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Transcription factor binding in human monocyte differentiation

This dataset consists of ChIP-seq data data from human monocytes, monocyte-derived dendritic cells as well as monocyte-derived cells that were subjected to mRNA transfection for PU.1, IRF4, and EGR2. In total, it the data set includes 18 samples.

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Data access agreement specifying the policy for sharing. Specific limitations on areas of research: The donor consent allows the use of this data for health/medical/biomedical research only. (DUO:0000006, DUO:0000014). Data use is use is limited to not-for-profit organizations (DUO:0000018). Its use is also limited to approved users (DUO:0000026), projects (DUO:0000027) and institutions (DUO:0000028).

DATA ACCESS AGREEMENT Between University Hospital Regensburg, represented by the Director of Administration, Executing Department: Hospital and Outpatient Department of Internal Medicine III (Director: Prof. Dr. Wolfgang Herr), Project Leader: Prof. Dr. Michael Rehli, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany -Data Producers / University Hospital Regensburg - and (…) -User Institution- These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom University Hospital Regensburg grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: University Hospital Regensburg and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to comply with all applicable regulations, especially the General Data Protection Regulation (GDPR), to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (https://icgc.org/files/daco/WT_SharingData_FTLauderdale_2003_en.pdf) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the OECD’s (Organisation for Economic Co-operation and Development) Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/sti/emerging-tech/guidelinesforthelicensingofgeneticinventions.htm). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify University Hospital Regensburg within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify University Hospital Regensburg prior to any significant changes to the protocol for the Project. 14. The User Institution will notify University Hospital Regensburg as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. University Hospital Regensburg may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of Germany and shall be subject to the exclusive jurisdiction of the courts of Regensburg, Germany. Agreed for User Institution: Signature: Name: Title: Date: Principal Investigator: I confirm that I have read and understood this Agreement Signature: Name: Title: Date: Agreed for the Data Producers / University Hospital Regensburg: Signature: Name: Dr. Johannes Hies Title: Head of Legal Department Date: Acknowledged and agreed: Signature: Name: Prof. Dr. Michael Rehli Title: Project Leader Date: Signature: Name: Prof. Dr. Wolfgang Herr Title: Director Internal Medicine III Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the Data Producers before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) Name of project that created the dataset Mechanisms of active DNA demethylation in human monocytes Names of other data producers/collaborators N.A. Specific limitations on areas of research The donor consent allows the use of this data for health/medical/biomedical research only. (DUO:0000006, DUO:0000014). Data use is use is limited to not-for-profit organizations (DUO:0000018). Its use is also limited to approved users (DUO:0000026), projects (DUO:0000027) and institutions (DUO:0000028). Legal basis for data sharing Personal data and the protection of personal data are considered as defined in the General Data Protection Regulation (GDPR). All regulations therein including the principles relating to processing of personal data and the security of processing must be applied. For user institutions outside the EU in the absence of a decision pursuant to Article 45(3) GDPR standard data protection clauses adopted by the Commission in accordance with the examination procedure referred to in Article 93(2) GDPR should be concluded preferably. Technical and organisational measures to protect personal data The Technical and Organisational Measures are subject to technical progress and further development. In this respect, it is permissible for the Supplier to implement alternative adequate measures. In so doing, the security level of the defined measures must not be reduced. Substantial changes must be documented. Minimum protection measures required Measures suitable for preventing unauthorised persons from gaining access to data processing equipment with which personal data are processed or used. Access control measures for building and room security include automatic access control systems, the use of chip cards and transponders, access control by gatekeepers and alarm systems. Servers, telecommunications equipment, network technology and similar equipment must be protected in lockable server cabinets. In addition, access control should be supported by organisational measures (e.g., service instructions which provide for the locking of the offices during absence). Measures suitable to prevent data processing systems (computers) from being used by unauthorised persons. User identification with password for operating systems and software products used, screen saver with password. Up-to-date Anti-Virus-Software and firewalls on client computers and servers. Server hardening, intrusion detection systems and encryption of data media or data files. Use of VPN for remote accesses. Ssh-based client-server communication. Central management of user rights and permissions. File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall, for a limited period of time (up to 3 month) for primary analysis. They can be again decrypted if primary analysis has to be repeated. The hard drives of Laptops holding these data must be encrypted. If held on USB keys or other portable hard drives, the data must be encrypted. Measures to ensure that those authorised to use a data processing system can only access the data subject to their access authorisation and that personal data cannot be read, copied, altered or removed without authorisation during processing, use and after storage. Access control can be ensured, among other things, by means of suitable user authorization concepts that enable differentiated control of access to data. In doing so, it is important to differentiate both the content of the data and the possible access functions to the data. Furthermore, suitable control mechanisms and responsibilities must be defined to document the granting and withdrawal of authorizations and to keep them up to date (e.g., upon hiring, change of job, termination of employment). Special attention should always be paid to the role and possibilities of administrators. Logging of user and administrator access and retrieval of the data should be supported. Further measures should include data protection management by an internal / external data protection officer and incident response management should be in place to prevent the uncontrolled distribution of data during the period when data has to be store unencrypted for analysis. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor / User Institution) Details of dataset requested i.e., EGA Study and Dataset Accession Number Title of the Proposed Research Project in which the Data will be used Brief abstract of the Project in which the Data will be used (500 words max) All Individuals of the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor Name of Registered User Email Job Title Supervisor All Individuals that should have an account created at the EGA Name of Registered User Email Job Title Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with the Data Producers/University Hospital Regensburg.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004784 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004842306 fastq.gz 559.0 MB
EGAF00004842307 fastq.gz 608.9 MB
EGAF00004842308 fastq.gz 1.5 GB
EGAF00004842309 fastq.gz 1.6 GB
EGAF00004842310 fastq.gz 1.6 GB
EGAF00004842311 fastq.gz 1.1 GB
EGAF00004842312 fastq.gz 1.8 GB
EGAF00004842313 fastq.gz 1.4 GB
EGAF00004842314 fastq.gz 1.5 GB
EGAF00004842315 fastq.gz 1.4 GB
EGAF00004842316 fastq.gz 1.6 GB
EGAF00004842317 fastq.gz 710.5 MB
EGAF00004842318 fastq.gz 1.8 GB
EGAF00004842319 fastq.gz 1.3 GB
EGAF00004842320 fastq.gz 1.1 GB
EGAF00004842321 fastq.gz 678.5 MB
EGAF00004842322 fastq.gz 620.1 MB
EGAF00004842323 fastq.gz 606.3 MB
18 Files (21.4 GB)