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atrial appendage miRNA-seq in non-, paroxysmal and persistent atrial fibrillation

64 left atrial appendages from patients without atrial fibrillation (AF) undergoing cardiac surgery, patients with paroxysmal AF and with persistent AF (~20 per group). Trizol RNA isolation, size selection, single end miRNA sequencing on 4 lanes of illumina NextSeq 500. Provided are FastQ files, one per lane per sample. Additional data (e.g. clinical characteristics, RIN values etc.) can be provided upon request. The same RNA samples (62) were used for transcriptome sequencing. Results from transcriptome sequencing are stored in the EGA database and are managed by the same DAC.

Request Access

Adjusted standard DAA as for RNA seq data

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Amsterdam University Medical Center, Heart Center grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Amsterdam University Medical Center, Heart Center and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project or once the end of the term of data access is reached, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the Amsterdam University Medical Center, Heart Center within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the Amsterdam University Medical Center, Heart Center prior to any significant changes to the aims or protocol for the Project. 14. The User Institution will notify the Amsterdam University Medical Center, Heart Center as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The Amsterdam University Medical Center, Heart Center may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the Amsterdam University Medical Center, Heart Center. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. 20. The term of data access is terminated after 4 years unless an extension request is approved. The User Institution aims to finish the project for which the data is being used within 4 years since the day from which the access to the data was granted. A request for an extension of this period may be submitted to the Amsterdam University Medical Center, Heart Center no more than a month prior to the end of the agreement period. 21. The User Institution will notify the Amsterdam University Medical Center, Heart Center yearly about the progress of the project. This report should explain how the data is used, i.e., the dissemination of the data, such as in conferences or reports, and the progress achieved from the utilization of these data. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for the Amsterdam University Medical Center, Heart Center Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) Name of project that created the dataset Names of other data producers/collaborators Specific limitations on areas of research The application or amendments may be rejected if the use of the data by the User Institution presents a competing interest for research performed by the Amsterdam University Medical Center, Heart Center. Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used, including project aims (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY The Amsterdam University Medical Center, Heart Center intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The Amsterdam University Medical Center, Heart Center anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 8 months after these data were first made available on the relevant hosting database, unless The Amsterdam University Medical Center, Heart Center has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with The Amsterdam University Medical Center, Heart Center.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005296 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005296114 fastq.gz 80.4 MB
EGAF00005296115 fastq.gz 86.3 MB
EGAF00005296116 fastq.gz 102.8 MB
EGAF00005296117 fastq.gz 102.5 MB
EGAF00005296118 fastq.gz 100.1 MB
EGAF00005296119 fastq.gz 74.3 MB
EGAF00005296120 fastq.gz 73.5 MB
EGAF00005296121 fastq.gz 75.1 MB
EGAF00005296122 fastq.gz 130.9 MB
EGAF00005296123 fastq.gz 128.4 MB
EGAF00005296124 fastq.gz 127.9 MB
EGAF00005296125 fastq.gz 127.5 MB
EGAF00005296126 fastq.gz 125.0 MB
EGAF00005296127 fastq.gz 99.9 MB
EGAF00005296128 fastq.gz 100.8 MB
EGAF00005296129 fastq.gz 76.8 MB
EGAF00005296130 fastq.gz 102.4 MB
EGAF00005296131 fastq.gz 126.1 MB
EGAF00005296132 fastq.gz 88.5 MB
EGAF00005296133 fastq.gz 128.7 MB
EGAF00005296134 fastq.gz 90.6 MB
EGAF00005296135 fastq.gz 87.7 MB
EGAF00005296136 fastq.gz 93.2 MB
EGAF00005296137 fastq.gz 83.7 MB
EGAF00005296138 fastq.gz 84.3 MB
EGAF00005296139 fastq.gz 117.9 MB
EGAF00005296140 fastq.gz 74.9 MB
EGAF00005296141 fastq.gz 89.5 MB
EGAF00005296142 fastq.gz 76.6 MB
EGAF00005296143 fastq.gz 92.2 MB
EGAF00005296144 fastq.gz 76.7 MB
EGAF00005296145 fastq.gz 90.5 MB
EGAF00005296146 fastq.gz 117.3 MB
EGAF00005296147 fastq.gz 117.0 MB
EGAF00005296148 fastq.gz 120.8 MB
EGAF00005296149 fastq.gz 115.7 MB
EGAF00005296150 fastq.gz 118.0 MB
EGAF00005296151 fastq.gz 118.9 MB
EGAF00005296152 fastq.gz 86.0 MB
EGAF00005296153 fastq.gz 89.3 MB
EGAF00005296154 fastq.gz 73.8 MB
EGAF00005296155 fastq.gz 85.7 MB
EGAF00005296156 fastq.gz 75.7 MB
EGAF00005296157 fastq.gz 101.6 MB
EGAF00005296158 fastq.gz 76.1 MB
EGAF00005296159 fastq.gz 98.9 MB
EGAF00005296160 fastq.gz 74.6 MB
EGAF00005296161 fastq.gz 75.2 MB
EGAF00005296162 fastq.gz 96.7 MB
EGAF00005296163 fastq.gz 97.3 MB
EGAF00005296164 fastq.gz 92.8 MB
EGAF00005296165 fastq.gz 89.9 MB
EGAF00005296166 fastq.gz 71.5 MB
EGAF00005296167 fastq.gz 91.8 MB
EGAF00005296168 fastq.gz 90.5 MB
EGAF00005296169 fastq.gz 106.3 MB
EGAF00005296170 fastq.gz 109.1 MB
EGAF00005296171 fastq.gz 91.5 MB
EGAF00005296172 fastq.gz 110.1 MB
EGAF00005296173 fastq.gz 109.8 MB
EGAF00005296174 fastq.gz 113.6 MB
EGAF00005296175 fastq.gz 118.5 MB
EGAF00005296176 fastq.gz 88.4 MB
EGAF00005296177 fastq.gz 118.5 MB
EGAF00005296178 fastq.gz 116.1 MB
EGAF00005296179 fastq.gz 82.0 MB
EGAF00005296180 fastq.gz 81.8 MB
EGAF00005296181 fastq.gz 95.4 MB
EGAF00005296182 fastq.gz 99.5 MB
EGAF00005296183 fastq.gz 100.2 MB
EGAF00005296184 fastq.gz 74.2 MB
EGAF00005296185 fastq.gz 95.0 MB
EGAF00005296186 fastq.gz 87.2 MB
EGAF00005296187 fastq.gz 71.6 MB
EGAF00005296188 fastq.gz 69.7 MB
EGAF00005296189 fastq.gz 99.9 MB
EGAF00005296190 fastq.gz 100.9 MB
EGAF00005296191 fastq.gz 98.2 MB
EGAF00005296192 fastq.gz 46.8 MB
EGAF00005296193 fastq.gz 84.5 MB
EGAF00005296194 fastq.gz 87.4 MB
EGAF00005296195 fastq.gz 89.3 MB
EGAF00005296196 fastq.gz 100.3 MB
EGAF00005296197 fastq.gz 82.6 MB
EGAF00005296198 fastq.gz 99.9 MB
EGAF00005296199 fastq.gz 85.1 MB
EGAF00005296200 fastq.gz 91.3 MB
EGAF00005296201 fastq.gz 83.0 MB
EGAF00005296202 fastq.gz 101.9 MB
EGAF00005296203 fastq.gz 104.0 MB
EGAF00005296204 fastq.gz 124.9 MB
EGAF00005296205 fastq.gz 97.2 MB
EGAF00005296206 fastq.gz 121.6 MB
EGAF00005296207 fastq.gz 99.0 MB
EGAF00005296208 fastq.gz 101.7 MB
EGAF00005296209 fastq.gz 92.8 MB
EGAF00005296210 fastq.gz 95.6 MB
EGAF00005296211 fastq.gz 74.0 MB
EGAF00005296212 fastq.gz 86.5 MB
EGAF00005296213 fastq.gz 83.9 MB
EGAF00005296214 fastq.gz 72.7 MB
EGAF00005296215 fastq.gz 71.1 MB
EGAF00005296216 fastq.gz 84.5 MB
EGAF00005296217 fastq.gz 84.2 MB
EGAF00005296218 fastq.gz 86.0 MB
EGAF00005296219 fastq.gz 86.8 MB
EGAF00005296220 fastq.gz 92.0 MB
EGAF00005296221 fastq.gz 94.1 MB
EGAF00005296222 fastq.gz 147.1 MB
EGAF00005296223 fastq.gz 148.0 MB
EGAF00005296224 fastq.gz 56.8 MB
EGAF00005296225 fastq.gz 143.9 MB
EGAF00005296226 fastq.gz 95.0 MB
EGAF00005296227 fastq.gz 56.6 MB
EGAF00005296228 fastq.gz 98.0 MB
EGAF00005296229 fastq.gz 97.1 MB
EGAF00005296230 fastq.gz 97.8 MB
EGAF00005296231 fastq.gz 103.5 MB
EGAF00005296232 fastq.gz 119.7 MB
EGAF00005296233 fastq.gz 94.4 MB
EGAF00005296234 fastq.gz 91.7 MB
EGAF00005296235 fastq.gz 69.6 MB
EGAF00005296236 fastq.gz 120.2 MB
EGAF00005296237 fastq.gz 122.7 MB
EGAF00005296238 fastq.gz 83.7 MB
EGAF00005296239 fastq.gz 85.3 MB
EGAF00005296240 fastq.gz 118.9 MB
EGAF00005296241 fastq.gz 122.6 MB
EGAF00005296242 fastq.gz 84.7 MB
EGAF00005296243 fastq.gz 127.4 MB
EGAF00005296244 fastq.gz 86.6 MB
EGAF00005296245 fastq.gz 103.9 MB
EGAF00005296246 fastq.gz 92.8 MB
EGAF00005296247 fastq.gz 91.9 MB
EGAF00005296248 fastq.gz 90.1 MB
EGAF00005296249 fastq.gz 90.7 MB
EGAF00005296250 fastq.gz 118.0 MB
EGAF00005296251 fastq.gz 120.2 MB
EGAF00005296252 fastq.gz 90.0 MB
EGAF00005296253 fastq.gz 104.6 MB
EGAF00005296254 fastq.gz 108.3 MB
EGAF00005296255 fastq.gz 106.5 MB
EGAF00005296256 fastq.gz 116.7 MB
EGAF00005296257 fastq.gz 131.3 MB
EGAF00005296258 fastq.gz 114.3 MB
EGAF00005296259 fastq.gz 69.2 MB
EGAF00005296260 fastq.gz 84.9 MB
EGAF00005296261 fastq.gz 105.5 MB
EGAF00005296262 fastq.gz 113.1 MB
EGAF00005296263 fastq.gz 87.3 MB
EGAF00005296264 fastq.gz 127.4 MB
EGAF00005296265 fastq.gz 85.5 MB
EGAF00005296266 fastq.gz 61.7 MB
EGAF00005296267 fastq.gz 62.5 MB
EGAF00005296268 fastq.gz 123.4 MB
EGAF00005296269 fastq.gz 120.4 MB
EGAF00005296270 fastq.gz 86.3 MB
EGAF00005296271 fastq.gz 122.9 MB
EGAF00005296272 fastq.gz 84.8 MB
EGAF00005296273 fastq.gz 115.4 MB
EGAF00005296274 fastq.gz 82.5 MB
EGAF00005296275 fastq.gz 124.3 MB
EGAF00005296276 fastq.gz 87.5 MB
EGAF00005296277 fastq.gz 63.0 MB
EGAF00005296278 fastq.gz 112.4 MB
EGAF00005296279 fastq.gz 108.3 MB
EGAF00005296280 fastq.gz 112.3 MB
EGAF00005296281 fastq.gz 120.0 MB
EGAF00005296282 fastq.gz 78.5 MB
EGAF00005296283 fastq.gz 79.6 MB
EGAF00005296284 fastq.gz 124.8 MB
EGAF00005296285 fastq.gz 77.2 MB
EGAF00005296286 fastq.gz 72.8 MB
EGAF00005296287 fastq.gz 74.9 MB
EGAF00005296288 fastq.gz 115.1 MB
EGAF00005296289 fastq.gz 128.8 MB
EGAF00005296290 fastq.gz 129.9 MB
EGAF00005296291 fastq.gz 76.0 MB
EGAF00005296292 fastq.gz 73.3 MB
EGAF00005296293 fastq.gz 126.5 MB
EGAF00005296294 fastq.gz 74.8 MB
EGAF00005296295 fastq.gz 107.9 MB
EGAF00005296296 fastq.gz 79.7 MB
EGAF00005296297 fastq.gz 75.1 MB
EGAF00005296298 fastq.gz 77.0 MB
EGAF00005296299 fastq.gz 91.4 MB
EGAF00005296300 fastq.gz 109.7 MB
EGAF00005296301 fastq.gz 104.8 MB
EGAF00005296302 fastq.gz 142.0 MB
EGAF00005296303 fastq.gz 96.0 MB
EGAF00005296304 fastq.gz 58.0 MB
EGAF00005296305 fastq.gz 58.5 MB
EGAF00005296306 fastq.gz 94.8 MB
EGAF00005296307 fastq.gz 93.2 MB
EGAF00005296308 fastq.gz 116.9 MB
EGAF00005296309 fastq.gz 123.9 MB
EGAF00005296310 fastq.gz 90.4 MB
EGAF00005296311 fastq.gz 71.7 MB
EGAF00005296312 fastq.gz 70.3 MB
EGAF00005296313 fastq.gz 71.7 MB
EGAF00005296314 fastq.gz 88.4 MB
EGAF00005296315 fastq.gz 85.3 MB
EGAF00005296316 fastq.gz 87.4 MB
EGAF00005296317 fastq.gz 84.0 MB
EGAF00005296318 fastq.gz 123.6 MB
EGAF00005296319 fastq.gz 76.2 MB
EGAF00005296320 fastq.gz 94.5 MB
EGAF00005296321 fastq.gz 94.0 MB
EGAF00005296322 fastq.gz 68.0 MB
EGAF00005296323 fastq.gz 69.3 MB
EGAF00005296324 fastq.gz 67.3 MB
EGAF00005296325 fastq.gz 70.4 MB
EGAF00005296326 fastq.gz 72.6 MB
EGAF00005296327 fastq.gz 90.4 MB
EGAF00005296328 fastq.gz 93.3 MB
EGAF00005296329 fastq.gz 88.3 MB
EGAF00005296330 fastq.gz 48.4 MB
EGAF00005296331 fastq.gz 106.4 MB
EGAF00005296332 fastq.gz 106.1 MB
EGAF00005296333 fastq.gz 49.1 MB
EGAF00005296334 fastq.gz 104.0 MB
EGAF00005296335 fastq.gz 47.5 MB
EGAF00005296336 fastq.gz 120.1 MB
EGAF00005296337 fastq.gz 121.4 MB
EGAF00005296338 fastq.gz 91.2 MB
EGAF00005296339 fastq.gz 96.0 MB
EGAF00005296340 fastq.gz 90.3 MB
EGAF00005296341 fastq.gz 103.6 MB
EGAF00005296342 fastq.gz 117.4 MB
EGAF00005296343 fastq.gz 139.1 MB
EGAF00005296344 fastq.gz 142.0 MB
EGAF00005296345 fastq.gz 76.0 MB
EGAF00005296346 fastq.gz 137.2 MB
EGAF00005296347 fastq.gz 143.6 MB
EGAF00005296348 fastq.gz 92.5 MB
EGAF00005296349 fastq.gz 61.6 MB
EGAF00005296350 fastq.gz 70.3 MB
EGAF00005296351 fastq.gz 97.5 MB
EGAF00005296352 fastq.gz 81.9 MB
EGAF00005296353 fastq.gz 98.1 MB
EGAF00005296354 fastq.gz 96.9 MB
EGAF00005296355 fastq.gz 92.9 MB
EGAF00005296356 fastq.gz 97.5 MB
EGAF00005296357 fastq.gz 92.0 MB
EGAF00005296358 fastq.gz 97.0 MB
EGAF00005296359 fastq.gz 83.8 MB
EGAF00005296360 fastq.gz 94.8 MB
EGAF00005296361 fastq.gz 96.1 MB
248 Files (23.8 GB)