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Single circulating tumor cells in hepatocellular carcinoma

We determined intra- and inter-vascular transcriptional heterogeneity within the circulatory system using single-cell RNA-sequencing of 113 CTCs isolated from four key vascular sites along their dissemination route in ten HCC patients. The dataset consists of 146 paired-end fastq files from 113 sigle CTCs, HuH-7 cell line, Hep3B cellline, white blood cell, tumor and normal bulk tissue.

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The Data Access Agreement

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the BGI-Single Cell Clinical application Data Access Commitee grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The BGI-Single Cell Clinical application Data Access Commitee and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the BGI-Single Cell Clinical application Data Access Commitee within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the BGI-Single Cell Clinical application Data Access Commitee prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the BGI-Single Cell Clinical application Data Access Commitee as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The BGI-Single Cell Clinical application Data Access Commitee may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the BGI-Single Cell Clinical application Data Access Commitee. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. Comply with all applicable national, provincial and local laws and regulations, as well as laws and regulations related to human genetic resources management and related policies. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed and bound by the laws and regulations of the People’s Republic of China, and do not implement their conflicting laws. Any disputes related to these terms and conditions should be resolved through friendly consultation between the two parties. Either party has the right to file a lawsuit in a court with jurisdiction in Yantian District, Shenzhen, China.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005204 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005278232 fq.gz 2.9 GB
EGAF00005278233 fq.gz 3.2 GB
EGAF00005278234 fq.gz 1.3 GB
EGAF00005278235 fq.gz 1.3 GB
EGAF00005278236 fq.gz 2.0 GB
EGAF00005278237 fq.gz 2.0 GB
EGAF00005278238 fq.gz 2.8 GB
EGAF00005278239 fq.gz 3.0 GB
EGAF00005278240 fq.gz 312.6 MB
EGAF00005278241 fq.gz 371.5 MB
EGAF00005278242 fq.gz 273.7 MB
EGAF00005278243 fq.gz 342.3 MB
EGAF00005278244 fq.gz 920.6 MB
EGAF00005278245 fq.gz 967.6 MB
EGAF00005278246 fq.gz 517.8 MB
EGAF00005278247 fq.gz 584.3 MB
EGAF00005278248 fq.gz 898.1 MB
EGAF00005278249 fq.gz 915.9 MB
EGAF00005278250 fq.gz 1.1 GB
EGAF00005278251 fq.gz 1.1 GB
EGAF00005278252 fq.gz 794.6 MB
EGAF00005278253 fq.gz 813.2 MB
EGAF00005278254 fq.gz 361.4 MB
EGAF00005278255 fq.gz 414.4 MB
EGAF00005278256 fq.gz 3.2 GB
EGAF00005278257 fq.gz 3.5 GB
EGAF00005278258 fq.gz 974.1 MB
EGAF00005278259 fq.gz 992.2 MB
EGAF00005278260 fq.gz 303.6 MB
EGAF00005278261 fq.gz 386.3 MB
EGAF00005278262 fq.gz 929.9 MB
EGAF00005278263 fq.gz 957.1 MB
EGAF00005278264 fq.gz 937.4 MB
EGAF00005278265 fq.gz 986.7 MB
EGAF00005278266 fq.gz 298.3 MB
EGAF00005278267 fq.gz 370.8 MB
EGAF00005278268 fq.gz 269.0 MB
EGAF00005278269 fq.gz 313.6 MB
EGAF00005278270 fq.gz 429.1 MB
EGAF00005278271 fq.gz 483.6 MB
EGAF00005278272 fq.gz 353.4 MB
EGAF00005278273 fq.gz 422.5 MB
EGAF00005278274 fq.gz 2.3 GB
EGAF00005278275 fq.gz 2.4 GB
EGAF00005278276 fq.gz 222.5 MB
EGAF00005278277 fq.gz 248.4 MB
EGAF00005278278 fq.gz 304.2 MB
EGAF00005278279 fq.gz 346.9 MB
EGAF00005278280 fq.gz 316.6 MB
EGAF00005278281 fq.gz 368.7 MB
EGAF00005278282 fq.gz 265.0 MB
EGAF00005278283 fq.gz 324.9 MB
EGAF00005278284 fq.gz 1.0 GB
EGAF00005278285 fq.gz 1.1 GB
EGAF00005278286 fq.gz 301.4 MB
EGAF00005278287 fq.gz 393.9 MB
EGAF00005278288 fq.gz 2.8 GB
EGAF00005278289 fq.gz 3.0 GB
EGAF00005278290 fq.gz 1.0 GB
EGAF00005278291 fq.gz 1.1 GB
EGAF00005278292 fq.gz 377.1 MB
EGAF00005278293 fq.gz 432.8 MB
EGAF00005278294 fq.gz 1.7 GB
EGAF00005278295 fq.gz 1.7 GB
EGAF00005278296 fq.gz 263.9 MB
EGAF00005278297 fq.gz 318.8 MB
EGAF00005278298 fq.gz 250.9 MB
EGAF00005278299 fq.gz 287.0 MB
EGAF00005278300 fq.gz 2.0 GB
EGAF00005278301 fq.gz 2.0 GB
EGAF00005278302 fq.gz 342.3 MB
EGAF00005278303 fq.gz 358.2 MB
EGAF00005278304 fq.gz 1.1 GB
EGAF00005278305 fq.gz 1.1 GB
EGAF00005278306 fq.gz 336.0 MB
EGAF00005278307 fq.gz 402.3 MB
EGAF00005278308 fq.gz 416.4 MB
EGAF00005278309 fq.gz 467.1 MB
EGAF00005278310 fq.gz 2.5 GB
EGAF00005278311 fq.gz 2.5 GB
EGAF00005278312 fq.gz 1.1 GB
EGAF00005278313 fq.gz 1.1 GB
EGAF00005278314 fq.gz 434.6 MB
EGAF00005278315 fq.gz 477.7 MB
EGAF00005278316 fq.gz 257.8 MB
EGAF00005278317 fq.gz 298.7 MB
EGAF00005278318 fq.gz 178.1 MB
EGAF00005278319 fq.gz 176.8 MB
EGAF00005278320 fq.gz 1.7 GB
EGAF00005278321 fq.gz 1.8 GB
EGAF00005278322 fq.gz 1.7 GB
EGAF00005278323 fq.gz 1.7 GB
EGAF00005278324 fq.gz 314.8 MB
EGAF00005278325 fq.gz 390.1 MB
EGAF00005278326 fq.gz 2.1 GB
EGAF00005278327 fq.gz 2.1 GB
EGAF00005278328 fq.gz 2.0 GB
EGAF00005278329 fq.gz 2.0 GB
EGAF00005278330 fq.gz 592.5 MB
EGAF00005278331 fq.gz 654.8 MB
EGAF00005278332 fq.gz 2.7 GB
EGAF00005278333 fq.gz 3.0 GB
EGAF00005278334 fq.gz 2.0 GB
EGAF00005278335 fq.gz 2.1 GB
EGAF00005278336 fq.gz 2.6 GB
EGAF00005278337 fq.gz 2.6 GB
EGAF00005278338 fq.gz 242.2 MB
EGAF00005278339 fq.gz 267.9 MB
EGAF00005278340 fq.gz 767.5 MB
EGAF00005278341 fq.gz 893.9 MB
EGAF00005278342 fq.gz 988.6 MB
EGAF00005278343 fq.gz 996.0 MB
EGAF00005278344 fq.gz 342.7 MB
EGAF00005278345 fq.gz 450.8 MB
EGAF00005278346 fq.gz 399.2 MB
EGAF00005278347 fq.gz 458.7 MB
EGAF00005278348 fq.gz 450.2 MB
EGAF00005278349 fq.gz 496.3 MB
EGAF00005278350 fq.gz 646.1 MB
EGAF00005278351 fq.gz 660.7 MB
EGAF00005278352 fq.gz 256.7 MB
EGAF00005278353 fq.gz 311.8 MB
EGAF00005278354 fq.gz 296.8 MB
EGAF00005278355 fq.gz 324.3 MB
EGAF00005278356 fq.gz 298.6 MB
EGAF00005278357 fq.gz 352.5 MB
EGAF00005278358 fq.gz 812.4 MB
EGAF00005278359 fq.gz 858.8 MB
EGAF00005278360 fq.gz 1.3 GB
EGAF00005278361 fq.gz 1.3 GB
EGAF00005278362 fq.gz 898.9 MB
EGAF00005278363 fq.gz 948.0 MB
EGAF00005278364 fq.gz 1.2 GB
EGAF00005278365 fq.gz 1.3 GB
EGAF00005278366 fq.gz 211.7 MB
EGAF00005278367 fq.gz 227.0 MB
EGAF00005278368 fq.gz 404.1 MB
EGAF00005278369 fq.gz 466.5 MB
EGAF00005278370 fq.gz 331.6 MB
EGAF00005278371 fq.gz 384.7 MB
EGAF00005278372 fq.gz 1.2 GB
EGAF00005278373 fq.gz 1.2 GB
EGAF00005278374 fq.gz 2.0 GB
EGAF00005278375 fq.gz 2.0 GB
EGAF00005278376 fq.gz 371.0 MB
EGAF00005278377 fq.gz 418.7 MB
EGAF00005278378 fq.gz 286.7 MB
EGAF00005278379 fq.gz 345.1 MB
EGAF00005278380 fq.gz 1.7 GB
EGAF00005278381 fq.gz 1.8 GB
EGAF00005278382 fq.gz 268.8 MB
EGAF00005278383 fq.gz 330.1 MB
EGAF00005278384 fq.gz 295.6 MB
EGAF00005278385 fq.gz 342.4 MB
EGAF00005278386 fq.gz 1.4 GB
EGAF00005278387 fq.gz 1.3 GB
EGAF00005278388 fq.gz 370.1 MB
EGAF00005278389 fq.gz 416.4 MB
EGAF00005278390 fq.gz 319.6 MB
EGAF00005278391 fq.gz 351.0 MB
EGAF00005278392 fq.gz 2.9 GB
EGAF00005278393 fq.gz 3.2 GB
EGAF00005278394 fq.gz 1.8 GB
EGAF00005278395 fq.gz 1.8 GB
EGAF00005278396 fq.gz 288.1 MB
EGAF00005278397 fq.gz 358.4 MB
EGAF00005278398 fq.gz 2.7 GB
EGAF00005278399 fq.gz 3.1 GB
EGAF00005278400 fq.gz 3.6 GB
EGAF00005278401 fq.gz 3.8 GB
EGAF00005278402 fq.gz 839.1 MB
EGAF00005278403 fq.gz 893.1 MB
EGAF00005278404 fq.gz 209.3 MB
EGAF00005278405 fq.gz 245.7 MB
EGAF00005278406 fq.gz 1.2 GB
EGAF00005278407 fq.gz 1.2 GB
EGAF00005278408 fq.gz 288.2 MB
EGAF00005278409 fq.gz 352.1 MB
EGAF00005278410 fq.gz 1.3 GB
EGAF00005278411 fq.gz 1.4 GB
EGAF00005278412 fq.gz 2.5 GB
EGAF00005278413 fq.gz 2.9 GB
EGAF00005278414 fq.gz 288.1 MB
EGAF00005278415 fq.gz 349.5 MB
EGAF00005278416 fq.gz 1.0 GB
EGAF00005278417 fq.gz 1.1 GB
EGAF00005278418 fq.gz 316.6 MB
EGAF00005278419 fq.gz 324.6 MB
EGAF00005278420 fq.gz 293.0 MB
EGAF00005278421 fq.gz 355.4 MB
EGAF00005278422 fq.gz 506.8 MB
EGAF00005278423 fq.gz 608.7 MB
EGAF00005278424 fq.gz 1.6 GB
EGAF00005278425 fq.gz 1.6 GB
EGAF00005278426 fq.gz 323.9 MB
EGAF00005278427 fq.gz 376.0 MB
EGAF00005278428 fq.gz 2.6 GB
EGAF00005278429 fq.gz 2.8 GB
EGAF00005278430 fq.gz 2.9 GB
EGAF00005278431 fq.gz 3.1 GB
EGAF00005278432 fq.gz 465.5 MB
EGAF00005278433 fq.gz 490.2 MB
EGAF00005278434 fq.gz 303.2 MB
EGAF00005278435 fq.gz 381.6 MB
EGAF00005278436 fq.gz 985.0 MB
EGAF00005278437 fq.gz 988.6 MB
EGAF00005278438 fq.gz 259.6 MB
EGAF00005278439 fq.gz 316.0 MB
EGAF00005278440 fq.gz 283.2 MB
EGAF00005278441 fq.gz 362.4 MB
EGAF00005278442 fq.gz 307.3 MB
EGAF00005278443 fq.gz 357.1 MB
EGAF00005278444 fq.gz 2.0 GB
EGAF00005278445 fq.gz 2.1 GB
EGAF00005278446 fq.gz 2.9 GB
EGAF00005278447 fq.gz 3.1 GB
EGAF00005278448 fq.gz 1.2 GB
EGAF00005278449 fq.gz 1.3 GB
EGAF00005278450 fq.gz 282.8 MB
EGAF00005278451 fq.gz 341.4 MB
EGAF00005278452 fq.gz 2.5 GB
EGAF00005278453 fq.gz 2.6 GB
EGAF00005278454 fq.gz 845.3 MB
EGAF00005278455 fq.gz 863.7 MB
EGAF00005278456 fq.gz 271.6 MB
EGAF00005278457 fq.gz 332.2 MB
EGAF00005278458 fq.gz 265.7 MB
EGAF00005278459 fq.gz 296.5 MB
EGAF00005278460 fq.gz 285.3 MB
EGAF00005278461 fq.gz 351.5 MB
EGAF00005278462 fq.gz 328.9 MB
EGAF00005278463 fq.gz 400.5 MB
EGAF00005278464 fq.gz 2.0 GB
EGAF00005278465 fq.gz 2.0 GB
EGAF00005278466 fq.gz 287.7 MB
EGAF00005278467 fq.gz 344.7 MB
EGAF00005278468 fq.gz 2.7 GB
EGAF00005278469 fq.gz 3.0 GB
EGAF00005278470 fq.gz 295.1 MB
EGAF00005278471 fq.gz 377.0 MB
EGAF00005278472 fq.gz 292.1 MB
EGAF00005278473 fq.gz 344.4 MB
EGAF00005278474 fq.gz 418.3 MB
EGAF00005278475 fq.gz 423.5 MB
EGAF00005278476 fq.gz 315.8 MB
EGAF00005278477 fq.gz 392.2 MB
EGAF00005278478 fq.gz 692.2 MB
EGAF00005278479 fq.gz 727.2 MB
EGAF00005278480 fq.gz 288.2 MB
EGAF00005278481 fq.gz 357.3 MB
EGAF00005278482 fq.gz 875.0 MB
EGAF00005278483 fq.gz 884.1 MB
EGAF00005278484 fq.gz 268.2 MB
EGAF00005278485 fq.gz 339.8 MB
EGAF00005278486 fq.gz 363.4 MB
EGAF00005278487 fq.gz 390.1 MB
EGAF00005278488 fq.gz 824.2 MB
EGAF00005278489 fq.gz 835.3 MB
EGAF00005278490 fq.gz 3.8 GB
EGAF00005278491 fq.gz 4.1 GB
EGAF00005278492 fq.gz 357.6 MB
EGAF00005278493 fq.gz 353.5 MB
EGAF00005278494 fq.gz 287.5 MB
EGAF00005278495 fq.gz 346.9 MB
EGAF00005278496 fq.gz 278.0 MB
EGAF00005278497 fq.gz 335.5 MB
EGAF00005278498 fq.gz 1.2 GB
EGAF00005278499 fq.gz 1.2 GB
EGAF00005278500 fq.gz 363.5 MB
EGAF00005278501 fq.gz 431.9 MB
EGAF00005278502 fq.gz 241.6 MB
EGAF00005278503 fq.gz 287.4 MB
EGAF00005278504 fq.gz 428.7 MB
EGAF00005278505 fq.gz 472.3 MB
EGAF00005278506 fq.gz 396.2 MB
EGAF00005278507 fq.gz 447.3 MB
EGAF00005278508 fq.gz 281.1 MB
EGAF00005278509 fq.gz 296.4 MB
EGAF00005278510 fq.gz 292.0 MB
EGAF00005278511 fq.gz 353.4 MB
EGAF00005278512 fq.gz 899.3 MB
EGAF00005278513 fq.gz 951.2 MB
EGAF00005278514 fq.gz 890.5 MB
EGAF00005278515 fq.gz 937.8 MB
EGAF00005278516 fq.gz 252.9 MB
EGAF00005278517 fq.gz 306.8 MB
EGAF00005278518 fq.gz 1.1 GB
EGAF00005278519 fq.gz 1.1 GB
EGAF00005278520 fq.gz 1.1 GB
EGAF00005278521 fq.gz 1.1 GB
EGAF00005278522 fq.gz 292.8 MB
EGAF00005278523 fq.gz 340.4 MB
292 Files (286.4 GB)