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Leiomyosarcoma Whole Genome Sequencing

DNA was extracted from fresh frozen LMS material for 29 untreated tumors (24 primary tumors, 5 metastatic 13 relapses) and 13 tumors treated with radiation (7 primaries, 6 metastatic relapses). DNA from matched blood was used as a normal reference. Whole-genome sequencing was performed using established protocols on Illumina instruments.

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Sickkids policy

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom Shlien Lab, at The Hospital for Sick Children grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Shlien Lab, at The Hospital for Sick Children and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Hospital for Sick Children 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify EGA within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify EGA prior to any significant changes to the protocol for the Project. 14. The User Institution will notify EGA as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. EGA may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than EGA. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005341 Whole Genome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005307511 fastq.gz 37.1 GB
EGAF00005307512 fastq.gz 40.6 GB
EGAF00005307513 fastq.gz 36.6 GB
EGAF00005307514 fastq.gz 39.8 GB
EGAF00005307515 fastq.gz 35.6 GB
EGAF00005307516 fastq.gz 39.0 GB
EGAF00005307517 fastq.gz 37.7 GB
EGAF00005307518 fastq.gz 41.5 GB
EGAF00005307519 fastq.gz 37.6 GB
EGAF00005307520 fastq.gz 41.6 GB
EGAF00005307521 fastq.gz 37.4 GB
EGAF00005307522 fastq.gz 41.0 GB
EGAF00005307523 fastq.gz 37.0 GB
EGAF00005307524 fastq.gz 40.7 GB
EGAF00005307525 fastq.gz 39.3 GB
EGAF00005307526 fastq.gz 45.5 GB
EGAF00005307527 fastq.gz 36.6 GB
EGAF00005307528 fastq.gz 41.6 GB
EGAF00005307529 fastq.gz 37.5 GB
EGAF00005307530 fastq.gz 42.3 GB
EGAF00005307531 fastq.gz 40.0 GB
EGAF00005307532 fastq.gz 45.4 GB
EGAF00005307533 fastq.gz 37.4 GB
EGAF00005307534 fastq.gz 40.3 GB
EGAF00005307535 fastq.gz 37.6 GB
EGAF00005307536 fastq.gz 40.6 GB
EGAF00005307537 fastq.gz 35.1 GB
EGAF00005307538 fastq.gz 39.0 GB
EGAF00005307539 fastq.gz 35.6 GB
EGAF00005307540 fastq.gz 40.2 GB
EGAF00005307541 fastq.gz 34.9 GB
EGAF00005307542 fastq.gz 38.6 GB
EGAF00005307543 fastq.gz 34.0 GB
EGAF00005307544 fastq.gz 38.1 GB
EGAF00005307545 fastq.gz 34.8 GB
EGAF00005307546 fastq.gz 38.6 GB
EGAF00005307547 fastq.gz 34.8 GB
EGAF00005307548 fastq.gz 38.7 GB
EGAF00005307549 fastq.gz 42.0 GB
EGAF00005307550 fastq.gz 47.6 GB
EGAF00005307551 fastq.gz 37.1 GB
EGAF00005307552 fastq.gz 41.9 GB
EGAF00005307553 fastq.gz 37.7 GB
EGAF00005307554 fastq.gz 42.9 GB
EGAF00005307555 fastq.gz 36.7 GB
EGAF00005307556 fastq.gz 41.8 GB
EGAF00005307557 fastq.gz 38.3 GB
EGAF00005307558 fastq.gz 43.9 GB
EGAF00005307559 fastq.gz 37.2 GB
EGAF00005307560 fastq.gz 41.9 GB
EGAF00005307561 fastq.gz 35.8 GB
EGAF00005307562 fastq.gz 41.1 GB
EGAF00005307563 fastq.gz 40.5 GB
EGAF00005307564 fastq.gz 45.3 GB
EGAF00005307565 fastq.gz 41.6 GB
EGAF00005307566 fastq.gz 46.6 GB
EGAF00005307567 fastq.gz 39.9 GB
EGAF00005307568 fastq.gz 41.9 GB
EGAF00005307569 fastq.gz 38.7 GB
EGAF00005307570 fastq.gz 40.6 GB
EGAF00005307571 fastq.gz 39.8 GB
EGAF00005307572 fastq.gz 43.5 GB
EGAF00005307573 fastq.gz 38.3 GB
EGAF00005307574 fastq.gz 42.0 GB
EGAF00005307575 fastq.gz 38.7 GB
EGAF00005307576 fastq.gz 43.0 GB
EGAF00005307577 fastq.gz 40.3 GB
EGAF00005307578 fastq.gz 44.0 GB
EGAF00005307579 fastq.gz 39.2 GB
EGAF00005307580 fastq.gz 41.8 GB
EGAF00005307581 fastq.gz 39.3 GB
EGAF00005307582 fastq.gz 42.8 GB
EGAF00005307583 fastq.gz 40.3 GB
EGAF00005307584 fastq.gz 45.2 GB
EGAF00005307585 fastq.gz 38.4 GB
EGAF00005307586 fastq.gz 43.6 GB
EGAF00005307587 fastq.gz 39.1 GB
EGAF00005307588 fastq.gz 43.3 GB
EGAF00005307589 fastq.gz 38.3 GB
EGAF00005307590 fastq.gz 42.3 GB
EGAF00005307591 fastq.gz 38.0 GB
EGAF00005307592 fastq.gz 40.9 GB
EGAF00005307593 fastq.gz 57.0 GB
EGAF00005307594 fastq.gz 60.6 GB
EGAF00005307595 fastq.gz 35.9 GB
EGAF00005307596 fastq.gz 39.7 GB
EGAF00005307597 fastq.gz 35.8 GB
EGAF00005307598 fastq.gz 39.6 GB
EGAF00005307599 fastq.gz 41.0 GB
EGAF00005307600 fastq.gz 41.6 GB
EGAF00005307601 fastq.gz 38.9 GB
EGAF00005307602 fastq.gz 39.4 GB
EGAF00005307603 fastq.gz 36.5 GB
EGAF00005307604 fastq.gz 39.5 GB
EGAF00005307605 fastq.gz 39.0 GB
EGAF00005307606 fastq.gz 44.5 GB
EGAF00005307607 fastq.gz 39.8 GB
EGAF00005307608 fastq.gz 45.5 GB
EGAF00005307609 fastq.gz 42.5 GB
EGAF00005307610 fastq.gz 48.3 GB
EGAF00005307611 fastq.gz 43.5 GB
EGAF00005307612 fastq.gz 48.9 GB
EGAF00005307613 fastq.gz 28.0 GB
EGAF00005307614 fastq.gz 30.8 GB
EGAF00005307615 fastq.gz 28.4 GB
EGAF00005307616 fastq.gz 31.6 GB
EGAF00005307617 fastq.gz 28.0 GB
EGAF00005307618 fastq.gz 30.8 GB
EGAF00005307619 fastq.gz 27.3 GB
EGAF00005307620 fastq.gz 30.0 GB
EGAF00005307621 fastq.gz 37.3 GB
EGAF00005307622 fastq.gz 41.2 GB
EGAF00005307623 fastq.gz 27.2 GB
EGAF00005307624 fastq.gz 30.1 GB
EGAF00005307625 fastq.gz 37.6 GB
EGAF00005307626 fastq.gz 41.1 GB
EGAF00005307627 fastq.gz 39.0 GB
EGAF00005307628 fastq.gz 42.5 GB
EGAF00005307629 fastq.gz 37.9 GB
EGAF00005307630 fastq.gz 40.7 GB
EGAF00005307631 fastq.gz 37.5 GB
EGAF00005307632 fastq.gz 40.2 GB
EGAF00005307633 fastq.gz 28.3 GB
EGAF00005307634 fastq.gz 31.4 GB
EGAF00005307635 fastq.gz 37.6 GB
EGAF00005307636 fastq.gz 41.0 GB
EGAF00005307637 fastq.gz 49.3 GB
EGAF00005307638 fastq.gz 55.3 GB
EGAF00005307639 fastq.gz 39.8 GB
EGAF00005307640 fastq.gz 44.8 GB
EGAF00005307641 fastq.gz 38.7 GB
EGAF00005307642 fastq.gz 43.2 GB
EGAF00005307643 fastq.gz 38.4 GB
EGAF00005307644 fastq.gz 43.3 GB
EGAF00005307645 fastq.gz 38.8 GB
EGAF00005307646 fastq.gz 43.3 GB
EGAF00005307647 fastq.gz 39.5 GB
EGAF00005307648 fastq.gz 44.5 GB
EGAF00005307649 fastq.gz 35.8 GB
EGAF00005307650 fastq.gz 38.8 GB
EGAF00005307651 fastq.gz 37.0 GB
EGAF00005307652 fastq.gz 40.6 GB
EGAF00005307653 fastq.gz 38.7 GB
EGAF00005307654 fastq.gz 42.6 GB
EGAF00005307655 fastq.gz 38.6 GB
EGAF00005307656 fastq.gz 42.8 GB
EGAF00005307657 fastq.gz 38.4 GB
EGAF00005307658 fastq.gz 43.1 GB
EGAF00005307659 fastq.gz 37.8 GB
EGAF00005307660 fastq.gz 41.9 GB
EGAF00005307661 fastq.gz 38.0 GB
EGAF00005307662 fastq.gz 41.2 GB
EGAF00005307663 fastq.gz 35.8 GB
EGAF00005307664 fastq.gz 38.8 GB
EGAF00005307665 fastq.gz 36.8 GB
EGAF00005307666 fastq.gz 40.0 GB
EGAF00005307667 fastq.gz 39.2 GB
EGAF00005307668 fastq.gz 43.2 GB
EGAF00005307669 fastq.gz 38.2 GB
EGAF00005307670 fastq.gz 41.7 GB
EGAF00005307671 fastq.gz 37.9 GB
EGAF00005307672 fastq.gz 41.4 GB
EGAF00005307673 fastq.gz 36.1 GB
EGAF00005307674 fastq.gz 39.1 GB
EGAF00005307675 fastq.gz 36.1 GB
EGAF00005307676 fastq.gz 39.5 GB
EGAF00005307677 fastq.gz 37.1 GB
EGAF00005307678 fastq.gz 40.2 GB
EGAF00005307679 fastq.gz 35.7 GB
EGAF00005307680 fastq.gz 39.8 GB
EGAF00005307681 fastq.gz 37.5 GB
EGAF00005307682 fastq.gz 41.3 GB
EGAF00005307683 fastq.gz 38.1 GB
EGAF00005307684 fastq.gz 41.4 GB
174 Files (6.9 TB)