Dataset

Relapse series of two Pediatric ALL patients

Dataset ID Technology Samples
EGAD00001006948 Illumina NovaSeq 6000 10

Dataset Description

In this proof of principle study, we performed whole genome sequencing of two cases with multiple relapses in order to investigate whether groups of mutations separated in time show distinct mutational signatures. In patient 1, who experienced two relapses, the analysis unraveled a continuous interplay of aberrant AID/APOBEC-associated activities. Patient 2 had three relapses. We identified episodic mutational processes at diagnosis and first relapse leading to mutations resembling UV light-driven DNA damage, and thiopurine-associated damage at first relapse.

Data Use Conditions

HMB IRB RUO US IS PS TS

See further information on Data Use Conditions

Label Code Version Modifier
health or medical or biomedical research DUO:0000006 2019-01-07
ethics approval required DUO:0000021 2019-01-07
obsolete research use only DUO:0000014 2019-01-07
user specific restriction DUO:0000026 2019-01-07
institution specific restriction DUO:0000028 2019-01-07
project specific restriction DUO:0000027 2019-01-07
time limit on use DUO:0000025 2019-01-07