We study lymphocyte somatic evolution through the sequencing of normal healthy lymphocytes. We perform whole-genome sequencing of single-cell derived T and B cell colonies to identify somatic mutations, and perform targeted deep-sequencing of these mutations. The lineages of T and B cells, and the frequencies of these mutations reveals the neutral and non-neutral evolutionary processes underlying lymphocyte growth and function. . This dataset contains all the data available for this study on 2021-02-02.

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Dataset

Lymphocyte PanBody WGS H38 (2021-02-02)

Dataset ID	Technology	Samples
EGAD00001006935	HiSeq X Ten	9

Dataset Description

We study lymphocyte somatic evolution through the sequencing of normal healthy lymphocytes. We perform whole-genome sequencing of single-cell derived T and B cell colonies to identify somatic mutations, and perform targeted deep-sequencing of these mutations. The lineages of T and B cells, and the frequencies of these mutations reveals the neutral and non-neutral evolutionary processes underlying lymphocyte growth and function. .
This dataset contains all the data available for this study on 2021-02-02.

Label	Code	Version
obsolete general research use and clinical care	DUO:0000005	2017-10-16
obsolete research use only	DUO:0000014	2017-10-16
publication required	DUO:0000019	2017-10-16
user specific restriction	DUO:0000026	2017-10-16
institution specific restriction	DUO:0000028	2017-10-16

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WTSI CGP Data access committee
Contact person: Data Sharing
Email: datasharing [at] sanger [dot] ac [dot] uk
More details: EGAC00001000000

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