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Alloreactive T-cell receptor (TCR) repertoire in kidney transplantation

We analyzed the T-cell receptor (TCR) repertoires from twelve kidney transplant recipients. Six out of the twelve kidney transplant recipients experienced a cellular rejection after kidney transplantation. TCR repertoires of CD4+ and CD8+ positive T-cells were assessed prior to transplantation and after transplantation at time of allograft biopsy using RNA based T-cell receptor beta next generation sequencing (NGS). In addition, the pre-formed alloreactive TCR repertoire for each kidney transplant recipient was identified using mixed lymphocyte reaction and donor reactive T-cells were subjected to TCR beta sequencing. In two out of the six patients with cellular rejection the TCR repertoire of graft infiltrating T-cells was additionally captured. This dataset comprises a total of 98 samples. NGS TCR beta libraries of all samples were sequenced on an Illumina NextSeq 500 and raw sequencing data (in the form of fastq files) as well assembled clonotypes and their counts (in the form of clonotype tables) are provided.

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Study ID Study Title Study Type
EGAS00001005299 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF00005298853 fastq.gz 286.8 MB Report
EGAF00005298854 fastq.gz 460.1 MB Report
EGAF00005298855 fastq.gz 500.2 MB Report
EGAF00005298856 fastq.gz 736.5 MB Report
EGAF00005298857 fastq.gz 491.7 MB Report
EGAF00005298858 fastq.gz 740.8 MB Report
EGAF00005298859 fastq.gz 369.1 MB Report
EGAF00005298860 fastq.gz 512.7 MB Report
EGAF00005298861 fastq.gz 1.9 kB Report
EGAF00005298862 fastq.gz 2.5 kB Report
EGAF00005298863 fastq.gz 360.8 MB Report
EGAF00005298864 fastq.gz 531.5 MB Report
EGAF00005298865 fastq.gz 482.1 MB Report
EGAF00005298866 fastq.gz 683.5 MB Report
EGAF00005298867 fastq.gz 460.2 MB Report
EGAF00005298868 fastq.gz 619.5 MB Report
EGAF00005298869 fastq.gz 389.3 MB Report
EGAF00005298870 fastq.gz 587.9 MB Report
EGAF00005298871 fastq.gz 583.3 MB Report
EGAF00005298872 fastq.gz 814.4 MB Report
EGAF00005298873 fastq.gz 414.4 MB Report
EGAF00005298874 fastq.gz 639.9 MB Report
EGAF00005298875 fastq.gz 979.1 MB Report
EGAF00005298876 fastq.gz 1.5 GB Report
EGAF00005298877 fastq.gz 324.4 MB Report
EGAF00005298878 fastq.gz 485.6 MB Report
EGAF00005298879 fastq.gz 27.4 MB Report
EGAF00005298880 fastq.gz 37.6 MB Report
EGAF00005298881 fastq.gz 342.6 MB Report
EGAF00005298882 fastq.gz 511.1 MB Report
EGAF00005298883 fastq.gz 448.2 MB Report
EGAF00005298884 fastq.gz 744.4 MB Report
EGAF00005298885 fastq.gz 429.8 MB Report
EGAF00005298886 fastq.gz 636.7 MB Report
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EGAF00005298888 fastq.gz 648.8 MB Report
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EGAF00005298890 fastq.gz 340.2 MB Report
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EGAF00005298899 fastq.gz 242.9 MB Report
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EGAF00005298901 fastq.gz 416.6 MB Report
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EGAF00005298903 fastq.gz 334.0 MB Report
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EGAF00005298926 fastq.gz 474.8 MB Report
EGAF00005298927 fastq.gz 1.2 kB Report
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EGAF00005298929 fastq.gz 376.4 MB Report
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EGAF00005298931 fastq.gz 425.7 MB Report
EGAF00005298932 fastq.gz 678.3 MB Report
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EGAF00005298994 fastq.gz 362.0 MB Report
EGAF00005298995 fastq.gz 364.2 MB Report
EGAF00005298996 fastq.gz 534.5 MB Report
EGAF00005298997 fastq.gz 434.5 MB Report
EGAF00005298998 fastq.gz 597.1 MB Report
EGAF00005298999 fastq.gz 523.7 MB Report
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EGAF00005299012 fastq.gz 472.0 MB Report
EGAF00005299013 fastq.gz 519.7 MB Report
EGAF00005299014 fastq.gz 875.4 MB Report
EGAF00005299015 fastq.gz 442.4 MB Report
EGAF00005299016 fastq.gz 678.2 MB Report
EGAF00005299017 fastq.gz 386.3 MB Report
EGAF00005299018 fastq.gz 607.7 MB Report
EGAF00005299019 fastq.gz 501.1 MB Report
EGAF00005299020 fastq.gz 787.8 MB Report
EGAF00005299021 fastq.gz 271.3 MB Report
EGAF00005299022 fastq.gz 422.7 MB Report
EGAF00005299023 fastq.gz 360.8 MB Report
EGAF00005299024 fastq.gz 553.1 MB Report
EGAF00005299025 fastq.gz 321.0 MB Report
EGAF00005299026 fastq.gz 500.1 MB Report
EGAF00005299027 fastq.gz 364.1 MB Report
EGAF00005299028 fastq.gz 583.1 MB Report
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EGAF00005299033 fastq.gz 537.6 MB Report
EGAF00005299034 fastq.gz 789.6 MB Report
EGAF00005299035 fastq.gz 386.4 MB Report
EGAF00005299036 fastq.gz 564.5 MB Report
EGAF00005299037 fastq.gz 845.3 MB Report
EGAF00005299038 fastq.gz 1.3 GB Report
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EGAF00005299047 fastq.gz 338.1 MB Report
EGAF00005299048 fastq.gz 530.8 MB Report
EGAF00005299049 txt 90.4 kB
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294 Files (99.7 GB)