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Alloreactive T-cell receptor (TCR) repertoire in kidney transplantation

We analyzed the T-cell receptor (TCR) repertoires from twelve kidney transplant recipients. Six out of the twelve kidney transplant recipients experienced a cellular rejection after kidney transplantation. TCR repertoires of CD4+ and CD8+ positive T-cells were assessed prior to transplantation and after transplantation at time of allograft biopsy using RNA based T-cell receptor beta next generation sequencing (NGS). In addition, the pre-formed alloreactive TCR repertoire for each kidney transplant recipient was identified using mixed lymphocyte reaction and donor reactive T-cells were subjected to TCR beta sequencing. In two out of the six patients with cellular rejection the TCR repertoire of graft infiltrating T-cells was additionally captured. This dataset comprises a total of 98 samples. NGS TCR beta libraries of all samples were sequenced on an Illumina NextSeq 500 and raw sequencing data (in the form of fastq files) as well assembled clonotypes and their counts (in the form of clonotype tables) are provided.

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Study ID Study Title Study Type
EGAS00001005299 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005298853 fastq.gz 286.8 MB
EGAF00005298854 fastq.gz 460.1 MB
EGAF00005298855 fastq.gz 500.2 MB
EGAF00005298856 fastq.gz 736.5 MB
EGAF00005298857 fastq.gz 491.7 MB
EGAF00005298858 fastq.gz 740.8 MB
EGAF00005298859 fastq.gz 369.1 MB
EGAF00005298860 fastq.gz 512.7 MB
EGAF00005298861 fastq.gz 1.9 kB
EGAF00005298862 fastq.gz 2.5 kB
EGAF00005298863 fastq.gz 360.8 MB
EGAF00005298864 fastq.gz 531.5 MB
EGAF00005298865 fastq.gz 482.1 MB
EGAF00005298866 fastq.gz 683.5 MB
EGAF00005298867 fastq.gz 460.2 MB
EGAF00005298868 fastq.gz 619.5 MB
EGAF00005298869 fastq.gz 389.3 MB
EGAF00005298870 fastq.gz 587.9 MB
EGAF00005298871 fastq.gz 583.3 MB
EGAF00005298872 fastq.gz 814.4 MB
EGAF00005298873 fastq.gz 414.4 MB
EGAF00005298874 fastq.gz 639.9 MB
EGAF00005298875 fastq.gz 979.1 MB
EGAF00005298876 fastq.gz 1.5 GB
EGAF00005298877 fastq.gz 324.4 MB
EGAF00005298878 fastq.gz 485.6 MB
EGAF00005298879 fastq.gz 27.4 MB
EGAF00005298880 fastq.gz 37.6 MB
EGAF00005298881 fastq.gz 342.6 MB
EGAF00005298882 fastq.gz 511.1 MB
EGAF00005298883 fastq.gz 448.2 MB
EGAF00005298884 fastq.gz 744.4 MB
EGAF00005298885 fastq.gz 429.8 MB
EGAF00005298886 fastq.gz 636.7 MB
EGAF00005298887 fastq.gz 392.9 MB
EGAF00005298888 fastq.gz 648.8 MB
EGAF00005298889 fastq.gz 232.3 MB
EGAF00005298890 fastq.gz 340.2 MB
EGAF00005298891 fastq.gz 477.2 MB
EGAF00005298892 fastq.gz 759.7 MB
EGAF00005298893 fastq.gz 256.1 MB
EGAF00005298894 fastq.gz 360.4 MB
EGAF00005298895 fastq.gz 466.4 MB
EGAF00005298896 fastq.gz 710.2 MB
EGAF00005298897 fastq.gz 228.1 MB
EGAF00005298898 fastq.gz 366.5 MB
EGAF00005298899 fastq.gz 242.9 MB
EGAF00005298900 fastq.gz 376.0 MB
EGAF00005298901 fastq.gz 416.6 MB
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EGAF00005298903 fastq.gz 334.0 MB
EGAF00005298904 fastq.gz 442.1 MB
EGAF00005298905 fastq.gz 327.0 MB
EGAF00005298906 fastq.gz 468.1 MB
EGAF00005298907 fastq.gz 274.7 MB
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EGAF00005298909 fastq.gz 420.3 MB
EGAF00005298910 fastq.gz 583.2 MB
EGAF00005298911 fastq.gz 418.6 MB
EGAF00005298912 fastq.gz 641.0 MB
EGAF00005298913 fastq.gz 423.7 MB
EGAF00005298914 fastq.gz 660.3 MB
EGAF00005298915 fastq.gz 326.1 MB
EGAF00005298916 fastq.gz 482.5 MB
EGAF00005298917 fastq.gz 416.1 MB
EGAF00005298918 fastq.gz 633.2 MB
EGAF00005298919 fastq.gz 390.8 MB
EGAF00005298920 fastq.gz 594.9 MB
EGAF00005298921 fastq.gz 475.4 MB
EGAF00005298922 fastq.gz 735.5 MB
EGAF00005298923 fastq.gz 300.7 MB
EGAF00005298924 fastq.gz 433.6 MB
EGAF00005298925 fastq.gz 327.6 MB
EGAF00005298926 fastq.gz 474.8 MB
EGAF00005298927 fastq.gz 1.2 kB
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EGAF00005298929 fastq.gz 376.4 MB
EGAF00005298930 fastq.gz 522.3 MB
EGAF00005298931 fastq.gz 425.7 MB
EGAF00005298932 fastq.gz 678.3 MB
EGAF00005298933 fastq.gz 350.0 MB
EGAF00005298934 fastq.gz 526.7 MB
EGAF00005298935 fastq.gz 379.9 MB
EGAF00005298936 fastq.gz 604.5 MB
EGAF00005298937 fastq.gz 261.9 MB
EGAF00005298938 fastq.gz 405.5 MB
EGAF00005298939 fastq.gz 402.8 MB
EGAF00005298940 fastq.gz 565.0 MB
EGAF00005298941 fastq.gz 408.9 MB
EGAF00005298942 fastq.gz 607.4 MB
EGAF00005298943 fastq.gz 471.9 MB
EGAF00005298944 fastq.gz 730.8 MB
EGAF00005298945 fastq.gz 455.7 MB
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EGAF00005298950 fastq.gz 709.7 MB
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EGAF00005298952 fastq.gz 687.6 MB
EGAF00005298953 fastq.gz 389.5 MB
EGAF00005298954 fastq.gz 622.9 MB
EGAF00005298955 fastq.gz 489.6 MB
EGAF00005298956 fastq.gz 761.2 MB
EGAF00005298957 fastq.gz 310.7 MB
EGAF00005298958 fastq.gz 470.0 MB
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EGAF00005298960 fastq.gz 792.9 MB
EGAF00005298961 fastq.gz 397.3 MB
EGAF00005298962 fastq.gz 596.2 MB
EGAF00005298963 fastq.gz 393.5 MB
EGAF00005298964 fastq.gz 590.2 MB
EGAF00005298965 fastq.gz 29.9 MB
EGAF00005298966 fastq.gz 40.8 MB
EGAF00005298967 fastq.gz 484.0 MB
EGAF00005298968 fastq.gz 676.1 MB
EGAF00005298969 fastq.gz 623.2 MB
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EGAF00005298971 fastq.gz 455.8 MB
EGAF00005298972 fastq.gz 720.7 MB
EGAF00005298973 fastq.gz 287.9 MB
EGAF00005298974 fastq.gz 383.1 MB
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EGAF00005298977 fastq.gz 287.3 MB
EGAF00005298978 fastq.gz 458.5 MB
EGAF00005298979 fastq.gz 1.2 GB
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EGAF00005298981 fastq.gz 520.0 MB
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EGAF00005298993 fastq.gz 243.7 MB
EGAF00005298994 fastq.gz 362.0 MB
EGAF00005298995 fastq.gz 364.2 MB
EGAF00005298996 fastq.gz 534.5 MB
EGAF00005298997 fastq.gz 434.5 MB
EGAF00005298998 fastq.gz 597.1 MB
EGAF00005298999 fastq.gz 523.7 MB
EGAF00005299000 fastq.gz 762.8 MB
EGAF00005299001 fastq.gz 457.1 MB
EGAF00005299002 fastq.gz 660.5 MB
EGAF00005299003 fastq.gz 425.8 MB
EGAF00005299004 fastq.gz 691.0 MB
EGAF00005299005 fastq.gz 543.0 MB
EGAF00005299006 fastq.gz 818.2 MB
EGAF00005299007 fastq.gz 412.2 MB
EGAF00005299008 fastq.gz 623.9 MB
EGAF00005299009 fastq.gz 483.7 MB
EGAF00005299010 fastq.gz 757.4 MB
EGAF00005299011 fastq.gz 330.8 MB
EGAF00005299012 fastq.gz 472.0 MB
EGAF00005299013 fastq.gz 519.7 MB
EGAF00005299014 fastq.gz 875.4 MB
EGAF00005299015 fastq.gz 442.4 MB
EGAF00005299016 fastq.gz 678.2 MB
EGAF00005299017 fastq.gz 386.3 MB
EGAF00005299018 fastq.gz 607.7 MB
EGAF00005299019 fastq.gz 501.1 MB
EGAF00005299020 fastq.gz 787.8 MB
EGAF00005299021 fastq.gz 271.3 MB
EGAF00005299022 fastq.gz 422.7 MB
EGAF00005299023 fastq.gz 360.8 MB
EGAF00005299024 fastq.gz 553.1 MB
EGAF00005299025 fastq.gz 321.0 MB
EGAF00005299026 fastq.gz 500.1 MB
EGAF00005299027 fastq.gz 364.1 MB
EGAF00005299028 fastq.gz 583.1 MB
EGAF00005299029 fastq.gz 402.8 MB
EGAF00005299030 fastq.gz 646.9 MB
EGAF00005299031 fastq.gz 297.9 MB
EGAF00005299032 fastq.gz 467.4 MB
EGAF00005299033 fastq.gz 537.6 MB
EGAF00005299034 fastq.gz 789.6 MB
EGAF00005299035 fastq.gz 386.4 MB
EGAF00005299036 fastq.gz 564.5 MB
EGAF00005299037 fastq.gz 845.3 MB
EGAF00005299038 fastq.gz 1.3 GB
EGAF00005299039 fastq.gz 291.4 MB
EGAF00005299040 fastq.gz 447.3 MB
EGAF00005299041 fastq.gz 328.6 MB
EGAF00005299042 fastq.gz 526.7 MB
EGAF00005299043 fastq.gz 409.4 MB
EGAF00005299044 fastq.gz 639.4 MB
EGAF00005299045 fastq.gz 605.0 MB
EGAF00005299046 fastq.gz 844.2 MB
EGAF00005299047 fastq.gz 338.1 MB
EGAF00005299048 fastq.gz 530.8 MB
EGAF00005299049 txt 90.4 kB
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294 Files (99.7 GB)