About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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CM067 WES - Clinical Outcomes by Tumor Mutational Burden and Inflammatory Gene Expression With Combined Nivolumab and Ipilimumab or Monotherapy in Advanced Melanoma

Purpose Exploratory analyses of CheckMate 066 and 067 trials were conducted to investigate associations of tumor mutational burden (TMB), a 4-gene inflammatory gene expression signature, and BRAF mutation status with tumor response, progression-free survival (PFS), and overall survival (OS) in patients with advanced melanoma. Patients and Methods Patients with known programmed death ligand 1 (PD-L1) expression and BRAF mutation status received nivolumab (NIVO) or dacarbazine in CheckMate 066 and either NIVO, ipilimumab (IPI), or NIVO+IPI in CheckMate 067. Whole exome sequencing and RNA sequencing were used to determine TMB and inflammatory gene expression signature scores, respectively. These biomarkers were evaluated in terms of their association with PFS and OS. Results In the NIVO, NIVO+IPI, and IPI arms of CheckMate 067, longer survival was associated with high (> median) versus low (≤ median) TMB with hazard ratios (HRs) (95% confidence interval [CI]) for PFS of 0.45 (0.30–0.65), 0.55 (0.38–0.81), and 0.60 (0.43–0.82), and for OS of 0.46 (0.30–0.71), 0.53 (0.34–0.82), and 0.52 (0.36–0.74), respectively. For NIVO-treated patients, these results were confirmed in CheckMate 066. A survival benefit was observed with high TMB and absence of BRAF mutation. Survival was associated with high versus low inflammatory signature scores with HRs (95% CI) for PFS of 0.56 (0.34–0.94), 0.40 (0.23–0.72), and 0.43 (0.27–0.70), and for OS of 0.37 (0.20–0.66), 0.38 (0.19–0.74), and 0.46 (0.27–0.79), in the NIVO, NIVO+IPI, and IPI arms, respectively. Weak correlations were observed between PD-L1, TMB, and the inflammatory signature. Conclusions Combined assessment of TMB, inflammatory gene expression signature, and BRAF mutation status may be predictive for response to immunotherapy in advanced melanoma.

Request Access

DUO:0000006
version: 2019-01-07

health or medical or biomedical research

This data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.

DUO:0000007
version: 2019-01-07

disease specific research

This data use permission indicates that use is allowed provided it is related to the specified disease.

ModifiersMONDO:0005105

Requests for access the BMS accession numbers in EGA should be directed to the BMS FastTrack portal - https://fasttrack.bms.com/. This externally facing website serves as BMS’ request portal for all ISRs (both clinical and non-clinical), as well as for requests for data generated as a part of a BMS study. This portal is facilitated by BMS’ Clinical Trial Transparency organization.

Purpose Below you will find general notes and tips for when you are creating an ISR Request. General Notes and Tips • * [Asterisks] indicate a required field within the interface • You will not be able to move on to the next page if a required field is not completed • Periodically click Save (located at the bottom right corner on any form) in order to save your information. If you do not have all the information, which is necessary to submit your request, click Save and a draft will be available for you on your homepage when you are ready to return to the form. The forms do not auto-save. • FastTrack has a security time-out feature. After sixty (60) minutes of inactivity, you will be required to log back into the system. o If you are working on a record and leave it open while performing other tasks, it is recommend that you navigate to the bottom of the record and click Save to prevent you from losing data you have entered • You can return to any section of the form at any point by clicking the tabs at the top of the page or clicking Back in the lower left of the page We are committed to providing you with answers to your questions and concerns. Please contact us using the information below, and we will respond to your inquiry as quickly as possible. Technical Support Main Number: +1 844-439-5499 (US only) For Outside US, please see the “International BMS Help Desk Phone Number Guide” Main Email: hd-sci-apps@bms.com

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004555 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00005207785 fastq.gz 3.7 GB Report
EGAF00005207786 fastq.gz 3.8 GB Report
EGAF00005207787 fastq.gz 4.3 GB Report
EGAF00005207788 fastq.gz 4.6 GB Report
EGAF00005207789 fastq.gz 3.9 GB Report
EGAF00005207790 fastq.gz 4.1 GB Report
EGAF00005207791 fastq.gz 3.9 GB Report
EGAF00005207792 fastq.gz 4.2 GB Report
EGAF00005207793 fastq.gz 5.0 GB Report
EGAF00005207794 fastq.gz 5.3 GB Report
EGAF00005207795 fastq.gz 3.4 GB Report
EGAF00005207796 fastq.gz 3.5 GB Report
EGAF00005207797 fastq.gz 4.0 GB Report
EGAF00005207798 fastq.gz 4.1 GB Report
EGAF00005207799 fastq.gz 3.7 GB Report
EGAF00005207800 fastq.gz 3.8 GB Report
EGAF00005207801 fastq.gz 4.1 GB Report
EGAF00005207802 fastq.gz 4.0 GB Report
EGAF00005207803 fastq.gz 4.1 GB Report
EGAF00005207804 fastq.gz 4.3 GB Report
EGAF00005207805 fastq.gz 3.5 GB Report
EGAF00005207806 fastq.gz 3.5 GB Report
EGAF00005207807 fastq.gz 3.9 GB Report
EGAF00005207808 fastq.gz 3.8 GB Report
EGAF00005207809 fastq.gz 4.2 GB Report
EGAF00005207810 fastq.gz 4.1 GB Report
EGAF00005207811 fastq.gz 4.0 GB Report
EGAF00005207812 fastq.gz 4.0 GB Report
EGAF00005207813 fastq.gz 4.2 GB Report
EGAF00005207814 fastq.gz 4.4 GB Report
EGAF00005207815 fastq.gz 4.3 GB Report
EGAF00005207816 fastq.gz 4.4 GB Report
EGAF00005207817 fastq.gz 3.9 GB Report
EGAF00005207818 fastq.gz 4.2 GB Report
EGAF00005207819 fastq.gz 3.5 GB Report
EGAF00005207820 fastq.gz 3.7 GB Report
EGAF00005207821 fastq.gz 4.4 GB Report
EGAF00005207822 fastq.gz 4.8 GB Report
EGAF00005207823 fastq.gz 4.4 GB Report
EGAF00005207824 fastq.gz 4.7 GB Report
EGAF00005207825 fastq.gz 4.1 GB Report
EGAF00005207826 fastq.gz 4.3 GB Report
EGAF00005207827 fastq.gz 3.7 GB Report
EGAF00005207828 fastq.gz 3.7 GB Report
EGAF00005207829 fastq.gz 4.3 GB Report
EGAF00005207830 fastq.gz 4.5 GB Report
EGAF00005207831 fastq.gz 3.7 GB Report
EGAF00005207832 fastq.gz 3.9 GB Report
EGAF00005207833 fastq.gz 4.3 GB Report
EGAF00005207834 fastq.gz 4.4 GB Report
EGAF00005207835 fastq.gz 4.0 GB Report
EGAF00005207836 fastq.gz 4.0 GB Report
EGAF00005207837 fastq.gz 4.1 GB Report
EGAF00005207838 fastq.gz 4.5 GB Report
EGAF00005207839 fastq.gz 4.4 GB Report
EGAF00005207840 fastq.gz 4.6 GB Report
EGAF00005207841 fastq.gz 4.2 GB Report
EGAF00005207842 fastq.gz 4.3 GB Report
EGAF00005207843 fastq.gz 4.0 GB Report
EGAF00005207844 fastq.gz 4.1 GB Report
EGAF00005207845 fastq.gz 3.7 GB Report
EGAF00005207846 fastq.gz 3.9 GB Report
EGAF00005207847 fastq.gz 3.8 GB Report
EGAF00005207848 fastq.gz 3.9 GB Report
EGAF00005207849 fastq.gz 3.6 GB Report
EGAF00005207850 fastq.gz 3.6 GB Report
EGAF00005207851 fastq.gz 3.6 GB Report
EGAF00005207852 fastq.gz 3.8 GB Report
EGAF00005207853 fastq.gz 3.7 GB Report
EGAF00005207854 fastq.gz 3.9 GB Report
EGAF00005207855 fastq.gz 3.9 GB Report
EGAF00005207856 fastq.gz 4.1 GB Report
EGAF00005207857 fastq.gz 3.7 GB Report
EGAF00005207858 fastq.gz 4.0 GB Report
EGAF00005207859 fastq.gz 3.2 GB Report
EGAF00005207860 fastq.gz 3.3 GB Report
EGAF00005207861 fastq.gz 3.5 GB Report
EGAF00005207862 fastq.gz 3.8 GB Report
EGAF00005207863 fastq.gz 4.3 GB Report
EGAF00005207864 fastq.gz 4.5 GB Report
EGAF00005207865 fastq.gz 3.8 GB Report
EGAF00005207866 fastq.gz 4.1 GB Report
EGAF00005207867 fastq.gz 4.6 GB Report
EGAF00005207868 fastq.gz 4.9 GB Report
EGAF00005207869 fastq.gz 4.3 GB Report
EGAF00005207870 fastq.gz 4.5 GB Report
EGAF00005207871 fastq.gz 3.4 GB Report
EGAF00005207872 fastq.gz 3.6 GB Report
EGAF00005207873 fastq.gz 3.7 GB Report
EGAF00005207874 fastq.gz 4.0 GB Report
EGAF00005207875 fastq.gz 3.1 GB Report
EGAF00005207876 fastq.gz 3.3 GB Report
EGAF00005207877 fastq.gz 4.6 GB Report
EGAF00005207878 fastq.gz 4.8 GB Report
EGAF00005207879 fastq.gz 3.2 GB Report
EGAF00005207880 fastq.gz 3.3 GB Report
EGAF00005207881 fastq.gz 3.2 GB Report
EGAF00005207882 fastq.gz 3.5 GB Report
EGAF00005207883 fastq.gz 3.7 GB Report
EGAF00005207884 fastq.gz 3.8 GB Report
EGAF00005207885 fastq.gz 3.3 GB Report
EGAF00005207886 fastq.gz 3.3 GB Report
EGAF00005207887 fastq.gz 3.2 GB Report
EGAF00005207888 fastq.gz 3.4 GB Report
EGAF00005207889 fastq.gz 3.1 GB Report
EGAF00005207890 fastq.gz 3.2 GB Report
EGAF00005207891 fastq.gz 3.3 GB Report
EGAF00005207892 fastq.gz 3.5 GB Report
EGAF00005207893 fastq.gz 4.0 GB Report
EGAF00005207894 fastq.gz 4.2 GB Report
EGAF00005207895 fastq.gz 4.7 GB Report
EGAF00005207896 fastq.gz 5.0 GB Report
EGAF00005207897 fastq.gz 4.3 GB Report
EGAF00005207898 fastq.gz 4.6 GB Report
EGAF00005207899 fastq.gz 4.6 GB Report
EGAF00005207900 fastq.gz 4.9 GB Report
EGAF00005207901 fastq.gz 3.6 GB Report
EGAF00005207902 fastq.gz 3.8 GB Report
EGAF00005207903 fastq.gz 3.5 GB Report
EGAF00005207904 fastq.gz 3.7 GB Report
EGAF00005207905 fastq.gz 4.4 GB Report
EGAF00005207906 fastq.gz 4.8 GB Report
EGAF00005207907 fastq.gz 3.5 GB Report
EGAF00005207908 fastq.gz 3.7 GB Report
EGAF00005207909 fastq.gz 4.7 GB Report
EGAF00005207910 fastq.gz 4.9 GB Report
EGAF00005207911 fastq.gz 4.4 GB Report
EGAF00005207912 fastq.gz 4.8 GB Report
EGAF00005207913 fastq.gz 4.0 GB Report
EGAF00005207914 fastq.gz 3.9 GB Report
EGAF00005207915 fastq.gz 4.2 GB Report
EGAF00005207916 fastq.gz 4.6 GB Report
EGAF00005207917 fastq.gz 4.2 GB Report
EGAF00005207918 fastq.gz 4.5 GB Report
EGAF00005207919 fastq.gz 4.0 GB Report
EGAF00005207920 fastq.gz 4.4 GB Report
EGAF00005207921 fastq.gz 4.0 GB Report
EGAF00005207922 fastq.gz 4.4 GB Report
EGAF00005207923 fastq.gz 4.2 GB Report
EGAF00005207924 fastq.gz 4.5 GB Report
EGAF00005207925 fastq.gz 4.0 GB Report
EGAF00005207926 fastq.gz 4.2 GB Report
EGAF00005207927 fastq.gz 4.0 GB Report
EGAF00005207928 fastq.gz 4.2 GB Report
EGAF00005207929 fastq.gz 4.4 GB Report
EGAF00005207930 fastq.gz 4.3 GB Report
EGAF00005207931 fastq.gz 3.8 GB Report
EGAF00005207932 fastq.gz 4.0 GB Report
EGAF00005207933 fastq.gz 3.5 GB Report
EGAF00005207934 fastq.gz 3.7 GB Report
EGAF00005207935 fastq.gz 4.1 GB Report
EGAF00005207936 fastq.gz 4.0 GB Report
EGAF00005207937 fastq.gz 4.1 GB Report
EGAF00005207938 fastq.gz 4.3 GB Report
EGAF00005207939 fastq.gz 3.6 GB Report
EGAF00005207940 fastq.gz 3.7 GB Report
EGAF00005207941 fastq.gz 4.1 GB Report
EGAF00005207942 fastq.gz 4.4 GB Report
EGAF00005207943 fastq.gz 3.8 GB Report
EGAF00005207944 fastq.gz 3.8 GB Report
EGAF00005207945 fastq.gz 4.4 GB Report
EGAF00005207946 fastq.gz 4.3 GB Report
EGAF00005207947 fastq.gz 4.0 GB Report
EGAF00005207948 fastq.gz 4.1 GB Report
EGAF00005207949 fastq.gz 3.7 GB Report
EGAF00005207950 fastq.gz 3.9 GB Report
EGAF00005207951 fastq.gz 3.3 GB Report
EGAF00005207952 fastq.gz 3.6 GB Report
EGAF00005207953 fastq.gz 3.6 GB Report
EGAF00005207954 fastq.gz 3.7 GB Report
EGAF00005207955 fastq.gz 4.5 GB Report
EGAF00005207956 fastq.gz 4.7 GB Report
EGAF00005207957 fastq.gz 5.3 GB Report
EGAF00005207958 fastq.gz 5.6 GB Report
EGAF00005207959 fastq.gz 4.2 GB Report
EGAF00005207960 fastq.gz 4.1 GB Report
EGAF00005207961 fastq.gz 4.5 GB Report
EGAF00005207962 fastq.gz 4.7 GB Report
EGAF00005207963 fastq.gz 3.9 GB Report
EGAF00005207964 fastq.gz 4.3 GB Report
EGAF00005207965 fastq.gz 4.0 GB Report
EGAF00005207966 fastq.gz 4.2 GB Report
EGAF00005207967 fastq.gz 3.7 GB Report
EGAF00005207968 fastq.gz 3.6 GB Report
EGAF00005207969 fastq.gz 3.5 GB Report
EGAF00005207970 fastq.gz 3.7 GB Report
EGAF00005207971 fastq.gz 4.4 GB Report
EGAF00005207972 fastq.gz 4.8 GB Report
EGAF00005207973 fastq.gz 3.8 GB Report
EGAF00005207974 fastq.gz 4.0 GB Report
EGAF00005207975 fastq.gz 4.5 GB Report
EGAF00005207976 fastq.gz 4.7 GB Report
EGAF00005207977 fastq.gz 3.7 GB Report
EGAF00005207978 fastq.gz 3.7 GB Report
EGAF00005207979 fastq.gz 3.6 GB Report
EGAF00005207980 fastq.gz 3.7 GB Report
EGAF00005207981 fastq.gz 4.3 GB Report
EGAF00005207982 fastq.gz 4.4 GB Report
EGAF00005207983 fastq.gz 4.0 GB Report
EGAF00005207984 fastq.gz 4.2 GB Report
EGAF00005207985 fastq.gz 4.3 GB Report
EGAF00005207986 fastq.gz 4.5 GB Report
EGAF00005207987 fastq.gz 3.8 GB Report
EGAF00005207988 fastq.gz 3.9 GB Report
EGAF00005207989 fastq.gz 3.5 GB Report
EGAF00005207990 fastq.gz 3.6 GB Report
EGAF00005207991 fastq.gz 4.1 GB Report
EGAF00005207992 fastq.gz 4.2 GB Report
EGAF00005207993 fastq.gz 4.2 GB Report
EGAF00005207994 fastq.gz 4.4 GB Report
EGAF00005207995 fastq.gz 3.7 GB Report
EGAF00005207996 fastq.gz 3.9 GB Report
EGAF00005207997 fastq.gz 4.1 GB Report
EGAF00005207998 fastq.gz 4.2 GB Report
EGAF00005207999 fastq.gz 4.1 GB Report
EGAF00005208000 fastq.gz 4.3 GB Report
EGAF00005208001 fastq.gz 4.1 GB Report
EGAF00005208002 fastq.gz 4.3 GB Report
EGAF00005208003 fastq.gz 3.5 GB Report
EGAF00005208004 fastq.gz 3.6 GB Report
EGAF00005208005 fastq.gz 3.9 GB Report
EGAF00005208006 fastq.gz 4.0 GB Report
EGAF00005208007 fastq.gz 4.5 GB Report
EGAF00005208008 fastq.gz 4.7 GB Report
EGAF00005208009 fastq.gz 4.2 GB Report
EGAF00005208010 fastq.gz 4.5 GB Report
EGAF00005208011 fastq.gz 3.6 GB Report
EGAF00005208012 fastq.gz 3.7 GB Report
EGAF00005208013 fastq.gz 3.3 GB Report
EGAF00005208014 fastq.gz 3.4 GB Report
EGAF00005208015 fastq.gz 3.7 GB Report
EGAF00005208016 fastq.gz 3.8 GB Report
EGAF00005208017 fastq.gz 3.6 GB Report
EGAF00005208018 fastq.gz 3.8 GB Report
EGAF00005208019 fastq.gz 5.0 GB Report
EGAF00005208020 fastq.gz 5.4 GB Report
EGAF00005208021 fastq.gz 3.4 GB Report
EGAF00005208022 fastq.gz 3.5 GB Report
EGAF00005208023 fastq.gz 3.7 GB Report
EGAF00005208024 fastq.gz 3.8 GB Report
EGAF00005208025 fastq.gz 3.7 GB Report
EGAF00005208026 fastq.gz 3.9 GB Report
EGAF00005208027 fastq.gz 4.6 GB Report
EGAF00005208028 fastq.gz 4.7 GB Report
244 Files (985.1 GB)