GB
EGAF00004455015 cram 17.4 GB
EGAF00004455016 cram 16.4 GB
EGAF00004455017 cram 15.0 GB
EGAF00004455018 cram 14.3 GB
EGAF00004455019 cram 16.5 GB
EGAF00004455020 cram 18.2 GB
EGAF00004455021 cram 15.5 GB
EGAF00004455022 cram 20.4 GB
EGAF00004455023 cram 17.5 GB
EGAF00004455024 cram 16.8 GB
EGAF00004455025 cram 14.6 GB
EGAF00004455026 cram 16.0 GB
EGAF00004455027 cram 14.3 GB
EGAF00004455030 cram 15.1 GB
EGAF00004455031 cram 15.9 GB
EGAF00004455032 cram 17.7 GB
EGAF00004455033 cram 16.0 GB
EGAF00004455034 cram 16.3 GB
EGAF00004455035 cram 15.8 GB
EGAF00004455036 cram 18.8 GB
EGAF00004455037 cram 17.5 GB
EGAF00004455039 cram 12.9 GB
EGAF00004455040 cram 13.9 GB
EGAF00004455041 cram 17.0 GB
EGAF00004455042 cram 16.8 GB
EGAF00004455043 cram 18.2 GB
EGAF00004455044 cram 15.5 GB
EGAF00004455045 cram 14.6 GB
EGAF00004455046 cram 16.2 GB
EGAF00004455047 cram 15.7 GB
EGAF00004455048 cram 19.0 GB
EGAF00004455049 cram 18.5 GB
EGAF00004455050 cram 15.2 GB
EGAF00004455051 cram 15.4 GB
EGAF00004455052 cram 16.6 GB
EGAF00004455053 cram 15.0 GB
EGAF00004455054 cram 18.0 GB
EGAF00004455055 cram 16.9 GB
EGAF00004455056 cram 18.6 GB
EGAF00004455057 cram 15.2 GB
EGAF00004455058 cram 15.9 GB
EGAF00004455059 cram 16.7 GB
EGAF00004455060 cram 15.6 GB
EGAF00004455061 cram 15.5 GB
EGAF00004455062 cram 16.9 GB
EGAF00004455063 cram 15.1 GB
EGAF00004455066 cram 15.8 GB
EGAF00004455067 cram 16.3 GB
EGAF00004455068 cram 18.6 GB
EGAF00004455069 cram 17.3 GB
EGAF00004455070 cram 17.2 GB
EGAF00004455071 cram 16.5 GB
EGAF00004455072 cram 19.7 GB
EGAF00004455073 cram 18.4 GB
EGAF00004455075 cram 13.7 GB
EGAF00004455076 cram 14.8 GB
EGAF00004455077 cram 18.1 GB
EGAF00004455078 cram 17.7 GB
EGAF00004455079 cram 19.4 GB
EGAF00004455080 cram 16.3 GB
EGAF00004455081 cram 15.5 GB
EGAF00004455082 cram 17.2 GB
EGAF00004455083 cram 16.6 GB
EGAF00004455084 cram 19.7 GB
EGAF00004455085 cram 19.5 GB
EGAF00004455086 cram 16.2 GB
EGAF00004455087 cram 16.2 GB
EGAF00004455088 cram 17.5 GB
EGAF00004455089 cram 15.9 GB
EGAF00004455090 cram 18.7 GB
EGAF00004455091 cram 18.0 GB
EGAF00004455092 cram 19.2 GB
EGAF00004455093 cram 16.3 GB
EGAF00004455094 cram 16.8 GB
EGAF00004455095 cram 17.7 GB
EGAF00004455096 cram 16.6 GB
EGAF00004455097 cram 29.6 GB
EGAF00004455098 cram 34.9 GB
EGAF00004455099 cram 31.1 GB
EGAF00004455100 cram 33.4 GB
EGAF00004455102 cram 33.7 GB
EGAF00004455103 cram 29.6 GB
EGAF00004455104 cram 30.1 GB
EGAF00004455105 cram 27.7 GB
EGAF00004455106 cram 25.7 GB
EGAF00004455107 cram 33.0 GB
EGAF00004455112 cram 15.4 GB
EGAF00004455113 cram 15.5 GB
EGAF00004673046 cram 17.0 GB
EGAF00004693687 cram 32.8 GB
EGAF00004693688 cram 31.1 GB
EGAF00004693689 cram 34.0 GB
EGAF00004693690 cram 31.2 GB
EGAF00004693691 cram 33.1 GB
EGAF00004693692 cram 33.8 GB
EGAF00004693693 cram 32.0 GB
EGAF00004693694 cram 33.2 GB
EGAF00004693695 cram 28.2 GB
EGAF00004693696 cram 32.0 GB
EGAF00004693697 cram 34.6 GB
EGAF00004693698 cram 27.5 GB
EGAF00004693699 cram 34.8 GB
EGAF00004693700 cram 32.7 GB
EGAF00004693701 cram 32.2 GB
EGAF00004693702 cram 28.7 GB
EGAF00004693703 cram 31.5 GB
EGAF00004693704 cram 32.6 GB
EGAF00004693705 cram 33.5 GB
EGAF00004693706 cram 31.4 GB
EGAF00004693707 cram 33.9 GB
EGAF00004693708 cram 32.9 GB
EGAF00004693709 cram 28.5 GB
EGAF00004693710 cram 31.8 GB
EGAF00004693711 cram 35.1 GB
EGAF00004693712 cram 33.0 GB
EGAF00004693713 cram 29.9 GB
EGAF00004693714 cram 28.0 GB
EGAF00004693715 cram 32.7 GB
EGAF00004693716 cram 29.5 GB
EGAF00004693717 cram 31.4 GB
EGAF00004693718 cram 28.6 GB
EGAF00004693719 cram 28.9 GB
EGAF00004693720 cram 30.6 GB
EGAF00004693721 cram 27.3 GB
EGAF00004693722 cram 34.8 GB
EGAF00004693723 cram 29.2 GB
EGAF00004693724 cram 21.6 GB
EGAF00004693725 cram 28.7 GB
EGAF00004693726 cram 35.3 GB
EGAF00004693727 cram 30.2 GB
EGAF00004693728 cram 32.6 GB
EGAF00004693729 cram 31.0 GB
EGAF00004693730 cram 31.2 GB
EGAF00004693731 cram 33.1 GB
EGAF00004693732 cram 36.0 GB
EGAF00004693733 cram 32.0 GB
EGAF00004693734 cram 32.2 GB
EGAF00004693735 cram 16.4 GB
EGAF00004693736 cram 16.9 GB
EGAF00004693737 cram 17.5 GB
EGAF00004693738 cram 16.9 GB
EGAF00004693739 cram 14.3 GB
EGAF00004693740 cram 14.1 GB
EGAF00004693741 cram 17.6 GB
EGAF00004693742 cram 15.6 GB
EGAF00004693743 cram 15.0 GB
EGAF00004693744 cram 16.9 GB
EGAF00004693745 cram 13.2 GB
EGAF00004693746 cram 16.2 GB
EGAF00004693747 cram 13.6 GB
EGAF00004693748 cram 16.6 GB
EGAF00004693749 cram 16.3 GB
EGAF00004693750 cram 17.0 GB
EGAF00004693751 cram 16.7 GB
EGAF00004693752 cram 18.6 GB
EGAF00004693753 cram 14.9 GB
EGAF00004693754 cram 15.9 GB
EGAF00004693755 cram 16.6 GB
EGAF00004693756 cram 17.4 GB
EGAF00004693757 cram 16.0 GB
EGAF00004693758 cram 18.2 GB
EGAF00004693759 cram 15.5 GB
EGAF00004693760 cram 15.9 GB
EGAF00004693761 cram 17.7 GB
EGAF00004693762 cram 17.2 GB
EGAF00004693763 cram 15.2 GB
EGAF00004693764 cram 15.3 GB
EGAF00004693765 cram 16.5 GB
EGAF00004693766 cram 15.2 GB
EGAF00004693767 cram 14.9 GB
EGAF00004693768 cram 14.8 GB
EGAF00004693769 cram 15.0 GB
EGAF00004693770 cram 17.4 GB
EGAF00004693771 cram 15.1 GB
EGAF00004693772 cram 16.6 GB
EGAF00004693773 cram 15.5 GB
EGAF00004693774 cram 15.3 GB
EGAF00004693775 cram 14.8 GB
EGAF00004693776 cram 14.6 GB
EGAF00004693777 cram 14.8 GB
EGAF00004693778 cram 14.5 GB
EGAF00004693779 cram 17.2 GB
EGAF00004693780 cram 17.8 GB
EGAF00004693781 cram 14.4 GB
EGAF00004693782 cram 16.2 GB
EGAF00004693783 cram 15.9 GB
EGAF00004693784 cram 17.6 GB
EGAF00004693785 cram 16.1 GB
EGAF00004693786 cram 16.5 GB
EGAF00004693787 cram 15.3 GB
EGAF00004693788 cram 15.4 GB
EGAF00004693789 cram 17.1 GB
215 Files (4.4 TB)