| Dataset ID | Technology | Samples |
|---|---|---|
| EGAD00001006948 | Illumina NovaSeq 6000 | 10 |
Dataset Description
In this proof of principle study, we performed whole genome sequencing of two cases with multiple relapses in order to investigate whether groups of mutations separated in time show distinct mutational signatures. In patient 1, who experienced two relapses, the analysis unraveled a continuous interplay of aberrant AID/APOBEC-associated activities. Patient 2 had three relapses. We identified episodic mutational processes at diagnosis and first relapse leading to mutations resembling UV light-driven DNA damage, and thiopurine-associated damage at first relapse.
Data Use Conditions
HMB IRB RUO US IS PS TS
See further information on Data Use Conditions
| Label | Code | Version | Modifier |
|---|---|---|---|
| health or medical or biomedical research | DUO:0000006 | 2019-01-07 | |
| ethics approval required | DUO:0000021 | 2019-01-07 | |
| obsolete research use only | DUO:0000014 | 2019-01-07 | |
| user specific restriction | DUO:0000026 | 2019-01-07 | |
| institution specific restriction | DUO:0000028 | 2019-01-07 | |
| project specific restriction | DUO:0000027 | 2019-01-07 | |
| time limit on use | DUO:0000025 | 2019-01-07 |
